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    Isoprenyl Compounds and Methods Thereof
    2.
    发明申请
    Isoprenyl Compounds and Methods Thereof 审中-公开
    异戊二烯基化合物及其方法

    公开(公告)号：US20160361283A1

    公开(公告)日：2016-12-15

    申请号：US15151221

    申请日：2016-05-10

    Applicant: SIGNUM BIOSCIENCES, INC.

    Inventor： Jeffry B. Stock ,  Maxwell Stock ,  Keshava Rapole ,  Seung-Yub Lee ,  Michael Voronkov ,  Eduardo Perez ,  Joel Gordon ,  Shuyi Chen ,  Jinglong Chen

    IPC: A61K31/197 ,  A61K9/00

    CPC classification number: A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

    Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

    Abstract translation: 除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药​​妆和局部组合物。 本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。 本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。 因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。

    New sulfured compounds
    7.
    发明授权
    New sulfured compounds 失效
    新型硫化物

    公开(公告)号：US5324858A

    公开(公告)日：1994-06-28

    申请号：US940890

    申请日：1992-10-28

    Applicant: Ourida Aberkane ,  Maurice Born ,  Jean Luc Mielzoszynski ,  Daniel Paquer ,  Guy Barc

    Inventor： Ourida Aberkane ,  Maurice Born ,  Jean Luc Mielzoszynski ,  Daniel Paquer ,  Guy Barc

    IPC: C07C321/14 ,  C07C321/18 ,  C10M135/22

    CPC classification number: C07C321/14 ,  C07C321/18 ,  C10M135/22 ,  C10M2219/082 ,  C10M2221/043

    Abstract: New sulfurized compounds, their preparation and their use are described. They correspond to the general formula: {[R--S.sub.X --(CH.sub.2).sub.n --].sub.z CH.sub.3-z --(CH.sub.2).sub.P --}.sub.2 S.sub.y, in which R represents a monovalent hydrocarbon radical with 1 to 30 carbon atoms, optionally functionalized; x is a number equal to or greater than 1; z is an integer equal to 1 or 2; when z=1, n is an integer from 0 to 3 and p is an integer from 0 to 3, with n+p being an integer from 0 to 3; when z=2, n is an integer from 1 to 3 and p is an integer from 0 to 3; and y is a number equal to or greater than 1, at last one of the numbers x and y being strictly greater than 1. These sulfurized compounds can be used as extreme-pressure and anti-wear additives in lubricating oils, in particular oils for gear systems and oil for working metals.

    Abstract translation: PCT No.PCT / FR91 / 01026 Sec。 371日期：1992年10月28日 102（e）日期1992年10月28日PCT 1991年12月17日PCT PCT。 公开号WO92 / 12126 日期：1992年7月23日。新的硫化化合物，它们的制备及其用途被描述。 它们对应于以下通式：{[R-SX-（CH2）n-] zCH3-z-（CH2）P-} 2Sy，其中R表示具有1至30个碳原子的一价烃基，任选地官能化; x是等于或大于1的数字; z是等于1或2的整数; 当z = 1时，n为0〜3的整数，p为0〜3的整数，n + p为0〜3的整数。 当z = 2时，n为1〜3的整数，p为0〜3的整数。 并且y为等于或大于1的数，最后一个数字x和y严格大于1.这些硫化化合物可用作润滑油中的极压和抗磨添加剂，特别是用于 齿轮系统和工作金属油。

    Alkenyl trisulfides
    8.
    发明授权
    Alkenyl trisulfides 失效
    亚苄基三聚体

    公开(公告)号：US3717681A

    公开(公告)日：1973-02-20

    申请号：US3717681D

    申请日：1971-05-26

    Applicant: INT FLAVORS & FRAGRANCES INC

    Inventor： BRODNITZ M

    IPC: A23L23/10 ,  A23L27/20 ,  C07C321/18 ,  C07C149/12

    CPC classification number: C07C321/18 ,  A23L23/10 ,  A23L27/2022 ,  C07C321/00

    Abstract: Novel compounds have been discovered which impart cooked onion flavor and aroma to foods treated therewith. Said novel compounds are alkyl 1-alkenyl disulfides having the formula: WHEREIN R'' is hydrogen or alkyl and R and R1 are alkyl. Representative compounds are methyl propenyl disulfide, propyl propenyl disulfide, and ethyl propenyl disulfide. Compositions containing said compounds preferably at levels of from 0.01 to 20 percent by weight are also disclosed. Additionally, said compositions may contain other disulfides and trisulfides including novel alkenyl trisulfides having the formula: WHEREIN R7 and R8 are alkyl groups and R6 and R9 are hydrogen or alkyl.

    Abstract translation: 已经发现新的化合物，其赋予经过处理的食品烹制的洋葱风味和香气。 所述新化合物是具有下式的烷基1-烯基二硫化物：

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