利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

11 条记录 (耗时 0.024 秒)

    Optically active nicotine analogs and process for their preparation
    2.
    发明授权
    Optically active nicotine analogs and process for their preparation 失效
    光学活性尼古丁类似物及其制备方法

    公开(公告)号：US4332945A

    公开(公告)日：1982-06-01

    申请号：US229481

    申请日：1981-01-29

    申请人： William B. Edwards, III

    发明人： William B. Edwards, III

    IPC分类号： C07D401/04

    CPC分类号： C07D401/04

    摘要： This invention provides a process for the preparation of cotinine and nicotine analogs containing substituents on pyrrolidinone/pyrrolidine ring at the 3' position of cotinine and at the 4' and 5' position of nicotine.The process proceeds via a first step preparation of a cotinine intermediate which is represented by the formula: ##STR1## wherein M is an alkali metal cation.

    摘要翻译： 本发明提供了一种在可替宁的3'位和尼古丁的4'和5'位置上在吡咯烷酮/吡咯烷环上含有取代基的可替宁和尼古丁类似物的制备方法。 该方法通过由以下式表示的可替宁中间体的第一步制备进行：其中M是碱金属阳离子。

    Optically active nicotine analogs and process for their preparation
    3.
    发明授权
    Optically active nicotine analogs and process for their preparation 失效
    光学活性尼古丁类似物及其制备方法

    公开(公告)号：US4452984A

    公开(公告)日：1984-06-05

    申请号：US377989

    申请日：1982-05-13

    申请人： William B. Edwards, III

    发明人： William B. Edwards, III

    IPC分类号： C07D401/04

    CPC分类号： C07D401/04

    摘要： This invention provides a process for the preparation of cotinine and nicotine analogs containing substituents on pyrrolidinone/pyrrolidine ring at the 3' position of cotinine and at the 4' and 5' position of nicotine.The process proceeds via a first step preparation of a cotinine intermediate which is represented by the formula: ##STR1## wherein M is an alkali metal cation.

    摘要翻译： 本发明提供了一种在可替宁的3'位和尼古丁的4'和5'位置上在吡咯烷酮/吡咯烷环上含有取代基的可替宁和尼古丁类似物的制备方法。 该方法通过由以下式表示的可替宁中间体的第一步制备进行：其中M是碱金属阳离子。

    Preparation of oxycarboxylic acids
    4.
    发明授权
    Preparation of oxycarboxylic acids 失效
    羟基羧酸的制备

    公开(公告)号：US4612391A

    公开(公告)日：1986-09-16

    申请号：US189417

    申请日：1980-09-22

    申请人： William B. Edwards, III

    发明人： William B. Edwards, III

    IPC分类号： C07C51/34 ,  C07C59/76

    CPC分类号： C07C51/34

    摘要： This invention provides a process for the conversion of an alicyclic .alpha.,.beta.-olefinically unsaturated ketone compound to an acyclic oxocarboxylic acid product which contains at least one less carbon atom per molecule than the ketone starting material.The conversion involves ozonation of the alicyclic .alpha.,.beta.-olefinically unsaturated ketone in an aqueous alcohol reaction medium, followed by a heating step.

    摘要翻译： 本发明提供了一种将脂环族α，β-烯属不饱和酮化合物转化成每分子至少比酮原料少一个碳原子的非环氧基羧酸产物的方法。 该转化涉及醇水反应介质中脂环族α，β-烯属不饱和酮的臭氧化，随后进行加热步骤。

    Azetidine compounds and process for production
    5.
    发明授权
    Azetidine compounds and process for production 失效
    氮杂环丁烷化合物和生产工艺

    公开(公告)号：US4163856A

    公开(公告)日：1979-08-07

    申请号：US889188

    申请日：1978-03-23

    申请人： William B. Edwards, III ,  Henry V. Secor ,  Norman H. Cromwell

    发明人： William B. Edwards, III ,  Henry V. Secor ,  Norman H. Cromwell

    IPC分类号： C07D213/34 ,  C07D213/38 ,  C07D213/55 ,  C07D401/02

    CPC分类号： C07D213/38 ,  C07D213/34 ,  C07D213/55

    摘要： Novel azetidine, and particularly 3-pyridyl-azetidine, compounds are disclosed. These compounds are produced from .gamma.-amino alcohols by a sequence comprising disulfonation to produce the sulfonamido-alkylsulfonate and then cyclization to the N-sulfonylazetidine. These azetidine compounds may then be transformed, as desired, to various N-derivatives by substitution of hydrogen or other univalent organic groups on the secondary amine of the azetidine ring.

    摘要翻译： 公开了新的氮杂环丁烷，特别是3-吡啶基 - 氮杂环丁烷。 这些化合物由γ-氨基醇通过包含二磺化产生亚磺酰氨基 - 烷基磺酸酯的顺序产生，然后环化成N-磺酰基氮杂环丁烷。 然后可以根据需要将这些氮杂环丁烷化合物通过取代氮杂环丁烷的仲胺上的氢或其它一价有机基团而转化为各种N-衍生物。

    Azetidine compounds and process for production
    7.
    发明授权
    Azetidine compounds and process for production 失效
    氮杂环丁烷化合物和生产工艺

    公开(公告)号：US4163855A

    公开(公告)日：1979-08-07

    申请号：US889147

    申请日：1978-03-23

    申请人： Henry V. Secor ,  William B. Edwards, III

    发明人： Henry V. Secor ,  William B. Edwards, III

    IPC分类号： C07D213/34 ,  C07D213/38 ,  C07D213/55 ,  C07D401/02

    CPC分类号： C07D213/34 ,  C07D213/38 ,  C07D213/55

    摘要： Novel azetidine, and particularly 2-pyridyl-azetidine, compounds are disclosed. These compounds are produced from amino-esters by a sequence comprising conversion to the sulfonamide, reduction of the ester to the alcohol, sulfonation of the resultant alcohol and cylization to the N-sulfonylazetidine. This azetidine compound may then be transformed, as desired, to various N-derivatives by substitution of hydrogen or other univalent organic groups on the secondary amine of the azetidine ring.

    摘要翻译： 公开了新的氮杂环丁烷，特别是2-吡啶基 - 氮杂环丁烷化合物。 这些化合物由氨基酯通过包括转化为磺酰胺，将酯还原成醇，磺化所得醇并向N-磺酰基氮杂环丁烷烷基化的顺序由氨基酯制备。 然后可以根据需要将该氮杂环丁烷化合物通过取代氮杂环丁烷的仲胺上的氢或其它一价有机基团而转化为各种N-衍生物。

    Nicotine analogs
    10.
    发明授权
    Nicotine analogs 失效
    尼古丁类似物

    公开(公告)号：US4590278A

    公开(公告)日：1986-05-20

    申请号：US597329

    申请日：1984-04-06

    申请人： William B. Edwards, III

    发明人： William B. Edwards, III

    IPC分类号： C07D401/04

    CPC分类号： C07D401/04

    摘要： This invention provides a process for the preparation of cotinine and nicotine analogs containing substituents on pyrrolidinone/pyrrolidine ring at the 3' position of cotinine and at the 4' and 5' position of nicotine.The process proceeds via a first step preparation of a cotinine intermediate which is represented by the formula: ##STR1## wherein M is an alkali metal cation.

    摘要翻译： 本发明提供了一种在可替宁的3'位和尼古丁的4'和5'位置上在吡咯烷酮/吡咯烷环上含有取代基的可替宁和尼古丁类似物的制备方法。 该方法通过由以下式表示的可替宁中间体的第一步制备进行：其中M是碱金属阳离子。