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1.发明申请公开(公告)号：US20070048735A1
公开(公告)日：2007-03-01
申请号：US10660997
申请日：2003-09-12
申请人： David Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley Crooke , James Hannis
发明人： David Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley Crooke , James Hannis
CPC分类号： C12Q1/689 , C12Q1/6813 , C12Q1/6858 , C12Q1/686 , C12Q1/6888 , C12Q2600/156 , Y02A50/59 , Y02A50/60 , Y02A90/24 , C12Q2565/627 , C12Q2545/113 , C12Q2563/167
摘要： The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.
摘要翻译： 本发明提供了通过识别与生物武器相关的生物标签和恐怖主义或犯罪行为进行快速法医调查的方法。 该方法也可用于通过基因分型生物学的流行病学调查。
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公开(公告)号：US20060275788A1
公开(公告)日：2006-12-07
申请号：US11331978
申请日：2006-01-13
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
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公开(公告)号：US20060121520A1
公开(公告)日：2006-06-08
申请号：US11331987
申请日：2006-01-13
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
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4.发明申请Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby 审中-公开定义数据库的二级结构和用于确定未知生物标签的身份和地理起源的方法公开(公告)号：US20050027459A1
公开(公告)日：2005-02-03
申请号：US10439706
申请日：2003-05-16
申请人： David Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley Crooke
发明人： David Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley Crooke
IPC分类号： A61B20060101 , C12P19/34 , C12Q1/68 , C12Q1/70 , G01N31/00 , G01N33/48 , G01N33/50 , G06F19/00 , G06F19/18
摘要： The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
摘要翻译： 本发明一般涉及研究生物信息学领域，更具体地涉及定义数据库的二级结构。 本发明还涉及询问数据库作为已知生物标签的分子量来源的方法，用于与未知或选择的生物标签的分子量进行比较以确定所选择的生物标签的身份，和/或确定所选生物标记的来源 所选的生物标签。 生物制剂的鉴定对于在诸如生物战争的情况下确定生物制剂的适当治疗过程和/或辐照是重要的。 此外，确定所选择的生物制剂的地理起源将有助于确定潜在的犯罪认同。
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公开(公告)号：US07108974B2
公开(公告)日：2006-09-19
申请号：US10156608
申请日：2002-05-24
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
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公开(公告)号：US20080160512A1
公开(公告)日：2008-07-03
申请号：US11233630
申请日：2005-09-21
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
摘要翻译： 通过核酸扩增和分子量测定的组合来检测和识别未知生物标签的方法，所述引物与衍生自生物制剂的核酸的保守序列区域杂交的引物以及独特的括号可变序列区域 识别生物制剂。 结果是“基本组成签名”（BCS），然后与基础组合签名的数据库进行匹配，通过该数据库识别生物标签。
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公开(公告)号：US08563250B2
公开(公告)日：2013-10-22
申请号：US11682259
申请日：2007-03-05
申请人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
CPC分类号： C12Q1/689 , C12Q1/6813 , C12Q1/6858 , C12Q1/686 , C12Q1/6888 , C12Q2600/156 , Y02A50/59 , Y02A50/60 , Y02A90/24 , C12Q2565/627 , C12Q2545/113 , C12Q2563/167
摘要： The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.
摘要翻译： 本发明提供了通过识别与生物武器相关的生物标签和恐怖主义或犯罪行为进行快速法医调查的方法。 该方法也可用于通过基因分型生物学的流行病学调查。
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公开(公告)号：US08017358B2
公开(公告)日：2011-09-13
申请号：US11331987
申请日：2006-01-13
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
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公开(公告)号：US07741036B2
公开(公告)日：2010-06-22
申请号：US11331978
申请日：2006-01-13
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
摘要翻译： 通过核酸扩增和分子量测定的组合来检测和识别未知生物标签的方法，所述引物与衍生自生物制剂的核酸的保守序列区域杂交的引物以及独特的括号可变序列区域 识别生物制剂。 结果是“基本组成签名”（BCS），然后与基础组合签名的数据库进行匹配，通过该数据库识别生物标签。
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公开(公告)号：US20060259249A1
公开(公告)日：2006-11-16
申请号：US11073362
申请日：2005-03-03
申请人： Rangarajan Sampath , Vivek Samant , Christian Massire , Harold Levene , David Ecker , John McNeil
发明人： Rangarajan Sampath , Vivek Samant , Christian Massire , Harold Levene , David Ecker , John McNeil
IPC分类号： G06F19/00
摘要： The method described herein relate generally the identification of bioagents on the basis of base composition signatures for bioagent-identifying amplicons. Specifically, methods of the present invention are directed to the application of pattern recognition models, particularly probability pattern classifiers, to the identification of both known and previously unrecognized bioagents. In certain embodiments, the pattern classifiers relate to probability cloud patterns, such as mutational probability patterns. In other embodiments the pattern classifiers relate to polytope pattern models.
摘要翻译： 本文所述的方法一般涉及基于用于生物鉴别扩增子的碱基组成特征的生物标记的鉴定。 具体地，本发明的方法涉及模式识别模型，特别是概率模式分类器在识别已知和以前未被认识的生物标签的应用。 在某些实施例中，模式分类器涉及概率云模式，例如突变概率模式。 在其他实施例中，模式分类器涉及多面体图案模型。
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