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公开(公告)号：US07763262B2
公开(公告)日：2010-07-27
申请号：US12425599
申请日：2009-04-17
IPC分类号： A61K39/102
CPC分类号： A61K39/102 , A61K2039/522 , C07K14/285 , C12N1/20
摘要： Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.
摘要翻译： 识别革兰氏阴性细菌毒力基因，从而允许鉴定靶向这些毒力基因及其产物的新型抗细菌剂，以及提供可用于疫苗的新型革兰氏阴性细菌突变体。
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公开(公告)号：US06923957B2
公开(公告)日：2005-08-02
申请号：US09809524
申请日：2001-03-15
IPC分类号： C12N15/01 , A61K38/00 , A61K39/112 , A61K48/00 , A61P1/00 , A61P1/12 , A61P31/04 , A61P37/02 , C07K14/255 , C12N1/20 , A01N63/00 , A01N65/00
CPC分类号： C07K14/255 , A61K2039/522 , A61K2039/523
摘要： Attenuated mutant Salmonella bacteria containing inactivated virulence genes are provided for use in safe, efficacious vaccines.
摘要翻译： 提供了含有灭活毒力基因的减毒突变体沙门氏菌，用于安全有效的疫苗。
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公开(公告)号：US08974798B2
公开(公告)日：2015-03-10
申请号：US13162023
申请日：2011-06-16
IPC分类号： A61K39/02
CPC分类号： A61K39/102 , A61K2039/522 , C07K14/285 , C12N1/20
摘要： Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.
摘要翻译： 识别革兰氏阴性细菌毒力基因，从而允许鉴定靶向这些毒力基因及其产物的新型抗细菌剂，以及提供可用于疫苗的新型革兰氏阴性细菌突变体。
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公开(公告)号：US20120148625A1
公开(公告)日：2012-06-14
申请号：US13162023
申请日：2011-06-16
IPC分类号： A61K39/102 , A61P31/04 , A61K39/02 , A61P37/04 , C12N1/20
CPC分类号： A61K39/102 , A61K2039/522 , C07K14/285 , C12N1/20
摘要： Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.
摘要翻译： 识别革兰氏阴性细菌毒力基因，从而允许鉴定靶向这些毒力基因及其产物的新型抗细菌剂，以及提供可用于疫苗的新型革兰氏阴性细菌突变体。
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公开(公告)号：US20100322975A1
公开(公告)日：2010-12-23
申请号：US12816485
申请日：2010-06-16
IPC分类号： A61K39/102 , A61P31/04 , C12N1/21
CPC分类号： A61K39/102 , A61K2039/522 , C07K14/285 , C12N1/20
摘要： Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.
摘要翻译： 识别革兰氏阴性细菌毒力基因，从而允许鉴定靶向这些毒力基因及其产物的新型抗细菌剂，以及提供可用于疫苗的新型革兰氏阴性细菌突变体。
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公开(公告)号：US20090202594A1
公开(公告)日：2009-08-13
申请号：US12425599
申请日：2009-04-17
IPC分类号： A61K39/102 , C12N1/21
CPC分类号： A61K39/102 , A61K2039/522 , C07K14/285 , C12N1/20
摘要： Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.
摘要翻译： 识别革兰氏阴性细菌毒力基因，从而允许鉴定靶向这些毒力基因及其产物的新型抗细菌剂，以及提供用于疫苗的新型革兰氏阴性细菌突变体。
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公开(公告)号：US07476391B2
公开(公告)日：2009-01-13
申请号：US10854299
申请日：2004-05-26
IPC分类号： A61K39/102
CPC分类号： C07K14/285 , A61K2039/522
摘要： Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.
摘要翻译： 识别革兰氏阴性细菌毒力基因，从而允许鉴定靶向这些毒力基因及其产物的新型抗细菌剂，以及提供可用于疫苗的新型革兰氏阴性细菌突变体。
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公开(公告)号：US06790950B2
公开(公告)日：2004-09-14
申请号：US09809665
申请日：2001-03-15
IPC分类号： C07H2100
CPC分类号： C07K14/285 , A61K2039/522
摘要： Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.
摘要翻译： 识别革兰氏阴性细菌毒力基因，从而允许鉴定靶向这些毒力基因及其产物的新型抗细菌剂，以及提供可用于疫苗的新型革兰氏阴性细菌突变体。
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公开(公告)号：US07208591B2
公开(公告)日：2007-04-24
申请号：US10650467
申请日：2003-08-28
IPC分类号： C12N15/12
CPC分类号： C07K14/70571
摘要： The invention provides neuropeptide ligands, G protein-coupled receptors and methods of screening for modulators of receptor activity. Identified modulators, including neuropeptide ligand mimetics, are useful as biostatic and biocidal agents of varying scope, ranging from lethal activity restricted to particular invertebrate parasites to broad spectrum invertebrate parasiticides active on a wide range of invertebrates, including helminths and insects.
摘要翻译： 本发明提供神经肽配体，G蛋白偶联受体和筛选受体活性调节剂的方法。 鉴定的调节剂，包括神经肽配体模拟物，可用作不同范围的生物杀灭剂和杀生物剂，从限制于特定无脊椎寄生虫的致死活性到广泛无脊椎动物（包括蠕虫和昆虫）的广谱无脊椎寄生虫寄生虫。
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公开(公告)号：US06835546B1
公开(公告)日：2004-12-28
申请号：US09693746
申请日：2000-10-20
IPC分类号： G01N33566
CPC分类号： C07K14/705 , C12N2799/021
摘要： The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention also provides methods for the identification of homologs in other animals, and of DmGPCR agonists/antagonists, useful for the treatment of diseases in animals and for the control of insects that are injurious or harmful to plants or animals.
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