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公开(公告)号：US4943561A
公开(公告)日：1990-07-24
申请号：US276985
申请日：1988-11-28
CPC分类号： C07K14/57572 , A61K38/00
摘要： Small cell lung carcinoma (SCLC) cells contain gastrin releasing peptide (GRP) receptors. The response of the cells to GRP is rapid growth. We have found a group of peptide derivatives that act as GRP antagonists by blocking the binding of GRP to its receptor thereby inhibiting the growth of cells that are sensitive to the growth promoting activity of GRP.
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公开(公告)号：US20050137207A1
公开(公告)日：2005-06-23
申请号：US11059084
申请日：2005-02-15
申请人： Neal Rosen , Laura Sepp-Lorenzino , Mark Moasser , Allen Oliff , Jackson Gibbs , Nancy Kohl , Samuel Graham , George Prendergast
发明人： Neal Rosen , Laura Sepp-Lorenzino , Mark Moasser , Allen Oliff , Jackson Gibbs , Nancy Kohl , Samuel Graham , George Prendergast
IPC分类号： C07D233/64 , A61K31/198 , A61K31/223 , A61K31/4178 , A61K31/4439 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K35/00 , A61K41/00 , A61K45/06 , A61P43/00 , C07C323/25 , C07D241/04 , C07D307/33 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12
CPC分类号： A61K31/415 , A61K31/495 , A61K41/00 , A61K45/06
摘要： The present invention relates to methods of treating cancer using a combination of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase, which methods comprise administering to said mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound which is an antineoplastic agent and a compound which is a inhibitor of prenyl-protein transferase. The invention also relates to methods of preparing such compositions.
摘要翻译： 本发明涉及使用抗肿瘤剂化合物和作为异戊烯基 - 蛋白转移酶抑制剂的化合物的组合来治疗癌症的方法，该方法包括以任何顺序依次或同时向所述哺乳动物施用量 的选自由抗肿瘤剂的化合物和作为异戊烯基 - 蛋白转移酶的抑制剂的化合物组成的组中的至少两种治疗剂。 本发明还涉及制备这种组合物的方法。
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