公开(公告)号：US06817990B2

公开(公告)日：2004-11-16

申请号：US09940369

申请日：2001-08-24

申请人： Darren Y. K. Yap ,  Poonam Gulati ,  Paul H. Kovelman ,  William P. Van Antwerp ,  Bradley J. Enegren ,  Eric P. Geismar ,  Philip J. Hudak ,  Susan McConnell ,  Sheldon B. Moberg

发明人： Darren Y. K. Yap ,  Poonam Gulati ,  Paul H. Kovelman ,  William P. Van Antwerp ,  Bradley J. Enegren ,  Eric P. Geismar ,  Philip J. Hudak ,  Susan McConnell ,  Sheldon B. Moberg

IPC分类号： A61M5315

CPC分类号： A61M5/162 ,  A61M5/1452 ,  A61M5/1456 ,  A61M5/14566 ,  A61M5/16831 ,  A61M39/10 ,  A61M39/12 ,  A61M39/14 ,  A61M2005/1623 ,  A61M2205/581 ,  A61M2205/582 ,  Y10S128/01 ,  Y10S128/12 ,  Y10S215/03

摘要： An improved pump, reservoir and reservoir piston are provided for controlled delivery of fluids. A motor is operably coupled to a drive member, such as a drive screw, which is adapted to advance a plunger slide in response to operation of the motor. The plunger slide is removably coupled to the piston. The piston comprises a first member and a second member. The first member has an external proximate side and an external distal side. The external proximate side is adapted to contact the fluid and is made of a material having a first stiffness. The second member has a first side and a second side and is at least partially disposed within the first member. The first side of the second member is adjacent to the external proximate side of the first member and is made of a material having a stiffness which is greater than the first stiffness.

摘要翻译： 提供改进的泵，储存器和储存器活塞用于流体的控制输送。 电动机可操作地联接到诸如驱动螺杆的驱动构件，驱动构件适于响应于电动机的操作而推进柱塞滑块。 柱塞滑块可拆卸地联接到活塞。 活塞包括第一构件和第二构件。 第一构件具有外部近侧和外部远端侧。 外部接近侧适于接触流体并且由具有第一刚度的材料制成。 第二构件具有第一侧和第二侧，并且至少部分地设置在第一构件内。 第二构件的第一侧邻近第一构件的外部近侧并由具有大于第一刚度的刚度的材料制成。

公开(公告)号：US08425493B2

公开(公告)日：2013-04-23

申请号：US10515152

申请日：2003-05-20

申请人： Peter C. Lord ,  Clyde K. Nason ,  Darren Y. K. Yap ,  Stephen D. Das ,  Ronald J. Lebel

发明人： Peter C. Lord ,  Clyde K. Nason ,  Darren Y. K. Yap ,  Stephen D. Das ,  Ronald J. Lebel

IPC分类号： A61K9/22

CPC分类号： A61M5/14224 ,  A61M5/14276 ,  A61M39/0208 ,  A61M2005/14264 ,  A61M2039/242 ,  A61M2210/0693

摘要： An implantable medication delivery device that is highly space efficient and can reliably and safely deliver controlled medication doses to a target site. The system includes a variable volume medication reservoir that is exposed to an ambient pressure equal to the ambient pressure at a system outlet port. A pump/valve subassembly is provided to draw medication from the reservoir and force a medication dose along a fluid transfer passageway to the outlet port. The pump/valve subassembly incorporates a safety mechanism, e.g., a balanced valve, which normally blocks medication flow to the outlet port and opens only in response to a pump induced unbalancing force. A protective shell is also disclosed for protecting the ambient reservoir.

摘要翻译： 可植入药物输送装置，其具有高度的空间效率并能可靠且安全地将受控的药物剂量递送至目标部位。 该系统包括暴露于等于系统出口处的环境压力的环境压力的可变体积药物储存器。 提供泵/阀子组件以从储存器抽取药物并且迫使药物剂量沿流体输送通道流到出口。 泵/阀子组件包括安全机构，例如平衡阀，其通常阻止药物流向出口并且仅响应于泵引起的不平衡力而打开。 还公开了用于保护环境储存器的保护壳。