公开(公告)号：US20060166209A1

公开(公告)日：2006-07-27

申请号：US10535005

申请日：2003-11-04

申请人： David Cooper ,  Ann Procter ,  John Gregory ,  David Millar ,  Mark Lewis ,  Angeles Ulied

发明人： David Cooper ,  Ann Procter ,  John Gregory ,  David Millar ,  Mark Lewis ,  Angeles Ulied

IPC分类号： C12Q1/68

CPC分类号： C07K16/40 ,  A61K38/00 ,  C07K14/61 ,  C12Q1/37 ,  C12Q2600/156 ,  G01N33/6803

摘要： The present invention relates to a naturally-occurring growth hormone mutation; to a method for detecting it and its use in screening patients for growth hormone dysfunction or for producing variant proteins suitable for treating such irregularities.

摘要翻译： 本发明涉及天然存在的生长激素突变; 检测它的方法及其在筛选患者生长激素功能障碍或用于产生适于治疗这种不规则的变体蛋白质中的用途。

公开(公告)号：US20050233417A1

公开(公告)日：2005-10-20

申请号：US10495235

申请日：2002-11-12

申请人： David Cooper ,  Ann Procter ,  John Gregory ,  David Millar ,  Mark Lewis ,  Angeles Ulied

发明人： David Cooper ,  Ann Procter ,  John Gregory ,  David Millar ,  Mark Lewis ,  Angeles Ulied

IPC分类号： G01N33/53 ,  A61K48/00 ,  A61P19/00 ,  A61P43/00 ,  C07K14/61 ,  C07K16/26 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/00 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C07K14/61 ,  C12Q1/6883 ,  C12Q2600/156

摘要： The present invention relates to naturally-occurring growth hormone mutations; to a method for detecting them and their use in screening patients for growth hormone irregularities or for producing variant proteins suitable for treating such irregularities. In one aspect there is disclosed variants of GH1, selected from the group consisting of: (a) (i) +480 C→T; (ii) +446 C→T; (iii) +1491 C→G; (iv) −60 G→A; (v) −40 to −39 GG→CT; (vi) −360 A→G; and (vii) +748 A→G (where figures relate to GH1 nucleotide position number, counting from TSS); (b) a sequence substantially homologous to or that hybridises to sequence (a) under stringent conditions; (c) a sequence substantially homologous to or that hybridises to the sequences (a) or (b) but for degeneracy of the genetic code; and (d) an oligonucleotide specific for any of the sequences (a), (b) or (c) above.

摘要翻译： 本发明涉及天然存在的生长激素突变; 检测它们的方法及其在筛选患者生长激素不规则或用于产生适于治疗这种不规则的变体蛋白质的用途。 一方面，公开了GH1的变体，其选自：（a）（i）+480C-> T; （ii）+446 C-> T; （iii）+1491 C-> G; （iv）-60 G-> A; （v）-40至-39 GG-> CT; （vi）-360 A-> G; 和（vii）+748 A-> G（其中数字涉及GH1核苷酸位置号，从TSS计数）; （b）在严格条件下与序列（a）基本同源或杂交的序列; （c）与序列（a）或（b）基本上同源或杂交的序列，但是遗传密码的简并性; 和（d）对上述（a），（b）或（c）中任一项的特异性寡核苷酸。

公开(公告)号：US20050130150A1

公开(公告)日：2005-06-16

申请号：US10495234

申请日：2002-11-12

申请人： David Cooper ,  Ann Marie Procter ,  John Gregory ,  David Millar

发明人： David Cooper ,  Ann Marie Procter ,  John Gregory ,  David Millar

IPC分类号： G01N33/53 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/6883 ,  G01N37/00 ,  C12P19/34

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

摘要： The present invention relates to naturally-occuring growth hormone mutations; to a method for detecting them and their use in screening patients for growth hormone irregularities or for producing variant proteins suitable for treating such irregularities. In one aspect there is disclosed a detection method for detecting a variation in GH1 effective to act as an indicator of GH dysfunction in an individual, which detection method comprises the steps of: (a) obtaining a test sample comprising a nucleotide sequence of the human GH1 gene from the individual; and (b) comparing the sequence obtained from the test sample with the standard sequence known to be that of the human GH1 gene, wherein a difference between the test sample sequence and the standard sequence indicates the presence of a variation (hereinafter “variant of GH1”) effective to act as an indicator of GH1 dysfunction characterised in that the test sample is obtained from an individual, either or both: exhibiting intra-uterine growth retardation (IUGR), defined as sufficient foetal height velocity diagnosed by standard methods known in the art; and/or small for gestational age (SGA), defined as insufficient (small) foetal body size (weight and/or length) for gestional age diagnosed by standard methods known in the art.

摘要翻译： 本发明涉及天然存在的生长激素突变; 检测它们的方法及其在筛选患者生长激素不规则或用于产生适于治疗这种不规则的变体蛋白质的用途。 一方面，公开了一种检测方法，用于检测有效地作为个体的GH功能障碍的指标的GH1的变异，所述检测方法包括以下步骤：（a）获得包含人的核苷酸序列的测试样品 个体GH1基因; 和（b）将从测试样品获得的序列与已知为人类GH1基因的标准序列进行比较，其中测试样品序列与标准序列之间的差异表明存在变异（以下称为GH1的变体 “）有效地作为GH1功能障碍的指标，其特征在于，测试样品是从个体获得的，其中一种或两种：呈现子宫内生长迟缓（IUGR），定义为通过标准方法诊断的足够的胎儿高度速度 艺术; 和/或小于胎龄（SGA），定义为通过本领域已知的标准方法诊断的胎龄不足（小）胎儿体型（体重和/或长度）。

公开(公告)号：USD597777S1

公开(公告)日：2009-08-11

申请号：US29333185

申请日：2009-03-04

申请人： David Millar ,  Manuchehr Neshat

设计人： David Millar ,  Manuchehr Neshat

公开(公告)号：US20050102975A1

公开(公告)日：2005-05-19

申请号：US10990792

申请日：2004-11-17

申请人： Gary Hughes ,  Robert Millar ,  David Millar

发明人： Gary Hughes ,  Robert Millar ,  David Millar

IPC分类号： B65B31/04 ,  B65B31/06 ,  B65B31/02

CPC分类号： B65B31/042 ,  B65B31/06

摘要： A vacuum sealing apparatus has an inlet portion and an intermediate portion. The inlet portion is adapted to couple to, or insert into, a container to be vacuum sealed. The intermediate portion connects to a vacuum source, such as an in-house vacuum system. When the vacuum source is active, air is drawn in through the inlet portion. The vacuum sealing apparatus may also have a contamination filter disposed therein that substantially impedes contaminants from entering the vacuum source. In another configuration, the vacuum sealing apparatus is self-contained and includes a dedicated vacuum source.

摘要翻译： 真空密封装置具有入口部和中间部。 入口部分适于联接到或被插入待真空密封的容器中。 中间部分连接到诸如内部真空系统的真空源。 当真空源有效时，空气通过入口部分被吸入。 真空密封装置还可以具有设置在其中的污染过滤器，其基本上阻止污染物进入真空源。 在另一种构造中，真空密封装置是独立的并且包括专用的真空源。

公开(公告)号：US06799700B2

公开(公告)日：2004-10-05

申请号：US10407068

申请日：2003-04-04

申请人： Andrew Durant ,  David Millar ,  Steven Baranek

发明人： Andrew Durant ,  David Millar ,  Steven Baranek

IPC分类号： B67D556

CPC分类号： A01G25/145 ,  B05B9/0816 ,  B05B11/30

摘要： Dilute chemical carrying systems include multiple embodiments of pressurizable and gravity feed reservoirs, and are provided for support and carriage of a segregated accommodation space, in some cases separately provided and in others integrally provided, for metered introduction of a concentrate into such reservoir. The structures both provide storage for concentrated chemical containers, and metered measurement while eliminating waste, make up time and minimizing contact between workers and the chemicals or nutrients in their concentrated state. Metering may be preferably provided by a pump assembly, and operational blocking of the pump assembly may be provided in separate or integrated structures. A concentrate container system enables users to recycle sealed containers to even further eliminate the necessity to directly handle concentrate.

摘要翻译： 稀释化学品携带系统包括可加压和重力进料储存器的多个实施方案，并且被提供用于支撑和运输隔离的容纳空间，在一些情况下单独提供并且在其它方面一体地提供，用于将精矿计量引入这种储存器。 这些结构既提供集中化学品容器的储存，又可以消除浪费，计量时间，减少工作人员与浓缩化学品或营养物质之间的接触。 测量可以优选地由泵组件提供，并且泵组件的操作阻塞可以以单独的或一体的结构提供。 浓缩容器系统使用户能够回收密封容器，从而进一步消除了直接处理浓缩物的必要性。

公开(公告)号：USD476628S1

公开(公告)日：2003-07-01

申请号：US29154825

申请日：2002-01-31

申请人： David Millar

设计人： David Millar

公开(公告)号：US08209792B1

公开(公告)日：2012-07-03

申请号：US13087317

申请日：2011-04-14

申请人： Richard Quintana ,  Kermit L. Achterman ,  David Millar ,  David Michael Parrish

发明人： Richard Quintana ,  Kermit L. Achterman ,  David Millar ,  David Michael Parrish

IPC分类号： E03D11/18

CPC分类号： E03D1/00 ,  E03D11/00 ,  Y02A10/34

摘要： A shut-off valve for connecting between a water supply valve and a tank inlet port of a toilet tank includes a housing having an inlet port, an outlet port, a valve mechanism, a trip mechanism, and a trip circuit electrically connected with the trip mechanism. The valve mechanism includes a valve housing rotationally confining a first ceramic disk and a ceramic second disk, each disk having at least one aperture therethrough that, when mutually aligned, allow for fluid communication between the inlet and outlet ports. The trip mechanism includes a rotational spring that urges rotation of an axial shaft fixed coaxially with the second disk. A trip latch is adapted to prevent rotation of the axial shaft and second disk except when withdrawn from the axial shaft by a solenoid electrically connected to the trip circuit that is electrically connected with a toilet tank overflow sensor, a toilet bowl overflow sensor, or the like. Upon detection of a fault condition, the trip circuit trips the trip mechanism to prevent water from flowing into the toilet tank until the fault can be corrected, thereby conserving water and often preventing water damage.

摘要翻译： 用于连接马桶水箱的供水阀和水箱入口之间的截止阀包括具有入口，出口，阀机构，脱扣机构以及与行程电连接的跳闸回路的壳体 机制。 阀机构包括旋转地限制第一陶瓷盘和陶瓷第二盘的阀壳，每个盘具有穿过其中的至少一个孔，当彼此对准时，允许入口和出口之间的流体连通。 跳闸机构包括旋转弹簧，其推动与第二盘同轴固定的轴向轴的旋转。 跳闸闩锁适于防止轴向轴和第二盘的旋转，除了通过电磁连接到与马桶水箱溢流传感器，马桶盆溢流传感器电连接的跳闸回路的螺线管从轴向轴拔出，或者 喜欢。 在检测到故障状态时，跳闸电路跳闸跳闸机构，以防止水流入马桶水箱，直到故障得以纠正，从而节约用水并经常防止水的损坏。

公开(公告)号：US20080222815A1

公开(公告)日：2008-09-18

申请号：US12074717

申请日：2008-03-04

申请人： John T. Yurek ,  David Millar

发明人： John T. Yurek ,  David Millar

IPC分类号： B26B11/00

CPC分类号： B67B7/24 ,  B67B7/44

摘要： A multifunction container-piercing tool is provided. The tool includes a base and a piercing element having a pointed tip and a triangle base. The triangle base is attached to the front of the base. A hook is connected to the bottom of the base. The hook base extends from the bottom of the tool base and the catch faces toward the pointed tip. The distance between the catch and the base is about equal to the length of the piercing element. A handle extends from the back of the base, where the handle has at least one fork element. The fork element is disposed to leverage a mass of turf, such as a divot in a putting green. The hook pivots about a container bottom, and the piercing element provides an opening in a beverage can sidewall to enable rapid delivery of the contents when the pull-tab is lifted.

摘要翻译： 提供了一种多功能容器穿孔工具。 该工具包括基部和具有尖端和三角形基座的穿孔元件。 三角形底座连接到底座的前部。 钩子连接到底座的底部。 钩形基座从工具基座的底部延伸，并且卡扣面朝向尖端。 卡扣与底座之间的距离约等于穿孔元件的长度。 手柄从基座的后部延伸，手柄至少有一个叉形元件。 叉元件被设置为利用大量草皮，例如果岭中的树皮。 钩子围绕容器底部枢转，并且刺穿元件在饮料罐侧壁中提供开口，以在拉片抬起时能够快速输送内容物。

公开(公告)号：USD505182S1

公开(公告)日：2005-05-17

申请号：US29197512

申请日：2004-01-14

申请人： Andrew Durant ,  David Millar ,  Steven Baranek

设计人： Andrew Durant ,  David Millar ,  Steven Baranek