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    Processes for the Preparation of Morphinane and Morphinone Compounds
    1.
    发明申请
    Processes for the Preparation of Morphinane and Morphinone Compounds 有权
    吗啡和吗啡酮化合物的制备方法

    公开(公告)号：US20120046465A1

    公开(公告)日：2012-02-23

    申请号：US13264182

    申请日：2010-04-22

    Applicant: Tomas Hudlicky ,  Robert Carroll ,  Hannes Leisch ,  Ales Machara ,  Lukas Werner ,  David R. Adams

    Inventor： Tomas Hudlicky ,  Robert Carroll ,  Hannes Leisch ,  Ales Machara ,  Lukas Werner ,  David R. Adams

    IPC: C07D489/12 ,  C07D489/02 ,  C07D489/04

    CPC classification number: C07D489/02 ,  C07D489/04

    Abstract: The present application describes processes for the synthesis of morphinane and morphinone compounds, useful as pharmaceutical agents. Also included are novel intermediates useful in the preparation of these compounds. The process comprises quaternization of oripavine to provide a mixture of the R- and S-isomeric (at the nitrogen) quaternary salts. The R-isomer is readily isolated and converted to various N-(R)-morphinane and N-(S)-morphinone compounds. The R-isomer, S-isomer or a mixture of R- and S-isomers may be demethylated and converted to various morphinane and morphinone compounds.

    Abstract translation: 本申请描述了可用作药剂的吗啡烷和吗啡酮化合物的合成方法。 还包括可用于制备这些化合物的新型中间体。 该方法包括二磷酸的季铵化以提供R-和S-异构体（在氮）季盐的混合物。 R-异构体容易分离并转化成各种N-（R） - 吗啡烷和N-（S） - 吗啡酮化合物。 R-异构体，S-异构体或R-和S-异构体的混合物可以去甲基化并转化成各种吗啡烷和吗啡酮化合物。

    RUNOFF COLLECTION SYSTEM WITH FIRST FLUSH CONTROL AND PRETREATMENT
    2.
    发明申请
    RUNOFF COLLECTION SYSTEM WITH FIRST FLUSH CONTROL AND PRETREATMENT 审中-公开
    RUNOFF采集系统与第一次FLUSH控制和预处理

    公开(公告)号：US20120305492A1

    公开(公告)日：2012-12-06

    申请号：US13325692

    申请日：2011-12-14

    Applicant: Gregory W. Byrne, JR. ,  Gregory T. Kowalsky ,  Michael B. Brooks ,  David R. Adams ,  John H. Pedrick ,  Daniel W. Aberle

    Inventor： Gregory W. Byrne, JR. ,  Gregory T. Kowalsky ,  Michael B. Brooks ,  David R. Adams ,  John H. Pedrick ,  Daniel W. Aberle

    IPC: F16L41/00 ,  C02F1/00

    CPC classification number: E03B1/04 ,  E03B1/042 ,  E03B2001/047 ,  Y02A20/108 ,  Y10T137/85938

    Abstract: A rainwater collection system is described which includes generally a rainwater routing system and a collection unit. The rainwater routing system may comprise a first flush diversion unit designed to discharge to a run-off path, an initial amount of rainwater such that initial particulate matter from rooftops, etc., are not collected. The rainwater routing system may comprise a pre-treatment unit, the pre-treatment unit designed to remove particulate matter from the rainwater. The collection unit of the rainwater collection system comprises a storage tank having an internal day tank compartment. The described rainwater collection system allows for the collection of rainwater with a substantially reduced amount of particulate matter.

    Abstract translation: 描述了一种雨水收集系统，其通常包括雨水路线系统和收集单元。 雨水路线系统可以包括设计成排放到径流路径的初始量的雨水，使得不收集来自屋顶等的初始颗粒物质的第一冲洗分流单元。 雨水路线系统可以包括预处理单元，预处理单元被设计成从雨水中去除颗粒物质。 雨水收集系统的收集单元包括具有内部日间罐室的储罐。 所描述的雨水收集系统允许收集大量减少的颗粒物质的雨水。

    STORMWATER CHAMBER DETENTION SYSTEM
    3.
    发明申请
    STORMWATER CHAMBER DETENTION SYSTEM 有权
    STORMWATER CHAMBER检测系统

    公开(公告)号：US20100059430A1

    公开(公告)日：2010-03-11

    申请号：US12556728

    申请日：2009-09-10

    Applicant: David R. Adams ,  Daniel W. Aberle ,  Daniel P. Cobb ,  Gregory W. Byrne

    Inventor： David R. Adams ,  Daniel W. Aberle ,  Daniel P. Cobb ,  Gregory W. Byrne

    IPC: C02F1/00

    CPC classification number: E03F1/002

    Abstract: A stormwater detention system includes a containment row for removing and collecting solids from stormwater. The containment row may be surrounded by a water-impermeable membrane, and designed to receive incoming water before other rows of the detention system. The containment row collects solids from the stormwater before the water is redirected into one or more additional rows, which are water permeable and buried in water permeable media. Filter structure may be associated with a flow system that delivers water from the containment row to the additional rows.

    Abstract translation: 雨水滞留系统包括一个用于从暴雨水中清除和收集固体物质的容器排。 容纳排可以被不透水的膜包围，并被设计成在其他行的拘留系统之前接收进入的水。 在水被重定向到一个或多个额外的一排，这些水是可透水的并且被埋在水可渗透的介质中之前，容纳排从雨水中收集固体。 过滤器结构可以与将水从容纳排输送到附加行的流系统相关联。

    Using urazole analogs of prostaglandins for bronchodilation
    4.
    发明授权
    Using urazole analogs of prostaglandins for bronchodilation 失效
    使用前列腺素的唑类似物进行支气管扩张

    公开(公告)号：US4460595A

    公开(公告)日：1984-07-17

    申请号：US371128

    申请日：1982-04-23

    Applicant: David R. Adams ,  Alexander C. Goudie

    Inventor： David R. Adams ,  Alexander C. Goudie

    IPC: A61K31/41 ,  C07C57/03 ,  C07D249/12

    CPC classification number: C07D249/12 ,  C07C309/00 ,  C07C57/03

    Abstract: Compounds of the formula (I) ##STR1## wherein; n is 1 to 5Y is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--;R.sub.1 is hydrogen or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1-12 carbon atoms;R.sub.2 is hydrogen, C.sub.1-4 alkyl, or phenyl;R.sub.3 is hydroxy or protected hydroxy;R.sub.4 is hydrogen, C.sub.1-9 alkyl, C.sub.3-8 cycloalkyl, C.sub.3-8 cycloalkyl-C.sub.1-6 alkyl, phenyl, phenyl -C.sub.1-6 alkyl, naphthyl, naphthyl C.sub.1-6 alkyl, any of which phenyl moieties or naphthyl moieties may be substituted by one or more halogen trifluoromethyl, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkoxy, phenyl C.sub.1-6 alkoxy or nitro groups;R.sub.5 is hydrogen, C.sub.1-6 alkyl, C.sub.5-8 cycloalkyl, phenyl, phenyl-C.sub.1-6 alkyl or phenyl C.sub.3-6 cycloalkyl, any of which phenyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or nitro groups; orR.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; and salts thereof are useful for their prostaglandin-like activity.

    Abstract translation: 式（I）化合物其中： n为1至5，Y为-CH 2 -CH 2或-CH = CH-; R 1是氢或CO 2 R 1表示其中R 1部分含有1-12个碳原子的酯基; R2是氢，C1-4烷基或苯基; R3是羟基或被保护的羟基; R4是氢，C1-9烷基，C3-8环烷基，C3-8环烷基-C 1-6烷基，苯基，苯基-C 1-6烷基，萘基，萘基C 1-6烷基，任何苯基部分或萘基部​​分可以 被一个或多个卤素三氟甲基，C 1-6烷基，羟基，C 1-6烷氧基，苯基C 1-6烷氧基或硝基取代; R 5是氢，C 1-6烷基，C 5-8环烷基，苯基，苯基-C 1-6烷基或苯基C 3-6环烷基，其中任何一个苯基部分可以被一个或多个卤素，三氟甲基，C 1-6烷基， C 1-6烷氧基或硝基; 或与其连接的碳原子取代的R 2和R 4表示C 5-8环烷基; 及其盐可用于其前列腺素样活性。

    Processes for the preparation of morphinane and morphinone compounds
    5.
    发明授权
    Processes for the preparation of morphinane and morphinone compounds 有权
    吗啡和吗啡酮化合物的制备方法

    公开(公告)号：US08853401B2

    公开(公告)日：2014-10-07

    申请号：US13264182

    申请日：2010-04-22

    Applicant: Tomas Hudlicky ,  Robert Carroll ,  Hannes Leisch ,  Ales Machara ,  Lukas Werner ,  David R. Adams

    Inventor： Tomas Hudlicky ,  Robert Carroll ,  Hannes Leisch ,  Ales Machara ,  Lukas Werner ,  David R. Adams

    IPC: C07D489/02 ,  C07D489/12

    CPC classification number: C07D489/02 ,  C07D489/04

    Abstract: The present application describes processes for the synthesis of morphinane and morphinone compounds, useful as pharmaceutical agents. Also included are novel intermediates useful in the preparation of these compounds. The process comprises quaternization of oripavine to provide a mixture of the R- and S-isomeric (at the nitrogen) quaternary salts. The R-isomer is readily isolated and converted to various N-(R)-morphinane and N-(S)-morphinone compounds. The R-isomer, S-isomer or a mixture of R- and S-isomers may be demethylated and converted to various morphinane and morphinone compounds.

    Abstract translation: 本申请描述了可用作药剂的吗啡烷和吗啡酮化合物的合成方法。 还包括可用于制备这些化合物的新型中间体。 该方法包括二磷酸的季铵化以提供R-和S-异构体（在氮）季盐的混合物。 R-异构体容易分离并转化成各种N-（R） - 吗啡烷和N-（S） - 吗啡酮化合物。 R-异构体，S-异构体或R-和S-异构体的混合物可以去甲基化并转化成各种吗啡烷和吗啡酮化合物。

    Carrying case for personal items
    6.
    发明授权
    Carrying case for personal items 失效
    个人物品手提箱

    公开(公告)号：US5020673A

    公开(公告)日：1991-06-04

    申请号：US495737

    申请日：1990-03-15

    Applicant: David R. Adams

    Inventor： David R. Adams

    IPC: A45C3/00 ,  A45C3/02 ,  A45C7/00 ,  A45C11/24

    CPC classification number: A45C3/02 ,  A45C11/24 ,  A45C3/00 ,  A45C7/0095 ,  A45C2011/007

    Abstract: A carrying case for carrying personal items includes three hinged, generally planar, semi-rigid panel members having a plurality of pockets thereon to receive and hold items to be carried. The members may be folded to a folded or closed condition wherein the members overlap one another in side-by-side configuration to form a relatively compact case during transportation and storage or the members may be unfolded to an open condition to allow access to the members and to support the members in an upright position. In the open, upright position, the invention serves as a conveniently accessed dispenser for its contents. In the closed position, the invention conforms in general shape to its contents, thus taking up less space than a rigid case when not full, yet offering protection to the contents. The pockets of the case can include transparent windows so that a user can see what is in a pocket without having to open the pocket and remove the contents.

    Abstract translation: 用于携带个人物品的手提箱包括三个铰接的，大致平面的半刚性面板构件，其中具有多个口袋，用于接收和保持要携带的物品。 构件可以折叠成折叠或关闭状态，其中构件在并排配置下彼此重叠以在运输和储存期间形成相对紧凑的壳体，或者构件可以展开到打开状态以允许接近构件 并支持成员处于直立状态。 在开放，直立的位置，本发明用作其内容物的方便访问的分配器。 在关闭位置，本发明总体上符合其内容，因此占用较少的空间比刚性的情况下不满，但提供保护的内容。 盒子的口袋可以包括透明窗口，使得用户可以看到口袋里的是什么，而不必打开口袋并移除内容物。

    Stormwater chamber detention system
    8.
    发明授权
    Stormwater chamber detention system 有权
    雨水室拘留制度

    公开(公告)号：US08147688B2

    公开(公告)日：2012-04-03

    申请号：US12556728

    申请日：2009-09-10

    Applicant: David R. Adams ,  Daniel W. Aberle ,  Daniel P. Cobb ,  Gregory W. Byrne

    Inventor： David R. Adams ,  Daniel W. Aberle ,  Daniel P. Cobb ,  Gregory W. Byrne

    IPC: E03F1/00

    CPC classification number: E03F1/002

    Abstract: A stormwater detention system includes a containment row for removing and collecting solids from stormwater. The containment row may be surrounded by a water-impermeable membrane, and designed to receive incoming water before other rows of the detention system. The containment row collects solids from the stormwater before the water is redirected into one or more additional rows, which are water permeable and buried in water permeable media. Filter structure may be associated with a flow system that delivers water from the containment row to the additional rows.

    Abstract translation: 雨水滞留系统包括一个用于从暴雨水中清除和收集固体物质的容器排。 容纳排可以被不透水的膜包围，并被设计成在其他行的拘留系统之前接收进入的水。 在水被重定向到一个或多个额外的一排，这些水是可透水的并且被埋在水可渗透的介质中之前，容纳排从雨水中收集固体。 过滤器结构可以与将水从容纳排输送到附加行的流系统相关联。

    Combination suitcase-garment bag
    10.
    发明授权
    Combination suitcase-garment bag 失效
    组合手提包 - 服装包

    公开(公告)号：US4817791A

    公开(公告)日：1989-04-04

    申请号：US127254

    申请日：1987-12-01

    Applicant: David R. Adams

    Inventor： David R. Adams

    IPC: A45C3/00 ,  A47G25/54 ,  B65D85/18

    CPC classification number: A45C3/004 ,  A47G25/54

    Abstract: A foldable, suitcase-garment bag has flexible, elongate, substantially rectangular front and rear panels secured together to form an interior, garment bag like space between the panels. The bag is adapted to be folded into three overlapping sections and secured in such folded condition wherein the bag is configured similarly to a suitcase. Bottom means are provided to act as a bottom for the bag when in folded condition and a plurality of pockets are provided in at least the front panel of the bag, separate pockets being located in separate sections of the bag when folded. The pockets located in one section of the bag are adapted to expand inwardly into the interior space of the bag when filled while the pockets located in another section of the bag are adapted to expand outwardly when filled, thereby facilitating the folding of the bag into overlapping sections.

    Abstract translation: 可折叠的手提箱服装袋具有固定在一起的柔性，细长的，基本矩形的前后面板，以在面板之间形成类似空间的内部衣服袋。 该袋适于折叠成三个重叠的部分并且在这种折叠状态下被固定，其中袋被类似于手提箱的构造。 提供底部装置以在处于折叠状态时用作袋的底部，并且在袋的至少前面板中设置多个袋，当折叠时分离的袋位于袋的分开的部分中。 位于袋的一个部分中的口袋适于在填充时向内扩展到袋的内部空间中，同时位于袋的另一部分中的袋适于在填充时向外膨胀，从而有助于将袋折叠成重叠 部分。

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