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公开(公告)号：US06951558B2
公开(公告)日：2005-10-04
申请号：US10354187
申请日：2003-01-30
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/00458 , A61B2018/2025 , A61B2018/20359
摘要： A scanning optical system for delivering electromagnetic radiation onto tissue to be treated is cooperative with a lightguide or optical fiber. Radiation to be delivered is provided by a source thereof via the optical fiber. The optical system includes an optical projection arrangement comprising a plurality of lenses cooperatively arranged with the lightguide. A first of the lenses is arranged to receive radiation emerging from the lightguide. The beam of radiation is passed through the projection arrangement to form a treatment spot the radiation on the tissue. Scanning is effected by causing relative motion between the exit-end of said lightguide and at least the first lens, transverse to the optical axis of the projection arrangement. The treatment spot undergoes a related transverse motion over the tissue. In one example scanning is effected by moving the first lens with the lightguide fixed. The first lens is moved using an arrangement of piezo-electric actuators.
摘要翻译： 用于将电磁辐射传送到要处理的组织上的扫描光学系统与光导或光纤协调。 待传送的辐射通过其光源由光源提供。 光学系统包括光学投影装置，其包括与光导协同地布置的多个透镜。 第一透镜布置成接收从光导中出射的辐射。 辐射束通过突出装置，以形成处理点上的组织上的辐射。 通过使所述光导的出射端和至少第一透镜之间的横向于投影装置的光轴的相对运动来实现扫描。 治疗点在组织上经历相关的横向运动。 在一个示例中，通过使光固定器固定的第一透镜移动来实现扫描。 使用压电致动器的布置移动第一透镜。
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公开(公告)号：US20090105699A1
公开(公告)日：2009-04-23
申请号：US12255435
申请日：2008-10-21
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/00458 , A61B2018/2025 , A61B2018/20359 , A61B2090/036
摘要： A method for delivering electromagnetic radiation onto tissue to be ‘treated with the radiation includes delivering the radiation onto the tissue in a treatment-spot having a polygonal shape such as a rectangle or a hexagon. The polygonal shape is selected such that a region of the tissue to be treated’ can be completely covered by a plurality of such shapes essentially without overlapping the shapes. The radiation to be delivered is passed through a lightguide having a cross-section of the polygonal shape. Radiation exiting the lightguide is projected onto the tissue via a plurality of optical elements to provide the treatment-spot.
摘要翻译： 将电磁辐射递送到用“辐射”处理的组织上的方法包括将辐射传送到具有多边形形状的治疗点（例如矩形或六边形）上的组织上。 选择多边形形状使得要处理的组织的区域可以被完全被多个这样的形状覆盖，基本上不重叠形状。 要传送的辐射通过具有多边形形状的横截面的光导。 离开光导的辐射经由多个光学元件投射到组织上以提供治疗点。
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公开(公告)号：US07438713B2
公开(公告)日：2008-10-21
申请号：US10901080
申请日：2004-07-29
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/00458 , A61B2018/2025 , A61B2018/20359 , A61B2090/036
摘要： A method for delivering electromagnetic radiation onto tissue to be treated with the radiation includes delivering the radiation onto the tissue in a treatment-spot having a polygonal shape such as a rectangle or a hexagon. The polygonal shape is selected such that a region of the tissue to be treated can be completely covered by a plurality of such shapes essentially without overlapping the shapes. The radiation to be delivered is passed through a lightguide having a cross-section of the polygonal shape. Radiation exiting the lightguide is projected onto the tissue via a plurality of optical elements to provide the treatment-spot.
摘要翻译： 将电磁辐射递送到用辐射处理的组织上的方法包括将辐射传送到具有多边形形状的治疗点（例如矩形或六边形）上的组织上。 选择多边形形状使得待处理的组织的区域可以完全被多个这样的形状覆盖，基本上不重叠形状。 要传送的辐射通过具有多边形形状的横截面的光导。 离开光导的辐射经由多个光学元件投射到组织上以提供治疗点。
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公开(公告)号：US07824396B2
公开(公告)日：2010-11-02
申请号：US12255435
申请日：2008-10-21
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/00458 , A61B2018/2025 , A61B2018/20359 , A61B2090/036
摘要： A method for delivering electromagnetic radiation onto tissue to be ‘treated with the radiation includes delivering the radiation onto the tissue in a treatment-spot having a polygonal shape such as a rectangle or a hexagon. The polygonal shape is selected such that a region of the tissue to be treated’ can be completely covered by a plurality of such shapes essentially without overlapping the shapes. The radiation to be delivered is passed through a lightguide having a cross-section of the polygonal shape. Radiation exiting the lightguide is projected onto the tissue via a plurality of optical elements to provide the treatment-spot.
摘要翻译： 将电磁辐射递送到用“辐射”处理的组织上的方法包括将辐射传送到具有多边形形状的治疗点（例如矩形或六边形）上的组织上。 选择多边形形状使得要处理的组织的区域可以被完全被多个这样的形状覆盖，基本上不重叠形状。 要传送的辐射通过具有多边形形状的横截面的光导。 离开光导的辐射经由多个光学元件投射到组织上以提供治疗点。
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公开(公告)号：US07263255B2
公开(公告)日：2007-08-28
申请号：US10408783
申请日：2003-04-08
IPC分类号： G02B6/26
CPC分类号： G02B27/0927 , A61F9/008 , A61F9/00821 , A61F2009/00855 , A61F2009/00863 , A61F2009/00872 , G02B27/0994
摘要： An apparatus and method may provide uniform illumination on the retina using scanned continuous wave laser sources by making use of waveguides with regular shaped cross sections. Some embodiments of the present invention may provide illumination uniformity for selected spots and/or whole target scans, and may provide for constant dwell times every point of the scanned beam. Furthermore, the non-uniformities caused by starting and stopping scans may be eliminated by, for example, clipping-off both the beginning and end of the scan with a hard aperture. A modulator may be provided, enabling uniform irradiation of selected target areas.
摘要翻译： 一种装置和方法可以通过利用具有规则形状的横截面的波导，使用扫描的连续波激光源在视网膜上提供均匀的照明。 本发明的一些实施例可以为所选择的点和/或整个目标扫描提供照明均匀性，并且可以为扫描光束的每个点提供恒定的驻留时间。 此外，由扫描开始和停止引起的不均匀性可以通过例如用硬孔隙限制扫描的开始和结束来消除。 可以提供调制器，使得能够均匀地照射所选择的目标区域。
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6.发明授权Optical delivery systems and methods of providing adjustable beam diameter, spot size and/or spot shape 有权光学传送系统和提供可调光束直径，光点尺寸和/或光斑形状的方法公开(公告)号：US07599591B2
公开(公告)日：2009-10-06
申请号：US11653663
申请日：2007-01-12
申请人： Dan E. Andersen , David G. Angeley , Philip Gooding , Michael W. Wiltberger , David H. Mordaunt
发明人： Dan E. Andersen , David G. Angeley , Philip Gooding , Michael W. Wiltberger , David H. Mordaunt
IPC分类号： G02B6/06
CPC分类号： A61B3/0008 , A61B3/135 , A61F9/008 , A61F9/00821 , A61F9/00823 , A61F9/009 , A61F2009/00863 , A61F2009/00872 , A61F2009/00897 , G02B6/32 , G02B6/3512 , G02B6/3548 , G02B6/357 , G02B6/3582 , G02B26/105
摘要： An optical device and method for varying an optical characteristic of an optical beam can include a plurality of optical fibers each having an input end, an output end, and a core, wherein each of the optical fibers has an effective area and a numerical aperture, and a beam-deviating component for moving at least one of the optical fiber input ends and the optical beam relative to each other such that the optical beam selectively enters the input ends one at a time and is transmitted out the output ends one at a time, wherein at least one of the effective areas and the numerical apertures varies among the plurality of optical fibers such that the optical beam transmitted out of the output ends has a varying optical characteristic.
摘要翻译： 用于改变光束的光学特性的光学装置和方法可以包括多个光纤，每个光纤具有输入端，输出端和芯，其中每个光纤具有有效面积和数值孔径， 以及光束偏离部件，用于相对于彼此移动光纤输入端和光束中的至少一个，使得光束一次一个地选择性地进入输入端，并且一次一个地输出输出端 其中，所述有效面积和所述数值孔径中的至少一个在所述多根光纤中变化，使得从所述输出端传出的光束具有变化的光学特性。
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公开(公告)号：US06887233B2
公开(公告)日：2005-05-03
申请号：US09814443
申请日：2001-03-22
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/00458 , A61B2018/2025 , A61B2018/20359 , A61B2090/036
摘要： A method for delivering electromagnetic radiation onto tissue to be treated with the radiation includes delivering the radiation onto the tissue in a treatment-spot having a polygonal shape such as a rectangle or a hexagon. The polygonal shape is selected such that a region of the tissue to be treated can be completely covered by a plurality of such shapes essentially without overlapping the shapes. The radiation to be delivered is passed through a lightguide having a cross-section of the polygonal shape. Radiation exiting the lightguide is projected onto the tissue via a plurality of optical elements to provide the treatment-spot.
摘要翻译： 将电磁辐射递送到用辐射处理的组织上的方法包括将辐射传送到具有多边形形状的治疗点（例如矩形或六边形）上的组织上。 选择多边形形状使得待处理的组织的区域可以完全被多个这样的形状覆盖，基本上不重叠形状。 要传送的辐射通过具有多边形形状的横截面的光导。 离开光导的辐射经由多个光学元件投射到组织上以提供治疗点。
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8.发明授权Method and apparatus for automated placement of scanned laser capsulorhexis incisions 有权用于自动放置扫描的激光撕囊切口的方法和装置公开(公告)号：US08845625B2
公开(公告)日：2014-09-30
申请号：US13011807
申请日：2011-01-21
CPC分类号： A61F9/00825 , A61B3/102 , A61B3/107 , A61B5/0066 , A61F9/008 , A61F9/0084 , A61F9/009 , A61F2009/00851 , A61F2009/00865 , A61F2009/0087 , A61F2009/00872 , A61F2009/00876 , A61F2009/00889 , A61F2009/00897 , G06T7/0012 , G06T7/13 , G06T7/149 , G06T2207/10101 , G06T2207/30041
摘要： Systems and methods are described for cataract intervention. In one embodiment a system comprises a laser source configured to produce a treatment beam comprising a plurality of laser pulses; an integrated optical system comprising an imaging assembly operatively coupled to a treatment laser delivery assembly such that they share at least one common optical element, the integrated optical system being configured to acquire image information pertinent to one or more targeted tissue structures and direct the treatment beam in a 3-dimensional pattern to cause breakdown in at least one of the targeted tissue structures; and a controller operatively coupled to the laser source and integrated optical system, and configured to adjust the laser beam and treatment pattern based upon the image information, and distinguish two or more anatomical structures of the eye based at least in part upon a robust least squares fit analysis of the image information.
摘要翻译： 描述白内障干预的系统和方法。 在一个实施例中，系统包括被配置为产生包括多个激光脉冲的治疗束的激光源; 一种集成光学系统，包括可操作地耦合到治疗激光输送组件的成像组件，使得它们共享至少一个公共光学元件，所述集成光学系统被配置为获取与一个或多个目标组织结构相关的图像信息，并且指导治疗束 在3维图案中以引起至少一个目标组织结构中的破坏; 以及控制器，其可操作地耦合到所述激光源和集成光学系统，并且被配置为基于所述图像信息来调整所述激光束和治疗图案，并且至少部分地基于鲁棒的最小二乘法来区分所述眼睛的两个或多个解剖结构 适合分析图像信息。
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9.发明申请公开(公告)号：US20090180932A1
公开(公告)日：2009-07-16
申请号：US12289677
申请日：2008-10-31
申请人： David G. Angeley
发明人： David G. Angeley
IPC分类号： G01N21/75
CPC分类号： G01D5/35303 , G01N21/4788 , Y10S436/805
摘要： The present invention is directed to an optical grating sensor configured to detect a phase change in light passing though the system due to a binding event caused by an analyte. The grating sensor may include a light source that may be, for example, a coherent light source. The invention may also include a first diffraction grating having a first period. A micro-electrical mechanical system (MEMS) may be displaced from the first diffraction grating and may be configured to modulate the light received form the coherent light source. An analyte recognition material may be disposed on the surface of the first grating. A detector may be configured to receive light form the coherent light source after the light has been diffracted from the first diffraction grating and modulated by the MEMS. In another embodiment of the present invention, the grating sensor may be configured to operate in two modes. The first mode may be a mode the detect a phase change in the light due to a binding event. The second mode may include the detection of fluorescence due to a binding event and may employ tagging of the analytes.
摘要翻译： 本发明涉及一种光栅传感器，其被配置为检测由于由分析物引起的结合事件而通过系统的光的相位变化。 光栅传感器可以包括可以是例如相干光源的光源。 本发明还可以包括具有第一周期的第一衍射光栅。 微电气机械系统（MEMS）可以从第一衍射光栅移位，并且可以被配置为调制从相干光源接收的光。 分析物识别材料可以设置在第一光栅的表面上。 检测器可以被配置为在光从第一衍射光栅衍射并被MEMS调制之后接收来自相干光源的光。 在本发明的另一个实施例中，光栅传感器可被配置为以两种模式操作。 第一模式可以是检测由于绑定事件引起的光的相位变化的模式。 第二模式可以包括由于结合事件的荧光的检测，并且可以使用分析物的标记。
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10.发明授权公开(公告)号：US08040582B2
公开(公告)日：2011-10-18
申请号：US12253076
申请日：2008-10-16
IPC分类号： G02B26/08
CPC分类号： G02B6/0006 , A61F9/008 , A61F9/00821 , A61F2009/00863 , A61F2009/00897 , G02B13/22
摘要： A beam delivery system for treating target tissue that includes an input for receiving a light beam, a variable attenuator for providing variable attenuation of the light beam, a power and wavelength detection assembly, a spot size adjustment assembly, and a controller. The power and wavelength detection assembly measures the power level of the beam, and detects when unwanted wavelengths are present in the light beam. The spot size adjustment assembly selectively feeds the beam through different optical fibers to achieve different spot sizes of the beam. The controller controls the variable attenuator, the power and wavelength detection assembly, and the spot size adjustment assembly to achieve the desired power and wavelength, and beam spot size.
摘要翻译： 一种用于治疗靶组织的束传递系统，包括用于接收光束的输入，用于提供光束可变衰减的可变衰减器，功率和波长检测组件，光点尺寸调整组件和控制器。 功率和波长检测组件测量光束的功率电平，并检测光束中是否存在不需要的波长。 光斑尺寸调整组件通过不同的光纤选择性地馈送光束以实现光束的不同光斑尺寸。 控制器控制可变衰减器，功率和波长检测组件以及光斑尺寸调整组件以实现所需的功率和波长以及光斑尺寸。
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