公开(公告)号：US20140057939A1

公开(公告)日：2014-02-27

申请号：US13771685

申请日：2013-02-20

申请人： David Beattie ,  Fei Shen ,  Jacqueline A.M. Smith

发明人： David Beattie ,  Fei Shen ,  Jacqueline A.M. Smith

IPC分类号： A61K31/46 ,  A61K31/4545 ,  A61K31/445

CPC分类号： A61K31/46 ,  A61K31/445 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides methods for the treatment of cognitive disorders utilizing specific 5-HT4 receptor agonist compounds, in particular, methods utilizing these compounds in combination with other agents, specifically acetylcholinesterase inhibitors, for the treatment of Alzheimer's disease and other cognitive disorders.

摘要翻译： 本发明提供了使用特定的5-HT 4受体激动剂化合物治疗认知障碍的方法，特别是利用这些化合物与其它试剂，特别是乙酰胆碱酯酶抑制剂联合用于治疗阿尔茨海默氏病和其他认知障碍的方法。

公开(公告)号：US20100261752A1

公开(公告)日：2010-10-14

申请号：US12758631

申请日：2010-04-12

申请人： David Beattie ,  Fei Shen ,  Jacqueline A.M. Smith ,  Robert Murray McKinnell ,  Ray Chang

发明人： David Beattie ,  Fei Shen ,  Jacqueline A.M. Smith ,  Robert Murray McKinnell ,  Ray Chang

IPC分类号： A61K31/439 ,  A61K31/4545 ,  A61P25/28

CPC分类号： A61K31/46 ,  A61K31/445 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides methods for the treatment of cognitive disorders utilizing specific 5-HT4 receptor agonist compounds, in particular, methods utilizing these compounds in combination with other agents, specifically acetylcholinesterase inhibitors, for the treatment of Alzheimer's disease and other cognitive disorders.

摘要翻译： 本发明提供了使用特定的5-HT 4受体激动剂化合物治疗认知障碍的方法，特别是利用这些化合物与其它试剂，特别是乙酰胆碱酯酶抑制剂联合用于治疗阿尔茨海默氏病和其他认知障碍的方法。

公开(公告)号：US20110263631A1

公开(公告)日：2011-10-27

申请号：US13091874

申请日：2011-04-21

申请人： William J. Martin ,  Fei Shen ,  Jacqueline A.M. Smith

发明人： William J. Martin ,  Fei Shen ,  Jacqueline A.M. Smith

IPC分类号： A61K31/485 ,  C12Q1/02 ,  A61P29/00 ,  A61K31/451

CPC分类号： A61K31/138 ,  A61K31/38 ,  A61K31/451 ,  A61K31/485 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides a method of treating a pain condition in a mammal utilizing a specific serotonin and norepinephrine reuptake inhibitor (SNRI) and also the combination of the SNRI and an opioid agonist agent. The invention includes methods wherein the opioid agonist agent is administered at a dose that is lower than a dose administered for treating a pain condition when used alone.

摘要翻译： 本发明提供了使用特异性5-羟色胺和去甲肾上腺素再摄取抑制剂（SNRI）以及SNRI和阿片样物质激动剂的组合治疗哺乳动物疼痛状况的方法。 本发明包括其中阿片类激动剂以低于单独使用时用于治疗疼痛状况的剂量的剂量施用的方法。

公开(公告)号：US08404711B2

公开(公告)日：2013-03-26

申请号：US12758631

申请日：2010-04-12

申请人： David Beattie ,  Fei Shen ,  Jacqueline A. M. Smith

发明人： David Beattie ,  Fei Shen ,  Jacqueline A. M. Smith

IPC分类号： A61K31/439 ,  A61K31/4545

CPC分类号： A61K31/46 ,  A61K31/445 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4709 ,  A61K45/06 ,  A61K2300/00

摘要： The invention provides methods for the treatment of cognitive disorders utilizing specific 5-HT4 receptor agonist compounds, in particular, methods utilizing these compounds in combination with other agents, specifically acetylcholinesterase inhibitors, for the treatment of Alzheimer's disease and other cognitive disorders.

摘要翻译： 本发明提供了使用特定的5-HT 4受体激动剂化合物治疗认知障碍的方法，特别是利用这些化合物与其它试剂，特别是乙酰胆碱酯酶抑制剂联合用于治疗阿尔茨海默氏病和其他认知障碍的方法。

公开(公告)号：US09625242B1

公开(公告)日：2017-04-18

申请号：US14620796

申请日：2015-02-12

申请人： Mohamed Elalem ,  Gregory C. Burke ,  Viral Panchal ,  Philip Abbate ,  Chong Peng ,  Fei Shen

发明人： Mohamed Elalem ,  Gregory C. Burke ,  Viral Panchal ,  Philip Abbate ,  Chong Peng ,  Fei Shen

IPC分类号： F42B5/38

CPC分类号： F42B5/38

摘要： A modular artillery charge system module includes a central igniter container and cap end and body end igniter containers fixed to the central igniter container. The central igniter container is a rigid, longitudinal tube with opposing ends. The end igniter containers are fixed to the opposing ends of the central igniter container. Each end igniter container includes a large container portion and a small container portion that extends from the large container portion toward the central igniter container. The central igniter container and end igniter containers are made of a rigid material, such as foamed celluloid.

公开(公告)号：US08506812B2

公开(公告)日：2013-08-13

申请号：US13555668

申请日：2012-07-23

申请人： Yinhua Wan ,  Xiangrong Chen ,  Zhiguo Su ,  Guanghui Ma ,  Xiaoguang Jiao ,  Fei Shen ,  Zhanfeng Cui

发明人： Yinhua Wan ,  Xiangrong Chen ,  Zhiguo Su ,  Guanghui Ma ,  Xiaoguang Jiao ,  Fei Shen ,  Zhanfeng Cui

IPC分类号： B01D33/44 ,  B01D29/075

CPC分类号： B01D65/08 ,  B01D61/145 ,  B01D61/147 ,  B01D63/082 ,  B01D2321/26

摘要： The present invention relates to a membrane separation method and a relevant equipment, in particular to a method and an equipment for membrane separation utilizing concentration polarization during membrane filtration process, especially, to a concentration process and equipment and a drawer special for drawing a concentration polarization layer. The direct removal of the concentration polarization layer from membrane surface not only decreases the adverse influence of concentration polarization on membrane separation but also obtains concentrated retention components, thereby significantly improving the ability to maintain membrane flux, solving the twinborn problems concerning concentration polarization and membrane fouling during the membrane separation process, and achieving a high-efficiency concentration for retention components. The method and equipment of the present invention can be widely applied in various membrane techniques, in particular in a membrane separation process for concentrating biomacromolecule and organic micromolecule products such as sugars, organic acids and polypeptides etc.

摘要翻译： 本发明涉及一种膜分离方法和相关设备，特别涉及在膜过滤过程中利用浓度极化的膜分离方法和设备，特别涉及浓缩过程和设备以及特别用于绘制浓缩极化的抽屉 层。 从膜表面直接除去浓缩极化层不仅降低了浓度极化对膜分离的不利影响，而且获得了浓缩的保留成分，从而显着提高了保持膜通量的能力，解决了浓度极化和膜污染的双胎问题 在膜分离过程中，并且实现保留成分的高效浓缩。 本发明的方法和设备可以广泛地应用于各种膜技术中，特别是在用于浓缩生物大分子和有机小分子产物如糖，有机酸和多肽等的膜分离方法中。

公开(公告)号：US08252184B2

公开(公告)日：2012-08-28

申请号：US12443797

申请日：2008-03-05

申请人： Yinhua Wan ,  Xiangrong Chen ,  Zhiguo Su ,  Guanghui Ma ,  Xiaoguang Jiao ,  Fei Shen ,  Zhanfeng Cui

发明人： Yinhua Wan ,  Xiangrong Chen ,  Zhiguo Su ,  Guanghui Ma ,  Xiaoguang Jiao ,  Fei Shen ,  Zhanfeng Cui

IPC分类号： B01D29/075 ,  B01D33/44

CPC分类号： B01D65/08 ,  B01D61/145 ,  B01D61/147 ,  B01D63/082 ,  B01D2321/26

摘要： The present invention relates to a membrane separation method and a relevant equipment, in particular to a method and an equipment for membrane separation utilizing concentration polarization during membrane filtration process, especially, to a concentration process and equipment and a drawer special for drawing a concentration polarization layer. The direct removal of the concentration polarization layer from membrane surface not only decreases the adverse influence of concentration polarization on membrane separation but also obtains concentrated retention components, thereby significantly improving the ability to maintain membrane flux, solving the twinborn problems concerning concentration polarization and membrane fouling during the membrane separation process, and achieving a high-efficiency concentration for retention components. The method and equipment of the present invention can be widely applied in various membrane techniques, in particular in a membrane separation process for concentrating biomacromolecule and organic micromolecule products such as sugars, organic acids and polypeptides etc.

摘要翻译： 本发明涉及一种膜分离方法和相关设备，特别涉及在膜过滤过程中利用浓度极化的膜分离方法和设备，特别涉及浓缩过程和设备以及特别用于绘制浓缩极化的抽屉 层。 从膜表面直接除去浓缩极化层不仅降低了浓度极化对膜分离的不利影响，而且获得了浓缩的保留成分，从而显着提高了保持膜通量的能力，解决了浓度极化和膜污染的双胎问题 在膜分离过程中，并且实现保留成分的高效浓缩。 本发明的方法和设备可以广泛地应用于各种膜技术中，特别是在用于浓缩生物大分子和有机小分子产物如糖，有机酸和多肽等的膜分离方法中。

公开(公告)号：US10317182B1

公开(公告)日：2019-06-11

申请号：US14656005

申请日：2015-03-12

申请人： Mohamed Elalem ,  Philip Abbate ,  Vincent Gonsalves ,  Matthew P. Evangelisti ,  John W. Grassia ,  Steve Kotefski ,  Nikola Kotefski ,  Ming-Wan Young ,  Fei Shen ,  Chong Peng ,  Linjie Zhu ,  Viral Panchal

发明人： Mohamed Elalem ,  Philip Abbate ,  Vincent Gonsalves ,  Matthew P. Evangelisti ,  John W. Grassia ,  Steve Kotefski ,  Nikola Kotefski ,  Ming-Wan Young ,  Fei Shen ,  Chong Peng ,  Linjie Zhu ,  Viral Panchal

IPC分类号： F42C9/10 ,  F42B27/00 ,  F42B27/08 ,  F42C9/14

摘要： A safety fuze for use in military and commercial applications, includes a fuze body that is attached to a trigger mechanism, an energetic train contained within the fuze body, and a non-energetic fuze delay mixture that is formed in a rod form so that it can dropped inside the fuze body, without modification to the other components of the safety fuze. Preferably, the non-energetic fuze delay mixture is made of foamed celluloid.

公开(公告)号：US08597444B1

公开(公告)日：2013-12-03

申请号：US12977374

申请日：2010-12-23

申请人： Ming-Wan Young ,  Costas G. Gogos ,  Niloufar Faridi ,  Linjie Zhu ,  Peter Bonnett ,  Howard Shimm ,  Elbert Caravaca ,  Joseph Palk, Jr. ,  Dale Conti ,  Mohamed Elalem ,  Fei Shen

发明人： Ming-Wan Young ,  Costas G. Gogos ,  Niloufar Faridi ,  Linjie Zhu ,  Peter Bonnett ,  Howard Shimm ,  Elbert Caravaca ,  Joseph Palk, Jr. ,  Dale Conti ,  Mohamed Elalem ,  Fei Shen

IPC分类号： C06B45/10 ,  C06B25/00 ,  C06B25/18 ,  D03D23/00 ,  D03D43/00

CPC分类号： F42B5/38 ,  C06B23/002 ,  C06B25/20 ,  F42B5/188 ,  F42B5/192 ,  F42B30/12

摘要： By using generally known chemically, physically, or a combination thereof, means to foam celluloid, a foamed celluloid material is invented with a density of less than about 1.25 gm/cm3, which material is relatively low cost, very fast burning, very low residue, easily moldable, and which material exhibits good mechanical strength, and provides a good water barrier. These characteristics make this foamed celluloid a preferred choice for military artillery propellant charge bags, military mortar and civilian fireworks increment charges, combustible cartridges, flare housings, igniter tubes, as well as, closure disks, combustible enclosures and components thereof, among other applications.

摘要翻译： 通过使用通常已知的化学，物理或其组合的手段来泡沫赛璐id，发明了一种密度小于约1.25gm / cm 3的发泡赛璐id体材料，该材料成本相对较低，燃烧非常快，残渣极少 ，易模塑，哪种材料具有良好的机械强度，并提供良好的防水性。 这些特征使得这种发泡的赛璐id是军事炮兵推进剂充电袋，军用砂浆和民用烟花增压装置，可燃筒，火炬罩，点火器管以及封闭盘，可燃外壳及其部件以及其他应用的首选。

公开(公告)号：US20070235692A1

公开(公告)日：2007-10-11

申请号：US11390621

申请日：2006-03-28

申请人： Chifei Wu ,  Xuanquan Zhou ,  Weihong Guo ,  Xiliang Zhang ,  Guozhang Wu ,  Haiyan Xu ,  Xianhui Li ,  Jianfeng Huang ,  Na Yu ,  Shengying Qian ,  Jing Chen ,  Liang Fang ,  Fei Shen ,  Liang Zhang ,  Qiuying Li ,  Jingjie Han

发明人： Chifei Wu ,  Xuanquan Zhou ,  Weihong Guo ,  Xiliang Zhang ,  Guozhang Wu ,  Haiyan Xu ,  Xianhui Li ,  Jianfeng Huang ,  Na Yu ,  Shengying Qian ,  Jing Chen ,  Liang Fang ,  Fei Shen ,  Liang Zhang ,  Qiuying Li ,  Jingjie Han

IPC分类号： H01B1/12

CPC分类号： H01B1/04 ,  C08F2/44 ,  C08F292/00 ,  H01B1/24 ,  Y10T428/2989 ,  Y10T428/2991 ,  Y10T428/2998

摘要： The present invention discloses a nanophase carbon black grafted with organic compounds, comprising (a) a first component: 100 parts by weight of original carbon black particles, and (b) a second component: 5-300 parts by weight of grafting organic compounds having or producing free radicals which is grafted onto the surface of the carbon black, wherein the molecular weight of the grafting organic compounds is 100-10000, and the nanophase carbon black has a particle size of 1-100 nm. The invention also discloses the synthesis thereof and articles therefrom.

摘要翻译： 本发明公开了一种接枝有机化合物的纳米相炭黑，其包含（a）第一组分：100重量份的原始炭黑颗粒，和（b）第二组分：5-300重量份的接枝有机化合物，其具有 或产生接枝到炭黑表面的自由基，其中接枝有机化合物的分子量为100-10000，纳米相炭黑的粒度为1-100nm。 本发明还公开了其合成及其制品。