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公开(公告)号：US08407010B2
公开(公告)日：2013-03-26
申请号：US12049949
申请日：2008-03-17
Applicant: Steven A. Hofstadler , Thomas A. Hall , David J. Ecker , Lawrence B. Blyn , Mark W. Eshoo , Vivek Samant , Neill White
Inventor： Steven A. Hofstadler , Thomas A. Hall , David J. Ecker , Lawrence B. Blyn , Mark W. Eshoo , Vivek Samant , Neill White
IPC: G06F7/00
CPC classification number: G01N27/62 , C12Q1/683 , C12Q1/6846 , G01N27/447 , G06F19/28 , C12Q2565/627 , C12Q2521/301
Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.
Abstract translation: 本发明提供了通过扩增含有限制性位点的线粒体DNA片段，用限制酶消化线粒体DNA片段，确定限制性片段的分子量并将分子量与分子量进行比较的线粒体DNA的快速法医分析方法 已知线粒体DNA序列的理论限制性消化存储在数据库中。
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公开(公告)号：US20090239224A1
公开(公告)日：2009-09-24
申请号：US12326800
申请日：2008-12-02
Applicant: David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
Inventor： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
IPC: C12Q1/68
CPC classification number: C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
Abstract translation: 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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公开(公告)号：US08268565B2
公开(公告)日：2012-09-18
申请号：US12326800
申请日：2008-12-02
Applicant: David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Stephen A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
Inventor： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Stephen A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
CPC classification number: C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
Abstract translation: 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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4.发明申请Methods For Rapid Forensic Analysis Of Mitochondrial DNA And Characterization Of Mitochondrial DNA Heteroplasmy 有权线粒体DNA快速法医分析方法及线粒体DNA异质性表征公开(公告)号：US20090182511A1
公开(公告)日：2009-07-16
申请号：US11929930
申请日：2007-10-30
Applicant: David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Thomas Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared James Drader
Inventor： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Thomas Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared James Drader
CPC classification number: C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
Abstract translation: 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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公开(公告)号：US20130337452A1
公开(公告)日：2013-12-19
申请号：US13850683
申请日：2013-03-26
Applicant: Steven A. Hofstadler , Thomas A. Hall , David J. Ecker , Lawrence B. Blyn , Mark W. Eshoo , Vivek Samant , Neill White
Inventor： Steven A. Hofstadler , Thomas A. Hall , David J. Ecker , Lawrence B. Blyn , Mark W. Eshoo , Vivek Samant , Neill White
IPC: G01N27/62
CPC classification number: G01N27/62 , C12Q1/683 , C12Q1/6846 , G01N27/447 , G16B50/00 , C12Q2565/627 , C12Q2521/301
Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.
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Patent Agency Ranking
公开(公告)号：US20090125245A1
公开(公告)日：2009-05-14
申请号：US12049949
申请日：2008-03-17
Applicant: Steven A. Hofstadler , Thomas A. Hall , David J. Ecker , Lawrence B. Blyn , Mark W. Eshoo , Vivek Samant , Neill White
Inventor： Steven A. Hofstadler , Thomas A. Hall , David J. Ecker , Lawrence B. Blyn , Mark W. Eshoo , Vivek Samant , Neill White
CPC classification number: G01N27/62 , C12Q1/683 , C12Q1/6846 , G01N27/447 , G06F19/28 , C12Q2565/627 , C12Q2521/301
Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.
Abstract translation: 本发明提供了通过扩增含有限制性位点的线粒体DNA片段，用限制酶消化线粒体DNA片段，确定限制性片段的分子量并将分子量与分子量进行比较的线粒体DNA的快速法医分析方法 已知线粒体DNA序列的理论限制性消化存储在数据库中。
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公开(公告)号：US20060259249A1
公开(公告)日：2006-11-16
申请号：US11073362
申请日：2005-03-03
Applicant: Rangarajan Sampath , Vivek Samant , Christian Massire , Harold Levene , David Ecker , John McNeil
Inventor： Rangarajan Sampath , Vivek Samant , Christian Massire , Harold Levene , David Ecker , John McNeil
IPC: G06F19/00
Abstract: The method described herein relate generally the identification of bioagents on the basis of base composition signatures for bioagent-identifying amplicons. Specifically, methods of the present invention are directed to the application of pattern recognition models, particularly probability pattern classifiers, to the identification of both known and previously unrecognized bioagents. In certain embodiments, the pattern classifiers relate to probability cloud patterns, such as mutational probability patterns. In other embodiments the pattern classifiers relate to polytope pattern models.
Abstract translation: 本文所述的方法一般涉及基于用于生物鉴别扩增子的碱基组成特征的生物标记的鉴定。 具体地，本发明的方法涉及模式识别模型，特别是概率模式分类器在识别已知和以前未被认识的生物标签的应用。 在某些实施例中，模式分类器涉及概率云模式，例如突变概率模式。 在其他实施例中，模式分类器涉及多面体图案模型。
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8.发明授权Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 有权线粒体DNA快速法医分析方法及线粒体DNA异质性表征公开(公告)号：US08802372B2
公开(公告)日：2014-08-12
申请号：US11929930
申请日：2007-10-30
Applicant: David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared James Drader
Inventor： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared James Drader
CPC classification number: C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
Abstract translation: 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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公开(公告)号：US20050266411A1
公开(公告)日：2005-12-01
申请号：US10853660
申请日：2004-05-25
Applicant: Steven Hofstadler , Thomas Hall , David Ecker , Lawrence Blyn , Mark Eshoo , Vivek Samant , Neill White
Inventor： Steven Hofstadler , Thomas Hall , David Ecker , Lawrence Blyn , Mark Eshoo , Vivek Samant , Neill White
IPC: C12Q1/68 , G01N27/447 , G01N33/48 , G01N33/50 , G06F19/00
CPC classification number: G01N27/62 , C12Q1/683 , C12Q1/6846 , G01N27/447 , G16B50/00 , C12Q2565/627 , C12Q2521/301
Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA by amplification of a segment of mitochondrial DNA containing restriction sites, digesting the mitochondrial DNA segments with restriction enzymes, determining the molecular masses of the restriction fragments and comparing the molecular masses with the molecular masses of theoretical restriction digests of known mitochondrial DNA sequences stored in a database.
Abstract translation: 本发明提供了通过扩增含有限制性位点的线粒体DNA片段，用限制酶消化线粒体DNA片段，确定限制性片段的分子量并将分子量与分子量进行比较的线粒体DNA的快速法医分析方法 已知线粒体DNA序列的理论限制性消化存储在数据库中。
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10.发明申请Systems for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy 审中-公开线粒体DNA的快速法医分析系统和线粒体DNA异质性的表征公开(公告)号：US20100145626A1
公开(公告)日：2010-06-10
申请号：US12605628
申请日：2009-10-26
Applicant: David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
Inventor： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
CPC classification number: C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
Abstract translation: 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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