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公开(公告)号:US20240174613A1
公开(公告)日:2024-05-30
申请号:US18430478
申请日:2024-02-01
申请人: Southern Research Institute , UAB Research Foundation , The United States Government as Represented by the Department of Veterans Affairs
发明人: Mark J. Suto , Bini Mathew , Anupam Agarwal , Amie M. Traylor
IPC分类号: C07D215/36 , C07C321/28 , C07D213/70 , C07D215/40 , C07D215/48 , C07D217/22
CPC分类号: C07D215/36 , C07C321/28 , C07D213/70 , C07D215/40 , C07D215/48 , C07D217/22
摘要: The present disclosure is concerned with thioquinolinone compounds for the treatment of disorders associated with heme oxygenase-1 (HO-1) signaling dysfunction such as, for example, kidney diseases (e.g., chronic kidney disease, acute kidney injury). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号:US20230183193A1
公开(公告)日:2023-06-15
申请号:US18054089
申请日:2022-11-09
发明人: Hartmut AHRENS , Joerg TIEBES , Christian WALDRAFF , Hansjoerg DIETRICH , Elmar GATZWEILER , Christopher Hugh ROSINGER , Anu Bheemaiah MACHETTIRA
IPC分类号: C07D257/04 , A01N43/26 , A01N43/653 , A01N43/82 , C07C317/14 , C07C321/28 , C07D255/02 , C07D271/04 , C07D271/06
CPC分类号: C07D257/04 , A01N43/26 , A01N43/653 , A01N43/82 , C07C317/14 , C07C321/28 , C07D255/02 , C07D271/04 , C07D271/06
摘要: Benzoylamides of the general formula (I) are described as herbicides.
In this formula (I), X, R and Ra represent radicals such as alkyl, cycloalkyl and halogen. Q represents a five-membered heterocycle.-
公开(公告)号:US20230159438A1
公开(公告)日:2023-05-25
申请号:US17832384
申请日:2022-06-03
申请人: Genzyme Corporation
发明人: Junkai Liao , Mark Munson , Zhongli Gao , Gregory Hurlbut , Hans Peter Nestler , Helen Yeoman , Martin Smrcina , Ronghua Li , Ryan Hartung , William Wire , Bertrand Vivet , Nina Ma
IPC分类号: C07C235/66 , C07D231/12 , C07D317/54 , C07C317/14 , C07C321/28 , C07D277/24 , C07D213/30 , C07D261/08 , C07D277/64 , C07D277/30 , C07D305/06 , A61K31/198 , A61K31/415 , A61K31/36 , A61K31/426 , A61K31/44 , A61K31/42 , A61K31/428 , A61K31/337 , A61K45/06
CPC分类号: C07C235/66 , C07D231/12 , C07D317/54 , C07C317/14 , C07C321/28 , C07D277/24 , C07D213/30 , C07D261/08 , C07D277/64 , C07D277/30 , C07D305/06 , A61K31/198 , A61K31/415 , A61K31/36 , A61K31/426 , A61K31/44 , A61K31/42 , A61K31/428 , A61K31/337 , A61K45/06 , C07C2601/04 , C07C2601/08 , C07C2601/02 , C07C2601/14 , C07C2601/16 , C07C2602/10
摘要: The present disclosure relates to heterocyclic compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.
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公开(公告)号:US20190248766A1
公开(公告)日:2019-08-15
申请号:US16394302
申请日:2019-04-25
IPC分类号: C07D403/12 , C07D251/24 , C07D249/20 , C07C321/28 , C07C321/26 , C07C69/94 , C08K5/3475 , C08L101/00 , C09K3/00 , C08K5/372 , C08K5/37 , C07C49/84
CPC分类号: C07D403/12 , C07C49/84 , C07C69/94 , C07C321/26 , C07C321/28 , C07D249/20 , C07D251/24 , C08K5/3475 , C08K5/37 , C08K5/372 , C08L101/00 , C09K3/00
摘要: Provided is an additive for imparting ultraviolet absorbency, or an additive for imparting a high refractive index, which has satisfactory compatibility with a resin serving as a matrix and can maintain high transparency even if added in high concentrations. Also provided is an additive with which the function of imparting both ultraviolet absorbency and a high refractive index can be realized by means of one kind of additive. This additive is represented by the following Formula (I): wherein at least one of R1a to R9a is a monovalent sulfur-containing group represented by the following Formula (i-1) or Formula (i-2): R10amSH (i-1) R11anSR12a—SpR13a (i-2) wherein R10a to R12a each represent a divalent hydrocarbon group or the like; and R13a represents a monovalent hydrocarbon group or the like.
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公开(公告)号:US20180240977A1
公开(公告)日:2018-08-23
申请号:US15516492
申请日:2015-09-30
发明人: Shuhei Yamamoto , Daisuke Kitazawa
CPC分类号: H01L51/0036 , C07C43/20 , C07C43/205 , C07C49/67 , C07C321/28 , C08G2261/124 , C08G2261/1412 , C08G2261/146 , C08G2261/149 , C08G2261/3223 , C08G2261/3243 , C08G2261/414 , C08K3/045 , C08K5/01 , C08K5/06 , C08K5/07 , C08K5/15 , C08K5/372 , C08L65/00 , H01B1/12 , H01L51/0007 , H01L51/0037 , H01L51/0043 , H01L51/0046 , H01L51/4253 , H01L51/442 , H01L2251/308 , Y02E10/549 , Y02P70/521
摘要: A photovoltaic element has high photoelectric conversion efficiency as well as excellent processing properties/low environmental load. The organic semiconductor composition includes as an additive a compound in which one or two aromatic rings are substituted with a predetermined number of alkyl groups, alkoxy groups, alkanoyl groups, or thioalkyl groups. There is also a method of manufacturing a photovoltaic element which uses the composition.
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公开(公告)号:US20180132482A1
公开(公告)日:2018-05-17
申请号:US15572107
申请日:2016-05-12
发明人: Takashi Furuya , Atsushi Okada , Hiroto Harayama , Yutaka Abe , Naoto Shimizu , Eiji Yasukouchi , Yutaka Kato
IPC分类号: A01N37/46 , A01N41/10 , A01N47/02 , C07C317/44 , C07C323/62
CPC分类号: A01N37/46 , A01N41/10 , A01N47/02 , C07C317/44 , C07C317/46 , C07C321/28 , C07C321/30 , C07C323/62
摘要: In crop production in the fields of agriculture, horticulture and the like, the damage caused by diseases etc. is still immense, and diseases resistant to existing microbicides have emerged. Under such circumstances, the development of novel agricultural and horticultural microbicides is desired.The present invention provides an anthranilic acid ester compound represented by the general formula (1): (wherein A1, A3 and A4 each represent a CH group, A2 represents a C-haloalkyl group, R1 represents an alkyl group, R3 represents a hydrogen atom or an acyl group, R4, R5 and R7 each represent a hydrogen atom, R6 represents a haloalkyl group, Z represents an alkyl group, and m represents 0, 1 or 2), or a salt thereof, an agricultural and horticultural microbicide comprising the compound or a salt thereof as an active ingredient, and a method for using the microbicide.
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公开(公告)号:US09834509B2
公开(公告)日:2017-12-05
申请号:US15228364
申请日:2016-08-04
申请人: Ecolab USA Inc.
IPC分类号: C07C327/00 , C07C319/24
CPC分类号: C07C319/24 , C07C323/52 , C07C323/12 , C07C323/25 , C07C321/04 , C07C321/28 , C07C323/33 , C07C321/10
摘要: Disclosed are methods for preparing disulfide compounds through oxidative coupling of thiol compounds. Thiols are oxidized to the corresponding disulfide compound in high yield in presence of a base and a metal salt. The method uses low catalyst loadings and provides organic disulfide compounds with little to no byproducts.
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公开(公告)号:US09828401B2
公开(公告)日:2017-11-28
申请号:US14238270
申请日:2012-08-15
申请人: Julia Maria Jeschko , Douglas Stephan , Clinton Lund , Michael Sgro , Christopher Ong , Renan Cariou
发明人: Julia Maria Jeschko , Douglas Stephan , Clinton Lund , Michael Sgro , Christopher Ong , Renan Cariou
IPC分类号: C07F15/00 , B01J31/22 , C07C29/17 , C07C67/303 , C07D233/06 , C07C209/70 , C07F17/02 , C07C315/04 , C07C319/20 , C07C45/62 , C07C5/03 , C07C231/12 , C07C253/30 , C07D213/127 , C07C5/09 , C07C5/05 , B01J31/24
CPC分类号: C07F15/0046 , B01J31/2226 , B01J31/2273 , B01J31/2404 , B01J2231/645 , B01J2531/821 , B01J2540/10 , C07B2200/07 , C07C5/03 , C07C5/05 , C07C5/09 , C07C29/175 , C07C45/62 , C07C67/303 , C07C209/70 , C07C231/12 , C07C253/30 , C07C315/04 , C07C319/20 , C07C2531/22 , C07C2531/24 , C07C2601/14 , C07D213/127 , C07D233/06 , C07F17/02 , C07C69/34 , C07C321/28 , C07C255/03 , C07C211/06 , C07C233/47 , C07C317/14 , C07C49/10 , C07C47/02 , C07C31/10 , C07C9/14 , C07C13/18 , C07C15/46
摘要: The present invention provides novel Ruthenium-based transition metal complex catalysts comprising specific ligands, their preparation and their use in hydrogenation processes. Such complex catalysts are inexpensive, thermally robust, and olefin selective.
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公开(公告)号:US20170304332A1
公开(公告)日:2017-10-26
申请号:US15648250
申请日:2017-07-12
发明人: Alaric J. Dyckman , T.G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号: A61K31/695 , C07F9/6553 , C07F9/655 , C07F9/6509 , C07F9/6503 , C07F9/62 , C07F9/572 , C07F9/54 , C07F9/117 , C07F9/09 , C07F7/08 , C07D333/16 , C07D319/20 , C07D311/76 , C07D311/58 , C07D309/12 , C07D309/06 , C07D305/08 , C07D277/24 , C07D241/12 , C07D241/04 , C07D239/26 , C07D231/20 , C07D231/12 , C07D217/24 , C07D215/14 , C07D215/12 , C07D213/70 , C07D213/69 , C07D213/38 , C07D213/32 , C07D209/46 , C07C323/29 , C07C323/25 , C07C321/28 , C07C321/22 , C07C321/16 , C07C317/32 , C07C317/28 , C07C275/26 , C07C271/34 , C07C251/54 , C07C251/52 , C07C251/50 , C07C251/44 , C07C251/42 , C07C251/38 , C07C235/46 , C07C233/65 , C07C233/41 , C07C219/24 , C07C217/74 , C07C217/58 , C07C217/52 , C07C215/42 , A61K31/661 , A61K31/505 , A61K31/4965 , A61K31/47 , A61K31/4409 , A61K31/4406 , A61K31/4402 , A61K31/44 , A61K31/426 , A61K31/4174 , A61K31/415 , A61K31/381 , A61K31/352 , A61K31/351 , A61K31/337 , A61K31/27 , A61K31/24 , A61K31/222 , A61K31/17 , A61K31/166 , A61K31/165 , A61K31/15 , A61K31/137 , A61K31/135 , C07C2601/04 , C07C2601/08 , C07C2603/74 , C07C2602/10 , C07C2601/02
CPC分类号: A61K31/695 , A61K31/135 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661 , C07B2200/05 , C07C215/42 , C07C217/52 , C07C217/58 , C07C217/74 , C07C219/24 , C07C233/41 , C07C233/65 , C07C235/46 , C07C251/38 , C07C251/42 , C07C251/44 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C275/26 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/10 , C07C2603/74 , C07D209/46 , C07D213/32 , C07D213/38 , C07D213/69 , C07D213/70 , C07D215/12 , C07D215/14 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/04 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/081 , C07F9/091 , C07F9/117 , C07F9/5442 , C07F9/5728 , C07F9/62 , C07F9/65031 , C07F9/650952 , C07F9/65522 , C07F9/655345
摘要: Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
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公开(公告)号:US09770459B2
公开(公告)日:2017-09-26
申请号:US15337843
申请日:2016-10-28
发明人: Alaric J. Dyckman , T.G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号: C07D217/00 , A61K31/695 , C07C215/42 , C07C217/52 , C07C217/58 , C07C219/24 , C07C233/41 , C07C233/65 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07D213/32 , C07D213/69 , C07D213/70 , C07D215/12 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/08 , C07F9/117 , C07F9/62 , C07F9/6503 , C07F9/6509 , C07F9/655 , C07F9/6553 , A61K31/135 , C07D215/14 , C07D241/04 , C07C323/29 , C07C251/38 , C07C251/42 , C07C251/44 , C07D209/46 , C07D213/38 , C07C275/26 , C07C217/74 , C07C323/25 , C07C235/46 , C07F9/54 , C07F9/572 , C07F9/09 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661
CPC分类号: A61K31/695 , A61K31/135 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661 , C07B2200/05 , C07C215/42 , C07C217/52 , C07C217/58 , C07C217/74 , C07C219/24 , C07C233/41 , C07C233/65 , C07C235/46 , C07C251/38 , C07C251/42 , C07C251/44 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C275/26 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07C323/25 , C07C323/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/10 , C07C2603/74 , C07D209/46 , C07D213/32 , C07D213/38 , C07D213/69 , C07D213/70 , C07D215/12 , C07D215/14 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/04 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/081 , C07F9/091 , C07F9/117 , C07F9/5442 , C07F9/5728 , C07F9/62 , C07F9/65031 , C07F9/650952 , C07F9/65522 , C07F9/655345
摘要: Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
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