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    Mitral Valve System
    1.
    发明申请
    Mitral Valve System 有权
    二尖瓣系统

    公开(公告)号：US20080221672A1

    公开(公告)日：2008-09-11

    申请号：US12028572

    申请日：2008-02-08

    申请人： David G. Lamphere ,  Tuan Anh Nguyen ,  Howard C. Herrmann ,  Todd C. Tomba ,  Robert C. Gorman ,  Joseph H. Gorman

    发明人： David G. Lamphere ,  Tuan Anh Nguyen ,  Howard C. Herrmann ,  Todd C. Tomba ,  Robert C. Gorman ,  Joseph H. Gorman

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2418 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/008

    摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements. The proximal, distal, and intermediate tissue-engaging regions are cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure so as to stabilize a position of the valve prosthesis with respect to the anatomical structure, including wherein for purposes of so simultaneously engaging the separate corresponding areas of tissue, at least one of the first, second, and third elongate tissue-piercing elements is pointed at least partially opposite the direction of blood flow, and at least another thereof is pointed at least partially along the direction of blood flow. The valve prosthesis may also include a skirt mounted with respect to the resilient ring for sealing a periphery of the valve prosthesis against a reverse flow of blood around the valve prosthesis.

    摘要翻译： 公开了适于相对于心脏环的安全和对准放置的阀门假体。 瓣膜假体可以以非侵入性方式放置，例如通过反式导管技术。 瓣膜假体可以包括弹性环，相对于弹性环安装的多个传膜，以及相对于柔性环可移动地安装的多个定位元件。 每个定位元件限定相应的近端，中间和远侧组织接合区域，其协作地构造和尺寸设计成同时接合解剖结构的组织的分开的对应区域，包括相应的第一，第二和第三细长组织刺穿元件。 近端，远端和中间组织接合区域协同地构造和尺寸设计以同时接合解剖结构的组织的分开的对应区域，以便相对于解剖结构稳定瓣膜假体的位置，包括其中为了目的 同时接合组织的单独的对应区域，第一，第二和第三细长组织刺穿元件中的至少一个至少部分地相对于血流方向指向，并且至少另一个至少部分地沿着 血流方向。 瓣膜假体还可以包括相对于弹性环安装的裙部，用于抵抗瓣膜假体周围的逆流血液密封阀门假体的周边。

    Mitral valve system
    2.
    发明授权
    Mitral valve system 有权
    二尖瓣系统

    公开(公告)号：US08070802B2

    公开(公告)日：2011-12-06

    申请号：US12028572

    申请日：2008-02-08

    申请人： David G. Lamphere ,  Tuan Anh Nguyen ,  Howard C. Herrmann ,  Todd C. Tomba ,  Robert C. Gorman ,  Joseph H. Gorman, III

    发明人： David G. Lamphere ,  Tuan Anh Nguyen ,  Howard C. Herrmann ,  Todd C. Tomba ,  Robert C. Gorman ,  Joseph H. Gorman, III

    IPC分类号： A61F2/24 ,  A61F2/06

    CPC分类号： A61F2/2418 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2230/008

    摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via transcatheter techniques. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. Each of the positioning elements defines respective proximal, intermediate, and distal tissue engaging regions cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure, including respective first, second, and third elongate tissue-piercing elements. The proximal, distal, and intermediate tissue-engaging regions are cooperatively configured and dimensioned to simultaneously engage separate corresponding areas of the tissue of an anatomical structure so as to stabilize a position of the valve prosthesis with respect to the anatomical structure, including wherein for purposes of so simultaneously engaging the separate corresponding areas of tissue, at least one of the first, second, and third elongate tissue-piercing elements is pointed at least partially opposite the direction of blood flow, and at least another thereof is pointed at least partially along the direction of blood flow. The valve prosthesis may also include a skirt mounted with respect to the resilient ring for sealing a periphery of the valve prosthesis against a reverse flow of blood around the valve prosthesis.

    摘要翻译： 公开了适于相对于心脏环的安全和对准放置的阀门假体。 瓣膜假体可以以非侵入性方式放置，例如通过经导管技术。 瓣膜假体可以包括弹性环，相对于弹性环安装的多个传膜，以及相对于柔性环可移动地安装的多个定位元件。 每个定位元件限定相应的近端，中间和远侧组织接合区域，其协作地构造和尺寸设计成同时接合解剖结构的组织的分开的对应区域，包括相应的第一，第二和第三细长组织刺穿元件。 近端，远端和中间组织接合区域协同地构造和尺寸设计以同时接合解剖结构的组织的分开的对应区域，以便相对于解剖结构稳定瓣膜假体的位置，包括其中为了目的 同时接合组织的单独的对应区域，第一，第二和第三细长组织刺穿元件中的至少一个至少部分地相对于血流方向指向，并且至少另一个至少部分地沿着 血流方向。 瓣膜假体还可以包括相对于弹性环安装的裙部，用于抵抗瓣膜假体周围的逆流血液密封阀门假体的周边。

    Valve prosthesis systems and methods
    3.
    发明授权
    Valve prosthesis systems and methods 有权
    阀门假体系统及方法

    公开(公告)号：US07753949B2

    公开(公告)日：2010-07-13

    申请号：US11869972

    申请日：2007-10-10

    申请人： David G. Lamphere ,  Tuan Anh Nguyen ,  Howard C. Herrmann

    发明人： David G. Lamphere ,  Tuan Anh Nguyen ,  Howard C. Herrmann

    IPC分类号： A61F2/06 ,  A61F2/24

    CPC分类号： A61F2/2412 ,  A61F2/243 ,  A61F2/2436 ,  A61F2/2439

    摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positioned/repositioned until proper alignment and positioning is achieved. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region. The positioning elements are adapted to substantially completely invert by rotating relative to the resilient ring between a first position in which each of the first and second tissue engaging regions is inwardly directed for facilitating positioning of the valve prosthesis within a delivery catheter, and a second position in which each of the first and second tissue engaging regions is outwardly directed for engaging tissue. The valve prosthesis may also include a valve skirt mounted with respect to the resilient ring.

    摘要翻译： 公开了适于相对于心脏环的安全和对准放置的阀门假体。 瓣膜假体可以以非侵入性方式放置，例如经由导管技术，并且可以定位/重新定位，直到实现适当的对准和定位。 瓣膜假体可以包括弹性环，相对于弹性环安装的多个小叶膜和相对于柔性环可移动地安装的多个定位元件，每个定位元件限定第一组织接合区域和 第二组织接合区域与第一组织接合区域间隔开。 定位元件适于在第一位置和第二位置之间通过相对于弹性环的旋转基本上完全反转，在第一位置中，第一和第二组织接合区域中的每一个向内指向，以便于将瓣膜假体定位在输送导管内， 其中第一和第二组织接合区域中的每一个向外指向用于接合组织。 瓣膜假体还可以包括相对于弹性环安装的阀裙。

    Valve Prosthesis Systems and Methods
    4.
    发明申请
    Valve Prosthesis Systems and Methods 有权
    瓣膜假体系统和方法

    公开(公告)号：US20080208332A1

    公开(公告)日：2008-08-28

    申请号：US11869972

    申请日：2007-10-10

    申请人： David G. Lamphere ,  Tuan Anh Nguyen ,  Howard C. Herrmann

    发明人： David G. Lamphere ,  Tuan Anh Nguyen ,  Howard C. Herrmann

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2412 ,  A61F2/243 ,  A61F2/2436 ,  A61F2/2439

    摘要： Valve prostheses are disclosed that are adapted for secure and aligned placement relative to a heart annulus. The valve prostheses may be placed in a non-invasive manner, e.g., via trans-catheter techniques, and may be positioned/repositioned until proper alignment and positioning is achieved. The valve prosthesis may include a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring, each of the positioning elements defining a first tissue engaging region and a second tissue engaging region spaced from the first tissue engaging region. The positioning elements are adapted to substantially completely invert by rotating relative to the resilient ring between a first position in which each of the first and second tissue engaging regions is inwardly directed for facilitating positioning of the valve prosthesis within a delivery catheter, and a second position in which each of the first and second tissue engaging regions is outwardly directed for engaging tissue. The valve prosthesis may also include a valve skirt mounted with respect to the resilient ring.

    摘要翻译： 公开了适于相对于心脏环的安全和对准放置的阀门假体。 瓣膜假体可以以非侵入性方式放置，例如经由导管技术，并且可以定位/重新定位，直到实现适当的对准和定位。 瓣膜假体可以包括弹性环，相对于弹性环安装的多个小叶膜和相对于柔性环可移动地安装的多个定位元件，每个定位元件限定第一组织接合区域和 第二组织接合区域与第一组织接合区域间隔开。 定位元件适于在第一位置和第二位置之间通过相对于弹性环的旋转基本上完全反转，在第一位置中，第一和第二组织接合区域中的每一个向内指向，以便于将瓣膜假体定位在输送导管内， 其中第一和第二组织接合区域中的每一个向外指向用于接合组织。 瓣膜假体还可以包括相对于弹性环安装的阀裙。

    Systems and Methods For Placement of Valve Prosthesis System
    9.
    发明申请
    Systems and Methods For Placement of Valve Prosthesis System 审中-公开
    瓣膜假体系统的放置系统与方法

    公开(公告)号：US20080208328A1

    公开(公告)日：2008-08-28

    申请号：US11870001

    申请日：2007-10-10

    申请人： Joseph D. Antocci ,  David G. Lamphere ,  Salvatore Castro ,  Gregorio Ramon M. Abesames ,  Howard C. Herrmann

    发明人： Joseph D. Antocci ,  David G. Lamphere ,  Salvatore Castro ,  Gregorio Ramon M. Abesames ,  Howard C. Herrmann

    IPC分类号： A61F2/24

    CPC分类号： A61F2/2412 ,  A61F2/243 ,  A61F2/2436 ,  A61F2/2439

    摘要： Valve prosthesis systems and methods/systems for placement of such valve prostheses are provided that facilitate efficient, reliable and minimally invasive delivery modalities. The placement systems and methods permit remote manipulation and positioning of the valve prosthesis such that desirable placement relative to anatomical structures, e.g., the heart annulus, may be achieved. The valve prosthesis includes a resilient ring, a plurality of leaflet membranes mounted with respect to the resilient ring, and a plurality of positioning elements movably mounted with respect to the flexible ring. The delivery system includes a first elongate element that terminates at the valve prosthesis and is manipulable by an operator to remotely rotate the positioning elements relative to the flexible ring. A second elongate element terminates at the valve prosthesis and is manipulable by an operator to remotely advance the valve prosthesis downward into an anatomical annulus. The second elongate element may be manipulated to remotely advance the valve prosthesis into the anatomical annulus to assume a position for supporting post-implantation function of the valve prosthesis in situ. The first elongate element may be further manipulated to remotely rotate the positioning element relative to the flexible ring to cause the positioning element to engage tissue associated with the anatomical annulus and to thereby maintain the post-implantation position of the valve prosthesis in situ. Methods for valve prosthesis deployment are also provided.

    摘要翻译： 提供了用于放置这种瓣膜假体的瓣膜假体系统和方法/系统，其有助于有效，可靠和微创的递送方式。 放置系统和方法允许瓣膜假体的远程操作和定位，使得可以实现相对于解剖结构（例如心脏环）的期望的放置。 瓣膜假体包括弹性环，相对于弹性环安装的多个传膜，以及相对于柔性环可移动地安装的多个定位元件。 递送系统包括终止于瓣膜假体处的第一细长元件，并且可由操作者操纵以相对于柔性环远程旋转定位元件。 第二细长元件终止在瓣膜假体处，并且可由操作者操纵以将瓣膜假体向下远进地推进到解剖环形中。 第二细长元件可以被操纵以将瓣膜假体远程地推进到解剖环空中，以呈现用于在原位支撑瓣膜假体的植入后功能的位置。 可以进一步操作第一细长元件以相对于柔性环远程旋转定位元件，以使得定位元件接合与解剖学环带相关联的组织，并由此原位维持瓣膜假体的植入后位置。 还提供了用于瓣膜假体部署的方法。

    Shaped diaphragm for a centrifuge system rotor
    10.
    发明授权
    Shaped diaphragm for a centrifuge system rotor 失效
    用于离心机系统转子的隔膜

    公开(公告)号：US06824506B1

    公开(公告)日：2004-11-30

    申请号：US09733624

    申请日：2000-12-08

    申请人： David G. Lamphere ,  Thomas D. Headley

    发明人： David G. Lamphere ,  Thomas D. Headley

    IPC分类号： B04B1100

    CPC分类号： A61M1/3693 ,  A61M1/3696 ,  A61M1/3698 ,  B04B5/0428

    摘要： A shaped diaphragm as a part of a fluid processing disposable set acting as a centrifuge system rotor. The fluid processing disposable set has a variable-volume chamber and a fluid port. The shaped diaphragm defines a wall of the variable-volume chamber. The chamber is in fluid communication with the fluid port and is defined by a fixed wall and an elastic wall. The elastic wall is formed by the shaped diaphragm. The disposable set may also have a rotary seal coupled to the fluid port and fluidly coupled to the variable-volume chamber. The shaped diaphragm may be convoluted. The convolution may be a single fold and may have a plurality of folds located symmetrically about an axis. The shaped diaphragm may, alternatively, be essentially planar in an unstretched position while varying in thickness along a diaphragm dimension. Centrifuge rotors, systems, and methods for selective harvest of fluid constituents from a whole fluid are detailed.

    摘要翻译： 作为作为离心机系统转子的流体处理一次性组合的一部分的成形隔膜。 流体处理一次性装置具有可变容积室和流体端口。 成形隔膜限定可变容积室的壁。 室与流体端口流体连通，并由固定壁和弹性壁限定。 弹性壁由成形的隔膜形成。 一次性组件还可以具有联接到流体端口并且流体耦合到可变容积室的旋转密封件。 成形的隔膜可以被卷绕。 卷积可以是单个折叠，并且可以具有围绕轴对称定位的多个折叠。 可选地，成形隔膜可以在非拉伸位置基本上是平面的，同时沿隔膜尺寸变化的厚度。 详细说明了用于选择性收集整个流体的流体组分的离心机转子，系统和方法。