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公开(公告)号：US06752787B1
公开(公告)日：2004-06-22
申请号：US09533578
申请日：2000-03-23
申请人： James D. Causey, III , William H. Stutz, Jr. , Clyde K. Nason , Sheldon B. Moberg , Jay Yonemoto
发明人： James D. Causey, III , William H. Stutz, Jr. , Clyde K. Nason , Sheldon B. Moberg , Jay Yonemoto
IPC分类号： A61M3700
CPC分类号： A61M5/14566 , A61M5/172 , A61M2205/0266 , A61M2205/6018 , G06F19/00
摘要： A reusable external infusion device infuses a fluid into an individual's body. The infusion device controls the rate that fluid flows from a reservoir inside a housing, through an external tube, and into the individual's body. Essentially, the infused fluid is insulin. However, many other fluids may be administered through infusion such as, HIV drugs, drugs to treat pulmonary hypertension, iron chelation drugs, pain medications, anti-cancer treatments, vitamins, hormones, and others.
摘要翻译： 可重复使用的外部输液装置将流体注入个体的身体。 输注装置控制流体从壳体内的储存器通过外部管流入个体的速度。 基本上，输注的液体是胰岛素。 然而，许多其它流体可以通过输注来施用，例如HIV药物，用于治疗肺动脉高压的药物，铁螯合药物，止痛药物，抗癌治疗剂，维生素，激素等。
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公开(公告)号：US5951595A
公开(公告)日：1999-09-14
申请号：US852161
申请日：1997-05-06
申请人： Sheldon B. Moberg , Buehl E. Truex , Alfred D. Acken, deceased , Clyde K. Nason , William H. Stutz, Jr. , Edward Gene Rourke
发明人： Sheldon B. Moberg , Buehl E. Truex , Alfred D. Acken, deceased , Clyde K. Nason , William H. Stutz, Jr. , Edward Gene Rourke
CPC分类号： H01R13/5224 , A61N1/3752 , H01R24/58 , H01R2107/00 , H01R2201/12 , Y10S439/909
摘要： A connector assembly mounted on an implantable cardiac stimulation device has an actuator mechanism for fixing and sealing electrical leads inserted into lead receptacles within the connector assembly without the use of setscrews. Fixing and sealing of the leads is accomplished by compressing resilient lead lock seals of O-ring shape, disposed in annular recesses, with lip portions of a plunger drawn toward the molded support by the actuator mechanism. In a first embodiment of the actuator mechanism, rotation of a cam actuator transversely journaled within the support, using a torque wrench or similar tool, moves a cam slide attached to the plunger through a fixed displacement between lock and unlock positions as an offset camming portion of the actuator engages the surfaces of a slot within the cam slide. In a second embodiment, constant-force compression of the lead lock seals by the plunger is provided by using a torque wrench to rotate a screw actuator having one end coupled to the plunger and an opposite threaded end received within a screw block transversely disposed within the support. In a third embodiment, a rotatable toothed pinion engages a toothed slot within a slidable rack to provide incremental advancement of the rack, and thereby stepped displacement and force, with a resulting increased resolution. In a fourth embodiment, compliance provided by either a spring formed within the cam slide, or a spring nut mounted thereon, prevents excessive force from being exerted on leads of larger diameter.
摘要翻译： 安装在可植入心脏刺激装置上的连接器组件具有致动器机构，用于固定和密封插入到连接器组件内的引线插座中的电引线，而不使用固定螺丝。 引线的固定和密封是通过压缩环形形状的弹性引线锁定密封件来实现的，该密封件设置在环形凹槽中，其中柱塞的唇部通过致动器机构朝模制支撑件拉出。 在致动器机构的第一实施例中，使用扭矩扳手或类似工具横向安装在支撑件内的凸轮致动器的旋转使附接到柱塞的凸轮滑块在锁定和解锁位置之间通过固定位移移动，作为偏移凸轮部分 执行机构接合凸轮滑块内的槽的表面。 在第二实施例中，通过使用扭矩扳手来旋转具有联接到柱塞的一端的螺钉致动器以及容纳在横向设置在所述柱塞内的螺纹块内的相对的螺纹端，由柱塞提供引线锁定密封件的恒定力压缩 支持。 在第三实施例中，可旋转的齿形小齿轮与可滑动齿条内的齿槽接合，以提供齿条的增量前进，并由此产生阶梯式的位移和力，从而产生增加的分辨率。 在第四实施例中，由形成在凸轮滑块内的弹簧或安装在其上的弹簧螺母提供的顺应性防止过大的力施加在较大直径的引线上。
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公开(公告)号：US4678408A
公开(公告)日：1987-07-07
申请号：US779733
申请日：1985-09-24
申请人： Clyde K. Nason , Gordon W. Culp
发明人： Clyde K. Nason , Gordon W. Culp
CPC分类号： A61M5/1456 , A61M5/1458 , Y10T74/1529 , Y10T74/1555 , Y10T74/2133 , Y10T74/2136
摘要： A solenoid drive apparatus for driving a lead screw of an External Infusion Pump (1) having a housing (302), solenoid winding (356) within the housing (302), a solenoid armature (358) which is driven by the field of the solenoid winding (356), push rod (362) which is driven by the armature (358), pawn (314) which is driven by push rod (362), a first pawl (320) which is driven by pawn (314) and a second pawl (326) which is an antibacklash device, a ratchet wheel (318) having teeth (319) around its periphery and engaged by the first pawl (320) and the second pawl (326) and the drive shaft (316) which is drawn by the ratchet of the ratchet wheel (318).
摘要翻译： 一种用于驱动具有壳体（302）的外部输液泵（1）的导螺杆的螺线管驱动装置，在壳体（302）内的电磁线圈（356），螺线管衔铁（358），其由 螺线管绕组（356），由电枢（358）驱动的推杆（362），由推杆（362）驱动的典当（314）;由棋子（314）驱动的第一棘爪（320）和 作为反冲洗装置的第二棘爪（326），具有围绕其周边并与第一棘爪（320）和第二棘爪（326）以及驱动轴（316）啮合的齿（319）的棘轮（318），其中 由棘轮（318）的棘轮拉出。
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公开(公告)号：US08574215B2
公开(公告)日：2013-11-05
申请号：US11726330
申请日：2007-03-21
CPC分类号： F04B19/006 , A61M5/14216 , A61M5/14244 , A61M5/14248 , A61M2005/14268 , A61M2205/0266 , F04B17/00 , F05C2251/08
摘要： Apparatuses and methods for pumping fluid are disclosed. An exemplary apparatus is a miniature pump that includes a shape memory wire that obtains a plastic condition below a transformation temperature and has a memorized shape such that the shape memory wire produces a work stroke by returning to the memorize shape at least at the transformation temperature. A spring biased against the shape memory wire is deflected by the work stroke to deform the shape memory wire from the memorized shape below the transformation temperature. A fluid pump is coupled to the shape memory wire and driven by the biased spring and shape memory wire to produce a fluid flow. The miniature pump can be incorporated into a self-contained infusion device in the form of a compact self-adhesive patch including a fluid reservoir, control electronics and power supply that is place directly at the infusion site of a user.
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公开(公告)号：US07052251B2
公开(公告)日：2006-05-30
申请号：US10127094
申请日：2002-04-22
IPC分类号： F04B35/00
CPC分类号： F04B19/006 , A61M5/14216 , A61M5/14244 , A61M5/14248 , A61M2005/14268 , A61M2205/0266 , F04B17/00 , F05C2251/08
摘要： Apparatuses and methods for pumping fluid are disclosed. An exemplary apparatus is a miniature pump that includes a shape memory wire that obtains a plastic condition below a transformation temperature and has a memorized shape such that the shape memory wire produces a work stroke by returning to the memorize shape at least at the transformation temperature. A spring biased against the shape memory wire is deflected by the work stroke to deform the shape memory wire from the memorized shape below the transformation temperature. A fluid pump is coupled to the shape memory wire and driven by the biased spring and shape memory wire to produce a fluid flow. The miniature pump can be incorporated into a self-contained infusion device in the form of a compact self-adhesive patch including a fluid reservoir, control electronics and power supply that is place directly at the infusion site of a user.
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6.发明授权Shape memory alloy wire driven positive displacement micropump with pulsatile output 有权形状记忆合金丝驱动的正位移微型泵具有脉动输出公开(公告)号：US07226278B2
公开(公告)日：2007-06-05
申请号：US11230142
申请日：2005-09-19
CPC分类号： F04B19/006 , A61M5/14216 , A61M5/14244 , A61M5/14248 , A61M2005/14268 , A61M2205/0266 , F04B17/00 , F05C2251/08
摘要： Apparatuses and methods for pumping fluid are disclosed. An exemplary apparatus is a miniature pump that includes a shape memory wire that obtains a plastic condition below a transformation temperature and has a memorized shape such that the shape memory wire produces a work stroke by returning to the memorize shape at least at the transformation temperature. A spring biased against the shape memory wire is deflected by the work stroke to deform the shape memory wire from the memorized shape below the transformation temperature. A fluid pump is coupled to the shape memory wire and driven by the biased spring and shape memory wire to produce a fluid flow. The miniature pump can be incorporated into a self-contained infusion device in the form of a compact self-adhesive patch including a fluid reservoir, control electronics and power supply that is place directly at the infusion site of a user.
摘要翻译： 公开了用于泵送流体的装置和方法。 示例性装置是一种微型泵，其包括形状记忆线，该形状记忆线获得低于相变温度的塑性状态，并且具有记忆形状，使得形状记忆线至少在相变温度下返回至记忆形状而产生工作行程。 偏压在形状记忆线上的弹簧被工作冲程偏转，使形状记忆线从存储的形状变形到转变温度以下。 流体泵联接到形状记忆线并由偏置的弹簧和形状记忆线驱动以产生流体流。 微型泵可以以紧凑的自粘贴片的形式并入独立的输注装置，其包括流体储存器，控制电子器件和直接位于使用者的输注部位处的电源。
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公开(公告)号：US5080653A
公开(公告)日：1992-01-14
申请号：US509933
申请日：1990-04-16
申请人： Laveille Voss , Clyde K. Nason
发明人： Laveille Voss , Clyde K. Nason
CPC分类号： A61M5/1456 , Y10S128/12
摘要： An improved infusion pump is provided for controlled delivery of medication from a syringe to a patient, wherein a pump housing includes a syringe chamber and associated lock members for receiving and supporting the syringe in one of two different positions. The syringe includes a medication-containing barrel connected to a luer fitting at a nose end thereof by a luer neck of reduced cross sectional size. In one position, the syringe seats into the chamber with the luer neck protruding through an outlet port of mating size and with the luer fitting disposed outside the housing, such that the housing defines a lock member engaged axially between the syringe barrel and luer fitting to secure the barrel against axial displacement. In another position, a retainer key is adapted for installation into the syringe chamber at a position spaced inboard from the outlet port and defines an alternative lock member for axially securing the syringe with the luer fitting disposed inside the housing. In either position, a syringe piston plunger is controllably advanced by the pump into the barrel to deliver medication from the nose end of the syringe for administration to a patient via the luer fitting and infusion tubing or the like connected thereto.
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公开(公告)号：US08425493B2
公开(公告)日：2013-04-23
申请号：US10515152
申请日：2003-05-20
IPC分类号： A61K9/22
CPC分类号： A61M5/14224 , A61M5/14276 , A61M39/0208 , A61M2005/14264 , A61M2039/242 , A61M2210/0693
摘要： An implantable medication delivery device that is highly space efficient and can reliably and safely deliver controlled medication doses to a target site. The system includes a variable volume medication reservoir that is exposed to an ambient pressure equal to the ambient pressure at a system outlet port. A pump/valve subassembly is provided to draw medication from the reservoir and force a medication dose along a fluid transfer passageway to the outlet port. The pump/valve subassembly incorporates a safety mechanism, e.g., a balanced valve, which normally blocks medication flow to the outlet port and opens only in response to a pump induced unbalancing force. A protective shell is also disclosed for protecting the ambient reservoir.
摘要翻译： 可植入药物输送装置，其具有高度的空间效率并能可靠且安全地将受控的药物剂量递送至目标部位。 该系统包括暴露于等于系统出口处的环境压力的环境压力的可变体积药物储存器。 提供泵/阀子组件以从储存器抽取药物并且迫使药物剂量沿流体输送通道流到出口。 泵/阀子组件包括安全机构，例如平衡阀，其通常阻止药物流向出口并且仅响应于泵引起的不平衡力而打开。 还公开了用于保护环境储存器的保护壳。
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公开(公告)号：US20100160861A1
公开(公告)日：2010-06-24
申请号：US12689887
申请日：2010-01-19
申请人： James D. Causey, III , William H. Stutz, Jr. , Clyde K. Nason , Sheldon B. Moberg , Jay Yonemoto , Richard E. Purvis , Cary Talbot
发明人： James D. Causey, III , William H. Stutz, Jr. , Clyde K. Nason , Sheldon B. Moberg , Jay Yonemoto , Richard E. Purvis , Cary Talbot
IPC分类号： A61M5/14
CPC分类号： A61M5/14566 , A61M5/1456 , A61M5/172 , A61M2205/0266 , A61M2205/3331 , A61M2205/50 , A61M2205/6018
摘要： An external infusion device that infuses a fluid into an individual's body includes a housing, a reservoir, a drive system, a power supply, electrical elements, and a tab. The reservoir contains the fluid, and the drive system forces the fluid from the reservoir. The electrical elements control the power to the drive system to regulate the rate that fluid is forced from the reservoir. The tab mates with the housing, and contains at least one electrical element. The tab is removable, and may be replaced with a different tab. The different tab may change the rate fluid is forced from the reservoir. A tab may be removed from one external infusion device and installed in a different external infusion device. The tab may be limited to use in a predetermined number of external infusion devices and may include a power supply.
摘要翻译： 将流体注入个体的外部输注装置包括壳体，储存器，驱动系统，电源，电气元件和突片。 储存器包含流体，并且驱动系统迫使来自储存器的流体。 电气元件控制驱动系统的功率，以调节流体从储存器被迫的速率。 该卡舌与外壳配合，并且至少包含一个电气元件。 标签是可移动的，可以用不同的标签替换。 不同的标签可能会改变流体从储存器被迫的速率。 可以从一个外部输注装置移除翼片并将其安装在不同的外部输注装置中。 可以将突片限制为在预定数量的外部输注装置中使用，并且可以包括电源。
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10.发明授权Hermetically sealed feedthrough connector using shape memory alloy for implantable medical device 失效用于可植入医疗设备的形状记忆合金的密封馈通连接器公开(公告)号：US06498952B2
公开(公告)日：2002-12-24
申请号：US09802231
申请日：2001-03-08
申请人： Ray Imani , Clyde K. Nason
发明人： Ray Imani , Clyde K. Nason
IPC分类号： A61N1375
CPC分类号： A61N1/3752
摘要： A feedthrough connector for an implantable medical device includes a hermetically sealed housing containing an electrical circuit and a tubular barrel with an open end and a closed end defining a tubular channel that protrudes into the sealed housing while maintaining the seal of the housing. The inside of the tubular channel is open to the outside of the sealed housing through the open end and the tubular barrel also has a plurality of circumferentially spaced openings extending between an outer peripheral surface and the tubular channel. An electrical contact assembly electrically in common with the electrical circuit within the housing serves to make electrical contact with an electrical lead axially inserted into the open end of the tubular channel. The electrical contact assembly includes a plurality of contact members received in and projecting radially through a plurality of circumferentially spaced openings and a sleeve member of shape memory alloy freely overlies the contact members when in a first deformed-shape configuration but engage the contact members and the outer peripheral surface of the tubular barrel when in a second memory-shaped configuration, urging the contact members into mechanical, electrical, and hermetically sealed engagement with the electrical lead. The tubular channel may include a plurality of conductive cylindrical portions coaxial with the axis of the tubular barrel, the dimensions of the diameter of the successive cylindrical portions progressively decreasing from the open end to the closed end.
摘要翻译： 用于可植入医疗装置的馈通连接器包括容纳电路的气密密封壳体和具有开口端的管状筒体，并且封闭端限定突出到密封壳体中的管状通道，同时保持壳体的密封。 管状通道的内部通过开口端向密封壳体的外部开口，并且管状筒体还具有在外周表面和管状通道之间延伸的多个周向间隔开的开口。 电气接触组件与壳体内的电路电共同地用于与轴向插入管状通道的开口端的电引线电接触。 电接触组件包括多个接触构件，其容纳在径向通过多个周向间隔开的开口并且形状记忆合金的套筒构件在处于第一变形形状构造时自由地覆盖在接触构件上，但是接合接触构件和 当处于第二记忆形状构造时，管状筒的外周表面促使接触构件与电引线机械，电气和密封地接合。 管状通道可以包括与管状筒的轴线同轴的多个导电圆柱形部分，连续圆柱形部分的直径尺寸从开口端逐渐减小到封闭端。
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