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1.发明申请MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146 有权通过MICRORNA MIR-146调节免疫系统发育和功能公开(公告)号：US20090203136A1
公开(公告)日：2009-08-13
申请号：US12337525
申请日：2008-12-17
申请人： David Baltimore , Mark Boldin , Konstantin Taganov
发明人： David Baltimore , Mark Boldin , Konstantin Taganov
IPC分类号： C12N5/08
CPC分类号： C12N15/113 , C12N2310/111 , C12N2310/113 , C12N2310/141 , C12N2330/10
摘要： The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed.
摘要翻译： 本公开涉及微RNA-146在调节免疫系统的发育和功能中起作用的发现。 免疫细胞发育和功能可以通过将microRNA-146（miR-146）或反义miR-146递送到靶向免疫细胞或前体细胞来调节。 例如，在一些实施方案中，通过施用miR-146寡核苷酸或抗miR-146寡核苷酸调节某些免疫细胞的活性和/或增殖。 在其它实施方案中，通过施用miR-146寡核苷酸或抗miR-146调节免疫细胞中的促炎细胞因子表达。 在另外的实施方案中，提供了使用反义miR-146调节巨噬细胞活性的方法。 公开了使用miR-146调节免疫系统功能和发育的其它方法和组合物。
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2.发明申请MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146 审中-公开通过MICRORNA MIR-146调节免疫系统发育和功能公开(公告)号：US20110258716A1
公开(公告)日：2011-10-20
申请号：US13151053
申请日：2011-06-01
申请人： David Baltimore , Mark Boldin , Konstantin Taganov
发明人： David Baltimore , Mark Boldin , Konstantin Taganov
IPC分类号： A01K67/027 , C12N5/10
CPC分类号： C12N15/113 , C12N2310/111 , C12N2310/113 , C12N2310/141 , C12N2330/10
摘要： The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed.
摘要翻译： 本公开涉及微RNA-146在调节免疫系统的发育和功能中起作用的发现。 免疫细胞发育和功能可以通过将microRNA-146（miR-146）或反义miR-146递送到靶向免疫细胞或前体细胞来调节。 例如，在一些实施方案中，通过施用miR-146寡核苷酸或抗miR-146寡核苷酸调节某些免疫细胞的活性和/或增殖。 在其它实施方案中，通过施用miR-146寡核苷酸或抗miR-146调节免疫细胞中的促炎细胞因子表达。 在另外的实施方案中，提供了使用反义miR-146调节巨噬细胞活性的方法。 公开了使用miR-146调节免疫系统功能和发育的其它方法和组合物。
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3.发明申请MODULATION OF INNATE IMMUNITY RECEPTORS' SIGNALING BY microRNAs miR-146a AND miR-146b 失效免疫调节免疫小鼠miR-146a和miR-146b的信号转导公开(公告)号：US20070232553A1
公开(公告)日：2007-10-04
申请号：US11690105
申请日：2007-03-22
申请人： David Baltimore , Mark Boldin , Konstantin Taganov
发明人： David Baltimore , Mark Boldin , Konstantin Taganov
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , C12N15/113 , C12N2310/111 , C12N2310/13 , C12N2310/14 , C12N2330/10
摘要： The present disclosure relates to the finding that microRNA-146 plays a role modulating the innate immune response. Innate immunity receptor signaling can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells. In some embodiments, IL-1 receptor associated kinase 1 (IRAK1) and TNF receptor associated factor 6 (TRAF6) expression levels are downregulated in a target cell by administering a miR-146 oligonucleotide. Modulation of the innate immune system through miR-146 can be used to treat a variety of diseases and disorders associated with activation of the innate immune system, such as sepsis and Crohn's disease.
摘要翻译： 本公开涉及微RNA-146起调节先天免疫应答的作用的发现。 可以通过将microRNA-146（miR-146）或反义miR-146递送至靶免疫细胞来调节先天免疫受体信号传导。 在一些实施方案中，通过施用miR-146寡核苷酸，在靶细胞中下调IL-1受体相关激酶1（IRAK1）和TNF受体相关因子6（TRAF6）表达水平。 通过miR-146调节先天免疫系统可用于治疗与先天性免疫系统的活化相关的各种疾病和病症，例如败血症和克罗恩病。
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4.发明授权Microrna inhibition for the treatment of inflammation and myeloproliferative disorders 有权Microrna抑制治疗炎症和骨髓增生性疾病公开(公告)号：US08697672B2
公开(公告)日：2014-04-15
申请号：US12122595
申请日：2008-05-16
CPC分类号： C12N15/113 , A61K31/56 , A61K31/7105 , A61K45/06 , C12N2310/11 , C12N2310/113 , C12N2310/141 , C12N2320/31
摘要： The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing and treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arnt1, Picalm, Jarid2, PU.1, Csf1r, HIF1α, Sla, Cepbβ, and Bach1, and the like.
摘要翻译： 本公开涉及microRNA-155在炎症，造血和骨髓增生中起作用的发现，并且微小RNA-155表达的调节异常与特定的骨髓增生性疾病相关。 本文公开了用于诊断和治疗疾病的方法和组合物，包括炎症和骨髓增生，调节选自Cutl1，Arnt1，Picalm，Jarid2，PU.1，Csf1r，HIF1α，Sla的一种或多种基因的表达水平 ，Cepb＆bgr，和Bach1等。
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5.发明授权Modulating immune system development and function through microRNA MIR-146 有权通过microRNA MIR-146调节免疫系统发育和功能公开(公告)号：US09090894B2
公开(公告)日：2015-07-28
申请号：US12337525
申请日：2008-12-17
申请人： David Baltimore , Mark Boldin , Konstantin Taganov
发明人： David Baltimore , Mark Boldin , Konstantin Taganov
IPC分类号： C12N15/11 , C12Q1/68 , C12N15/113 , C07H21/04
CPC分类号： C12N15/113 , C12N2310/111 , C12N2310/113 , C12N2310/141 , C12N2330/10
摘要： The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed.
摘要翻译： 本公开涉及微RNA-146在调节免疫系统的发育和功能中起作用的发现。 免疫细胞发育和功能可以通过将microRNA-146（miR-146）或反义miR-146递送到靶向免疫细胞或前体细胞来调节。 例如，在一些实施方案中，通过施用miR-146寡核苷酸或抗miR-146寡核苷酸调节某些免疫细胞的活性和/或增殖。 在其它实施方案中，通过施用miR-146寡核苷酸或抗miR-146调节免疫细胞中的促炎细胞因子表达。 在另外的实施方案中，提供了使用反义miR-146调节巨噬细胞活性的方法。 公开了使用miR-146调节免疫系统功能和发育的其它方法和组合物。
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6.发明授权Modulation of innate immunity receptors' signaling by microRNAs miR-146a and miR-146b 失效通过微RNA miR-146a和miR-146b调节先天免疫受体的信号传导公开(公告)号：US08669235B2
公开(公告)日：2014-03-11
申请号：US11690105
申请日：2007-03-22
申请人： David Baltimore , Mark Boldin , Konstantin Taganov
发明人： David Baltimore , Mark Boldin , Konstantin Taganov
CPC分类号： C12N15/1137 , C12N15/113 , C12N2310/111 , C12N2310/13 , C12N2310/14 , C12N2330/10
摘要： The present disclosure relates to the finding that microRNA-146 plays a role modulating the innate immune response. Innate immunity receptor signaling can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells. In some embodiments, IL-1 receptor associated kinase 1 (IRAK1) and TNF receptor associated factor 6 (TRAF6) expression levels are downregulated in a target cell by administering a miR-146 oligonucleotide. Modulation of the innate immune system through miR-146 can be used to treat a variety of diseases and disorders associated with activation of the innate immune system, such as sepsis and Crohn's disease.
摘要翻译： 本公开涉及微RNA-146起调节先天免疫应答的作用的发现。 可以通过将microRNA-146（miR-146）或反义miR-146递送至靶免疫细胞来调节先天免疫受体信号传导。 在一些实施方案中，通过施用miR-146寡核苷酸，在靶细胞中下调IL-1受体相关激酶1（IRAK1）和TNF受体相关因子6（TRAF6）表达水平。 通过miR-146调节先天免疫系统可用于治疗与先天性免疫系统的活化相关的各种疾病和病症，例如败血症和克罗恩病。
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7.发明申请公开(公告)号：US20080300211A1
公开(公告)日：2008-12-04
申请号：US12122595
申请日：2008-05-16
CPC分类号： C12N15/113 , A61K31/56 , A61K31/7105 , A61K45/06 , C12N2310/11 , C12N2310/113 , C12N2310/141 , C12N2320/31
摘要： The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated with particular myeloproliferative disorders. Disclosed herein are methods and compositions for diagnosing and treating disorders, including inflammation and myeloproliferation, modulating the levels of expression of one or more genes selected from the group consisting of Cutl1, Arnt1, Picalm, Jarid2, PU.1, Csf1r, HIF1α, Sla, Cepbβ, and Bach1, and the like.
摘要翻译： 本公开涉及microRNA-155在炎症，造血和骨髓增生中起作用的发现，并且微小RNA-155表达的调节异常与特定的骨髓增生性疾病相关。 本文公开了用于诊断和治疗疾病的方法和组合物，包括炎症和骨髓增殖，调节选自Cutl1，Arnt1，Picalm，Jarid2，PU.1，Csf1r，HIF1alpha，Sla中的一种或多种基因的表达水平 ，Cepbbeta和Bach1等。
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