公开(公告)号：US20240339218A1

公开(公告)日：2024-10-10

申请号：US18681425

申请日：2022-08-03

Applicant: Deepull Diagnostics S.L.

Inventor： Jordi CARRERA FABRA ,  Rafael BRU GIBERT ,  Richard Max IVEY

IPC: G16H50/20 ,  C12Q1/18 ,  C12Q1/686 ,  C12Q1/689 ,  G01N21/65 ,  G16B25/20 ,  G16B40/10 ,  G16H10/60 ,  G16H20/10

CPC classification number: G16H50/20 ,  C12Q1/18 ,  C12Q1/686 ,  C12Q1/689 ,  G01N21/65 ,  G16B25/20 ,  G16B40/10 ,  G16H10/60 ,  G16H20/10

Abstract: A sepsis detection system includes a first subsystem configured to detect a presence of an infection in a patient, a second subsystem configured to detect a presence of a dysregulated host response in the patient, a third subsystem configured to detect organ dysfunction in the patient, a fourth subsystem configured to detect antimicrobial resistance (AMR) of a pathogen in the patient, and a processing device. The first, second, third, and fourth subsystems and the processing device are communicatively coupled together via a network. The processing device is configured to determine a presence of sepsis in the patient based on the presence of the infection, the presence of the dysregulated host response, and clinical data indicative of the organ dysfunction in the patient. The subsystems utilize at least one of polymerase chain reaction (PCR) processing. Raman spectroscopy, clinical data, electronic health record (EHR) data, and antimicrobial susceptibility testing (AST).

公开(公告)号：US20250075248A1

公开(公告)日：2025-03-06

申请号：US18728766

申请日：2023-01-13

Applicant: Deepull Diagnostics S.L.

Inventor： Rafael BRU GIBERT ,  Jordi CARRERA FABRA ,  Marta MARÍ ALMIRALL ,  Ariadna SANGLAS BAULENAS

IPC: C12Q1/18 ,  B01L3/00

Abstract: Described herein are systems, methods, and devices for antimicrobial susceptibility testing (AST) directly from blood samples. A system for enriching samples includes a housing configured to receive sample containers, sample preparation cartridges, and AST cartridges, for processing and testing samples using one or more centrifuges, pipetting systems, a controller, AST subsystem, magnet station, microscope, and heater disposed inside the housing. The system is configured to transfer a sample from a blood sample container into a processing tube in a sample preparation cartridge using a septum and needle-based pipetting system. Upon transfer of the sample, the system performs steps to separate, enrich, and concentrate pathogens in the sample for rapid detection. The system then dispenses aliquots of the enriched sample into antimicrobial-containing reaction wells in an AST cartridge, acquires images of each reaction well after incubation, and determines pathogen susceptibility to antimicrobials based on analyzing the acquired images.