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公开(公告)号:US20080221137A1
公开(公告)日:2008-09-11
申请号:US11598576
申请日:2006-11-13
申请人: Dean Wilson , Lev T.D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
发明人: Dean Wilson , Lev T.D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
IPC分类号: A61K31/517 , C07D403/04 , A61P25/00
CPC分类号: C07D403/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20080167305A1
公开(公告)日:2008-07-10
申请号:US12050289
申请日:2008-03-18
申请人: Dean Wilson , Lev T.D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
发明人: Dean Wilson , Lev T.D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
IPC分类号: A61K31/5377 , A61K31/517 , C07D413/14 , C07D403/14
CPC分类号: C07D403/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20080255147A1
公开(公告)日:2008-10-16
申请号:US11441487
申请日:2006-05-26
申请人: Dean Wilson , Andreas Termin , Lev T.D. Fanning , Paul Krenitsky , Pramod Joshi
发明人: Dean Wilson , Andreas Termin , Lev T.D. Fanning , Paul Krenitsky , Pramod Joshi
IPC分类号: A61K31/496 , A61K31/454 , C07D417/04 , A61P25/00 , C07D417/14
CPC分类号: C07D277/38 , C07D285/08 , C07D417/04
摘要: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US08809353B2
公开(公告)日:2014-08-19
申请号:US12050289
申请日:2008-03-18
申请人: Dean Wilson , Lev T. D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
发明人: Dean Wilson , Lev T. D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
IPC分类号: A61K31/517 , C07D239/72
CPC分类号: C07D403/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US08283354B2
公开(公告)日:2012-10-09
申请号:US11216376
申请日:2005-08-31
申请人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
发明人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
IPC分类号: A01N43/54 , A61K31/517 , C07D401/00
CPC分类号: C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20060173018A1
公开(公告)日:2006-08-03
申请号:US11216376
申请日:2005-08-31
申请人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
发明人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
IPC分类号: A61K31/517 , C07D403/04
CPC分类号: C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号:US08158637B2
公开(公告)日:2012-04-17
申请号:US11598576
申请日:2006-11-13
申请人: Dean Wilson , Lev T. D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
发明人: Dean Wilson , Lev T. D. Fanning , Paul Krenitsky , Andreas Termin , Pramod Joshi , Urvi Sheth
IPC分类号: A01N43/54 , A61K31/517 , C07D239/72
CPC分类号: C07D403/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US07858786B2
公开(公告)日:2010-12-28
申请号:US11418163
申请日:2006-05-04
申请人: Dean Wilson , Andreas Termin , Dewey Fanning , Paul Krenitsky , Pramod Joshi , Urvi Sheth
发明人: Dean Wilson , Andreas Termin , Dewey Fanning , Paul Krenitsky , Pramod Joshi , Urvi Sheth
IPC分类号: C07D403/04 , C07D401/04 , A61K31/506 , A61K31/496 , A61P19/02 , A61P25/02 , A61P25/06
CPC分类号: C07D239/42 , C07D241/20 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14 , C07F9/65583
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US20090312342A1
公开(公告)日:2009-12-17
申请号:US11367954
申请日:2006-03-03
申请人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
发明人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
IPC分类号: A61K31/496 , C07D403/12 , A61K31/517 , A61P29/00 , A61P19/02 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/24 , A61P25/28 , A61P25/22
CPC分类号: C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D493/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号:US07928107B2
公开(公告)日:2011-04-19
申请号:US11367954
申请日:2006-03-03
申请人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
发明人: Dean Wilson , Andreas Termin , Jesus Gonzalez , Lev Fanning , Timothy Neubert , Paul Krenitsky , Pramod Joshi , Dennis Hurley , Urvi Sheth
IPC分类号: A61K31/496 , A61K31/517 , C07D239/94
CPC分类号: C07D239/94 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D493/04
摘要: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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