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公开(公告)号：US5110808A
公开(公告)日：1992-05-05
申请号：US738436
申请日：1991-07-31
申请人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
发明人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
IPC分类号： A61K31/255 , A61P3/08 , A61P3/10 , A61P43/00 , C07C317/40 , C07C317/42 , C07D295/14 , C07D295/185
CPC分类号： C07D295/185 , C07C317/40 , C07C317/42
摘要： The invention concerns novel (oxamido- and ureido-phenylsulfonyl)nitromethane derivatives and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.
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公开(公告)号：US5189031A
公开(公告)日：1993-02-23
申请号：US831434
申请日：1992-01-05
申请人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
发明人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
IPC分类号： A61K31/255 , A61P3/08 , A61P3/10 , A61P43/00 , C07C317/40 , C07C317/42 , C07D295/14 , C07D295/185
CPC分类号： C07D295/185 , C07C317/40 , C07C317/42
摘要： The invention concerns novel (oxamido- and ureido-phenylsulfonyl)nitromethane derivatives and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.
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公开(公告)号：US5430060A
公开(公告)日：1995-07-04
申请号：US120760
申请日：1993-09-15
申请人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
发明人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
IPC分类号： A61K31/255 , A61K31/00 , A61K31/04 , A61K31/10 , A61K31/16 , A61P3/00 , A61P3/08 , A61P3/10 , A61P5/00 , A61P25/02 , A61P27/00 , A61P43/00 , C07C313/04 , C07C315/00 , C07C315/02 , C07C317/14 , C07C317/40 , C07C323/41 , A61K31/165 , C07C233/57
CPC分类号： C07C317/40 , C07C313/04 , C07C323/41 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2102/06 , C07C2102/08 , Y10S514/866
摘要： The invention concerns novel N-phenylacetyl and related acyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.
摘要翻译： 本发明涉及（4-氨基-2,6-二甲基苯磺酰基）硝基甲烷的新型N-苯基乙酰基和相关酰基衍生物及其药学上可接受的盐，其是酶醛糖还原酶的抑制剂，并且具有例如某些 糖尿病和半乳糖血症的外周作用。 还公开了含有制备和使用衍生物的衍生物和方法之一的药物组合物。
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公开(公告)号：US5250570A
公开(公告)日：1993-10-05
申请号：US999690
申请日：1992-12-31
申请人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
发明人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
IPC分类号： C07C313/04 , C07C317/40 , C07C323/41 , C07C323/60 , A61K31/165
CPC分类号： C07C317/40 , C07C313/04 , C07C323/41 , C07C323/60 , Y10S514/866
摘要： The invention concerns novel phenoxy- and phenylthio-acetyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.
摘要翻译： 本发明涉及（4-氨基-2,6-二甲基苯基磺酰基）硝基甲烷的新型苯氧基 - 和苯硫基 - 乙酰基衍生物及其药学上可接受的盐，其是酶醛糖还原酶的抑制剂，并且具有例如某些 糖尿病和半乳糖血症的外周作用。 还公开了含有制备和使用衍生物的衍生物和方法之一的药物组合物。
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公开(公告)号：US5270342A
公开(公告)日：1993-12-14
申请号：US738437
申请日：1991-07-31
申请人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Salter
发明人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Salter
IPC分类号： A61K31/255 , A61K31/00 , A61K31/04 , A61K31/10 , A61K31/16 , A61P3/00 , A61P3/08 , A61P3/10 , A61P5/00 , A61P25/02 , A61P27/00 , A61P43/00 , C07C313/04 , C07C315/00 , C07C315/02 , C07C317/14 , C07C317/40 , C07C323/41 , A61K31/165 , C07C233/05
CPC分类号： C07C317/40 , C07C313/04 , C07C323/41 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2102/06 , C07C2102/08 , Y10S514/866
摘要： The invention concerns novel N-phenylacetyl and related acyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.
摘要翻译： 本发明涉及（4-氨基-2,6-二甲基苯磺酰基）硝基甲烷的新型N-苯基乙酰基和相关酰基衍生物及其药学上可接受的盐，其是酶醛糖还原酶的抑制剂，并且具有例如某些 糖尿病和半乳糖血症的外周作用。 还公开了含有制备和使用衍生物的衍生物和方法之一的药物组合物。
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公开(公告)号：US5153227A
公开(公告)日：1992-10-06
申请号：US306676
申请日：1989-02-06
IPC分类号： C12N9/99 , A61K31/10 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/275 , A61K31/335 , A61K31/357 , A61K31/36 , A61P3/08 , A61P3/10 , A61P43/00 , C07C67/00 , C07C313/00 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/36 , C07C317/44 , C07C323/09 , C07C323/18 , C07C323/22 , C07C323/31 , C07C323/62 , C07D317/22 , C07D317/60 , C07D317/62
CPC分类号： C07D317/60 , A61K31/10 , C07C317/00 , C07C323/00
摘要： The invention concerns novel pharmaceutical compositions for use in the treatment of certain complications of diabetes and galactosemia and which contain a nitromethane derivative (or its non-toxic salt) as active ingredient. The nitromethane derivatives are inhibitors of the enzyme aldose reductase. Many of the inhibitors are novel and are provided, together with processes for their manufacture and use, as further features of the invention.
摘要翻译： 本发明涉及用于治疗糖尿病和半乳糖血症某些并发症的新型药物组合物，其含有硝基甲烷衍生物（或其无毒盐）作为活性成分。 硝基甲烷衍生物是醛糖还原酶的抑制剂。 许多抑制剂是新颖的，并且与其制备和使用的方法一起提供，作为本发明的进一步特征。
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公开(公告)号：US5456573A
公开(公告)日：1995-10-10
申请号：US113919
申请日：1993-08-31
申请人： Jeffrey J. Morris , Robert M. Swec , Leslie P. Lazzeri , Robert S. Frantz , August A. Zachmeier , Horace W. Weeks
发明人： Jeffrey J. Morris , Robert M. Swec , Leslie P. Lazzeri , Robert S. Frantz , August A. Zachmeier , Horace W. Weeks
摘要： An improved stacker for an automatic document sorter is described. The stacker is vertical and receives documents at the top thereof and expels them at the bottom. The stacker includes a paddle normally disposed at the top for receiving the first document and subsequent documents stacked thereon. As documents enter the stacker, the paddle drops due to the action of a timing belt and sensor arrangement until it reaches the bottom. At the bottom, a horizontally directed timing belt withdraws the paddle from the stacker and the paddle is then returned by reverse action to the top of the stacker and reinserted thereinto for receiving the next stack of documents. Both timing belts are independently driven by motors.
摘要翻译： 描述了用于自动文件分类器的改进的堆垛机。 堆垛机是垂直的，并在顶部接收文件并将其排出底部。 堆垛机包括通常设置在顶部的用于接收第一文件和堆叠在其上的随后文件的桨叶。 当文件进入堆垛机时，桨叶由于同步带和传感器装置的作用而下降，直到其到达底部。 在底部，水平定向的定时带从堆垛机中取出桨叶，然后通过反向作用将桨板返回到堆垛机的顶部并重新插入其中以接收下一堆文件。 两个同步皮带由电机独立驱动。
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