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    MODULATION OF INNATE IMMUNITY RECEPTORS' SIGNALING BY microRNAs miR-146a AND miR-146b
    3.
    发明申请
    MODULATION OF INNATE IMMUNITY RECEPTORS' SIGNALING BY microRNAs miR-146a AND miR-146b 失效
    免疫调节免疫小鼠miR-146a和miR-146b的信号转导

    公开(公告)号：US20070232553A1

    公开(公告)日：2007-10-04

    申请号：US11690105

    申请日：2007-03-22

    申请人： David Baltimore ,  Mark Boldin ,  Konstantin Taganov

    发明人： David Baltimore ,  Mark Boldin ,  Konstantin Taganov

    IPC分类号： A61K48/00

    CPC分类号： C12N15/1137 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/13 ,  C12N2310/14 ,  C12N2330/10

    摘要： The present disclosure relates to the finding that microRNA-146 plays a role modulating the innate immune response. Innate immunity receptor signaling can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells. In some embodiments, IL-1 receptor associated kinase 1 (IRAK1) and TNF receptor associated factor 6 (TRAF6) expression levels are downregulated in a target cell by administering a miR-146 oligonucleotide. Modulation of the innate immune system through miR-146 can be used to treat a variety of diseases and disorders associated with activation of the innate immune system, such as sepsis and Crohn's disease.

    摘要翻译： 本公开涉及微RNA-146起调节先天免疫应答的作用的发现。 可以通过将microRNA-146（miR-146）或反义miR-146递送至靶免疫细胞来调节先天免疫受体信号传导。 在一些实施方案中，通过施用miR-146寡核苷酸，在靶细胞中下调IL-1受体相关激酶1（IRAK1）和TNF受体相关因子6（TRAF6）表达水平。 通过miR-146调节先天免疫系统可用于治疗与先天性免疫系统的活化相关的各种疾病和病症，例如败血症和克罗恩病。

    MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146
    4.
    发明申请
    MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146 审中-公开
    通过MICRORNA MIR-146调节免疫系统发育和功能

    公开(公告)号：US20110258716A1

    公开(公告)日：2011-10-20

    申请号：US13151053

    申请日：2011-06-01

    申请人： David Baltimore ,  Mark Boldin ,  Konstantin Taganov

    发明人： David Baltimore ,  Mark Boldin ,  Konstantin Taganov

    IPC分类号： A01K67/027 ,  C12N5/10

    CPC分类号： C12N15/113 ,  C12N2310/111 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2330/10

    摘要： The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed.

    摘要翻译： 本公开涉及微RNA-146在调节免疫系统的发育和功能中起作用的发现。 免疫细胞发育和功能可以通过将microRNA-146（miR-146）或反义miR-146递送到靶向免疫细胞或前体细胞来调节。 例如，在一些实施方案中，通过施用miR-146寡核苷酸或抗miR-146寡核苷酸调节某些免疫细胞的活性和/或增殖。 在其它实施方案中，通过施用miR-146寡核苷酸或抗miR-146调节免疫细胞中的促炎细胞因子表达。 在另外的实施方案中，提供了使用反义miR-146调节巨噬细胞活性的方法。 公开了使用miR-146调节免疫系统功能和发育的其它方法和组合物。

    MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146
    5.
    发明申请
    MODULATING IMMUNE SYSTEM DEVELOPMENT AND FUNCTION THROUGH MICRORNA MIR-146 有权
    通过MICRORNA MIR-146调节免疫系统发育和功能

    公开(公告)号：US20090203136A1

    公开(公告)日：2009-08-13

    申请号：US12337525

    申请日：2008-12-17

    申请人： David Baltimore ,  Mark Boldin ,  Konstantin Taganov

    发明人： David Baltimore ,  Mark Boldin ,  Konstantin Taganov

    IPC分类号： C12N5/08

    CPC分类号： C12N15/113 ,  C12N2310/111 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2330/10

    摘要： The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed.

    摘要翻译： 本公开涉及微RNA-146在调节免疫系统的发育和功能中起作用的发现。 免疫细胞发育和功能可以通过将microRNA-146（miR-146）或反义miR-146递送到靶向免疫细胞或前体细胞来调节。 例如，在一些实施方案中，通过施用miR-146寡核苷酸或抗miR-146寡核苷酸调节某些免疫细胞的活性和/或增殖。 在其它实施方案中，通过施用miR-146寡核苷酸或抗miR-146调节免疫细胞中的促炎细胞因子表达。 在另外的实施方案中，提供了使用反义miR-146调节巨噬细胞活性的方法。 公开了使用miR-146调节免疫系统功能和发育的其它方法和组合物。

    Modulating immune system development and function through microRNA MIR-146
    6.
    发明授权
    Modulating immune system development and function through microRNA MIR-146 有权
    通过microRNA MIR-146调节免疫系统发育和功能

    公开(公告)号：US09090894B2

    公开(公告)日：2015-07-28

    申请号：US12337525

    申请日：2008-12-17

    申请人： David Baltimore ,  Mark Boldin ,  Konstantin Taganov

    发明人： David Baltimore ,  Mark Boldin ,  Konstantin Taganov

    IPC分类号： C12N15/11 ,  C12Q1/68 ,  C12N15/113 ,  C07H21/04

    CPC分类号： C12N15/113 ,  C12N2310/111 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2330/10

    摘要： The present disclosure relates to the finding that microRNA-146 plays a role in modulating the development and function of the immune system. Immune cell development and function can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells or precursor cells. For example, in some embodiments, activity and/or proliferation of certain immune cells is regulated by administering miR-146 oligonucleotides or anti-miR-146 oligonucleotides. In other embodiments, pro-inflammatory cytokine expression in immune cells is regulated by administering a miR-146 oligonucleotide or anti-miR-146. In further embodiments, methods of regulating macrophage activity using antisense miR-146 are provided. Additional methods and compositions for regulating immune system function and development using miR-146 are disclosed.

    摘要翻译： 本公开涉及微RNA-146在调节免疫系统的发育和功能中起作用的发现。 免疫细胞发育和功能可以通过将microRNA-146（miR-146）或反义miR-146递送到靶向免疫细胞或前体细胞来调节。 例如，在一些实施方案中，通过施用miR-146寡核苷酸或抗miR-146寡核苷酸调节某些免疫细胞的活性和/或增殖。 在其它实施方案中，通过施用miR-146寡核苷酸或抗miR-146调节免疫细胞中的促炎细胞因子表达。 在另外的实施方案中，提供了使用反义miR-146调节巨噬细胞活性的方法。 公开了使用miR-146调节免疫系统功能和发育的其它方法和组合物。

    Modulation of innate immunity receptors' signaling by microRNAs miR-146a and miR-146b
    7.
    发明授权
    Modulation of innate immunity receptors' signaling by microRNAs miR-146a and miR-146b 失效
    通过微RNA miR-146a和miR-146b调节先天免疫受体的信号传导

    公开(公告)号：US08669235B2

    公开(公告)日：2014-03-11

    申请号：US11690105

    申请日：2007-03-22

    申请人： David Baltimore ,  Mark Boldin ,  Konstantin Taganov

    发明人： David Baltimore ,  Mark Boldin ,  Konstantin Taganov

    IPC分类号： A61K48/00 ,  C12N15/00 ,  C07H21/04 ,  C12N5/00

    CPC分类号： C12N15/1137 ,  C12N15/113 ,  C12N2310/111 ,  C12N2310/13 ,  C12N2310/14 ,  C12N2330/10

    摘要： The present disclosure relates to the finding that microRNA-146 plays a role modulating the innate immune response. Innate immunity receptor signaling can be modulated by delivery of microRNA-146 (miR-146) or antisense miR-146 to target immune cells. In some embodiments, IL-1 receptor associated kinase 1 (IRAK1) and TNF receptor associated factor 6 (TRAF6) expression levels are downregulated in a target cell by administering a miR-146 oligonucleotide. Modulation of the innate immune system through miR-146 can be used to treat a variety of diseases and disorders associated with activation of the innate immune system, such as sepsis and Crohn's disease.

    摘要翻译： 本公开涉及微RNA-146起调节先天免疫应答的作用的发现。 可以通过将microRNA-146（miR-146）或反义miR-146递送至靶免疫细胞来调节先天免疫受体信号传导。 在一些实施方案中，通过施用miR-146寡核苷酸，在靶细胞中下调IL-1受体相关激酶1（IRAK1）和TNF受体相关因子6（TRAF6）表达水平。 通过miR-146调节先天免疫系统可用于治疗与先天性免疫系统的活化相关的各种疾病和病症，例如败血症和克罗恩病。