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1.发明申请Phosphorylation and regulation of AKT/PKB by the rictor-mTOR complex 审中-公开通过rictor-mTOR复合物的AKT / PKB的磷酸化和调节公开(公告)号：US20100173928A1
公开(公告)日：2010-07-08
申请号：US12218629
申请日：2008-07-15
申请人： David M. Sabatini , Dos D. Sarbassov , Michael Andreeff , Marina Konopleva , Zhihong Zeng , Francis J. Giles
发明人： David M. Sabatini , Dos D. Sarbassov , Michael Andreeff , Marina Konopleva , Zhihong Zeng , Francis J. Giles
IPC分类号： A61K31/436 , C12N5/00 , C12Q1/02 , A61P35/00
CPC分类号： C12Q1/485 , G01N33/5011 , G01N33/573 , G01N33/57426 , G01N2500/02 , G01N2800/52
摘要： In certain aspects, the invention relates to methods for identifying compounds which modulate Akt activity mediated by the rictor-mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activity.
摘要翻译： 在某些方面，本发明涉及用于鉴定调节由rictor-mTOR复合物介导的Akt活性的化合物的方法以及用于治疗或预防与异常Akt活性相关的病症的方法。
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公开(公告)号：US20130137633A1
公开(公告)日：2013-05-30
申请号：US13584607
申请日：2012-08-13
IPC分类号： C07K14/47
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00 , C07K14/4705
摘要： The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.
摘要翻译： 本发明描述了分离的mTOR相关蛋白（“mTOR-AP”）以及其分离的变体和片段以及编码它们的分离的核酸。 本发明还描述了含有编码mTOR-AP多肽的核酸和产生mTOR-AP多肽的方法的载体和宿主细胞。 还描述了筛选调节mTOR-AP活性的化合物的方法和用于治疗或预防对mTOR-AP调节有反应的病症的方法。
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公开(公告)号：US07052870B2
公开(公告)日：2006-05-30
申请号：US10782244
申请日：2004-02-18
IPC分类号： C12P21/06
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00 , C07K14/4705
摘要： The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.
摘要翻译： 本发明描述了分离的mTOR相关蛋白（“mTOR-AP”）以及其分离的变体和片段以及编码它们的分离的核酸。 本发明还描述了含有编码mTOR-AP多肽的核酸和产生mTOR-AP多肽的方法的载体和宿主细胞。 还描述了筛选调节mTOR-AP活性的化合物的方法和用于治疗或预防对mTOR-AP调节有反应的病症的方法。
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公开(公告)号：US08999660B2
公开(公告)日：2015-04-07
申请号：US13584607
申请日：2012-08-13
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00 , C07K14/4705
摘要： The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.
摘要翻译： 本发明描述了分离的mTOR相关蛋白（“mTOR-AP”）以及其分离的变体和片段以及编码它们的分离的核酸。 本发明还描述了含有编码mTOR-AP多肽的核酸和产生mTOR-AP多肽的方法的载体和宿主细胞。 还描述了筛选调节mTOR-AP活性的化合物的方法和用于治疗或预防对mTOR-AP调节有反应的病症的方法。
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公开(公告)号：US08258271B2
公开(公告)日：2012-09-04
申请号：US11436394
申请日：2006-05-17
IPC分类号： C07K14/00
CPC分类号： C07K14/4703 , A01K2217/05 , A61K38/00 , C07K14/4705
摘要： The invention describes isolated mTOR-associated proteins (“mTOR-APs”) as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.
摘要翻译： 本发明描述了分离的mTOR相关蛋白（“mTOR-AP”）以及其分离的变体和片段以及编码它们的分离的核酸。 本发明还描述了含有编码mTOR-AP多肽的核酸和产生mTOR-AP多肽的方法的载体和宿主细胞。 还描述了筛选调节mTOR-AP活性的化合物的方法和用于治疗或预防对mTOR-AP调节有反应的病症的方法。
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6.发明授权Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex 有权由rictor-mTOR复合物对Akt / PKB进行磷酸化和调节公开(公告)号：US07906308B2
公开(公告)日：2011-03-15
申请号：US11341908
申请日：2006-01-27
CPC分类号： C12N9/1205 , A61K38/00 , C12Q1/485 , G01N33/573 , G01N33/574 , G01N2500/02
摘要： In certain aspects, the invention relates to methods for identifying compounds which modulate Akt activity mediated by the rictor-mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activity.
摘要翻译： 在某些方面，本发明涉及用于鉴定调节由rictor-mTOR复合物介导的Akt活性的化合物的方法以及用于治疗或预防与异常Akt活性相关的病症的方法。
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