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    Labeling reagents for analyte determination and methods and compounds used in making the same
    8.
    发明授权
    Labeling reagents for analyte determination and methods and compounds used in making the same 有权
    用于分析物测定的标记试剂和用于制备其的方法和化合物

    公开(公告)号：US08975404B2

    公开(公告)日：2015-03-10

    申请号：US11625688

    申请日：2007-01-22

    申请人： Sasi K. Pillai ,  Subhakar Dey ,  Subhasish Purkayastha ,  Darryl J. C. Pappin

    发明人： Sasi K. Pillai ,  Subhakar Dey ,  Subhasish Purkayastha ,  Darryl J. C. Pappin

    IPC分类号： C07D295/15 ,  C07D403/12 ,  G01N33/58 ,  G01N33/68

    CPC分类号： C07D295/15 ,  C07D403/12 ,  G01N33/58 ,  G01N33/6848

    摘要： Provided herein are labeling reagents for analyte determination in a sample, and methods of manufacturing the labeling reagents. By way of non-limiting example, analytes may include one or more of peptides, proteins, nucleic acid molecules, carbohydrates, lipids, steroids and/or small molecules. Also provided are labeled analytes themselves after one or more labeling reagents binds to an analyte. Analytes may be labeled for determination of the analyte by mass analysis, such as by mass spectrometry. Further provided are compounds that may be used in making the labeling reagents and labeled analytes, such as reporter group compounds. Also provided are kits that include at least one labeling reagent, and may further include or more other reagents, containers, enzymes, buffers, a labeled analyte (e.g., as a standard) and/or instructions. Further examples are also possible.

    摘要翻译： 本文提供了样品中用于分析物测定的标记试剂和制备标记试剂的方法。 作为非限制性实例，分析物可以包括肽，蛋白质，核酸分子，碳水化合物，脂质，类固醇和/或小分子中的一种或多种。 还提供了在一种或多种标记试剂结合分析物之后本身标记的分析物。 分析物可以标记用于通过质谱分析来测定分析物，例如通过质谱法测定。 还提供了可用于制备标记试剂和标记分析物的化合物，例如报道基团化合物。 还提供了包括至少一种标记试剂的试剂盒，并且还可以包括或多于其它试剂，容器，酶，缓冲液，标记的分析物（例如，作为标准）和/或说明书。 其他实例也是可能的。