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公开(公告)号:US08078252B2
公开(公告)日:2011-12-13
申请号:US12765630
申请日:2010-04-22
CPC分类号: A61B5/04001 , A61B5/7232 , A61B2018/00434 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/375 , A61N1/3756
摘要: In some preferred embodiments, without limitation, the present invention comprises an implantable, intracranial neural interface node which is an integrated and minimally invasive platform system and supports cross-modal neural interfaces to the cerebrum and other associated structures in the central nervous system. The neural interfaces comprise electrical and chemical interfaces for neural recording, electrical stimulation, chemical delivery, chemical sensing, chemical sampling, cell delivery, genetic material delivery and/or other functions of interest.
摘要翻译: 在一些优选实施例中,但不限于,本发明包括可植入的颅内神经接口节点,其是集成的和微创的平台系统,并且支持中枢神经系统中大脑和其他相关结构的交叉模式神经接口。 神经接口包括用于神经记录,电刺激,化学递送,化学感测,化学取样,细胞递送,遗传物质递送和/或感兴趣的其它功能的电和化学界面。
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公开(公告)号:US08412302B2
公开(公告)日:2013-04-02
申请号:US13314680
申请日:2011-12-08
CPC分类号: A61B5/04001 , A61B5/7232 , A61B2018/00434 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/375 , A61N1/3756
摘要: In some preferred embodiments, without limitation, the present invention comprises an implantable, intracranial neural interface node which is an integrated and minimally invasive platform system and supports cross-modal neural interfaces to the cerebrum and other associated structures in the central nervous system. The neural interfaces comprise electrical and chemical interfaces for neural recording, electrical stimulation, chemical delivery, chemical sensing, chemical sampling, cell delivery, genetic material delivery and/or other functions of interest.
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公开(公告)号:US07979105B2
公开(公告)日:2011-07-12
申请号:US12483696
申请日:2009-06-12
CPC分类号: A61B5/04001 , A61B5/7232 , A61B2018/00434 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/375 , A61N1/3756
摘要: In some preferred embodiments, without limitation, the present invention comprises an implantable, intracranial neural interface node which is an integrated and minimally invasive platform system and supports cross-modal neural interfaces to the cerebrum and other associated structures in the central nervous system. The neural interfaces comprise electrical and chemical interfaces for neural recording, electrical stimulation, chemical delivery, chemical sensing, chemical sampling, cell delivery, genetic material delivery and/or other functions of interest.
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公开(公告)号:US20110046470A1
公开(公告)日:2011-02-24
申请号:US12765630
申请日:2010-04-22
IPC分类号: A61B5/0478
CPC分类号: A61B5/04001 , A61B5/7232 , A61B2018/00434 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/375 , A61N1/3756
摘要: In some preferred embodiments, without limitation, the present invention comprises an implantable, intracranial neural interface node which is an integrated and minimally invasive platform system and supports cross-modal neural interfaces to the cerebrum and other associated structures in the central nervous system. The neural interfaces comprise electrical and chemical interfaces for neural recording, electrical stimulation, chemical delivery, chemical sensing, chemical sampling, cell delivery, genetic material delivery and/or other functions of interest.
摘要翻译: 在一些优选实施例中,但不限于,本发明包括可植入的颅内神经接口节点,其是集成的和微创的平台系统,并且支持中枢神经系统中大脑和其他相关结构的交叉模式神经接口。 神经接口包括用于神经记录,电刺激,化学递送,化学感测,化学取样,细胞递送,遗传物质递送和/或感兴趣的其它功能的电和化学界面。
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公开(公告)号:US20090253977A1
公开(公告)日:2009-10-08
申请号:US12483696
申请日:2009-06-12
IPC分类号: A61B5/0478 , A61N1/05
CPC分类号: A61B5/04001 , A61B5/7232 , A61B2018/00434 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/375 , A61N1/3756
摘要: In some preferred embodiments, without limitation, the present invention comprises an implantable, intracranial neural interface node which is an integrated and minimally invasive platform system and supports cross-modal neural interfaces to the cerebrum and other associated structures in the central nervous system. The neural interfaces comprise electrical and chemical interfaces for neural recording, electrical stimulation, chemical delivery, chemical sensing, chemical sampling, cell delivery, genetic material delivery and/or other functions of interest.
摘要翻译: 在一些优选实施例中,但不限于,本发明包括可植入的颅内神经接口节点,其是集成的和微创的平台系统,并且支持中枢神经系统中大脑和其他相关结构的交叉模式神经接口。 神经接口包括用于神经记录,电刺激,化学递送,化学感测,化学取样,细胞递送,遗传物质递送和/或感兴趣的其它功能的电和化学界面。
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公开(公告)号:US07548775B2
公开(公告)日:2009-06-16
申请号:US10970268
申请日:2004-10-21
CPC分类号: A61B5/04001 , A61B5/7232 , A61B2018/00434 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/375 , A61N1/3756
摘要: In some preferred embodiments, without limitation, the present invention comprises an implantable, intracranial neural interface node which is an integrated and minimally invasive platform system and supports cross-modal neural interfaces to the cerebrum and other associated structures in the central nervous system. The neural interfaces comprise electrical and chemical interfaces for neural recording, electrical stimulation, chemical delivery, chemical sensing, chemical sampling, cell delivery, genetic material delivery and/or other functions of interest.
摘要翻译: 在一些优选实施例中,但不限于,本发明包括可植入的颅内神经接口节点,其是集成的和微创的平台系统,并且支持中枢神经系统中大脑和其他相关结构的交叉模式神经接口。 神经接口包括用于神经记录,电刺激,化学递送,化学感测,化学取样,细胞递送,遗传物质递送和/或感兴趣的其它功能的电和化学界面。
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公开(公告)号:US20120083752A1
公开(公告)日:2012-04-05
申请号:US13314680
申请日:2011-12-08
IPC分类号: A61M31/00
CPC分类号: A61B5/04001 , A61B5/7232 , A61B2018/00434 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/375 , A61N1/3756
摘要: In some preferred embodiments, without limitation, the present invention comprises an implantable, intracranial neural interface node which is an integrated and minimally invasive platform system and supports cross-modal neural interfaces to the cerebrum and other associated structures in the central nervous system. The neural interfaces comprise electrical and chemical interfaces for neural recording, electrical stimulation, chemical delivery, chemical sensing, chemical sampling, cell delivery, genetic material delivery and/or other functions of interest.
摘要翻译: 在一些优选实施例中,但不限于,本发明包括可植入的颅内神经接口节点,其是集成的和微创的平台系统,并且支持中枢神经系统中大脑和其他相关结构的交叉模式神经接口。 神经接口包括用于神经记录,电刺激,化学递送,化学感测,化学取样,细胞递送,遗传物质递送和/或感兴趣的其它功能的电和化学界面。
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公开(公告)号:US20050143790A1
公开(公告)日:2005-06-30
申请号:US10970268
申请日:2004-10-21
申请人: Daryl Kipke , Justin Williams , Jamille Hetke , Jaimie Henderson , P. Garell
发明人: Daryl Kipke , Justin Williams , Jamille Hetke , Jaimie Henderson , P. Garell
IPC分类号: A61B5/04 , A61N1/05 , A61N1/375 , A61N1/40 , A61N1/08 , A61N1/10 , A61N1/18 , A61N1/20 , A61N1/32 , A61N1/34
CPC分类号: A61B5/04001 , A61B5/7232 , A61B2018/00434 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/375 , A61N1/3756
摘要: In some preferred embodiments, without limitation, the present invention comprises an implantable, intracranial neural interface node which is an integrated and minimally invasive platform system and supports cross-modal neural interfaces to the cerebrum and other associated structures in the central nervous system. The neural interfaces comprise electrical and chemical interfaces for neural recording, electrical stimulation, chemical delivery, chemical sensing, chemical sampling, cell delivery, genetic material delivery and/or other functions of interest.
摘要翻译: 在一些优选实施例中,但不限于,本发明包括可植入的颅内神经接口节点,其是集成的和微创的平台系统,并且支持中枢神经系统中大脑和其他相关结构的交叉模式神经接口。 神经接口包括用于神经记录,电刺激,化学递送,化学感测,化学取样,细胞递送,遗传物质递送和/或感兴趣的其它功能的电和化学界面。
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公开(公告)号:US20080114579A1
公开(公告)日:2008-05-15
申请号:US12008760
申请日:2008-01-14
IPC分类号: G06G7/60
CPC分类号: G06F19/3437 , A61B90/37 , A61B2090/364 , A61N1/0534 , A61N1/0539 , A61N1/36082 , A61N1/36135 , A61N1/36146 , G06F19/00 , G06F19/321 , G16H50/50
摘要: This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. A model computes a volume of influence region for a simulated electrical stimulation using certain stimulation parameters, such as amplitude, pulsewidth, frequency, pulse morphology, electrode contact selection or location, return path electrode selection, pulse polarity, etc. The model uses a non-uniform tissue conductivity. This accurately represents brain tissue, which has highly directionally conductive neuron pathways yielding a non-homogeneous and anisotropic tissue medium. In one example, the non-uniform tissue conductivity is obtained from diffusion tensor imaging (DTI) data. In one example, a second difference of an electric potential distribution is used to define a volume of activation (VOA) or similar volume of influence. In another example, a neuron or axon model is used to calculate the volume of influence without computing the second difference of the electric potential distribution.
摘要翻译: 本文件还讨论了脑刺激模型,系统,设备和方法,例如深部脑刺激(DBS)或其他电刺激。 模型使用某些刺激参数(如幅度,脉冲宽度,频率,脉冲形态,电极接触选择或位置,返回路径电极选择,脉冲极性等)来计算模拟电刺激的影响区域的体积。该模型使用非 - 组织电导率不均匀。 这准确地表示脑组织,其具有产生非均匀和各向异性的组织培养基的高度定向导电的神经元途径。 在一个示例中,从扩散张量成像(DTI)数据获得非均匀组织电导率。 在一个示例中,电位分布的第二差异用于定义激活量(VOA)或类似的影响体积。 在另一个例子中,使用神经元或轴突模型来计算影响的体积,而不计算电势分布的第二差异。
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公开(公告)号:US20070208352A1
公开(公告)日:2007-09-06
申请号:US11745099
申请日:2007-05-07
申请人: Jaimie Henderson , Richard Bucholz , Kurt Smith , Kevin Frank , John Clayton , Catalina Carroll , Phillip Ulberg
发明人: Jaimie Henderson , Richard Bucholz , Kurt Smith , Kevin Frank , John Clayton , Catalina Carroll , Phillip Ulberg
CPC分类号: A61B19/52 , A61B34/20 , A61B90/11 , A61B90/36 , A61B2034/107 , A61B2034/2055 , A61B2034/2072 , A61B2034/256 , A61B2090/3983
摘要: A system is provided to align a surgical guide instrument over a burr hole in a patient's body. Adjustments of a surgical instrument can be made in x, y, z, and angular directions using the system. An instrument guide unit can include an instrument guide for guiding a surgical instrument into the body of a patient and a base unit operative to be secured to the body near an area in which surgery is to occur. The base unit is coupled to the instrument guide. An adjustment mechanism, coupled to the base unit and the instrument guide, is operative to adjust the instrument guide in lateral directions with respect the surface of the area.
摘要翻译: 提供一种系统,用于将手术引导器械对准患者体内的钻孔。 可以使用系统在x,y,z和角度方向上进行手术器械的调整。 仪器引导单元可以包括用于将外科器械引导到患者体内的仪器引导件和在手术发生的区域附近操作以固定到身体的基部单元。 基座单元耦合到仪器导轨。 联接到基座单元和仪器引导件的调节机构可操作以相对于该区域的表面在横向方向上调节仪器引导件。
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