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公开(公告)号：US06846928B2
公开(公告)日：2005-01-25
申请号：US10389707
申请日：2003-03-14
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard , Albert C. Pierce
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard , Albert C. Pierce
IPC分类号： A61P35/00 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D239/28
CPC分类号： C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07863282B2
公开(公告)日：2011-01-04
申请号：US11504528
申请日：2006-08-15
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号： A01N43/54 , A61K31/517 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00
CPC分类号： C07D403/12
摘要： A compound of formula Ia: or a pharmaceutically acceptable salt thereof.
摘要翻译： 式Ia化合物或其药学上可接受的盐。
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公开(公告)号：US07091343B2
公开(公告)日：2006-08-15
申请号：US10389296
申请日：2003-03-14
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号： C07D403/12 , C07D409/14 , C07D417/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07179826B2
公开(公告)日：2007-02-20
申请号：US10389709
申请日：2003-03-14
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号： A01N43/78 , C07D271/02 , C07D253/00
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20110086856A1
公开(公告)日：2011-04-14
申请号：US12967675
申请日：2010-12-14
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Juliam M.C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Juliam M.C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号： A61K31/53 , A61K31/517 , A61K31/519 , A61K31/506 , A61K31/496 , C12N9/99 , A61P35/00 , A61P35/02 , A61P25/00 , A61P37/08 , A61P11/06 , A61P25/28 , A61P25/16 , A61P25/18 , A61P9/00 , A61P9/10 , A61P29/00 , A61P19/10 , A61P37/06 , A61P31/12 , A61P19/08 , A61P3/10
CPC分类号： C07D403/12
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20070179133A1
公开(公告)日：2007-08-02
申请号：US11504528
申请日：2006-08-15
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/53 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D403/12
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US08669081B2
公开(公告)日：2014-03-11
申请号：US11786150
申请日：2007-04-11
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M.C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M.C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20070190634A1
公开(公告)日：2007-08-16
申请号：US11786150
申请日：2007-04-11
申请人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人： David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号： C02F3/34
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07691853B2
公开(公告)日：2010-04-06
申请号：US11369220
申请日：2006-03-06
申请人： David Bebbington , Hayley Binch , Ronald Knegtel , Julian M. C. Golec , Sanjay Patel , Jean-Damien Charrier , David Kay , Robert J. Davies , Pan Li , Marion W. Wannamaker , Cornelia J. Forster , Albert C. Pierce
发明人： David Bebbington , Hayley Binch , Ronald Knegtel , Julian M. C. Golec , Sanjay Patel , Jean-Damien Charrier , David Kay , Robert J. Davies , Pan Li , Marion W. Wannamaker , Cornelia J. Forster , Albert C. Pierce
IPC分类号： C07D403/12 , C07D239/94 , A61K31/517 , A61K31/506 , A61P25/18 , A61P25/28
CPC分类号： C07D401/14 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D473/16 , C07D487/04 , C07D491/04 , C07D491/10 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04
摘要： This invention describes novel pyrazole compounds of formula IV: wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T—R3, or taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-8 membered ring having 1-3 ring heteroatoms selected from oxygen, sulfur, or nitrogen; and R2, R2′, T, and R3 are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
摘要翻译： 本发明描述了式IV的新型吡唑化合物：其中环D是5-7元单环或选自芳基，杂芳基，杂环基或碳环基的8-10元双环; R x和R y独立地选自T-R 3，或与它们的插入原子一起形成具有1-3个选自氧，硫或氮的环杂原子的稠合的，不饱和的或部分不饱和的5-8元环; R2，R2'，T和R3如说明书中所述。 这些化合物可用作蛋白激酶抑制剂，特别是作为用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病的极光-2和GSK-3的抑制剂。
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10.发明授权Pyrazolylamine substituted quinazoline compounds useful as protein kinase inhibitors 有权用作蛋白激酶抑制剂的吡唑啉胺取代喹唑啉化合物公开(公告)号：US07098330B2
公开(公告)日：2006-08-29
申请号：US09952878
申请日：2001-09-14
申请人： David Bebbington , Hayley Binch , Ronald Knegtel , Julian M. C. Golec , Sanjay Patel , Jean-Damien Charrier , David Kay , Robert J. Davies
发明人： David Bebbington , Hayley Binch , Ronald Knegtel , Julian M. C. Golec , Sanjay Patel , Jean-Damien Charrier , David Kay , Robert J. Davies
IPC分类号： C07D401/14 , C07D403/12 , C07D405/04 , A61K31/517
CPC分类号： C07D401/14 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D473/16 , C07D487/04 , C07D491/04 , C07D493/04 , C07D495/04 , C07D513/04
摘要： This invention describes novel pyrazole compounds of formula III: wherein Ring D is a 5–7 membered monocyclic ring or 8–10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5–8 membered carbocyclo ring; and R2 and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
摘要翻译： 本发明描述了式III的新型吡唑化合物：其中环D是选自芳基，杂芳基，杂环基或碳环基的5-7元单环或8-10元双环; R x和R y与它们的插入原子一起形成稠合的，不饱和的或部分不饱和的5-8元碳环; 和R 2和R 2'如说明书中所述。 这些化合物可用作蛋白激酶抑制剂，特别是作为用于治疗诸如癌症，糖尿病和阿尔茨海默病的疾病的极光-2和GSK-3的抑制剂。
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