公开(公告)号：US08940902B2

公开(公告)日：2015-01-27

申请号：US13554698

申请日：2012-07-20

Applicant: R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Yixian Chen ,  Jurgen Dinges ,  Karla Drescher ,  Peer Jacobson ,  Hwan-soo Jae ,  Ravi Kurukulasuriya ,  James T. Link ,  David J. Madar ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Lynne E. Rueter ,  Qi Shuai ,  Bryan K. Sorensen ,  Jiahong Wang ,  Karsten M. Wicke ,  Martin Winn ,  Dariusz Wodka ,  Vince Yeh ,  Hong Yong

Inventor： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Yixian Chen ,  Jurgen Dinges ,  Karla Drescher ,  Peer Jacobson ,  Hwan-soo Jae ,  Ravi Kurukulasuriya ,  James T. Link ,  David J. Madar ,  Jyoti R. Patel ,  Marina A. Pliushchev ,  Jeffrey J. Rohde ,  Lynne E. Rueter ,  Qi Shuai ,  Bryan K. Sorensen ,  Jiahong Wang ,  Karsten M. Wicke ,  Martin Winn ,  Dariusz Wodka ,  Vince Yeh ,  Hong Yong

IPC: C07D211/74 ,  A61K31/44 ,  A61K31/495

CPC classification number: C07D403/12 ,  A61K31/44 ,  A61K31/495 ,  C07D207/267 ,  C07D401/12 ,  C07D401/14

Abstract: A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention deficit disorder in general, attention deficit hyperactivity disorder (ADHD), Alzheimer's disease (AD), mild cognitive impairment, senile dementia, AIDS dementia, neurodegeneration, depression, and schizophrenia, comprising administering to a patient in need of such treatment an effective amount of a selective inhibitor of the 11-β-hydroxysteroid dehydrogenase Type 1 enzyme activity.

Abstract translation: 一种治疗患有与老化和神经变性相关的糖尿病中枢神经系统紊乱和缺陷的患者的方法，包括注意力缺陷障碍，注意力缺陷多动障碍（ADHD），阿尔茨海默病（AD），轻度认知障碍 老年性痴呆，艾滋病痴呆，神经退行性疾病，抑郁症和精神分裂症，包括向需要这种治疗的患者施用有效量的11-羟基类固醇脱氢酶1型酶活性的选择性抑制剂。

公开(公告)号：US08485307B2

公开(公告)日：2013-07-16

申请号：US13481484

申请日：2012-05-25

Applicant: Sung Ho Ji ,  Hong Yong Bhae

Inventor： Sung Ho Ji ,  Hong Yong Bhae

IPC: B62D5/04

CPC classification number: B62D5/0448 ,  B62D5/0403 ,  B62D5/0424

Abstract: A rack driving-type power assisted steering apparatus having effects of preventing a lock screw from being loosened due to vibration in axial and radial directions generated by a rack bar, a ball nut, and a rack housing when the rack bar slides while the ball nut rotates, reducing vibration and noise of the ball nut and the rack bar transferred through a bearing, and providing a driver with steering comfortability.

Abstract translation: 一种齿条驱动型动力辅助转向装置，其具有当齿条杆滑动时防止由于齿条，球形螺母和齿条壳体产生的轴向和径向方向的振动而导致的锁定螺钉松动的效果，而滚珠螺母 旋转，减少滚珠螺母和通过轴承传递的齿条的振动和噪音，并为司机提供转向舒适性。

公开(公告)号：US20130060029A1

公开(公告)日：2013-03-07

申请号：US13612259

申请日：2012-09-12

Applicant: Weichun Chen ,  Hong-Yong Kim ,  Jessica Liang ,  Michael Mutz ,  Mahavir Prashad ,  Christopher Towler ,  Ruoqiu Wu

Inventor： Weichun Chen ,  Hong-Yong Kim ,  Jessica Liang ,  Michael Mutz ,  Mahavir Prashad ,  Christopher Towler ,  Ruoqiu Wu

IPC: C07D239/91 ,  C07D401/04

CPC classification number: C07D239/91 ,  A61K31/517

Abstract: There is described a process for the manufacture of compounds of the formula I said process comprising reacting a compound of the formula II as described herein, or a salt thereof, under simultaneous or sequential condensation and cyclisation conditions with an aniline compound of the formula III, wherein R2 and m are as defined for a compound of the formula I. Further reactions and related embodiments are also claimed and disclosed.

Abstract translation: 描述了制备式I化合物的方法，所述方法包括使本文所述的式II化合物或其盐在同时或连续的缩合和环化条件下与式III的苯胺化合物反应， 其中R 2和m如式I化合物所定义。其他反应和相关实施方案也被要求保护和公开。

公开(公告)号：US08314270B2

公开(公告)日：2012-11-20

申请号：US12878813

申请日：2010-09-09

Applicant: James T. Link ,  Qi Shuai ,  Martin Winn ,  Hong Yong

Inventor： James T. Link ,  Qi Shuai ,  Martin Winn ,  Hong Yong

IPC: C07C233/05 ,  A61K31/65

CPC classification number: C07C233/23 ,  C07C235/14 ,  C07C237/24 ,  C07C255/31 ,  C07C255/47 ,  C07C259/16 ,  C07C311/08 ,  C07C311/29 ,  C07C311/46 ,  C07C311/51 ,  C07C317/22 ,  C07C317/30 ,  C07C317/44 ,  C07C323/41 ,  C07C323/60 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2603/74 ,  C07D207/48 ,  C07D213/64 ,  C07D233/64 ,  C07D257/04 ,  C07D261/08

Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

Abstract translation: 本发明涉及作为11-β-羟基类固醇脱氢酶1型酶抑制剂的化合物。 本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征和其他介导的疾病和病症的用途 由过度的糖皮质激素作用。

公开(公告)号：US07855308B2

公开(公告)日：2010-12-21

申请号：US12355909

申请日：2009-01-19

Applicant: Michael E. Brune ,  Peer B. Jacobson ,  James T. Link ,  Jyoti R. Patel ,  Jeffrey J. Rohde ,  Qi Shuai ,  Martin Winn ,  Vince S. Yeh ,  Hong Yong

Inventor： Michael E. Brune ,  Peer B. Jacobson ,  James T. Link ,  Jyoti R. Patel ,  Jeffrey J. Rohde ,  Qi Shuai ,  Martin Winn ,  Vince S. Yeh ,  Hong Yong

IPC: C07C233/05 ,  A61K31/65

CPC classification number: C07C233/23 ,  C07C235/14 ,  C07C237/24 ,  C07C255/31 ,  C07C255/47 ,  C07C259/16 ,  C07C311/08 ,  C07C311/29 ,  C07C311/46 ,  C07C311/51 ,  C07C317/22 ,  C07C317/30 ,  C07C317/44 ,  C07C323/41 ,  C07C323/60 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2603/74 ,  C07D207/48 ,  C07D213/64 ,  C07D233/64 ,  C07D257/04 ,  C07D261/08

Abstract: The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome and other diseases and conditions that are mediated by excessive glucocorticoid action.

Abstract translation: 本发明涉及作为11-β-羟基类固醇脱氢酶1型酶抑制剂的化合物。 本发明还涉及11-β-羟基类固醇脱氢酶1型抑制剂用于治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征和其他介导的疾病和病症的用途 由过度的糖皮质激素作用。

公开(公告)号：US20080123965A1

公开(公告)日：2008-05-29

申请号：US11792871

申请日：2005-12-12

Applicant: Hong Yong Yang ,  Seung Gol Lee ,  Sang Hoon Kim

Inventor： Hong Yong Yang ,  Seung Gol Lee ,  Sang Hoon Kim

IPC: G06K9/46 ,  G06K9/00

CPC classification number: G06F3/03545 ,  G06F3/0321

Abstract: A system and method of recognizing absolute coordinates are provided. The absolute coordinate recognition system includes: a pattern recording medium in which each cell is diagrammatized, and a predetermined microcode is allocated to the pattern formed by each arrangement of the diagrammatized cells; a pattern sensing unit recognizing the microcode by sensing the pattern; and a signal processing unit calculating the position of the pattern sensing unit on the pattern recording medium, from the sensed pattern. By constructing the simpler patterns of the pattern recording medium, the absolute coordinate recognition system and method therefor enable imaging system and image sensor with not-high resolutions to recognize the patterns.

Abstract translation: 提供了一种识别绝对坐标的系统和方法。 绝对坐标识别系统包括：图形记录介质，其中每个单元被图示化，并且将预定的微码分配给由图示化单元的每个布置形成的图案; 图案感测单元，通过感测图案识别微码; 以及信号处理单元，从感测图案计算图案记录介质上的图案感测单元的位置。 通过构造图案记录介质的更简单的图案，绝对坐标识别系统及其方法能够使不具有高分辨率的成像系统和图像传感器识别图案。

公开(公告)号：US06992069B2

公开(公告)日：2006-01-31

申请号：US10422401

申请日：2003-04-24

Applicant: Yu-Gui Gu ,  Zhenkun Ma ,  Hong Yong

Inventor： Yu-Gui Gu ,  Zhenkun Ma ,  Hong Yong

IPC: A61K31/70 ,  C07H17/08

CPC classification number: C07H17/08

Abstract: Antibacterial compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis or treatment of bacterial infections using the compounds are disclosed.

Abstract translation: 公开了具有式（I）的抗菌化合物及其前体药物的前体药物和前体药物，其制备方法中使用的化合物和中间体，含该化合物的组合物，以及使用该化合物预防或治疗细菌感染的方法。

公开(公告)号：US20050215784A1

公开(公告)日：2005-09-29

申请号：US11036258

申请日：2005-01-13

Applicant: David Madar ,  Stevan Djuric ,  Melissa Michmerhuizen ,  Hana Kopecka ,  Xiaofeng Li ,  Kenton Longenecker ,  Zhonghua Pei ,  Daisy Pireh ,  Hing Sham ,  Kent Stewart ,  Bruce Szczepankiewicz ,  Paul Wiedeman ,  Hong Yong

Inventor： David Madar ,  Stevan Djuric ,  Melissa Michmerhuizen ,  Hana Kopecka ,  Xiaofeng Li ,  Kenton Longenecker ,  Zhonghua Pei ,  Daisy Pireh ,  Hing Sham ,  Kent Stewart ,  Bruce Szczepankiewicz ,  Paul Wiedeman ,  Hong Yong

IPC: A61K31/551 ,  C07D207/16 ,  C07D207/26 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D413/02 ,  C07D417/02 ,  C07D417/12 ,  C07D43/02

CPC classification number: C07D207/16 ,  C07D207/27 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D417/12

Abstract: The present invention relates to compounds that inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases.

Abstract translation: 本发明涉及抑制二肽基肽酶IV（DPP-IV）并可用于预防或治疗糖尿病，特别是II型糖尿病以及高血糖症，X综合症，高胰岛素血症，肥胖症，动脉粥样硬化和各种免疫调节疾病的化合物 。

公开(公告)号：US06737708B2

公开(公告)日：2004-05-18

申请号：US10219920

申请日：2002-08-15

Applicant: Hong Yong Zhang ,  Yoshio Nagahiro

Inventor： Hong Yong Zhang ,  Yoshio Nagahiro

IPC: H01L2362

CPC classification number: H01L27/124 ,  G02F1/136204 ,  G02F2202/104 ,  H01L27/0248 ,  H01L29/78621

Abstract: When a thin-film transistor (TFT) is formed on a glass substrate, electric charges caused in the TFT can be removed so as to avoid electrostatic damage in the TFT. A short-circuiting pattern that short-circuits the source region and the drain region of the TFT is added to a polysilicon pattern that constitutes the TFT. This short-circuiting pattern is removed at the same time as or after the wiring formation in the source region and the drain region.

Abstract translation: 当在玻璃基板上形成薄膜晶体管（TFT）时，可以去除在TFT中产生的电荷，以避免TFT中的静电损伤。 将TFT的源极区域和漏极区域短路的短路图案添加到构成TFT的多晶硅图案中。 在源极区域和漏极区域中的布线形成之后或之后的同时移除该短路图案。

公开(公告)号：US08993632B2

公开(公告)日：2015-03-31

申请号：US13469021

申请日：2012-05-10

Applicant: R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Steven Fung ,  Peer B. Jacobson ,  Lynne E. Rueter ,  Marina I. Strakhova ,  Jiahong Wang ,  Jeffrey J. Rohde ,  Qi Shuai ,  James T. Link ,  Jyoti R. Patel ,  Jurgen Dinges ,  Bryan K. Sorensen ,  Hong Yong ,  Vince S. Yeh ,  Ravi Kurukulasuriya

Inventor： R. Scott Bitner ,  Kaitlin E. Browman ,  Michael E. Brune ,  Steven Fung ,  Peer B. Jacobson ,  Lynne E. Rueter ,  Marina I. Strakhova ,  Jiahong Wang ,  Jeffrey J. Rohde ,  Qi Shuai ,  James T. Link ,  Jyoti R. Patel ,  Jurgen Dinges ,  Bryan K. Sorensen ,  Hong Yong ,  Vince S. Yeh ,  Ravi Kurukulasuriya

IPC: A61K31/16 ,  C07C233/11 ,  A61K31/165 ,  A61K31/195 ,  A61K31/44 ,  A61K31/45 ,  A61K31/5377 ,  C07C233/52 ,  C07C233/58 ,  C07C233/63 ,  C07C237/24 ,  C07C311/46 ,  C07D207/277 ,  C07D211/78 ,  C07D213/56 ,  C07D231/12 ,  C07D261/08 ,  C07D333/24

CPC classification number: A61K31/498 ,  A61K31/165 ,  A61K31/195 ,  A61K31/196 ,  A61K31/381 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4409 ,  A61K31/45 ,  A61K31/451 ,  A61K31/5377 ,  C07C233/11 ,  C07C233/52 ,  C07C233/58 ,  C07C233/63 ,  C07C237/24 ,  C07C311/46 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2603/74 ,  C07D207/277 ,  C07D211/78 ,  C07D213/56 ,  C07D231/12 ,  C07D261/08 ,  C07D333/24

Abstract: The present invention relates to inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

Abstract translation: 本发明涉及11-β-羟基类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖性2型糖尿病，胰岛素抵抗，肥胖症，脂质障碍，代谢综合征，中枢神经系统疾病和疾病中的用途，以及 与过量糖皮质激素有关的病症。