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![Solid forms of gyrase inhibitor (R)-1-ethyl-3-[5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-YL]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-YL]urea](/abs-image/US/2013/07/09/US08481552B2/abs.jpg.150x150.jpg)
1.发明授权Solid forms of gyrase inhibitor (R)-1-ethyl-3-[5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-YL]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-YL]urea 有权回旋酶抑制剂（R）-1-乙基-3- [5- [2-（1-羟基-1-甲基 - 乙基）嘧啶-5-基] -7-（四氢呋喃-2-基）-1H - 苯并咪唑-2-基]脲公开(公告)号：US08481552B2
公开(公告)日：2013-07-09
申请号：US13349845
申请日：2012-01-13
申请人： Dean Shannon , Brian Luisi , Yusheng Liao , Mariusz Krawiec
发明人： Dean Shannon , Brian Luisi , Yusheng Liao , Mariusz Krawiec
IPC分类号： A01N43/54 , C07D239/42 , C07D471/04
CPC分类号： C07D405/14 , C07D407/04
摘要： The present application is directed to solid forms of compounds of formula (I): and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infection.
摘要翻译： 本申请涉及抑制细菌促旋酶和/或Topo IV的式（I）化合物及其药学上可接受的盐的固体形式，以及包含所述化合物和盐的药物组合物。 这些化合物和盐可用于治疗细菌感染。
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![SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[5-[2-(1-HYDROXY-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA](/abs-image/US/2012/07/19/US20120184741A1/abs.jpg.150x150.jpg)
2.发明申请SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[5-[2-(1-HYDROXY-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA 有权γ-乙基-3- [5- [2-（1-羟基 - 甲基）乙基]嘧啶-5-基] -7-（四氢呋喃-2-基）-1H-苯并咪唑的固体形式 -2-YL]尿素公开(公告)号：US20120184741A1
公开(公告)日：2012-07-19
申请号：US13349845
申请日：2012-01-13
申请人： Dean Shannon , Brian Luisi , Yusheng Liao , Mariusz Krawiec
发明人： Dean Shannon , Brian Luisi , Yusheng Liao , Mariusz Krawiec
IPC分类号： C07D405/14
CPC分类号： C07D405/14 , C07D407/04
摘要： The present application is directed to solid forms of compounds of formula (I): and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infection.
摘要翻译： 本申请涉及抑制细菌促旋酶和/或Topo IV的式（I）化合物及其药学上可接受的盐的固体形式，以及包含所述化合物和盐的药物组合物。 这些化合物和盐可用于治疗细菌感染。
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![Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea](/abs-image/US/2013/07/02/US08476281B2/abs.jpg.150x150.jpg)
3.发明授权Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea 有权回旋酶抑制剂（R）-1-乙基-3- [6-氟-5- [2-（1-羟基-1-甲基 - 乙基）嘧啶-5-基] -7-（四氢呋喃-2-基） 吡啶-2-基] -1H-苯并咪唑-2-基]脲公开(公告)号：US08476281B2
公开(公告)日：2013-07-02
申请号：US13349984
申请日：2012-01-13
IPC分类号： A01N43/54 , C07D239/42 , C07D471/04
CPC分类号： C07D405/14 , A61K31/4184 , A61K31/506
摘要： The present application is directed to solid forms of compounds of formula I: and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infections.
摘要翻译： 本申请涉及固体形式的式I化合物及其药学上可接受的盐，其抑制细菌促旋酶和/或Topo IV以及包含所述化合物和盐的药物组合物。 这些化合物和盐可用于治疗细菌感染。
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![SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[6-FLUORO-5-[2-(1-HYDROXY-1-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA](/abs-image/US/2012/07/19/US20120184564A1/abs.jpg.150x150.jpg)
4.发明申请SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[6-FLUORO-5-[2-(1-HYDROXY-1-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA 有权γ-烯丙基-3- [6-氟-5- [2-（1-羟基-1-甲基 - 乙基）嘧啶-5-基] -7-（四氢呋喃-2-基） YL）-1H-BENZIMIDAZOL-2-YL] UREA公开(公告)号：US20120184564A1
公开(公告)日：2012-07-19
申请号：US13349984
申请日：2012-01-13
IPC分类号： A61K31/506 , A61P31/04 , C07D405/14
CPC分类号： C07D405/14 , A61K31/4184 , A61K31/506
摘要： The present application is directed to solid forms of compounds of formula I: and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infections.
摘要翻译： 本申请涉及固体形式的式I化合物及其药学上可接受的盐，其抑制细菌促旋酶和/或Topo IV以及包含所述化合物和盐的药物组合物。 这些化合物和盐可用于治疗细菌感染。
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![Solid forms of N-(4-(7-Azabicyclo[2.2.1]Heptan-7-yl)-2-Trifluoromethyl)Phenyl)-4-Oxo-5-(Trifluoromethyl)-1,4-Dihydroquinoline-3-Carboxamide](/abs-image/US/2013/03/05/US08389727B2/abs.jpg.150x150.jpg)
5.发明授权Solid forms of N-(4-(7-Azabicyclo[2.2.1]Heptan-7-yl)-2-Trifluoromethyl)Phenyl)-4-Oxo-5-(Trifluoromethyl)-1,4-Dihydroquinoline-3-Carboxamide 有权固体形式的N-（4-（7-氮杂双环[2.2.1]庚烷-7-基）-2-三氟甲基）苯基）-4-氧代-5-（三氟甲基）-1,4-二氢喹啉-3-甲酰胺公开(公告)号：US08389727B2
公开(公告)日：2013-03-05
申请号：US12909789
申请日：2010-10-21
申请人： Beili Zhang , Mariusz Krawiec , Brian Luisi , Ales Medek
发明人： Beili Zhang , Mariusz Krawiec , Brian Luisi , Ales Medek
IPC分类号： C07D215/38
CPC分类号： A61K31/4748 , A61K31/4709 , C07B2200/13 , C07D487/08
摘要： The present invention relates to substantially crystalline and solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide (Form A-HCl, Form B, Form B-HCl, or any combination of these forms), pharmaceutical compositions thereof, and methods of treatment therewith.
摘要翻译： 本发明涉及N-（4-（7-氮杂双环[2.2.1]庚-7-基）-2-（三氟甲基）苯基）-4-氧代-5-（三氟甲基） -1,4-二氢喹啉-3-甲酰胺（A-HCl型，B型，B-HCl型，或这些形式的任何组合），其药物组合物及其处理方法。
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![Solid Forms of N-(4-(7-Azabicyclo[2.2.1]Heptan-7-yl)-2-Trifluoromethyl)Phenyl)-4-Oxo-5-(Trifluoromethyl)-1,4-Dihydroquinoline-3-Carboxamide](/abs-image/US/2011/05/26/US20110123449A1/abs.jpg.150x150.jpg)
6.发明申请Solid Forms of N-(4-(7-Azabicyclo[2.2.1]Heptan-7-yl)-2-Trifluoromethyl)Phenyl)-4-Oxo-5-(Trifluoromethyl)-1,4-Dihydroquinoline-3-Carboxamide 有权固体形式的N-（4-（7-氮杂双环[2.2.1]庚烷-7-基）-2-三氟甲基）苯基）-4-氧代-5-（三氟甲基）-1,4-二氢喹啉-3-甲酰胺公开(公告)号：US20110123449A1
公开(公告)日：2011-05-26
申请号：US12909789
申请日：2010-10-21
申请人： Beili Zhang , Mariusz Krawiec , Brian Luisi , Ales Medek
发明人： Beili Zhang , Mariusz Krawiec , Brian Luisi , Ales Medek
IPC分类号： A61K49/00 , C07D401/14 , A61K31/4709 , A61P11/00 , A61P1/00 , A61P3/00 , A61P19/02 , A61P25/00 , C12Q1/02
CPC分类号： A61K31/4748 , A61K31/4709 , C07B2200/13 , C07D487/08
摘要： The present invention relates to substantially crystalline and solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide (Form A-HCl, Form B, Form B-HCl, or any combination of these forms), pharmaceutical compositions thereof, and methods of treatment therewith.
摘要翻译： 本发明涉及N-（4-（7-氮杂双环[2.2.1]庚-7-基）-2-（三氟甲基）苯基）-4-氧代-5-（三氟甲基） -1,4-二氢喹啉-3-甲酰胺（A-HCl型，B型，B-HCl型，或这些形式的任何组合），其药物组合物及其处理方法。
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![Solid forms of 3-(6-(1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid](/abs-image/US/2014/02/18/US08653103B2/abs.jpg.150x150.jpg)
7.发明授权Solid forms of 3-(6-(1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid 有权固体形式的3-（6-（1-（2,2-二氟苯并[D] [1,3]二氧杂环戊烯-5-基）环丙烷甲酰氨基）-3-甲基吡啶-2-基）苯甲酸公开(公告)号：US08653103B2
公开(公告)日：2014-02-18
申请号：US13467185
申请日：2012-05-09
IPC分类号： A61K31/4709
CPC分类号： C07D405/12 , A61K31/4709 , C07B2200/13
摘要： The present invention relates to a substantially crystalline and free solid state form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Form I), pharmaceutical compositions thereof, and methods of treatment therewith.
摘要翻译： 本发明涉及3-（6-（1-（2,2-二氟苯并[d] [1,3]间二氧杂环戊烯-5-基）环丙烷甲酰氨基）-3-甲基吡啶-2-基的结晶和游离固体形式 - 基）苯甲酸（I型），其药物组合物及其处理方法。
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![SOLID FORMS OF (R)-1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL) CYCLOPROPANECARBOXAMIDE](/abs-image/US/2011/10/13/US20110251253A1/abs.jpg.150x150.jpg)
8.发明申请SOLID FORMS OF (R)-1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL) CYCLOPROPANECARBOXAMIDE 审中-公开（R）-1-（2,2-二氟苯并[D] [1,3]二氧杂环戊烯-5-基）-N-（1-（2,3-二羟基丙基）-6-氟-2-（ 1-羟基-2-甲基丙-2-炔基）-1H-吲哚-5-基）环丙烷甲酰胺公开(公告)号：US20110251253A1
公开(公告)日：2011-10-13
申请号：US13072380
申请日：2011-03-25
申请人： Ali Keshavarz-Shokri , Beili Zhang , Tim Edward Alcacio , Elaine Chungmin Lee , Yuegang Zhang , Mariusz Krawiec
发明人： Ali Keshavarz-Shokri , Beili Zhang , Tim Edward Alcacio , Elaine Chungmin Lee , Yuegang Zhang , Mariusz Krawiec
IPC分类号： A61K31/4045 , A61P11/06 , A61P1/16 , A61P11/00 , A61P29/00 , A61P25/00 , A61P25/28 , A61P27/02 , A61P31/00 , C07D405/12 , A61P3/10
CPC分类号： C07D405/12
摘要： The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.
摘要翻译： 本发明涉及（R）-1-（2,2-二氟苯并[d] [1,3]间二氧杂环戊烯-5-基）-N-（1-（2,3-二羟丙基）-6- （A型）或无定形形式的2-氟-2-（1-羟基-2-甲基丙-2-基）-1H-吲哚-5-基）环丙烷甲酰胺（化合物1）及其药物组合物，以及 治疗。
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![SOLID FORMS OF N-(4-(7-AZABICYCLO[2.2.1]HEPTAN-7-YL)-2-(TRIFLUORORMETHYL)PHENYL)-4-OXO-5-(TRIFLUOROMETHYL)-1,4-DIHYROQUINOLINE-3-CARBOXAMIDE](/abs-image/US/2010/05/27/US20100130547A1/abs.jpg.150x150.jpg)
9.发明申请SOLID FORMS OF N-(4-(7-AZABICYCLO[2.2.1]HEPTAN-7-YL)-2-(TRIFLUORORMETHYL)PHENYL)-4-OXO-5-(TRIFLUOROMETHYL)-1,4-DIHYROQUINOLINE-3-CARBOXAMIDE 有权N-（4-（7-氮杂双环[2.2.1]庚烷-7-基）-2-（三氟甲基）苯基）-4-氧代-5-（三氟甲基）-1,4-二氢喹啉-3-酮的固体形式 碳酰胺公开(公告)号：US20100130547A1
公开(公告)日：2010-05-27
申请号：US12605266
申请日：2009-10-23
IPC分类号： A61K31/4709 , C07D401/12 , A61P7/12 , A61P11/06 , A61P11/08 , A61P25/16 , A61P25/28 , A61P1/16 , C12Q1/02
CPC分类号： C07D487/08 , C07D215/56
摘要： The present invention relates to solid state forms, for example, crystalline forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, pharmaceutical compositions thereof, and methods therewith.
摘要翻译： 本发明涉及固体形式，例如N-（4-（7-氮杂双环[2.2.1]庚-7-基）-2-（三氟甲基）苯基）-4-氧代-5- （三氟甲基）-1,4-二氢喹啉-3-甲酰胺及其药物组合物及其方法。
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![Solid forms of 3-(6-(1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid](/abs-image/US/2013/08/13/US08507687B2/abs.jpg.150x150.jpg)
10.发明授权Solid forms of 3-(6-(1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid 有权固体形式的3-（6-（1-（2,2-二氟苯并[D] [1,3]二氧杂环戊烯-5-基）环丙烷甲酰氨基）-3-甲基吡啶-2-基）苯甲酸公开(公告)号：US08507687B2
公开(公告)日：2013-08-13
申请号：US13082156
申请日：2011-04-07
IPC分类号： A61K31/44 , C07D405/00
CPC分类号： A61K31/443 , A61K31/47 , A61K45/06 , C07D213/75 , C07D405/12 , C07D405/14 , C07D407/12 , Y10T428/2982
摘要： The present invention relates to a substantially a solid form of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1, Solvate Form A and Compound 1, HCl Salt Form A), processes for making such forms, pharmaceutical compositions thereof, and methods of treatment therewith.
摘要翻译： 本发明涉及基本上固体形式的3-（6-（1-（2,2-二氟苯并[d] [1,3]二氧杂环戊烯-5-基）环丙烷甲酰氨基）-3-甲基吡啶-2-基） 苯甲酸（化合物1，溶剂化物形式A和化合物1，盐酸盐形式A），制备这种形式的方法，其药物组合物及其处理方法。
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