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公开(公告)号：US4769322A
公开(公告)日：1988-09-06
申请号：US929564
申请日：1986-11-12
申请人： David P. Henry , Kenneth M. Verburg
发明人： David P. Henry , Kenneth M. Verburg
CPC分类号： C12N9/1007 , C12Q1/48 , Y10S435/815
摘要： A new procedure for isolating histamine N-methyltransferase in pure form has permitted the development of a new and highly sensitive radioenzymatic assay for histamine.
摘要翻译： 以纯形式分离组胺N-甲基转移酶的新方法允许开发用于组胺的新的和高度敏感的放射性酶测定。
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2.发明授权Method for the treatment of cardiac arrhythmias and shortening of action potential duration 失效治疗心律失常的方法和动作电位持续时间的缩短
公开(公告)号：US5840762A
公开(公告)日：1998-11-24
申请号：US585872
申请日：1996-01-12
IPC分类号： A61K31/165 , A61K31/16
CPC分类号： A61K31/165
摘要： The invention relates to the use of zucapsaicin (cis-8-methly-N-vanillly-6-nonenamide), the cis-isomer of capsaicin, to treat myocardial disorders, including the prevention, suppression or reversal of an abnormal cardiac rhythm, such as ventricular tachycardia. In vitro, zucapsaicin exhibits electrophysiologic properties distinct from capsaicin. In contrast to capsaicin, zucapsaicin significantly shortens the action potential duration at a dose of 10.sup.-5 M and has no effect on the amplitude of Phase 1 of the action potential in normal Purkinje cells. Zucapsaicin also prevents the induction of ventricular tachycardia of focal Purkinje origin when given intravenously after coronary occlusion in a dog model of acute myocardial infarction.
摘要翻译： 本发明涉及痤疮黄疸（顺式8-甲基-N-香精-6-壬烯酰胺）（辣椒素的顺式异构体）用于治疗心肌疾病的用途，包括预防，抑制或逆转异常心律，例如 作为室性心动过速。 在体外，zucapsaicin表现出与辣椒素不同的电生理学性质。 与辣椒素相反，zucapsaicin以10-5M的剂量显着缩短动作电位持续时间，并且对正常浦肯野细胞中动作电位的阶段1的幅度没有影响。 当在急性心肌梗塞的狗模型中，冠状动脉闭塞后静脉注射时，Zucapsaicin还可防止引发局部Purkinje起源的室性心动过速。
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