-
公开(公告)号：US07465825B2
公开(公告)日：2008-12-16
申请号：US11283437
申请日：2005-11-18
IPC分类号： C07C229/00 , C07D333/00 , C07D307/91 , A01N43/12 , A01N43/08
CPC分类号： C07D307/79 , C07C271/22 , C07C311/29 , C07C317/14 , C07C317/32 , C07C323/52 , C07C323/65 , C07C2603/74 , C07D307/91
摘要： Disclosed are compounds and pharmaceutically acceptable salts of formula (A): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译： 公开了式（A）的化合物和药学上可接受的盐：其可用于治疗与胰岛素抵抗，瘦素抗性或高血糖相关的代谢紊乱。 本发明的化合物包括可用于治疗糖尿病和其它PTP介导的疾病如癌症，神经变性疾病等的蛋白质酪氨酸磷酸酶抑制剂，特别是蛋白质酪氨酸磷酸酶-1B（PTP-1B）。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
-
公开(公告)号：US07329680B2
公开(公告)日：2008-02-12
申请号：US10835818
申请日：2004-04-30
IPC分类号： C07D277/38 , A61K31/425
CPC分类号： C07D401/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D417/10 , C07D417/12
摘要： The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译： 本发明涉及式（I）的化合物和药学上可接受的盐：其可用于治疗与胰岛素抵抗，瘦素抵抗或高血糖相关的代谢紊乱。 本发明的化合物包括可用于治疗糖尿病和其它PTP介导的疾病如癌症，神经变性疾病等的蛋白质酪氨酸磷酸酶抑制剂，特别是蛋白质酪氨酸磷酸酶-1B（PTP-1B）。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
-
公开(公告)号：US07524878B2
公开(公告)日：2009-04-28
申请号：US10835924
申请日：2004-04-30
IPC分类号： A61K31/341 , A61K31/404 , C07D209/04 , C07D307/79
CPC分类号： C07D307/79 , C07C311/19 , C07C311/29 , C07D209/08 , C07D307/80 , C07D307/81 , C07D307/91 , C07D401/04
摘要： Disclosed are compounds and pharmaceutically acceptable salts of formula (A): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译： 公开了式（A）的化合物和药学上可接受的盐：其可用于治疗与胰岛素抵抗，瘦素抗性或高血糖相关的代谢紊乱。 本发明的化合物包括可用于治疗糖尿病和其它PTP介导的疾病如癌症，神经变性疾病等的蛋白质酪氨酸磷酸酶抑制剂，特别是蛋白质酪氨酸磷酸酶-1B（PTP-1B）。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
-
公开(公告)号：US20080146574A1
公开(公告)日：2008-06-19
申请号：US12029708
申请日：2008-02-12
IPC分类号： A61K31/53 , A61K31/497 , C07D403/14 , C07D405/10 , C07D239/24 , A61P3/10
CPC分类号： C07D401/14 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D417/10 , C07D417/12
摘要： The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia.Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译： 本发明涉及式（I）的化合物和药学上可接受的盐：其可用于治疗与胰岛素抵抗，瘦素抵抗或高血糖相关的代谢紊乱。 本发明的化合物包括可用于治疗糖尿病和其它PTP介导的疾病如癌症，神经变性疾病等的蛋白质酪氨酸磷酸酶抑制剂，特别是蛋白质酪氨酸磷酸酶-1B（PTP-1B）。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
-
公开(公告)号：US07498356B2
公开(公告)日：2009-03-03
申请号：US11283456
申请日：2005-11-18
IPC分类号： A61K31/343 , C07D307/91
CPC分类号： C07D307/79 , C07D209/08 , C07D215/12 , C07D307/80 , C07D307/91 , C07D317/56 , C07D333/76 , C07D405/04 , C07D405/12 , C07D417/04
摘要： Disclosed are compound and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compound of the invention include inhibitors of protein tyrosine phosphatase, in particular protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising aforementioned conditions using such compounds.
摘要翻译： 公开了式（I）的化合物和药学上可接受的盐：其可用于治疗与胰岛素抵抗，瘦素抗性或高血糖相关的代谢紊乱。 本发明的化合物包括可用于治疗糖尿病和其它PTP介导的疾病如癌症，神经变性疾病等的蛋白质酪氨酸磷酸酶抑制剂，特别是蛋白酪氨酸磷酸酶-1B（PTP-1B）。 还公开了包含使用这些化合物的上述条件的药物组合物。
-
公开(公告)号：US07358364B2
公开(公告)日：2008-04-15
申请号：US10823842
申请日：2004-04-14
IPC分类号： C07D471/00 , C07D498/00 , C07D513/00 , C07D405/00 , C07D307/87
CPC分类号： C07D263/57 , C07C69/736 , C07D209/08 , C07D277/66 , C07D307/80 , C07D307/91 , C07D307/92 , C07D405/10 , C07D417/04 , C07D471/04
摘要： The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.
摘要翻译： 本发明涉及式（I）的化合物和药学上可接受的盐：其可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。 这些化合物包括可用于治疗糖尿病和其它PTP-1B介导的疾病如癌症，神经变性疾病等的蛋白质酪氨酸磷酸酶（PTP-1B）的抑制剂。 本发明的化合物也可用于治疗上述病症的药物组合物和方法。
-
公开(公告)号：US20090082392A1
公开(公告)日：2009-03-26
申请号：US12103082
申请日：2008-04-15
IPC分类号： A61K31/343 , C07D307/80 , C07D307/91 , A61K31/437 , A61P3/10 , A61K31/404 , A61K31/215
CPC分类号： C07D263/57 , C07C69/736 , C07D209/08 , C07D277/66 , C07D307/80 , C07D307/91 , C07D307/92 , C07D405/10 , C07D417/04 , C07D471/04
摘要： The present invention relates to compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance or hyperglycemia. These compounds include inhibitors of protein tyrosine phosphatase (PTP-1B) that are useful in the treatment of diabetes and other PTP-1B mediated diseases, such as cancer, neurodegenerative diseases and the like. The compounds of the invention are also useful in pharmaceutical compositions and methods of treating the aforementioned conditions.
摘要翻译： 本发明涉及式（I）的化合物和药学上可接受的盐：其可用于治疗与胰岛素抵抗或高血糖相关的代谢紊乱。 这些化合物包括可用于治疗糖尿病和其它PTP-1B介导的疾病如癌症，神经变性疾病等的蛋白质酪氨酸磷酸酶（PTP-1B）的抑制剂。 本发明的化合物也可用于治疗上述病症的药物组合物和方法。
-
公开(公告)号：US07358248B2
公开(公告)日：2008-04-15
申请号：US10835817
申请日：2004-04-30
IPC分类号： A61K31/5355 , C07D265/30 , C07D295/02 , C07D307/79 , C07D323/02
CPC分类号： C07D239/26 , C07C323/59 , C07D209/08 , C07D307/79 , C07D307/81 , C07D307/91 , C07D317/56 , C07D333/76 , C07D405/04 , C07D405/12 , C07D417/04
摘要： Disclosed are compounds and pharmaceutically acceptable salts of formula (I): which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译： 公开了式（I）的化合物和药学上可接受的盐：其可用于治疗与胰岛素抵抗，瘦素抗性或高血糖相关的代谢紊乱。 本发明的化合物包括可用于治疗糖尿病和其它PTP介导的疾病如癌症，神经变性疾病等的蛋白质酪氨酸磷酸酶抑制剂，特别是蛋白质酪氨酸磷酸酶-1B（PTP-1B）。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
-
9.发明授权Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor 失效含有取代的吲哚烷酸和血管紧张素转换酶抑制剂的组合物公开(公告)号：US06521659B2
公开(公告)日：2003-02-18
申请号：US09795161
申请日：2001-02-28
申请人： Janet Sredy , Michael C. Van Zandt
发明人： Janet Sredy , Michael C. Van Zandt
IPC分类号： A61K3140
CPC分类号： A61K31/404 , A61K31/401 , A61K45/06 , A61K2300/00
摘要： Disclosed are methods of reducing serum glucose and triglyceride levels and for inhibiting angiogenesis, the methods comprising administration of substituted indolealkanoic acids to patients in need of such treatment. Also disclosed are such compounds useful in the treatment of angiogenesis, hyperglycemia, hyperlipidemia and chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds. Further, disclosed are combinations of an angiotensin converting enzyme inhibitor and a substituted indole acetic acid.
摘要翻译： 公开了降低血清葡萄糖和甘油三酯水平和抑制血管发生的方法，所述方法包括向需要这种治疗的患者施用取代的吲哚烷酸。 还公开了可用于治疗血糖发生，高血糖症，高脂血症和由糖尿病引起的慢性并发症的化合物。 还公开了含有这些化合物的药物组合物。 此外，公开了血管紧张素转换酶抑制剂和取代的吲哚乙酸的组合。
-
公开(公告)号：US20080214540A1
公开(公告)日：2008-09-04
申请号：US11999524
申请日：2007-12-04
IPC分类号： A61K31/428 , C07D419/06 , A61K31/5377 , A61P3/10 , C07D417/14
CPC分类号： C07D417/06
摘要： Disclosed are substituted indolealkanoic acids useful in the treatment of chronic complications arising from diabetes mellitus. Also disclosed are pharmaceutical compositions containing the compounds and methods of treatment employing the compounds, as well as methods for their synthesis.
摘要翻译： 公开了用于治疗由糖尿病引起的慢性并发症的取代吲哚烷酸。 还公开了含有化合物的化合物和使用该化合物的治疗方法的药物组合物，以及它们的合成方法。
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.031 秒)
