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公开(公告)号：US09187474B2
公开(公告)日：2015-11-17
申请号：US14383803
申请日：2013-03-05
发明人： Daniel L. Flynn , Michael D. Kaufman , Lakshminarayana Vogeti , Scott Wise , Wei-Ping Lu , Bryan Smith , Timothy Malcolm Caldwell , William C. Patt , James R. Henry , Philip A. Hipskind , Sheng-Bin Peng
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： This invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I); and use of a compound of Formula (I) for treating specified cancers.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐; 包含式（I）化合物的药物组合物; 以及式（I）化合物用于治疗特定癌症的用途。
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公开(公告)号：US20150105367A1
公开(公告)日：2015-04-16
申请号：US14383803
申请日：2013-03-05
发明人： Daniel L. Flynn , Michael D, Kaufman , Lakshminarayana Vogeti , Scott Wise , Wei-Ping Lu , Bryan Smith , Timothy Malcolm Caldwell , William C. Patt , James R. Henry , Philip A. Hipskind , Sheng-Bin Peng
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： This invention provides compounds of Formula (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising a compound of Formula (I); and use of a compound of Formula (I) for treating specified cancers.
摘要翻译： 本发明提供式（I）化合物或其药学上可接受的盐; 包含式（I）化合物的药物组合物; 以及式（I）化合物用于治疗特定癌症的用途。
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3.发明授权Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities 有权具有抗癌和抗增殖活性的咪唑啉酮和类似物公开(公告)号：US09133183B2
公开(公告)日：2015-09-15
申请号：US14214134
申请日：2014-03-14
发明人： Daniel L. Flynn , Michael D. Kaufman , Thiwanka Samarakoon , Timothy Malcolm Caldwell , Lakshminarayana Vogeti , YuMi Ahn , William C. Patt , Karen M. Yates
IPC分类号： A61K31/497 , C07D417/14 , C07D401/14 , C07D405/14 , C07D413/14
CPC分类号： C07D417/14 , C07B59/002 , C07B2200/05 , C07D401/14 , C07D405/14 , C07D413/14
摘要： Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.
摘要翻译： 描述了通过抑制c-FMS（CSF-1R），c-KIT和/或PDGFR激酶在治疗癌症，自身免疫疾病和代谢性骨骼疾病中有用的式I化合物。 这些化合物也可用于治疗由c-FMS，c-KIT或PDGFR激酶介导的其它哺乳动物疾病。
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4.发明授权N-acyl-N′-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities 有权N-酰基-N' - （吡啶-2-基）脲和表现出抗癌和抗增殖活性的类似物公开(公告)号：US09309224B2
公开(公告)日：2016-04-12
申请号：US14214179
申请日：2014-03-14
发明人： Daniel L. Flynn , Timothy Malcolm Caldwell , Thiwanka Samarakoon , Lakshminarayana Vogeti , Michael D. Kaufman , William C. Patt , YuMi Ahn
IPC分类号： C07D213/65 , C07D401/14 , C07D401/12 , C07D405/14 , C07D493/08
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D493/08
摘要： Described are compounds of Formula 1 which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.
摘要翻译： 描述了通过抑制c-FMS（CSF-1R），c-KIT和/或PDGFR激酶在治疗癌症，自身免疫性疾病和代谢性骨骼疾病中有效的式1化合物。 这些化合物也可用于治疗由c-FMS，c-KIT或PDGFR激酶介导的其它哺乳动物疾病。
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5.发明申请N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities 有权N-酰基-N' - （吡啶-2-基）脲和类似物展示抗癌和抗增殖活性公开(公告)号：US20140275016A1
公开(公告)日：2014-09-18
申请号：US14214179
申请日：2014-03-14
发明人： Daniel L. Flynn , Timothy Malcolm Caldwell , Thiwanka Samarakoon , Lakshminarayana Vogeti , Michael D. Kaufman , William C. Patt , YuMi Ahn
IPC分类号： C07D401/12 , C07D401/14 , C07D493/08 , C07D405/14
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D493/08
摘要： Described are compounds of Formula 1 which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.
摘要翻译： 描述了通过抑制c-FMS（CSF-1R），c-KIT和/或PDGFR激酶在治疗癌症，自身免疫性疾病和代谢性骨骼疾病中有用的式1化合物。 这些化合物也可用于治疗由c-FMS，c-KIT或PDGFR激酶介导的其它哺乳动物疾病。
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6.发明申请IMIDAZOLIDINONES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES 审中-公开咪达洛芬和类似物展示抗癌和抗增生活性公开(公告)号：US20160046619A1
公开(公告)日：2016-02-18
申请号：US14816833
申请日：2015-08-03
发明人： Daniel L. Flynn , Michael D. Kaufman , Thiwanka Samarakoon , Timothy Malcolm Caldwell , Lakshminarayana Vogeti , YuMi Ahn , William C. Patt , Karen M. Yates
IPC分类号： C07D417/14 , C07D413/14 , C07B59/00 , C07D405/14 , C07D401/14
CPC分类号： C07D417/14 , C07B59/002 , C07B2200/05 , C07D401/14 , C07D405/14 , C07D413/14
摘要： Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.
摘要翻译： 描述了通过抑制c-FMS（CSF-1R），c-KIT和/或PDGFR激酶在治疗癌症，自身免疫疾病和代谢性骨骼疾病中有用的式I化合物。 这些化合物也可用于治疗由c-FMS，c-KIT或PDGFR激酶介导的其它哺乳动物疾病。
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7.发明申请N-Acyl-N'-(pyridin-2-yl) Ureas and Analogs Exhibiting Anti-Cancer and Anti-Proliferative Activities 有权N-酰基-N' - （吡啶-2-基）脲和类似物展示抗癌和抗增殖活性公开(公告)号：US20140275080A1
公开(公告)日：2014-09-18
申请号：US14214185
申请日：2014-03-14
发明人： Daniel L. Flynn , Timothy Malcolm Caldwell , Michael D. Kaufman , William C. Patt , Thiwanka Samarakoon , Lakshminarayana Vogeti , Karen M. Yates
IPC分类号： C07D401/14 , C07D413/14 , C07D417/14 , C07D405/14
CPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要： Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.
摘要翻译： 描述了通过抑制c-FMS（CSF-1R），c-KIT和/或PDGFR激酶在治疗癌症，自身免疫疾病和代谢性骨骼疾病中有用的式I化合物。 这些化合物也可用于治疗由c-FMS，c-KIT或PDGFR激酶介导的其它哺乳动物疾病。
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8.发明授权1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities 有权1,2,4-三唑-5-酮和具有抗癌和抗增殖活性的类似物公开(公告)号：US09193719B2
公开(公告)日：2015-11-24
申请号：US14214160
申请日：2014-03-14
发明人： Daniel L. Flynn , Gary E. L. Brandt , Michael D. Kaufman , Hanumaiah Telikepalli , Timothy Malcolm Caldwell , Thiwanka Samarakoon
IPC分类号： A61K31/506 , C07D417/14 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/444
CPC分类号： C07D417/14 , A61K31/444 , A61K31/506 , C07D401/14 , C07D405/14 , C07D413/14
摘要： Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.
摘要翻译： 描述了通过抑制c-FMS（CSF-1R），c-KIT和/或PDGFR激酶在治疗癌症，自身免疫疾病和代谢性骨骼疾病中有用的式I化合物。 这些化合物也可用于治疗由c-FMS，c-KIT或PDGFR激酶介导的其它哺乳动物疾病。
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9.发明授权2-aminopyrimidin-6-ones and analogs exhibiting anti-cancer and anti-proliferative activities 有权2-氨基嘧啶-6-酮和具有抗癌和抗增殖活性的类似物公开(公告)号：US09181223B2
公开(公告)日：2015-11-10
申请号：US14214171
申请日：2014-03-14
发明人： Michael D. Kaufman , Daniel L. Flynn , YuMi Ahn , Lakshminarayana Vogeti , Timothy Malcolm Caldwell
IPC分类号： A61K31/506 , C07D401/14 , C07D405/14
CPC分类号： C07D401/14 , A61K31/506 , C07D405/14
摘要： Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.
摘要翻译： 描述了通过抑制c-FMS（CSF-1R），c-KIT和/或PDGFR激酶在治疗癌症，自身免疫疾病和代谢性骨骼疾病中有用的式I化合物。 这些化合物也可用于治疗由c-FMS，c-KIT或PDGFR激酶介导的其它哺乳动物疾病。
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10.发明申请IMIDAZOLIDINONES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES 有权咪达洛芬和类似物展示抗癌和抗增生活性公开(公告)号：US20140315917A1
公开(公告)日：2014-10-23
申请号：US14214134
申请日：2014-03-14
发明人： Daniel L. Flynn , Michael D. Kaufman , Thiwanka Samarakoon , Timothy Malcolm Caldwell , Lakshminarayana Vogeti , YuMi Ahn , William C. Patt , Karen M. Yates
IPC分类号： C07D417/14 , C07D405/14 , C07D413/14 , C07D401/14
CPC分类号： C07D417/14 , C07B59/002 , C07B2200/05 , C07D401/14 , C07D405/14 , C07D413/14
摘要： Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.
摘要翻译： 描述了通过抑制c-FMS（CSF-1R），c-KIT和/或PDGFR激酶在治疗癌症，自身免疫疾病和代谢性骨骼疾病中有用的式I化合物。 这些化合物也可用于治疗由c-FMS，c-KIT或PDGFR激酶介导的其它哺乳动物疾病。
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