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公开(公告)号：US07454387B2
公开(公告)日：2008-11-18
申请号：US10663218
申请日：2003-09-15
CPC分类号： G05B23/0254
摘要： A method of isolating sources of variance in parametric data includes steps of: (a) cleaning a data set of measurements for a plurality of parameters; (b) generating a principal component analysis basis from the cleaned data set; (c) estimating an independent component analysis model from the principal component analysis basis; (d) calculating percentages of variance for the plurality of parameters explained by each component in the estimated independent component analysis model; (e) if the calculated percentages of variance indicate that a component is a minor component, then transferring control to step (f), else transferring control to step (g); (f) removing the minor component from the principal component analysis basis and transferring control to step (c); and (g) generating as output the estimated independent component analysis model wherein no component of the independent component analysis model is a minor component.
摘要翻译： 一种隔离参数数据方差源的方法包括以下步骤：（a）清洁多个参数的测量数据集; （b）从清理的数据集中生成主成分分析基础; （c）从主成分分析的基础上估计独立成分分析模型; （d）计算由估计的独立分量分析模型中的每个分量解释的多个参数的方差百分比; （e）如果计算的方差百分比表示组分是次要组分，则将控制转移到步骤（f），否则将控制转移到步骤（g）; （f）从主成分分析基础中除去次要组分，并将控制转移到步骤（c）; 和（g）生成估计的独立分量分析模型作为输出，其中独立分量分析模型的分量不是次要分量。
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公开(公告)号：US20050060336A1
公开(公告)日：2005-03-17
申请号：US10663218
申请日：2003-09-15
CPC分类号： G05B23/0254
摘要： A method of isolating sources of variance in parametric data includes steps of: (a) cleaning a data set of measurements for a plurality of parameters; (b) generating a principal component analysis basis from the cleaned data set; (c) estimating an independent component analysis model from the principal component analysis basis; (d) calculating percentages of variance for the plurality of parameters explained by each component in the estimated independent component analysis model; (e) if the calculated percentages of variance indicate that a component is a minor component, then transferring control to step (f), else transferring control to step (g); (f) removing the minor component from the principal component analysis basis and transferring control to step (c); and (g) generating as output the estimated independent component analysis model wherein no component of the independent component analysis model is a minor component.
摘要翻译： 一种隔离参数数据方差源的方法包括以下步骤：（a）清洁多个参数的测量数据集; （b）从清理的数据集中生成主成分分析基础; （c）从主成分分析的基础上估计独立成分分析模型; （d）计算由估计的独立分量分析模型中的每个分量解释的多个参数的方差百分比; （e）如果计算的方差百分比表示组分是次要组分，则将控制转移到步骤（f），否则将控制转移到步骤（g）; （f）从主成分分析基础中除去次要组分，并将控制转移到步骤（c）; 和（g）生成估计的独立分量分析模型作为输出，其中独立分量分析模型的分量不是次要分量。
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公开(公告)号：US20060059452A1
公开(公告)日：2006-03-16
申请号：US10927802
申请日：2004-08-27
IPC分类号： G06F17/50
CPC分类号： G06F17/5081 , H01L21/70
摘要： A method for determining component patterns of a raw substrate map. A subset of substrate patterns is selected from a set of substrate patterns, and combined into a composite substrate map. The substrate patterns are weighted. The composite substrate map is compared to the raw substrate map, and a degree of correlation between the composite substrate map and the raw substrate map is determined. The steps are iteratively repeated until the degree of correlation is at least a desired degree, and the weighted subset of substrate patterns is output as the component patterns of the raw substrate map.
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公开(公告)号：US08529458B2
公开(公告)日：2013-09-10
申请号：US12891795
申请日：2010-09-27
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/412 , A61B5/4848 , A61B2505/03
摘要： Methods and apparatus for determining a cardiac parameter from cardiovascular pressure signals including arterial blood pressure (ABP) and the photoplethysmographic signal to quantify the degree of amplitude modulation due to respiration and predict fluid responsiveness are disclosed. Disclosed embodiments include a method for assessing fluid responsiveness implemented in a digital computer with one or more processors comprising: (a) measuring a cardiovascular signal, and (b) computing a dynamic index predictive of fluid responsiveness from said cardiovascular signal using a nonlinear state space estimator. According to one particular embodiment, and without limitation, the nonlinear state space estimator is based on a model for cardiovascular signals such as arterial blood pressure or plethysmogram signals, and employs a marginalized particle filter to estimate a dynamic index predictive of fluid responsiveness that is substantially equivalent to a variation in pulse pressure of said cardiovascular signal.
摘要翻译： 公开了用于从心血管压力信号（包括动脉血压（ABP））和光电体积描记信号确定心脏参数的方法和装置，以量化由呼吸引起的幅度调制程度并预测流体反应性。 公开的实施例包括用于评估在具有一个或多个处理器的数字计算机中实现的流体响应性的方法，包括：（a）测量心血管信号，以及（b）使用非线性状态空间计算预测来自所述心血管信号的流体响应性的动态指数 估计。 根据一个特定实施例，非限制性地，非线性状态空间估计器基于诸如动脉血压或体积描记信号的心血管信号的模型，并且使用边缘化的粒子滤波器来估计预测流体响应性的动态指数，其基本上 相当于所述心血管信号的脉压的变化。
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5.发明申请SYSTEM, METHOD, AND APPARATUS FOR OBJECTIVE ASSESSMENT OF MOTOR SIGNS AT THE EXTREMITIES 审中-公开用于目标评估电机标识的系统，方法和装置公开(公告)号：US20110213277A1
公开(公告)日：2011-09-01
申请号：US13037287
申请日：2011-02-28
申请人： James McNames , Lars Holstrom , Joshua Booren , Edward Katz , Forest Kernan , Brent Casady , John Nutt , Craig Kinnie , Pedro Mateo Riobo Aboy
发明人： James McNames , Lars Holstrom , Joshua Booren , Edward Katz , Forest Kernan , Brent Casady , John Nutt , Craig Kinnie , Pedro Mateo Riobo Aboy
IPC分类号： A61B5/11
CPC分类号： A61B5/1124 , A61B5/4082
摘要： Disclosed embodiments include a system for objective assessment of motor signs at the extremities that comprises (a) a device for objective motor sign measurement, (b) a test protocol defining a prescribed repetitive activity, and (c) a signal processing and analysis system to generate one or more impairment metrics. According to a particular embodiment, the device for objective motor sign measurement is characterized by including means for producing a continuous measure of position of a limb or extremity during said prescribed repetitive activity during the entire movement.
摘要翻译： 公开的实施例包括用于客观评估四肢运动符号的系统，其包括（a）用于客观运动符号测量的装置，（b）定义规定的重复活动的测试协议，以及（c）信号处理和分析系统， 产生一个或多个损伤度量。 根据具体实施例，用于目标电动机符号测量的装置的特征在于包括用于在整个运动期间在所述规定的重复活动期间产生连续测量肢体或肢体的位置的装置。
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6.发明申请METHOD AND APPARATUS FOR CONTINUOUS MEASUREMENT OF MOTOR SYMPTOMS IN PARKINSON'S DISEASE AND ESSENTIAL TREMOR WITH WEARABLE SENSORS 有权用于连续测量PARKINSON'S疾病和基本TREMOR与可靠传感器的运动症状的方法和装置公开(公告)号：US20100030119A1
公开(公告)日：2010-02-04
申请号：US12511038
申请日：2009-07-28
IPC分类号： A61B5/11
CPC分类号： A61B5/1101 , A61B5/4082
摘要： Disclosed embodiments include an apparatus for generating a plurality of movement impairment indices from one or more kinematic signals to characterize movement disorders. Additionally we disclose methods for generating a plurality of movement impairment indices from one or more kinematic signals obtained from one or more kinematic sensors, said methods implemented in a digital computer with one or more processors in order to characterize movement disorders based on spectral analysis, regularity metrics, and time-frequency analsysis.
摘要翻译： 公开的实施例包括用于从一个或多个运动学信号产生多个运动损伤指数以表征运动障碍的装置。 另外，我们公开了从一个或多个运动学传感器获得的一个或多个运动学信号产生多个运动损伤指标的方法，所述方法在具有一个或多个处理器的数字计算机中实现，以便基于频谱分析来表征运动障碍，规律性 指标和时频分析。
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7.发明申请METHOD, SYSTEM, AND APPARATUS FOR CARDIOVASCULAR SIGNAL ANALYSIS, MODELING, AND MONITORING 有权心脏信号分析，建模与监测的方法，系统和装置公开(公告)号：US20090069647A1
公开(公告)日：2009-03-12
申请号：US12200995
申请日：2008-08-29
IPC分类号： A61B5/02
CPC分类号： A61B5/0205 , A61B5/02405 , A61B5/031 , A61B5/0816 , A61B5/14551 , A61B5/412 , A61B5/725 , G06F19/00
摘要： The present invention provides a method, system, and apparatus to monitor cardiovascular signals such as arterial blood pressure (ABP), pulse oximetry (POX), and intracranial pressure (ICP). The system can be used to calculate and monitor useful clinical information such as heart rate, respiratory rate, pulse pressure variation (PPV), harmonic phases, pulse morphology, and for artifact removal. The method uses a statistical state-space model of cardiovascular signals and a generalized Kalman filter (EKF) to simultaneously estimate and track the cardiovascular parameters of interest such as the cardiac fundamental frequency and higher harmonics, respiratory fundamental frequency and higher harmonics, cardiac component harmonic amplitudes and phases, respiratory component harmonic amplitudes and phases, and PPV.
摘要翻译： 本发明提供一种监测心血管信号如血压（ABP），脉搏血氧饱和度（POX）和颅内压（ICP）的方法，系统和装置。 该系统可用于计算和监测有用的临床信息，如心率，呼吸频率，脉搏压力变化（PPV），谐波相位，脉冲形态和人为因素去除。 该方法使用心血管信号的统计状态空间模型和广义卡尔曼滤波器（EKF）来同时估计和跟踪感兴趣的心血管参数，例如心脏基频和高次谐波，呼吸基频和高次谐波，心脏分量谐波 振幅和相位，呼吸分量谐波幅度和相位以及PPV。
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公开(公告)号：US10117204B2
公开(公告)日：2018-10-30
申请号：US14146157
申请日：2014-01-02
申请人： Andrew Greenberg , Pedro Mateo Riobo Aboy , James McNames , Sean Pearson , Gavin Gallino , Timothy Brandon
发明人： Andrew Greenberg , Pedro Mateo Riobo Aboy , James McNames , Sean Pearson , Gavin Gallino , Timothy Brandon
摘要： Disclosed embodiments include an apparatus that comprises (a) a kinematics sensor module including an accelerometer, a gyroscope, a magnetometer, or combinations thereof; and (b) a bidirectional wireless communication module configured for wirelessly synchronizing the sampling time instances of the kinematics sensor module with the sampling time instances of at least a second wearable apparatus including a second kinematics sensor module.
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公开(公告)号：USD625729S1
公开(公告)日：2010-10-19
申请号：US29339740
申请日：2009-07-07
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公开(公告)号：US20100145236A1
公开(公告)日：2010-06-10
申请号：US12632778
申请日：2009-12-07
IPC分类号： A61B5/11
CPC分类号： G04G21/025 , A61B5/0002 , A61B5/1101 , A61B5/1118 , A61B5/681 , A61B2560/029 , A61B2560/0456 , A61B2560/0475 , A61B2562/0219 , G01S5/0257 , G01S5/0294 , G01S19/42
摘要： Disclosed embodiments include a complete system and platform which allows for continuous monitoring of movement disorders during normal daily activities in the clinic, home, and other normal daily environments. The system comprises: 1) a wearable apparatus for continuous monitoring of movement disorders, 2) a docking station, 3) a web server, and 4) methods for statistical analysis that generate movement impairment measures. Disclosed embodiments include a wearable movement monitoring apparatus comprising of (a) a sensor module including a plurality of low power micro-electromechanical systems kinematics sensors; (b) a microprocessor module including a low power microcontroller configured for device control, device status, and device communication; (c) a data storage module including a solid state local storage medium; (d) a wireless communication module including a low power surface mount transceiver and an integrated antenna; and (e) a power and docking module including a battery, an energy charging regulator circuit, and a docking connector.
摘要翻译： 公开的实施例包括完整的系统和平台，其允许在诊所，家庭和其他正常日常环境中的正常日常活动期间连续监测运动障碍。 该系统包括：1）用于连续监测运动障碍的穿戴式装置，2）对接站，3）网络服务器，以及4）产生运动损伤测量的统计分析方法。 公开的实施例包括一种可穿戴运动监测装置，包括：（a）包括多个低功率微机电系统运动传感器的传感器模块; （b）微处理器模块，其包括被配置用于设备控制，设备状态和设备通信的低功率微控制器; （c）包括固态本地存储介质的数据存储模块; （d）包括低功率表面安装收发器和集成天线的无线通信模块; 和（e）包括电池，能量充电调节器电路和对接连接器的电力和对接模块。
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