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公开(公告)号：US20100185121A1
公开(公告)日：2010-07-22
申请号：US12443249
申请日：2007-09-28
申请人： David L. Carroll , Faith M. Coldren , Nicole H. Levi , Lawrence X. Webb , William D. Wagner , Thomas L. Smith , Brian Werner , J. Baxter Mcguirt , Manoj Namboothiry
发明人： David L. Carroll , Faith M. Coldren , Nicole H. Levi , Lawrence X. Webb , William D. Wagner , Thomas L. Smith , Brian Werner , J. Baxter Mcguirt , Manoj Namboothiry
IPC分类号： A61B5/103
CPC分类号： G01L11/02 , A61B5/03 , A61B5/445 , A61B2562/0247
摘要： The present invention provides a method of sensing pressure in a region of interest by providing a plurality of metallic particles operatively associated with one another in the region of interest (for example, wherein the metallic particles sustain a plasmon upon excitation), and with the metallic particles configured or positioned in relationship to one another so that a physical property of the particles (for example, the energy of the plasmon) varies in response to pressure; measuring the physical property of the metallic particles that varies in response to pressure; and then determining the pressure in the region of interest from the detected physical property (e.g., resistance, energy of the plasmon). Compositions, articles and formulations for carrying out the method in industrial and biomedical applications are also described.
摘要翻译： 本发明提供了一种通过在感兴趣的区域（例如，其中金属颗粒在激发时维持等离子体激元）可操作地相关联的多个金属颗粒，并且与金属 相互关联地配置或定位的颗粒，使得颗粒的物理性质（例如，等离子体激元的能量）响应于压力而变化; 测量响应于压力变化的金属颗粒的物理性质; 然后从检测到的物理性质（例如，电阻，等离子体激元的能量）确定感兴趣区域中的压力。 还描述了用于在工业和生物医学应用中进行该方法的组合物，制品和制剂。
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公开(公告)号：US09671301B2
公开(公告)日：2017-06-06
申请号：US12443249
申请日：2007-09-28
申请人： David L. Carroll , Faith M. Coldren , Nicole H. Levi , Lawrence X. Webb , William D. Wagner , Thomas L. Smith , Brian Werner , J. Baxter Mcguirt , Manoj Namboothiry
发明人： David L. Carroll , Faith M. Coldren , Nicole H. Levi , Lawrence X. Webb , William D. Wagner , Thomas L. Smith , Brian Werner , J. Baxter Mcguirt , Manoj Namboothiry
CPC分类号： G01L11/02 , A61B5/03 , A61B5/445 , A61B2562/0247
摘要： The present invention provides a method of sensing pressure in a region of interest by providing a plurality of metallic particles operatively associated with one another in the region of interest (for example, wherein the metallic particles sustain a plasmon upon excitation), and with the metallic particles configured or positioned in relationship to one another so that a physical property of the particles (for example, the energy of the plasmon) varies in response to pressure; measuring the physical property of the metallic particles that varies in response to pressure; and then determining the pressure in the region of interest from the detected physical property (e.g., resistance, energy of the plasmon). Compositions, articles and formulations for carrying out the method in industrial and biomedical applications are also described.
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公开(公告)号：US08454603B2
公开(公告)日：2013-06-04
申请号：US13094233
申请日：2011-04-26
IPC分类号： A61F5/04
CPC分类号： A61B17/66 , A61B17/60 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00544
摘要： An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.
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4.发明申请APPARATUS AND METHOD FOR WOUND TREATMENT EMPLOYING PERIODIC SUB-ATMOSPHERIC PRESSURE 有权用于治疗周期性亚大气压力的装置和方法公开(公告)号：US20080208147A1
公开(公告)日：2008-08-28
申请号：US11621728
申请日：2007-01-10
IPC分类号： A61M1/00
CPC分类号： A61H7/001 , A61M1/0037 , A61M1/0088
摘要： A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.
摘要翻译： 提供了一种通过应用时变的次大气压来处理组织的组织处理装置和方法。 该装置包括适于覆盖伤口并适于在伤口的部位保持低于大气压的盖。 该装置还包括被配置为产生具有包括逐渐变化的周期性波形的时变的次大气压的抽吸源。 抽吸源与盖配合，将盖下的时变大气压提供给伤口。 时变的次大气压力可以在低于伤口组织的固有组织张力的第一压力值和高于伤口组织的固有组织张力的第二压力值之间变化。
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公开(公告)号：US20080181955A1
公开(公告)日：2008-07-31
申请号：US11699688
申请日：2007-01-30
申请人： Lawrence X. Webb
发明人： Lawrence X. Webb
IPC分类号： A61K31/05 , A61K36/899 , A61K38/43 , A61K38/46
CPC分类号： A61K36/87 , A61K31/05 , A61K38/45 , A61K2300/00
摘要： A dietary supplement includes resveratrol in a therapeutically effective amount to permit release of nitric oxide (NO) during sexual stimulation and at least one polyphenol in a therapeutically effective amount to inhibit formation of type 5 phosphodiesterase (PDE-5). The dietary supplement is a dry powder derived from Muscadine grapes that are pressed and then stored at a temperature greater than 32° F. (0° C.) and less than 60° F. (15° C.) for at least 14 days. The pressed and stored grapes are dried and then ground into the dry powder. The concentration of the resveratrol is between 0.01 mg and 100 mg per 100 g of dry powder and the concentration of the polyphenol is between 0.04 mg and 400 mg per 100 g. A method for enhancing human libido includes providing the dry powder and consuming at least 50 mg of the dry powder daily for a period of at least 21 days.
摘要翻译： 膳食补充剂包括治疗有效量的白藜芦醇，以允许在性刺激期间释放一氧化氮（NO），以及至少一种治疗有效量的多酚以抑制5型磷酸二酯酶（PDE-5）的形成。 膳食补充剂是来自麝香葡萄的干粉，经压制然后在大于32°F（0℃）和小于60°F（15℃）的温度下储存至少14天 。 将压榨和储存的葡萄干燥，然后研磨成干粉。 白藜芦醇的浓度为0.01mg至100mg / 100g干粉，多酚的浓度为0.04mg至400mg / 100g。 增强人性欲的方法包括提供干燥粉末并每天至少消耗至少50mg的干粉，持续至少21天的时间。
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6.发明授权Apparatus and method for wound treatment employing periodic sub-atmospheric pressure 有权使用周期性低于大气压的伤口治疗的装置和方法公开(公告)号：US08377016B2
公开(公告)日：2013-02-19
申请号：US11621728
申请日：2007-01-10
IPC分类号： A61F13/00
CPC分类号： A61H7/001 , A61M1/0037 , A61M1/0088
摘要： A tissue treatment apparatus and method are provided for treating tissue by the application of the time-varying sub-atmospheric pressure. The apparatus includes a cover adapted to cover a wound and adapted to maintain sub-atmospheric pressure the site of the wound. The apparatus further includes a source of suction configured to generate a time-varying sub-atmospheric pressure having a periodic waveform comprising a gradual change in pressure. The suction source cooperates with the cover to supply the time-varying sub-atmospheric pressure under the cover to the wound. The time-varying sub-atmospheric pressure may vary between a first pressure value below the inherent tissue tension of the wound tissue and a second pressure value above the inherent tissue tension of the wound tissue.
摘要翻译： 提供了一种通过应用时变的次大气压来处理组织的组织处理装置和方法。 该装置包括适于覆盖伤口并适于在伤口的部位保持低于大气压的盖。 该装置还包括被配置为产生具有包括逐渐变化的周期性波形的时变的次大气压的抽吸源。 抽吸源与盖配合，将盖下的时变大气压提供给伤口。 时变的次大气压力可以在低于伤口组织的固有组织张力的第一压力值和高于伤口组织的固有组织张力的第二压力值之间变化。
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公开(公告)号：US20110202059A1
公开(公告)日：2011-08-18
申请号：US13094233
申请日：2011-04-26
IPC分类号： A61B17/00
CPC分类号： A61B17/66 , A61B17/60 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00544
摘要： An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.
摘要翻译： 外部固定组件包括插入患者骨骼中的多个中空销。 每个销具有内孔和从孔延伸穿过销壁的多个孔。 销可以联接到真空压力源，可操作以在围绕销的组织中产生减小的压力。 一个盖被放置在销的周围并被密封以提供一个流体密封的外壳，其保持围绕销的减压。 使用上述固定销来施加外部固定的方法包括以下步骤：将每个销插入皮肤开口，将销孔定位在所选组织附近，用密封的外壳覆盖皮肤开口，将销连接到真空压力源 并且激活真空压力源以在患者的组织中在骨骼处或骨附近产生减压。
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公开(公告)号：US07931651B2
公开(公告)日：2011-04-26
申请号：US11694395
申请日：2007-03-30
IPC分类号： A61F5/04
CPC分类号： A61B17/66 , A61B17/60 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00544
摘要： An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.
摘要翻译： 外部固定组件包括插入患者骨骼中的多个中空销。 每个销具有内孔和从孔延伸穿过销壁的多个孔。 销可以联接到真空压力源，可操作以在围绕销的组织中产生减小的压力。 一个盖被放置在销的周围并被密封以提供一个流体密封的外壳，其保持围绕销的减压。 使用上述固定销来施加外部固定的方法包括以下步骤：将每个销插入皮肤开口，将销孔定位在所选组织附近，用密封的外壳覆盖皮肤开口，将销连接到真空压力源 并且激活真空压力源以在患者的组织中在骨骼处或骨附近产生减压。
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公开(公告)号：US20080281324A1
公开(公告)日：2008-11-13
申请号：US11694395
申请日：2007-03-30
CPC分类号： A61B17/66 , A61B17/60 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00544
摘要： An external fixation assembly includes a plurality of hollow pins that are inserted into a patient's bone. Each pin has an interior bore and a plurality of apertures extending through the pin wall from the bore. The pin may be coupled to a source of vacuum pressure operable to create reduced pressure in the tissue surrounding the pin. A cover is placed around the pin and sealed to provide a fluid-tight enclosure that maintains reduced pressure around the pin. A method for applying external fixation using the fixator pins described above includes the steps of inserting each pin through a skin opening, positioning the pin apertures near selected tissue, covering the skin opening with a sealed enclosure, connecting the pins to a source of vacuum pressure, and activating the source of vacuum pressure to create reduced pressure in the patient's tissue at or near the bone.
摘要翻译： 外部固定组件包括插入患者骨骼中的多个中空销。 每个销具有内孔和从孔延伸穿过销壁的多个孔。 销可以联接到真空压力源，可操作以在围绕销的组织中产生减小的压力。 一个盖被放置在销的周围并被密封以提供一个流体密封的外壳，其保持围绕销的减压。 使用上述固定销来施加外部固定的方法包括以下步骤：将每个销插入皮肤开口，将销孔定位在所选组织附近，用密封的外壳覆盖皮肤开口，将销连接到真空压力源 并且激活真空压力源以在患者的组织中在骨骼处或骨附近产生减压。
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公开(公告)号：US20080208171A1
公开(公告)日：2008-08-28
申请号：US11678403
申请日：2007-02-23
IPC分类号： A61M1/00
CPC分类号： A61M1/0088
摘要： The present invention relates to a device and method for removing edema from an edematous tissue. The device includes at least one aciculated component disposed in fluid communication with a suction manifold. A suction source is fluidically connected to the suction manifold to provide a suction force to the suction manifold. The suction force is transmitted through the suction manifold to the at least one aciculated component to withdraw the edema from edematous tissue through the suction manifold and the at least one aciculated component.
摘要翻译： 本发明涉及一种用于从水肿组织中去除水肿的装置和方法。 该装置包括与抽吸歧管流体连通地设置的至少一个接头部件。 抽吸源流体地连接到吸入歧管以向抽吸歧管提供吸力。 抽吸力通过抽吸歧管传递到至少一个咬合部件，以通过吸入歧管和至少一个咬合部件从水肿组织中撤出水肿。
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