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公开(公告)号：US4846005A
公开(公告)日：1989-07-11
申请号：US82076
申请日：1987-08-05
申请人： David V. Bacehowski , Arnold C. Bilstad , Patrick N. Huehls , Stephen B. Kaufman , Jeffrey E. Miripol
发明人： David V. Bacehowski , Arnold C. Bilstad , Patrick N. Huehls , Stephen B. Kaufman , Jeffrey E. Miripol
CPC分类号： A61J1/10 , B01L3/0296 , A61J1/12
摘要： A fluid delivery system has a container with an integrally attached sample cell. A selected fluid can be accumulated in the container. The sample cell can be filled with part of the fluid in the container and then isolated from the container by heat or dielectric sealing. The fluid in the sample cell can be brought into contact with selected test reagents. The test reagents can provide a visual indicia of the presence of selected characteristics in the fluid.
摘要翻译： 流体输送系统具有带有整体连接的样品池的容器。 所选择的流体可以积聚在容器中。 样品池可以在容器中填充一部分流体，然后通过加热或电介质密封与容器隔离。 样品池中的流体可以与选定的试剂接触。 测试试剂可以提供在流体中存在所选特征的视觉标记。
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公开(公告)号：US4267269A
公开(公告)日：1981-05-12
申请号：US118695
申请日：1980-02-05
CPC分类号： A01N1/02 , A01N1/0226
摘要： An aqueous red cell storage solution for packed cells which permits removal of essentially all plasma from a unit of blood, followed by reconstitution of the packed cells of the unit in preferably about 80 to 150 ml. of solution for improved cell viability on long term storage. The red cell storage solution contains adenine, glucose or fructose, sodium chloride, and mannitol.
摘要翻译： 用于填充细胞的水性红细胞储存溶液，其允许从血液单位中去除基本上所有的血浆，然后重构该单元的填充细胞，优选约80至150ml。 的解决方案，以改善长期储存时的细胞活力。 红细胞储存溶液含有腺嘌呤，葡萄糖或果糖，氯化钠和甘露醇。
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公开(公告)号：US4866282A
公开(公告)日：1989-09-12
申请号：US156637
申请日：1988-02-17
申请人： Jeffrey E. Miripol , Arnold Bilstad , John Foley , Dean Glash
发明人： Jeffrey E. Miripol , Arnold Bilstad , John Foley , Dean Glash
IPC分类号： A61M1/36
CPC分类号： A61M1/3681 , A61M1/3616
摘要： A thin film of white blood cells is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 15 milliwatts per square cm. At such a radiation intensity it is not necessary to agitate the thin film of white blood cells to accomplish the purposes of this invention. The white blood cells so processed substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation.
摘要翻译： 用紫外线辐射主要为280〜320nm的波长的白细胞的薄膜，优选为4〜15毫瓦每平方厘米的强度。 在这样的辐射强度下，不需要搅动白细胞的薄膜来实现本发明的目的。 如此处理的白细胞基本上丧失了在同种异体免疫的患者中引起免疫反应的能力。 白血细胞可以优选地放置在由聚（乙烯 - 乙酸乙烯酯）塑料制成的平坦柔性袋中的这种膜中，其中平的柔性袋沿着垂直于紫外线辐射的方向被拉伸。
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公开(公告)号：US4704352A
公开(公告)日：1987-11-03
申请号：US748513
申请日：1985-06-25
CPC分类号： A61K35/14 , A01N1/0226 , Y10S436/826 , Y10T436/10 , Y10T436/108331
摘要： A solution for blood cell storage having sugar-containing blood cell nutrients therein and additionally containing a magnesium or calcium L-ascorbate-2-phosphate salt is taught. The magnesium and calcium L-ascorbate-2-phosphate salts remain stable below pH 7 and thus permit sterilization of the solution at a pH at which degradation of both the L-ascorbate-2-phosphate salt and the nutrient sugar present in the solution is substantially avoided.
摘要翻译： 教导了其中含有含糖血细胞营养物并另外含有镁或钙L-抗坏血酸-2-磷酸盐的血液储存溶液。 L-抗坏血酸盐-2-磷酸镁镁盐在pH7以下保持稳定，从而允许溶液在溶液中存在的L-抗坏血酸-2-磷酸盐和营养糖两者的降解为 基本上避免了。
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公开(公告)号：US4952812A
公开(公告)日：1990-08-28
申请号：US346202
申请日：1989-05-02
CPC分类号： A61M1/3681 , A61L2/0011 , A61M1/3616
摘要： A thin film or layer of white blood cells, such as the contaminating white cells in a platelet concentrate, is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 20 milliwatts per square cm. to provide a total energy exposure of typically 800 to 20,000 millijoules per square cm. of ultraviolet radiation. The white blood cells so produced substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation. Novel irradiating devices are also disclosed.
摘要翻译： 用血小板浓缩物中的污染白细胞的薄膜或白细胞层照射紫外线，主要是波长为280至320纳米，优选强度为4至20毫瓦每平方厘米。 以提供通常为800至20,000毫焦耳/平方厘米的总能量暴露。 的紫外线辐射。 如此产生的白血球大大丧失了在同种异体免疫的患者中引发免疫反应的能力。 白血细胞可以优选地放置在由聚（乙烯 - 乙酸乙烯酯）塑料制成的平坦柔性袋中的这种膜中，其中平的柔性袋沿着垂直于紫外线辐射的方向被拉伸。 还公开了新颖的照射装置。
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6.发明授权Blood compatible polymers and medical devices made therefrom containing dioctyladipate plasticizer 失效由血液相容的聚合物和由此制成的医疗器械含有二辛酸二辛酯增塑剂
公开(公告)号：US4286597A
公开(公告)日：1981-09-01
申请号：US142290
申请日：1980-04-21
IPC分类号： A61J1/00 , A61J1/05 , A61J1/10 , A61K35/14 , A61L33/00 , A61M1/36 , A61M5/14 , C08K5/12 , A61M5/00
CPC分类号： A61J1/10 , A61L33/0005 , A61L33/0052 , A61M1/3687 , C08K5/12 , Y10S128/24
摘要： Blood-compatible, chlorine-free polymers such as a flexible, non-toxic, sterilizable polyester plastic formulation may contain from 5 to 70 percent by weight of a blood-extractable plasticizer such as di-2-ethylhexyladipate, to cause blood which is stored in contact with the polymer to exhibit a surprisingly low hemolysis rate when compared with corresponding polymers which are free of the plasticizer. Accordingly, blood bags, tubing and other medical blood-contacting devices may be advantageously made from these polymers.
摘要翻译： 血液相容的无氯聚合物如柔性无毒的可消毒的聚酯塑料制剂可以含有5-70重量％的血液可提取的增塑剂，例如己二酸二-2-乙基己酯，以引起储存的血液 与不含增塑剂的相应聚合物相比，与聚合物接触以显示惊人的低溶血速率。 因此，可以有利地由这些聚合物制造血袋，管道和其它医用血液接触装置。
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公开(公告)号：US5888328A
公开(公告)日：1999-03-30
申请号：US882854
申请日：1997-06-26
CPC分类号： B29C65/2046 , B29C66/5221 , G01N3/00 , B29C65/8207 , G01N2001/005 , G01N2203/0296
摘要： A kit for testing the integrity of sterile tubing welds made by a sterile tubing welding machine employing welding wafers includes a plurality of tubing samples, and a container having a series of receptacles for holding the tubing samples and the wafers used in the sterile tubing welding machine. A set of instructions is provided for making the sterile tubing welds with the tubing samples in the container, and a data sheet is included for recording particulars of the kit and reporting a weld analysis.
摘要翻译： 用于测试由使用焊接晶片的无菌管焊接机制成的无菌管焊接的完整性的试剂盒包括多个管样品和具有一系列容器的容器，用于容纳用于无菌管焊机的管道样品和晶片 。 提供了一套说明书，用于使无菌管道与容器中的管道样品焊接，并包括数据表，用于记录试剂盒的详细信息并报告焊接分析。
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公开(公告)号：US4726949A
公开(公告)日：1988-02-23
申请号：US900217
申请日：1986-08-26
申请人： Jeffrey E. Miripol , Arnold Bilstad , John Foley , Dean Glash
发明人： Jeffrey E. Miripol , Arnold Bilstad , John Foley , Dean Glash
CPC分类号： A61M1/3681 , A61M1/3616
摘要： A thin film of white blood cells is irradiated with ultraviolet radiation predominately of a wavelength of 280 to 320 nanometers, and preferably at an intensity of 4 to 15 milliwatts per square cm. At such a radiation intensity it is not necessary to agitate the thin film of white blood cells to accomplish the purposes of this invention. The white blood cells so processed substantially lose their capability to set off an immune reaction in an alloimmunized patient. The white blood cells may preferably be placed into such film in a flat, flexible bag made of poly(ethylene-vinyl acetate) plastic, with the flat, flexible bag being stretched in a direction normal to the path of ultraviolet radiation.
摘要翻译： 用紫外线辐射主要为280〜320nm的波长的白细胞的薄膜，优选为4〜15毫瓦每平方厘米的强度。 在这样的辐射强度下，不需要搅动白细胞的薄膜来实现本发明的目的。 如此处理的白细胞基本上丧失了在同种异体免疫的患者中引起免疫反应的能力。 白血细胞可以优选地放置在由聚（乙烯 - 乙酸乙烯酯）塑料制成的平坦柔性袋中的这种膜中，其中平的柔性袋沿着垂直于紫外线辐射的方向被拉伸。
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