-
![Solid forms of gyrase inhibitor (R)-1-ethyl-3-[5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-YL]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-YL]urea](/abs-image/US/2013/07/09/US08481552B2/abs.jpg.150x150.jpg)
1.发明授权Solid forms of gyrase inhibitor (R)-1-ethyl-3-[5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-YL]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-YL]urea 有权回旋酶抑制剂（R）-1-乙基-3- [5- [2-（1-羟基-1-甲基 - 乙基）嘧啶-5-基] -7-（四氢呋喃-2-基）-1H - 苯并咪唑-2-基]脲公开(公告)号：US08481552B2
公开(公告)日：2013-07-09
申请号：US13349845
申请日：2012-01-13
申请人： Dean Shannon , Brian Luisi , Yusheng Liao , Mariusz Krawiec
发明人： Dean Shannon , Brian Luisi , Yusheng Liao , Mariusz Krawiec
IPC分类号： A01N43/54 , C07D239/42 , C07D471/04
CPC分类号： C07D405/14 , C07D407/04
摘要： The present application is directed to solid forms of compounds of formula (I): and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infection.
摘要翻译： 本申请涉及抑制细菌促旋酶和/或Topo IV的式（I）化合物及其药学上可接受的盐的固体形式，以及包含所述化合物和盐的药物组合物。 这些化合物和盐可用于治疗细菌感染。
-
![SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[5-[2-(1-HYDROXY-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA](/abs-image/US/2012/07/19/US20120184741A1/abs.jpg.150x150.jpg)
2.发明申请SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[5-[2-(1-HYDROXY-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA 有权γ-乙基-3- [5- [2-（1-羟基 - 甲基）乙基]嘧啶-5-基] -7-（四氢呋喃-2-基）-1H-苯并咪唑的固体形式 -2-YL]尿素公开(公告)号：US20120184741A1
公开(公告)日：2012-07-19
申请号：US13349845
申请日：2012-01-13
申请人： Dean Shannon , Brian Luisi , Yusheng Liao , Mariusz Krawiec
发明人： Dean Shannon , Brian Luisi , Yusheng Liao , Mariusz Krawiec
IPC分类号： C07D405/14
CPC分类号： C07D405/14 , C07D407/04
摘要： The present application is directed to solid forms of compounds of formula (I): and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infection.
摘要翻译： 本申请涉及抑制细菌促旋酶和/或Topo IV的式（I）化合物及其药学上可接受的盐的固体形式，以及包含所述化合物和盐的药物组合物。 这些化合物和盐可用于治疗细菌感染。
-
![Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea](/abs-image/US/2013/07/02/US08476281B2/abs.jpg.150x150.jpg)
3.发明授权Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea 有权回旋酶抑制剂（R）-1-乙基-3- [6-氟-5- [2-（1-羟基-1-甲基 - 乙基）嘧啶-5-基] -7-（四氢呋喃-2-基） 吡啶-2-基] -1H-苯并咪唑-2-基]脲公开(公告)号：US08476281B2
公开(公告)日：2013-07-02
申请号：US13349984
申请日：2012-01-13
IPC分类号： A01N43/54 , C07D239/42 , C07D471/04
CPC分类号： C07D405/14 , A61K31/4184 , A61K31/506
摘要： The present application is directed to solid forms of compounds of formula I: and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infections.
摘要翻译： 本申请涉及固体形式的式I化合物及其药学上可接受的盐，其抑制细菌促旋酶和/或Topo IV以及包含所述化合物和盐的药物组合物。 这些化合物和盐可用于治疗细菌感染。
-
![SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[6-FLUORO-5-[2-(1-HYDROXY-1-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA](/abs-image/US/2012/07/19/US20120184564A1/abs.jpg.150x150.jpg)
4.发明申请SOLID FORMS OF GYRASE INHIBITOR (R)-1-ETHYL-3-[6-FLUORO-5-[2-(1-HYDROXY-1-METHYL-ETHYL)PYRIMIDIN-5-YL]-7-(TETRAHYDROFURAN-2-YL)-1H-BENZIMIDAZOL-2-YL]UREA 有权γ-烯丙基-3- [6-氟-5- [2-（1-羟基-1-甲基 - 乙基）嘧啶-5-基] -7-（四氢呋喃-2-基） YL）-1H-BENZIMIDAZOL-2-YL] UREA公开(公告)号：US20120184564A1
公开(公告)日：2012-07-19
申请号：US13349984
申请日：2012-01-13
IPC分类号： A61K31/506 , A61P31/04 , C07D405/14
CPC分类号： C07D405/14 , A61K31/4184 , A61K31/506
摘要： The present application is directed to solid forms of compounds of formula I: and pharmaceutically acceptable salts thereof, that inhibit bacterial gyrase and/or Topo IV and pharmaceutical compositions comprising said compounds and salts. These compounds and salts are useful in treating bacterial infections.
摘要翻译： 本申请涉及固体形式的式I化合物及其药学上可接受的盐，其抑制细菌促旋酶和/或Topo IV以及包含所述化合物和盐的药物组合物。 这些化合物和盐可用于治疗细菌感染。
-
公开(公告)号：US20110207774A1
公开(公告)日：2011-08-25
申请号：US13099643
申请日：2011-05-03
申请人： David Lauffer , Pan Li , Dean Shannon , Jianglin Liang
发明人： David Lauffer , Pan Li , Dean Shannon , Jianglin Liang
IPC分类号： A61K31/4709 , A61P35/00
CPC分类号： C07D513/04
摘要： The present invention relates to compound 1, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising Compound 1 and methods of using the compositions in the treatment of proliferative disorders.
摘要翻译： 本发明涉及可用于抑制c-Met蛋白激酶的化合物1。 本发明还提供包含化合物1的药学上可接受的组合物和使用该组合物治疗增殖性疾病的方法。
-
公开(公告)号：US20120184742A1
公开(公告)日：2012-07-19
申请号：US13349884
申请日：2012-01-13
申请人： Dean Shannon , Tiansheng Wang , Simon Giroux
发明人： Dean Shannon , Tiansheng Wang , Simon Giroux
IPC分类号： C07D405/14 , C07D405/10
CPC分类号： C07D405/14 , C07D405/10
摘要： The present application is directed to compounds, intermediates and methods for preparing compounds of formula (I) or a pharmaceutically acceptable salts thereof, wherein R is H or F, and each of R3, R4, and R5 are as defined herein. The compounds of formula (I) and pharmaceutical compositions comprising said compounds and salts inhibit bacterial gyrase and/or Topo IV and are useful in treating bacterial infections.
摘要翻译： 本申请涉及用于制备式（I）化合物或其药学上可接受的盐的化合物，中间体和方法，其中R是H或F，并且R 3，R 4和R 5中的每一个如本文所定义。 式（I）化合物和包含所述化合物和盐的药物组合物抑制细菌促旋酶和/或Topo IV，并且可用于治疗细菌感染。
-
公开(公告)号：US08481524B2
公开(公告)日：2013-07-09
申请号：US12751016
申请日：2010-03-31
申请人： David Lauffer , Pan Li , Nathan Waal , Kira Mcginty , Qing Tang , Steven Ronkin , Luc Farmer , Dean Shannon , Dylan Jacobs
发明人： David Lauffer , Pan Li , Nathan Waal , Kira Mcginty , Qing Tang , Steven Ronkin , Luc Farmer , Dean Shannon , Dylan Jacobs
IPC分类号： C07D417/14
CPC分类号： C07D401/14 , C07D409/14 , C07D417/14
摘要： The present invention relates to compounds of formula I useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative disorders.
-
公开(公告)号：US08471014B2
公开(公告)日：2013-06-25
申请号：US13349884
申请日：2012-01-13
申请人： Dean Shannon , Tiansheng Wang , Simon Giroux
发明人： Dean Shannon , Tiansheng Wang , Simon Giroux
IPC分类号： C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07C413/00
CPC分类号： C07D405/14 , C07D405/10
摘要： The present application is directed to compounds, intermediates and methods for preparing compounds of formula (I) or a pharmaceutically acceptable salts thereof, wherein R is H or F, and each of R3, R4, and R5 are as defined herein. The compounds of formula (I) and pharmaceutical compositions comprising said compounds and salts inhibit bacterial gyrase and/or Topo IV and are useful in treating bacterial infections.
摘要翻译： 本申请涉及用于制备式（I）化合物或其药学上可接受的盐的化合物，中间体和方法，其中R是H或F，并且R 3，R 4和R 5中的每一个如本文所定义。 式（I）化合物和包含所述化合物和盐的药物组合物抑制细菌促旋酶和/或Topo IV，并且可用于治疗细菌感染。
-
公开(公告)号：US08217056B2
公开(公告)日：2012-07-10
申请号：US12620845
申请日：2009-11-18
申请人： David Lauffer , Pan Li , Dean Shannon , Jianglin Liang
发明人： David Lauffer , Pan Li , Dean Shannon , Jianglin Liang
IPC分类号： C07D215/12 , A01N43/42 , A61K31/47
CPC分类号： C07D513/04
摘要： The present invention relates to compound 1, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising Compound 1 and methods of using the compositions in the treatment of proliferative disorders.
摘要翻译： 本发明涉及可用于抑制c-Met蛋白激酶的化合物1。 本发明还提供包含化合物1的药学上可接受的组合物和使用该组合物治疗增殖性疾病的方法。
-
公开(公告)号：US20110301195A1
公开(公告)日：2011-12-08
申请号：US13206954
申请日：2011-08-10
申请人： David Lauffer , Pan Li , Dean Shannon , Jianglin Liang
发明人： David Lauffer , Pan Li , Dean Shannon , Jianglin Liang
IPC分类号： A61K31/4709 , A61P35/00 , C07D215/12
CPC分类号： C07D513/04
摘要： The present invention relates to compound 1, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising Compound 1 and methods of using the compositions in the treatment of proliferative disorders.
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.028 秒)
