Evolving New Molecular Function
    2.
    发明申请
    Evolving New Molecular Function 有权
    进化新分子功能

    公开(公告)号:US20110190141A1

    公开(公告)日:2011-08-04

    申请号:US12834072

    申请日:2010-07-12

    IPC分类号: C40B10/00

    CPC分类号: C12Q1/68 C12N15/1068

    摘要: Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.

    摘要翻译: 自然会通过迭代多样化,选择和扩增进化生物分子,如蛋白质。 自然的力量和有机合成的灵活性结合在核酸模板合成中。 本发明提供用于进行核酸模板合成的多种模板结构,用于增加核酸模板化反应的选择性的方法,用于进行立体选择性核酸模板化反应的方法,选择由核酸 - 模板合成,以及基于核酸模板合成鉴定新化学反应的方法。

    Iterated Branching Reaction Pathways Via Nucleic Acid-Mediated Chemistry
    3.
    发明申请
    Iterated Branching Reaction Pathways Via Nucleic Acid-Mediated Chemistry 有权
    通过核酸介导化学的迭代分支反应途径

    公开(公告)号:US20080318807A1

    公开(公告)日:2008-12-25

    申请号:US11917609

    申请日:2006-06-16

    IPC分类号: C40B40/06 C40B50/00

    CPC分类号: C12N15/1068

    摘要: The present invention provides methods and compositions for performing multi-step nucleic acid mediated synthesis of a highly diverse collection of molecules, for example, small molecules and polymers. In the method, in at least two steps, multiple reaction intermediates and/or products are produced in the same step by different chemical reactions.

    摘要翻译: 本发明提供用于进行多步骤核酸介导的高度多样化分子收集的方法和组合物,例如小分子和聚合物。 在该方法中,在至少两个步骤中,通过不同的化学反应在同一步骤中产生多个反应中间体和/或产物。

    Iterated branching reaction pathways via nucleic acid-mediated chemistry
    4.
    发明授权
    Iterated branching reaction pathways via nucleic acid-mediated chemistry 有权
    通过核酸介导的化学反应进行迭代分支反应途径

    公开(公告)号:US08183178B2

    公开(公告)日:2012-05-22

    申请号:US11917609

    申请日:2006-06-16

    IPC分类号: C40B40/00 C40B50/00

    CPC分类号: C12N15/1068

    摘要: The present invention provides methods and compositions for performing multi-step nucleic acid mediated synthesis of a highly diverse collection of molecules, for example, small molecules and polymers. In the method, in at least two steps, multiple reaction intermediates and/or products are produced in the same step by different chemical reactions.

    摘要翻译: 本发明提供用于进行多步骤核酸介导的高度多样化分子收集的方法和组合物,例如小分子和聚合物。 在该方法中,在至少两个步骤中,通过不同的化学反应在同一步骤中产生多个反应中间体和/或产物。

    Evolving new molecular function
    5.
    发明授权
    Evolving new molecular function 有权
    进化新分子功能

    公开(公告)号:US07491494B2

    公开(公告)日:2009-02-17

    申请号:US10643752

    申请日:2003-08-19

    IPC分类号: C12Q1/68

    CPC分类号: C12Q1/68 C12N15/1068

    摘要: Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.

    摘要翻译: 自然会通过迭代多样化,选择和扩增进化生物分子,如蛋白质。 自然的力量和有机合成的灵活性结合在核酸模板合成中。 本发明提供用于进行核酸模板合成的多种模板结构,用于增加核酸模板化反应的选择性的方法,用于进行立体选择性核酸模板化反应的方法,选择由核酸 - 模板合成,以及基于核酸模板合成鉴定新化学反应的方法。

    Evolving new molecular function
    6.
    发明授权
    Evolving new molecular function 有权
    进化新分子功能

    公开(公告)号:US08206914B2

    公开(公告)日:2012-06-26

    申请号:US12834072

    申请日:2010-07-12

    IPC分类号: C12Q1/68

    CPC分类号: C12Q1/68 C12N15/1068

    摘要: Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.

    摘要翻译: 自然会通过迭代多样化,选择和扩增进化生物分子,如蛋白质。 自然的力量和有机合成的灵活性结合在核酸模板合成中。 本发明提供用于进行核酸模板合成的多种模板结构,用于增加核酸模板化反应的选择性的方法,用于进行立体选择性核酸模板化反应的方法,选择由核酸 - 模板合成,以及基于核酸模板合成鉴定新化学反应的方法。

    Evolving new molecular function
    7.
    发明授权
    Evolving new molecular function 有权
    进化新分子功能

    公开(公告)号:US07771935B2

    公开(公告)日:2010-08-10

    申请号:US10950367

    申请日:2004-09-24

    IPC分类号: C12Q1/68

    CPC分类号: C12Q1/68 C12N15/1068

    摘要: Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.

    摘要翻译: 自然会通过迭代多样化,选择和扩增进化生物分子,如蛋白质。 自然的力量和有机合成的灵活性结合在核酸模板合成中。 本发明提供用于进行核酸模板合成的多种模板结构,用于增加核酸模板化反应的选择性的方法,用于进行立体选择性核酸模板化反应的方法,选择由核酸 - 模板合成,以及基于核酸模板合成鉴定新化学反应的方法。