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公开(公告)号：US08197493B2
公开(公告)日：2012-06-12
申请号：US12981336
申请日：2010-12-29
CPC分类号： A61F2/82 , A61B17/12118 , A61B17/1214 , A61B17/221 , A61B17/320725 , A61B2017/00309 , A61B2017/00867 , A61B2017/22001 , A61B2017/22034 , A61B2017/22039 , A61B2017/22079 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61B2017/32096 , A61B2090/3966 , A61F2/91 , A61F2/915 , A61M25/0074 , A61M2025/0042
摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.
摘要翻译： 用于治疗急性缺血性卒中的系统，方法和装置，其为血栓阻塞的血管提供即时血流恢复，并且在重新建立血流之后，解决凝块本身。 立即血流恢复有利地可以促进凝块的自然裂解，并且还可以减少或消除由于凝块断裂引起的远端栓塞的担忧。 本发明的几个实施方案基于凝块的性质提供逐步或模块化的治疗。 例如，逐步治疗可以包括三步逐步治疗过程，其包括根据治疗的具体情况立即恢复血流，原位血块管理和/或血块去除。 原位血块管理可以包括例如裂解和浸渍。 逐步或模块化的治疗可以由一个或多个治疗装置的系统或试剂盒提供。
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公开(公告)号：US20110160760A1
公开(公告)日：2011-06-30
申请号：US12981362
申请日：2010-12-29
IPC分类号： A61M29/00
CPC分类号： A61F2/82 , A61B17/12118 , A61B17/1214 , A61B17/221 , A61B17/320725 , A61B2017/00309 , A61B2017/00867 , A61B2017/22001 , A61B2017/22034 , A61B2017/22039 , A61B2017/22079 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61B2017/32096 , A61B2090/3966 , A61F2/91 , A61F2/915 , A61M25/0074 , A61M2025/0042
摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.
摘要翻译： 用于治疗急性缺血性卒中的系统，方法和装置，其为血栓阻塞的血管提供即时血流恢复，并且在重新建立血流之后，解决凝块本身。 立即血流恢复有利地可以促进凝块的自然裂解，并且还可以减少或消除由于凝块断裂引起的远端栓塞的担忧。 本发明的几个实施方案基于凝块的性质提供逐步或模块化的治疗。 例如，逐步治疗可以包括三步逐步治疗过程，其包括根据治疗的具体情况立即恢复血流，原位血块管理和/或血块去除。 原位血块管理可以包括例如裂解和浸渍。 逐步或模块化的治疗可以由一个或多个治疗装置的系统或试剂盒提供。
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公开(公告)号：US10123803B2
公开(公告)日：2018-11-13
申请号：US13172778
申请日：2011-06-29
IPC分类号： A61B17/12 , A61B17/221 , A61B17/3207 , A61F2/91 , A61F2/915 , A61M25/10 , A61B17/00 , A61B17/22 , A61B17/3209 , A61M25/00 , A61M25/06 , A61M25/09
摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can include immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis, maceration, and/or removal.
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公开(公告)号：US08585713B2
公开(公告)日：2013-11-19
申请号：US13281363
申请日：2011-10-25
IPC分类号： A61B17/22
CPC分类号： A61B17/320725 , A61B17/22031 , A61B17/221 , A61B2017/00867 , A61B2017/22038 , A61F2/01 , A61F2/91 , A61F2/95 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0069 , A61F2230/0091 , A61F2230/0093 , A61F2230/0097
摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can include immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis, maceration, and/or removal.
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公开(公告)号：US20120041460A1
公开(公告)日：2012-02-16
申请号：US13281348
申请日：2011-10-25
IPC分类号： A61B17/22
CPC分类号： A61F2/82 , A61B17/12118 , A61B17/1214 , A61B17/221 , A61B17/320725 , A61B2017/00309 , A61B2017/00867 , A61B2017/22001 , A61B2017/22034 , A61B2017/22039 , A61B2017/22079 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61B2017/32096 , A61B2090/3966 , A61F2/91 , A61F2/915 , A61M25/0074 , A61M2025/0042
摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can include immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis, maceration, and/or removal.
摘要翻译： 用于治疗急性缺血性卒中的系统，方法和装置，其为血栓阻塞的血管提供即时血流恢复，并且在重新建立血流之后，解决凝块本身。 立即血流恢复有利地可以促进凝块的自然裂解，并且还可以减少或消除由于凝块断裂引起的远端栓塞的担忧。 本发明的几个实施方案基于凝块的性质提供逐步或模块化的治疗。 例如，渐进式治疗可以包括根据治疗的具体情况立即恢复血流，原位血块管理和/或血块去除。 原位血块管理可以包括例如裂解，浸渍和/或去除。
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公开(公告)号：US20120016406A1
公开(公告)日：2012-01-19
申请号：US13245190
申请日：2011-09-26
IPC分类号： A61M29/00
CPC分类号： A61F2/82 , A61B17/12118 , A61B17/1214 , A61B17/221 , A61B17/320725 , A61B2017/00309 , A61B2017/00867 , A61B2017/22001 , A61B2017/22034 , A61B2017/22039 , A61B2017/22079 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61B2017/32096 , A61B2090/3966 , A61F2/91 , A61F2/915 , A61M25/0074 , A61M2025/0042
摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.
摘要翻译： 用于治疗急性缺血性卒中的系统，方法和装置，其为血栓阻塞的血管提供即时血流恢复，并且在重新建立血流之后，解决凝块本身。 立即血流恢复有利地可以促进凝块的自然裂解，并且还可以减少或消除由于凝块断裂引起的远端栓塞的担忧。 本发明的几个实施方案基于凝块的性质提供逐步或模块化的治疗。 例如，逐步治疗可以包括三步逐步治疗过程，其包括根据治疗的具体情况立即恢复血流，原位血块管理和/或血块去除。 原位血块管理可以包括例如裂解和浸渍。 逐步或模块化的治疗可以由一个或多个治疗装置的系统或试剂盒提供。
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7.发明申请DEVICES FOR RESTORING BLOOD FLOW AND CLOT REMOVAL DURING ACUTE ISCHEMIC STROKE 有权用于恢复血液流动的装置和在急性发作期间的衣服去除公开(公告)号：US20120116443A1
公开(公告)日：2012-05-10
申请号：US13341186
申请日：2011-12-30
IPC分类号： A61B17/22
CPC分类号： A61B17/221 , A61B17/320783 , A61B2017/22039 , A61B2017/22094 , A61B2017/2212 , A61F2/013 , A61F2002/016 , A61F2230/0069 , A61F2230/0076 , A61F2230/0097 , A61M25/09 , A61M25/09025
摘要： Devices for restoring blood flow to facilitate lysis of clots and/or enable capture of clots are disclosed. The devices can be configured to be disposed within a lumen of a microcatheter that is inserted within neurovasculature above a carotid siphon to a location of a clot. The devices can include an elongate pusher member and a self-expandable capturing member coupled to a distal end of the elongate pusher member. The capturing member can comprise a generally cylindrical body having an cell structure that is configured to compress the clot against an inner wall of the neurovasculature and capture the clot at least partially on a surface of the generally cylindrical body upon deployment of the capturing member from the microcatheter, thereby restoring blood flow to the neurovasculature downstream of the clot.
摘要翻译： 公开了用于恢复血液流动以促进凝块裂解和/或能够捕获凝块的装置。 所述装置可以被配置为设置在微导管的内腔中，所述微导管插入到颈动脉虹吸管以上的神经血管内至凝块的位置。 该装置可以包括细长的推动器构件和联接到细长推动构件的远端的自扩张捕获构件。 捕获构件可以包括大致圆柱形的主体，其具有细胞结构，所述细胞结构被配置为相对于神经血管系统的内壁压缩凝块，并且在从所述捕获构件展开时至少部分地将所述凝块至少部分地捕获在所述大致圆柱形主体的表面上 微导管，从而恢复到凝块下游神经血管的血流。
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公开(公告)号：US08070791B2
公开(公告)日：2011-12-06
申请号：US12981363
申请日：2010-12-29
CPC分类号： A61F2/82 , A61B17/12118 , A61B17/1214 , A61B17/221 , A61B17/320725 , A61B2017/00309 , A61B2017/00867 , A61B2017/22001 , A61B2017/22034 , A61B2017/22039 , A61B2017/22079 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61B2017/32096 , A61B2090/3966 , A61F2/91 , A61F2/915 , A61M25/0074 , A61M2025/0042
摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.
摘要翻译： 用于治疗急性缺血性卒中的系统，方法和装置，其为血栓阻塞的血管提供即时血流恢复，并且在重新建立血流之后，解决凝块本身。 立即血流恢复有利地可以促进凝块的自然裂解，并且还可以减少或消除由于凝块断裂引起的远端栓塞的担忧。 本发明的几个实施方案基于凝块的性质提供逐步或模块化的治疗。 例如，逐步治疗可以包括三步逐步治疗过程，其包括根据治疗的具体情况立即恢复血流，原位血块管理和/或血块去除。 原位血块管理可以包括例如裂解和浸渍。 逐步或模块化的治疗可以由一个或多个治疗装置的系统或试剂盒提供。
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公开(公告)号：US20110238106A1
公开(公告)日：2011-09-29
申请号：US13151200
申请日：2011-06-01
IPC分类号： A61F2/01
CPC分类号： A61F2/82 , A61B17/12118 , A61B17/1214 , A61B17/221 , A61B17/320725 , A61B2017/00309 , A61B2017/00867 , A61B2017/22001 , A61B2017/22034 , A61B2017/22039 , A61B2017/22079 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61B2017/32096 , A61B2090/3966 , A61F2/91 , A61F2/915 , A61M25/0074 , A61M2025/0042
摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.
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公开(公告)号：US20110160763A1
公开(公告)日：2011-06-30
申请号：US12980039
申请日：2010-12-28
IPC分类号： A61F2/01
CPC分类号： A61F2/82 , A61B17/12118 , A61B17/1214 , A61B17/221 , A61B17/320725 , A61B2017/00309 , A61B2017/00867 , A61B2017/22001 , A61B2017/22034 , A61B2017/22039 , A61B2017/22079 , A61B2017/22094 , A61B2017/2212 , A61B2017/2215 , A61B2017/32096 , A61B2090/3966 , A61F2/91 , A61F2/915 , A61M25/0074 , A61M2025/0042
摘要： Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.
摘要翻译： 用于治疗急性缺血性卒中的系统，方法和装置，其为血栓阻塞的血管提供即时血流恢复，并且在重新建立血流之后，解决凝块本身。 立即血流恢复有利地可以促进凝块的自然裂解，并且还可以减少或消除由于凝块断裂引起的远端栓塞的担忧。 本发明的几个实施方案基于凝块的性质提供逐步或模块化的治疗。 例如，逐步治疗可以包括三步逐步治疗过程，其包括根据治疗的具体情况立即恢复血流，原位血块管理和/或血块去除。 原位血块管理可以包括例如裂解和浸渍。 逐步或模块化的治疗可以由一个或多个治疗装置的系统或试剂盒提供。
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