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1.发明授权Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效药物组合物作为二肽基肽酶-IV（DPP-IV）的抑制剂公开(公告)号：US08119664B2
公开(公告)日：2012-02-21
申请号：US12727558
申请日：2010-03-19
申请人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号： A61K31/445 , C07D295/00
CPC分类号： C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖，动脉粥样硬化和各种免疫调节疾病 。
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2.发明申请Pharmaceutical Compositions As Inhibitors of Dipeptidyl Peptidase-IV (DPP-IV) 失效药物组合物作为二肽基肽酶-IV（DPP-IV）的抑制剂公开(公告)号：US20100190822A1
公开(公告)日：2010-07-29
申请号：US12727558
申请日：2010-03-19
申请人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号： A61K31/4725 , C07D207/16 , A61K31/40 , A61P3/10 , A61P3/04 , A61P3/08 , C07D401/08 , C07D401/14 , A61K31/4545 , C07D401/12 , A61K31/454 , A61K31/4439 , C07D403/08 , A61K31/4025
CPC分类号： C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖，动脉粥样硬化和各种免疫调节疾病 。
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3.发明申请PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 失效作为DIPPTIDYL PEPTIDASE-IV（DPP-IV）抑制剂的药物组合物公开(公告)号：US20130059873A1
公开(公告)日：2013-03-07
申请号：US13437999
申请日：2012-04-03
申请人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号： A61K31/40 , C07D401/08 , A61K31/4725 , C07D401/14 , A61K31/4545 , C07D401/12 , A61K31/454 , A61K31/4439 , C07D403/08 , A61K31/4025 , C07D405/06 , A61K31/506 , A61P3/10 , A61P3/04 , C07D207/16
CPC分类号： C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖，动脉粥样硬化和各种免疫调节疾病 。
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4.发明授权Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效药物组合物作为二肽基肽酶-IV（DPP-IV）的抑制剂公开(公告)号：US07262207B2
公开(公告)日：2007-08-28
申请号：US10788993
申请日：2004-02-27
申请人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号： A61K31/445 , C07D401/00
CPC分类号： C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖，动脉粥样硬化和各种免疫调节疾病 。
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5.发明授权Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DDP-IV) 失效作为二肽基肽酶-IV（DDP-IV）抑制剂的药物组合物公开(公告)号：US08637546B2
公开(公告)日：2014-01-28
申请号：US13437999
申请日：2012-04-03
申请人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号： A61K31/445 , C07D295/00
CPC分类号： C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖，动脉粥样硬化和各种免疫调节疾病 。
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6.发明授权Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效药物组合物作为二肽基肽酶-IV（DPP-IV）的抑制剂公开(公告)号：US07238724B2
公开(公告)日：2007-07-03
申请号：US11036258
申请日：2005-01-13
申请人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
发明人： David J. Madar , Stevan W. Djuric , Melissa J. Michmerhuizen , Hana A. Kopecka , Xiaofeng Li , Kenton L. Longenecker , Zhonghua Pei , Daisy Pireh , Hing L. Sham , Kent D. Stewart , Bruce G. Szczepankiewicz , Paul E. Wiedeman , Hong Yong
IPC分类号： A61K31/40 , A61K31/401 , A61K31/454 , A61K31/4545 , A61K31/506 , C07D405/12 , C07D401/12 , C07D211/58 , C07D239/42
CPC分类号： C07D207/16 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）并可用于预防或治疗糖尿病，特别是II型糖尿病以及高血糖症，X综合症，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病的化合物 。
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7.发明申请Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) 失效药物组合物作为二肽基肽酶-IV（DPP-IV）的抑制剂公开(公告)号：US20050215784A1
公开(公告)日：2005-09-29
申请号：US11036258
申请日：2005-01-13
申请人： David Madar , Stevan Djuric , Melissa Michmerhuizen , Hana Kopecka , Xiaofeng Li , Kenton Longenecker , Zhonghua Pei , Daisy Pireh , Hing Sham , Kent Stewart , Bruce Szczepankiewicz , Paul Wiedeman , Hong Yong
发明人： David Madar , Stevan Djuric , Melissa Michmerhuizen , Hana Kopecka , Xiaofeng Li , Kenton Longenecker , Zhonghua Pei , Daisy Pireh , Hing Sham , Kent Stewart , Bruce Szczepankiewicz , Paul Wiedeman , Hong Yong
IPC分类号： A61K31/551 , C07D207/16 , C07D207/26 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/02 , C07D417/02 , C07D417/12 , C07D43/02
CPC分类号： C07D207/16 , C07D207/27 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）并可用于预防或治疗糖尿病，特别是II型糖尿病以及高血糖症，X综合症，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病的化合物 。
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8.发明申请Pharmaceutical Compositions as Inhibitors of Dipeptidyl Peptidase-IV (DPP-IV) 审中-公开药物组合物作为二肽基肽酶-IV抑制剂（DPP-IV）公开(公告)号：US20070238753A1
公开(公告)日：2007-10-11
申请号：US11757173
申请日：2007-06-01
申请人： David Madar , Stevan Djuric , Melissa Michmerhuizen , Hana Kopecka , Xiaofeng Li , Kenton Longenecker , Zhonghua Pei , Daisy Pireh , Hing Sham , Kent Stewart , Bruce Szczepankiewicz , Paul Wiedeman , Hong Yong
发明人： David Madar , Stevan Djuric , Melissa Michmerhuizen , Hana Kopecka , Xiaofeng Li , Kenton Longenecker , Zhonghua Pei , Daisy Pireh , Hing Sham , Kent Stewart , Bruce Szczepankiewicz , Paul Wiedeman , Hong Yong
IPC分类号： A61K31/40 , A61K31/44 , A61K31/445 , A61P3/10 , C07D207/00 , C07D207/02 , C07D401/00
CPC分类号： C07D207/16
摘要： The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）并可用于预防或治疗糖尿病，特别是II型糖尿病以及高血糖症，X综合症，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病的化合物 。
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9.发明申请PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) 审中-公开作为DIPPTIDYL PEPTIDASE-IV（DPP-IV）抑制剂的药物组合物公开(公告)号：US20070265302A1
公开(公告)日：2007-11-15
申请号：US11828099
申请日：2007-07-25
申请人： David Madar , Stevan Djuric , Melissa Michmerhuizen , Hana Kopecka , Xiaofeng Li , Kenton Longenecker , Zhonghua Pei , Daisy Pireh , Hing Sham , Kent Stewart , Bruce Szezepankiewicz , Paul Wiedeman , Hong Yong
发明人： David Madar , Stevan Djuric , Melissa Michmerhuizen , Hana Kopecka , Xiaofeng Li , Kenton Longenecker , Zhonghua Pei , Daisy Pireh , Hing Sham , Kent Stewart , Bruce Szezepankiewicz , Paul Wiedeman , Hong Yong
IPC分类号： A61K31/47 , A61K31/40 , A61P3/08 , C07D211/00 , C07D215/00 , C07D207/04 , A61K31/445
CPC分类号： C07D207/27 , C07D207/16 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.
摘要翻译： 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，X综合征，高胰岛素血症，肥胖，动脉粥样硬化和各种免疫调节疾病 。
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公开(公告)号：US5459152A
公开(公告)日：1995-10-17
申请号：US162034
申请日：1993-12-02
申请人： James B. Summers , Steven K. Davidsen , James H. Holms , Daisy Pireh , H. Robin Heyman , Michael B. Martin , Douglas H. Steinman , George S. Sheppard , George M. Carrera, Jr.
发明人： James B. Summers , Steven K. Davidsen , James H. Holms , Daisy Pireh , H. Robin Heyman , Michael B. Martin , Douglas H. Steinman , George S. Sheppard , George M. Carrera, Jr.
IPC分类号： A61K31/44 , A61K31/4406 , A61K49/00 , A61K49/06 , A61P1/04 , A61P7/02 , A61P7/06 , A61P9/02 , A61P11/06 , A61P17/06 , A61P29/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07B47/00 , C07D213/69 , C07D487/04 , C07D498/04 , C07D513/04 , C07F5/00 , C07F13/00
CPC分类号： C07D487/04 , A61K49/06 , C07D213/69 , C07D513/04
摘要： Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
摘要翻译： PCT No.PCT / US92 / 05890 Sec。 371日期1993年12月2日第 102（e）日期1993年12月2日PCT提交1992年7月14日PCT公布。 出版物WO93 / 01813 日期：1993年2月4日。通过7-羰基（吡啶-3-基）吡咯并[1,2-c]噻唑，7-羰基（吡啶-3-基）吡咯并[1 ，2-c]恶唑或7-羰基（吡啶-3-基）吡咯并[1,2-c]吡咯基是PAF的有效的抗药剂，可用于治疗PAF相关疾病，包括哮喘，休克，呼吸 窘迫综合征，急性炎症，移植器官排斥，胃肠道溃疡，过敏性皮肤病，延迟细胞免疫，分娩，胎儿肺成熟和细胞分化。
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