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公开(公告)号：US5270342A
公开(公告)日：1993-12-14
申请号：US738437
申请日：1991-07-31
申请人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Salter
发明人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Salter
IPC分类号： A61K31/255 , A61K31/00 , A61K31/04 , A61K31/10 , A61K31/16 , A61P3/00 , A61P3/08 , A61P3/10 , A61P5/00 , A61P25/02 , A61P27/00 , A61P43/00 , C07C313/04 , C07C315/00 , C07C315/02 , C07C317/14 , C07C317/40 , C07C323/41 , A61K31/165 , C07C233/05
CPC分类号： C07C317/40 , C07C313/04 , C07C323/41 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2102/06 , C07C2102/08 , Y10S514/866
摘要： The invention concerns novel N-phenylacetyl and related acyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.
摘要翻译： 本发明涉及（4-氨基-2,6-二甲基苯磺酰基）硝基甲烷的新型N-苯基乙酰基和相关酰基衍生物及其药学上可接受的盐，其是酶醛糖还原酶的抑制剂，并且具有例如某些 糖尿病和半乳糖血症的外周作用。 还公开了含有制备和使用衍生物的衍生物和方法之一的药物组合物。
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公开(公告)号：US5110808A
公开(公告)日：1992-05-05
申请号：US738436
申请日：1991-07-31
申请人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
发明人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
IPC分类号： A61K31/255 , A61P3/08 , A61P3/10 , A61P43/00 , C07C317/40 , C07C317/42 , C07D295/14 , C07D295/185
CPC分类号： C07D295/185 , C07C317/40 , C07C317/42
摘要： The invention concerns novel (oxamido- and ureido-phenylsulfonyl)nitromethane derivatives and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.
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公开(公告)号：US5189031A
公开(公告)日：1993-02-23
申请号：US831434
申请日：1992-01-05
申请人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
发明人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
IPC分类号： A61K31/255 , A61P3/08 , A61P3/10 , A61P43/00 , C07C317/40 , C07C317/42 , C07D295/14 , C07D295/185
CPC分类号： C07D295/185 , C07C317/40 , C07C317/42
摘要： The invention concerns novel (oxamido- and ureido-phenylsulfonyl)nitromethane derivatives and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.
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公开(公告)号：US5430060A
公开(公告)日：1995-07-04
申请号：US120760
申请日：1993-09-15
申请人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
发明人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
IPC分类号： A61K31/255 , A61K31/00 , A61K31/04 , A61K31/10 , A61K31/16 , A61P3/00 , A61P3/08 , A61P3/10 , A61P5/00 , A61P25/02 , A61P27/00 , A61P43/00 , C07C313/04 , C07C315/00 , C07C315/02 , C07C317/14 , C07C317/40 , C07C323/41 , A61K31/165 , C07C233/57
CPC分类号： C07C317/40 , C07C313/04 , C07C323/41 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2102/06 , C07C2102/08 , Y10S514/866
摘要： The invention concerns novel N-phenylacetyl and related acyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.
摘要翻译： 本发明涉及（4-氨基-2,6-二甲基苯磺酰基）硝基甲烷的新型N-苯基乙酰基和相关酰基衍生物及其药学上可接受的盐，其是酶醛糖还原酶的抑制剂，并且具有例如某些 糖尿病和半乳糖血症的外周作用。 还公开了含有制备和使用衍生物的衍生物和方法之一的药物组合物。
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公开(公告)号：US5250570A
公开(公告)日：1993-10-05
申请号：US999690
申请日：1992-12-31
申请人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
发明人： David R. Brittain , Steven P. Brown , Anthony L. Cooper , Jethro L. Longridge , Jeffrey J. Morris , John Preston , Linda Slater
IPC分类号： C07C313/04 , C07C317/40 , C07C323/41 , C07C323/60 , A61K31/165
CPC分类号： C07C317/40 , C07C313/04 , C07C323/41 , C07C323/60 , Y10S514/866
摘要： The invention concerns novel phenoxy- and phenylthio-acetyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.
摘要翻译： 本发明涉及（4-氨基-2,6-二甲基苯基磺酰基）硝基甲烷的新型苯氧基 - 和苯硫基 - 乙酰基衍生物及其药学上可接受的盐，其是酶醛糖还原酶的抑制剂，并且具有例如某些 糖尿病和半乳糖血症的外周作用。 还公开了含有制备和使用衍生物的衍生物和方法之一的药物组合物。
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公开(公告)号：US5153227A
公开(公告)日：1992-10-06
申请号：US306676
申请日：1989-02-06
IPC分类号： C12N9/99 , A61K31/10 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/275 , A61K31/335 , A61K31/357 , A61K31/36 , A61P3/08 , A61P3/10 , A61P43/00 , C07C67/00 , C07C313/00 , C07C317/14 , C07C317/22 , C07C317/24 , C07C317/32 , C07C317/36 , C07C317/44 , C07C323/09 , C07C323/18 , C07C323/22 , C07C323/31 , C07C323/62 , C07D317/22 , C07D317/60 , C07D317/62
CPC分类号： C07D317/60 , A61K31/10 , C07C317/00 , C07C323/00
摘要： The invention concerns novel pharmaceutical compositions for use in the treatment of certain complications of diabetes and galactosemia and which contain a nitromethane derivative (or its non-toxic salt) as active ingredient. The nitromethane derivatives are inhibitors of the enzyme aldose reductase. Many of the inhibitors are novel and are provided, together with processes for their manufacture and use, as further features of the invention.
摘要翻译： 本发明涉及用于治疗糖尿病和半乳糖血症某些并发症的新型药物组合物，其含有硝基甲烷衍生物（或其无毒盐）作为活性成分。 硝基甲烷衍生物是醛糖还原酶的抑制剂。 许多抑制剂是新颖的，并且与其制备和使用的方法一起提供，作为本发明的进一步特征。
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7.发明授权Thienyl benzothienyl and dibenzothienyl compounds as inhibitors of aldose reductase 失效作为降解酶抑制剂的苯乙烯苯并噻吩和二苯并噻吩化合物
公开(公告)号：US5102905A
公开(公告)日：1992-04-07
申请号：US344804
申请日：1989-04-28
IPC分类号： A61K31/34 , A61K31/341 , A61K31/343 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/403 , A61K31/404 , A61P3/08 , A61P3/10 , A61P43/00 , C07D207/36 , C07D209/30 , C07D307/64 , C07D307/82 , C07D307/91 , C07D333/34 , C07D333/62 , C07D333/76 , C07D521/00
CPC分类号： C07D307/82 , C07D209/30 , C07D307/64 , C07D307/91 , C07D333/34 , C07D333/62 , C07D333/76
摘要： The invention concerns heterocyclic nitromethane derivatives of the formula 1 as defined hereinafter (and their non-toxic salts) wherein the heterocyclic moiety Q is thienyl, benzothienyl or dibenzothienyl and may bear a wide variety of optional substituents, together with pharmaceutical compositions containing them. The nitromethane derivatives are inhibitors of the enzyme aldose reductase and are of value in the treatment of certain complications of diabetes and galactosemia.
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