专利检索 ap:("David M. Sabatini" OR "Dos D. Sarbassov" OR "Michael Andreeff" OR "Marina Konopleva" OR "Zhihong Zeng" OR "Francis J. Giles") AND inv:"Zhihong Zeng" 第 1 页

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发明申请
Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex 审中-公开
标题翻译：通过rictor-mTOR复合物的AKT / PKB的磷酸化和调节

公开(公告)号：US20100173928A1

公开(公告)日：2010-07-08

申请号：US12218629

申请日：2008-07-15

申请人： David M. Sabatini , Dos D. Sarbassov , Michael Andreeff , Marina Konopleva , Zhihong Zeng , Francis J. Giles

发明人： David M. Sabatini , Dos D. Sarbassov , Michael Andreeff , Marina Konopleva , Zhihong Zeng , Francis J. Giles

IPC分类号： A61K31/436 , C12N5/00 , C12Q1/02 , A61P35/00

CPC分类号： C12Q1/485 , G01N33/5011 , G01N33/573 , G01N33/57426 , G01N2500/02 , G01N2800/52

摘要： In certain aspects, the invention relates to methods for identifying compounds which modulate Akt activity mediated by the rictor-mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activity.

摘要翻译： 在某些方面，本发明涉及用于鉴定调节由rictor-mTOR复合物介导的Akt活性的化合物的方法以及用于治疗或预防与异常Akt活性相关的病症的方法。