摘要:
The invention relates in part to methods for inhibiting proliferation of cancer cells and treating one or more cell proliferative conditions using compounds described herein.
摘要:
The present application is generally directed to compounds, compositions and methods of combination therapy for the treatment of neoplastic disorders.
摘要:
The invention provides methods for the treatment or amelioration of disorders associated with undesired activity of protein kinase CK2, using compounds of Formula (I) that are potent, selective inhibitors of CK2, and pharmaceutical compositions of such compounds, wherein Z5, R6B, R6D, R8, n, R9 and p are defined as further described herein,
摘要:
Provided herein are procedures for rapidly determining oral bioavailability of two or more compounds by administering the two or more compounds to an animal, extracting fluid from an eye region of the animal and determining the amount of each of the two or more compounds in the fluid by mass spectrometry. Such procedures can provide cost advantages for determining oral bioavailability as they allow for (i) utilizing relatively small animals, (ii) extracting multiple samples from a single animal, and (iii) analyzing multiple compounds in a single animal, for example.
摘要:
The invention relates in part to methods for treating ophthalmic conditions using compounds described herein. The conditions to be treated include various ocular cancers. The compositions employed include a polycyclic quinolinone derivative or related heteroaromatic analog thereof.
摘要:
The present application is directed to a process of forming a photomask pattern comprising one or more sub-resolution assist features (SRAF). The process comprises generating a first set of SRAF patterns. Each of the SRAF patterns in the first set having a first assigned mask position. After the first set of SRAF patterns are generated, determining if the SRAF patterns of the first set comply with a preselected set of rules, wherein one or more of the SRAF patterns are found to be illegal because they do not comply with at least one of the preselected rules. One or more of the illegal SRAF patterns are reassigned to second mask positions that are different from the first mask positions, the second mask positions allowing the illegal SRAF patterns to comply with the at least one preselected rule to form corrected SRAF patterns. The present application also discloses systems for generating a sub-resolution assist feature pattern for a photomask, as well as SRAF modules embodied on a computer readable medium comprising instructions operable to carry out the processes of the present application.
摘要:
The present invention provides a business method, computer system and software that permit a digital media peer-to-peer or server-to-peer exchange, with sponsored media access, while providing a secure and high speed transmission of media files across an internet, intranet or cable network in such a manner as to avoid illegal or un-permitted end user digital file sharing or copying. More particularly, the invention provides a method that combines a digital media encryption technique and unique user key to permit transmission of digital media information in a very compressed or compacted small-size file that is essentially incapable of being decoded without a legitimate user key. The network or virtual private network provides computer hardware, software and at least one interface for advertisers to view marketing factor listings corresponding to network end users and to provide sponsored digital media access for selected listings of end users in exchange for targeted advertising of users.