公开(公告)号：US20100222549A1

公开(公告)日：2010-09-02

申请号：US12451193

申请日：2008-04-29

申请人： David Crich ,  Maheswaran Karatholuvhu ,  Venkataramanan Krishnamurthy ,  Thomas K. Hutton ,  Franck Brebion ,  Venkataraman Subramanian

发明人： David Crich ,  Maheswaran Karatholuvhu ,  Venkataramanan Krishnamurthy ,  Thomas K. Hutton ,  Franck Brebion ,  Venkataraman Subramanian

IPC分类号： C07K7/06 ,  C07C319/14 ,  C07H15/14 ,  C07K5/037 ,  C07K5/083 ,  C07C319/24 ,  C07B45/06

CPC分类号： C07D209/20 ,  C07C319/14 ,  C07C319/24 ,  C07C391/00 ,  C07C2603/74 ,  C07D213/70 ,  C07K5/081 ,  C07K7/06 ,  C07K14/78 ,  C07C321/18 ,  C07C321/28 ,  C07C323/59 ,  C07C321/20 ,  C07C323/60 ,  C07C323/14 ,  C07C323/20

摘要： A dechalcogenative method for the preparation of an allylic sulfide comprises contacting an activated chalcogenide of Formula (I) with a thiol of Formula (II) for a period of time sufficient to form an intermediate of Formula (III), and supplying sufficient activation energy to the intermediate of Formula (III), in a suitable solvent, preferably in the absence of a phosphine or other thiophile, to induce a [2,3]-sigmatropic rearrangement therein to form an allylic sulfide of Formula (IV), with concomitant loss of chalcogen Z, as set forth in the following reaction scheme, wherein X is an activating group selected from the group consisting of CN, S-pyridyl, S-heteroaryl, SO2-aryl, and SO3Y; Y is an alkali metal ion; Z is Se or S; R1, R2, R3, R4, and R5 are each independently H or a hydrocarbon moiety; and R is an organic moiety.

摘要翻译： 用于制备烯丙基硫醚的脱钙方法包括使式（I）的活化硫属化物与式（II）的硫醇接触足够长的时间以形成式（III）的中间体，并将足够的活化能提供给 式（III）的中间体在合适的溶剂中，优选在不存在膦或其他硫菌灵的情况下，以引起其中的[2,3] -sigmatropic重排以形成式（IV）的烯丙基硫醚，并伴随损失 的硫族元素Z，如以下反应图解所示，其中X是选自CN，S-吡啶基，S-杂芳基，SO 2 - 芳基和SO 3 Y的活化基团; Y是碱金属离子; Z为Se或S; R 1，R 2，R 3，R 4和R 5各自独立地为H或烃部分; 和R是有机部分。

公开(公告)号：US20080234526A1

公开(公告)日：2008-09-25

申请号：US11999381

申请日：2007-12-04

申请人： Stephen C. Scherrer ,  Anne P. Noonan ,  Thomas K. Hutton

发明人： Stephen C. Scherrer ,  Anne P. Noonan ,  Thomas K. Hutton

IPC分类号： C07C17/38

CPC分类号： C07H5/02 ,  C07C17/395 ,  Y02P20/582 ,  C07C22/04

摘要： Methods of recovering a triarylmethyl halide from a sucrose derivatization process include the steps of (a) forming a mixture including 1) a triarylmethylated sucrose derivative including at least one triarylmethyl substituent and at least one acyl substituent on the sucralose, 2) triarylmethylated sucrose ester byproducts, and 3) an amine; (b) separating from the output of step (a) i) the triarylmethylated sucrose derivative, and ii) a mixture including the triarylmethylated sucrose ester byproducts and the amine; (c) removing the amine from the mixture of step (b) ii); (d) contacting the product of step (c) with hydrogen halide to cleave triarylmethyl groups and thereby form a crude triarylmethyl halide component; (e) contacting the crude triarylmethyl halide component with hydrogen halide to form a purified triarylmethyl halide component; and (f) recovering the triarylmethyl halide from the output of step (e).

摘要翻译： 从蔗糖衍生化方法回收三芳基甲基卤化物的方法包括以下步骤：（a）形成混合物，其包括1）三酰基甲基化蔗糖衍生物，其包含至少一个三芳基甲基取代基和至少一个酰氯基取代基;二）三芳基甲基化蔗糖酯副产物 ，和3）胺; （b）从步骤（a）的输出分离i）三芳基甲基化蔗糖衍生物，和ii）包含三芳基甲基化蔗糖酯副产物和胺的混合物; （c）从步骤（b）ii）的混合物中除去胺; （d）使步骤（c）的产物与卤化氢接触以裂解三芳基甲基，从而形成粗三芳基甲基卤化物组分; （e）将粗三芳基甲基卤化物组分与卤化氢接触以形成纯化的三芳基甲基卤化物组分; 和（f）从步骤（e）的输出中回收三芳基甲基卤化物。

公开(公告)号：US08153849B2

公开(公告)日：2012-04-10

申请号：US11999381

申请日：2007-12-04

申请人： Stephen C. Scherrer ,  Anne P. Noonan ,  Thomas K. Hutton

发明人： Stephen C. Scherrer ,  Anne P. Noonan ,  Thomas K. Hutton

IPC分类号： C07C17/38 ,  C07H11/00

CPC分类号： C07H5/02 ,  C07C17/395 ,  Y02P20/582 ,  C07C22/04

摘要： Methods of recovering a triarylmethyl halide from a sucrose derivatization process include the steps of (a) forming a mixture including 1) a triarylmethylated sucrose derivative including at least one triarylmethyl substituent and at least one acyl substituent on the sucrose, 2) triarylmethylated sucrose ester byproducts, and 3) an amine; (b) separating from the output of step (a) i) the triarylmethylated sucrose derivative, and ii) a mixture including the triarylmethylated sucrose ester byproducts and the amine; (c) removing the amine from the mixture of step (b) ii); (d) contacting the product of step (c) with hydrogen halide to cleave triarylmethyl groups and thereby form a crude triarylmethyl halide component; (e) contacting the crude triarylmethyl halide component with hydrogen halide to form a purified triarylmethyl halide component; and (f) recovering the triarylmethyl halide from the output of step (e).

摘要翻译： 从蔗糖衍生化方法回收三芳基甲基卤化物的方法包括以下步骤：（a）形成混合物，其包括1）三芳基甲基化蔗糖衍生物，其包含至少一个三芳基甲基取代基和至少一个在蔗糖上的酰基取代基，2）三芳基甲基化蔗糖酯副产物 ，和3）胺; （b）从步骤（a）的输出分离i）三芳基甲基化蔗糖衍生物，和ii）包含三芳基甲基化蔗糖酯副产物和胺的混合物; （c）从步骤（b）ii）的混合物中除去胺; （d）使步骤（c）的产物与卤化氢接触以裂解三芳基甲基，从而形成粗三芳基甲基卤化物组分; （e）将粗三芳基甲基卤化物组分与卤化氢接触以形成纯化的三芳基甲基卤化物组分; 和（f）从步骤（e）的输出中回收三芳基甲基卤化物。