公开(公告)号：US09642822B2

公开(公告)日：2017-05-09

申请号：US14119499

申请日：2012-05-25

申请人： Denisa D. Wagner ,  Tobias A. Fuchs ,  Simon De Meyer ,  Kimberly Martinod ,  Alexander Brill ,  Grace M. Thomas

发明人： Denisa D. Wagner ,  Tobias A. Fuchs ,  Simon De Meyer ,  Kimberly Martinod ,  Alexander Brill ,  Grace M. Thomas

IPC分类号： A61K31/166 ,  A61K31/155 ,  A61K38/46 ,  A61K39/395 ,  A61K45/06 ,  A61K38/49 ,  A61M1/34

CPC分类号： A61K38/465 ,  A61K31/155 ,  A61K31/166 ,  A61K38/49 ,  A61K39/3955 ,  A61K45/06 ,  A61M1/0209 ,  A61M1/34 ,  C12Y301/21001 ,  A61K2300/00

摘要： Embodiments of the technology described herein are based upon the discoveries that neturophil extracellular traps (NETs) provide a stimulus for thrombus formation and that NETs are present in stored blood products. Accordingly, some embodiments relate to methods of treating and preventing toxicity of NETs and thrombosis caused by NETs. Additional embodiments are directed towards methods of treating stored blood products to prevent transfusion-related injuries.

公开(公告)号：US20140199329A1

公开(公告)日：2014-07-17

申请号：US14119499

申请日：2012-05-25

申请人： Denisa D. Wagner ,  Tobias A. Fuchs ,  Simon De Meyer ,  Kimberly Martinod ,  Alexander Brill ,  Grace M. Thomas

发明人： Denisa D. Wagner ,  Tobias A. Fuchs ,  Simon De Meyer ,  Kimberly Martinod ,  Alexander Brill ,  Grace M. Thomas

IPC分类号： A61K38/46 ,  A61M1/34 ,  A61K31/166 ,  A61K45/06 ,  A61K39/395

CPC分类号： A61K38/465 ,  A61K31/155 ,  A61K31/166 ,  A61K38/49 ,  A61K39/3955 ,  A61K45/06 ,  A61M1/0209 ,  A61M1/34 ,  C12Y301/21001 ,  A61K2300/00

摘要： Embodiments of the technology described herein are based upon the discoveries that neturophil extracellular traps (NETs) provide a stimulus for thrombus formation and that NETs are present in stored blood products. Accordingly, some embodiments relate to methods of treating and preventing toxicity of NETs and thrombosis caused by NETs. Additional embodiments are directed towards methods of treating stored blood products to prevent transfusion-related injuries.

摘要翻译： 本文描述的技术的实施方案基于neturophil细胞外捕获物（NETs）为血栓形成提供刺激并且NETs存在于储存的血液制品中的发现。 因此，一些实施方案涉及治疗和预防NETs的毒性和由NET引起的血栓形成的方法。 另外的实施方案涉及治疗存储的血液制品以防止输血相关损伤的方法。

公开(公告)号：US20090311267A1

公开(公告)日：2009-12-17

申请号：US12383315

申请日：2009-03-23

申请人： Guido Stoll ,  Christoph Kleinschnitz ,  Bernhard Nieswandt ,  Hans Deckmyn ,  Simon De Meyer

发明人： Guido Stoll ,  Christoph Kleinschnitz ,  Bernhard Nieswandt ,  Hans Deckmyn ,  Simon De Meyer

IPC分类号： A61K39/395

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76

摘要： The invention relates generally to an anti-thrombotic treatment of occlusive syndromes in the cerebral vascular system causing cerebral infarct due to stroke or ischemic stroke, which is a major cause of death and permanent disability in industrialized countries. More particularly, the invention relates to a system and method of preventing and treating such occlusive syndromes in the cerebral vascular by inhibiting initial adhesion/attachment of platelets to the endothelium by preventing or inhibiting binding of von Willebrand factor to platelet glycoprotein Ib by administration of a subject in such need anti-glycoprotein Ib monovalent antibodies and/or anti-vWF monovalent antibodies, rather than by blocking the common pathway of platelet aggregation by blockade of platelet aggregation with anti-glycoprotein IIb/IIIa.

摘要翻译： 本发明一般涉及脑血管系统中由于卒中或缺血性卒中导致脑梗塞的闭塞综合征的抗血栓形成治疗，这是工业化国家死亡和永久性残疾的主要原因。 更具体地说，本发明涉及一种通过预防或抑制血管性血友病因子与血小板糖蛋白Ib的结合来抑制血小板初始粘附/附着至内皮的预防和治疗脑血管闭塞综合征的系统和方法， 需要抗糖蛋白Ib单价抗体和/或抗vWF单价抗体，而不是通过阻断与抗糖蛋白IIb / IIIa的血小板聚集来阻断血小板聚集的共同途径。