-
1.发明授权Method for reducing the weight of a subject or inhibiting weight gain in a subject 有权用于减轻受试者体重或抑制受试者体重增加的方法公开(公告)号：US08242171B2
公开(公告)日：2012-08-14
申请号：US12683998
申请日：2010-01-07
CPC分类号： A61K31/05 , A61K31/00 , A61K31/12 , A61K31/353
摘要： Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
摘要翻译： 本文提供了用于调节沉默调节蛋白的活性或水平的方法和组合物，从而治疗或预防肥胖或胰岛素抵抗障碍，例如受试者中的糖尿病。 示例性方法包括使细胞与沉默调节蛋白的活化化合物或抑制化合物接触，从而分别增加或减少脂肪蓄积。
-
2.发明申请COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS 有权用于治疗或预防肥胖和胰岛素抵抗障碍的组合物公开(公告)号：US20120029065A1
公开(公告)日：2012-02-02
申请号：US13192011
申请日：2011-07-27
CPC分类号： A61K31/455 , A61K31/00 , A61K31/05 , A61K31/12 , A61K31/353 , A61K31/7048 , A61K31/7052 , A61K31/706 , A61K45/06 , Y10S514/866 , Y10S514/909
摘要： Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
摘要翻译： 本文提供了用于调节沉默调节蛋白的活性或水平的方法和组合物，从而治疗或预防肥胖或胰岛素抵抗障碍，例如受试者中的糖尿病。 示例性方法包括使细胞与沉默调节蛋白的活化化合物或抑制化合物接触，从而分别增加或减少脂肪蓄积。
-
3.发明申请COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS 有权用于治疗或预防肥胖和胰岛素抵抗障碍的组合物公开(公告)号：US20100316679A1
公开(公告)日：2010-12-16
申请号：US12683998
申请日：2010-01-07
CPC分类号： A61K31/05 , A61K31/00 , A61K31/12 , A61K31/353
摘要： Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
摘要翻译： 本文提供了用于调节沉默调节蛋白的活性或水平的方法和组合物，从而治疗或预防肥胖或胰岛素抵抗障碍，例如受试者中的糖尿病。 示例性方法包括使细胞与沉默调节蛋白的活化化合物或抑制化合物接触，从而分别增加或减少脂肪蓄积。
-
公开(公告)号：US08017634B2
公开(公告)日：2011-09-13
申请号：US11174000
申请日：2005-07-01
IPC分类号： A61K31/44 , A61K31/35 , A61K31/155
CPC分类号： A61K31/455 , A61K31/00 , A61K31/05 , A61K31/12 , A61K31/353 , A61K31/7048 , A61K31/7052 , A61K31/706 , A61K45/06 , Y10S514/866 , Y10S514/909
摘要： Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
摘要翻译： 本文提供了用于调节沉默调节蛋白的活性或水平的方法和组合物，从而治疗或预防肥胖或胰岛素抵抗障碍，例如受试者中的糖尿病。 示例性方法包括使细胞与沉默调节蛋白的活化化合物或抑制化合物接触，从而分别增加或减少脂肪蓄积。
-
公开(公告)号：US08846724B2
公开(公告)日：2014-09-30
申请号：US13192011
申请日：2011-07-27
IPC分类号： A61K31/44 , A61K31/35 , A61K31/155 , A61K31/12 , A61K31/05 , A61K31/7048 , A61K31/353 , A61K31/00
CPC分类号： A61K31/455 , A61K31/00 , A61K31/05 , A61K31/12 , A61K31/353 , A61K31/7048 , A61K31/7052 , A61K31/706 , A61K45/06 , Y10S514/866 , Y10S514/909
摘要： Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
摘要翻译： 本文提供了用于调节沉默调节蛋白的活性或水平的方法和组合物，从而治疗或预防肥胖或胰岛素抵抗障碍，例如受试者中的糖尿病。 示例性方法包括使细胞与沉默调节蛋白的活化化合物或抑制化合物接触，从而分别增加或减少脂肪蓄积。
-
公开(公告)号：US20120258069A1
公开(公告)日：2012-10-11
申请号：US13156047
申请日：2011-06-08
CPC分类号： G01N33/5023 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/61 , C12N15/1086
摘要： Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.
摘要翻译： 本文提供了通过靶向选择的细胞外和细胞外蛋白质的RGD结合位点来预防和治疗与代谢综合征相关的疾病和危险因素的组合物和方法。 典型的组合物包括通过酯键的RGD-多酚共轭物; 与RGD类似物或模拟物缀合的多酚聚合物; 和与多酚连接的RGD聚合物缀合物。
-
7.发明申请Compositions for treating or preventing obesity and insulin resistance disorders 有权用于治疗或预防肥胖症和胰岛素抵抗障碍的组合物公开(公告)号：US20060111435A1
公开(公告)日：2006-05-25
申请号：US11174000
申请日：2005-07-01
IPC分类号： A61K31/353 , A61K31/05
CPC分类号： A61K31/455 , A61K31/00 , A61K31/05 , A61K31/12 , A61K31/353 , A61K31/7048 , A61K31/7052 , A61K31/706 , A61K45/06 , Y10S514/866 , Y10S514/909
摘要： Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
摘要翻译： 本文提供了用于调节沉默调节蛋白的活性或水平的方法和组合物，从而治疗或预防肥胖或胰岛素抵抗障碍，例如受试者中的糖尿病。 示例性方法包括使细胞与沉默调节蛋白的活化化合物或抑制化合物接触，从而分别增加或减少脂肪蓄积。
-
8.发明授权Methods of stimulating fat mobilization using a polymer conjugated polyphenol 有权使用聚合物缀合的多酚刺激脂肪动员的方法公开(公告)号：US09272049B2
公开(公告)日：2016-03-01
申请号：US13156047
申请日：2011-06-08
CPC分类号： G01N33/5023 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/61 , C12N15/1086
摘要： Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.
摘要翻译： 本文提供了通过靶向选择的细胞外和细胞外蛋白质的RGD结合位点来预防和治疗与代谢综合征相关的疾病和危险因素的组合物和方法。 典型的组合物包括通过酯键的RGD-多酚共轭物; 与RGD类似物或模拟物缀合的多酚聚合物; 和与多酚连接的RGD聚合物缀合物。
-
9.发明申请公开(公告)号：US20100209382A1
公开(公告)日：2010-08-19
申请号：US11992152
申请日：2006-09-18
IPC分类号： A61K31/74 , A61K31/765 , A61K31/785 , A61K31/08 , A61K31/352 , A61K31/12 , G01N33/50 , C12Q1/68 , C40B30/04 , G01N33/567 , A61K31/715 , A61P3/10
CPC分类号： G01N33/5023 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/61 , C12N15/1086
摘要： Provided herein are compositions and methods for preventing and treating diseases and risk factors associated with metabolic syndrome by targeting the RGD-binding site of selected intra- and extracellular proteins. Exemplary compositions include RGD-polyphenol conjugates via an ester linkage; polyphenol polymer conjugated to RGD analogs or mimetics; and RGD polymer conjugates linked to polyphenol.
摘要翻译： 本文提供了通过靶向选择的细胞外和细胞外蛋白质的RGD结合位点来预防和治疗与代谢综合征相关的疾病和危险因素的组合物和方法。 典型的组合物包括通过酯键的RGD-多酚共轭物; 与RGD类似物或模拟物缀合的多酚聚合物; 和与多酚连接的RGD聚合物缀合物。
-
10.发明申请Compositions for treating or preventing obesity and insulin resistance disorders 审中-公开用于治疗或预防肥胖症和胰岛素抵抗障碍的组合物公开(公告)号：US20050171027A1
公开(公告)日：2005-08-04
申请号：US11027779
申请日：2004-12-29
IPC分类号： A61K31/00 , A61K31/05 , A61K31/12 , A61K31/353 , A61K31/7048
CPC分类号： A61K31/05 , A61K31/00 , A61K31/12 , A61K31/353
摘要： Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a subject. Exemplary methods comprise contacting a cell with a sirtuin activating compound or an inhibitory compound to thereby increase or decrease fat accumulation, respectively.
摘要翻译： 本文提供了用于调节沉默调节蛋白的活性或水平的方法和组合物，从而治疗或预防肥胖或胰岛素抵抗障碍，例如受试者中的糖尿病。 示例性方法包括使细胞与沉默调节蛋白的活化化合物或抑制化合物接触，从而分别增加或减少脂肪蓄积。
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.029 秒)
