公开(公告)号：US20140199329A1

公开(公告)日：2014-07-17

申请号：US14119499

申请日：2012-05-25

申请人： Denisa D. Wagner ,  Tobias A. Fuchs ,  Simon De Meyer ,  Kimberly Martinod ,  Alexander Brill ,  Grace M. Thomas

发明人： Denisa D. Wagner ,  Tobias A. Fuchs ,  Simon De Meyer ,  Kimberly Martinod ,  Alexander Brill ,  Grace M. Thomas

IPC分类号： A61K38/46 ,  A61M1/34 ,  A61K31/166 ,  A61K45/06 ,  A61K39/395

CPC分类号： A61K38/465 ,  A61K31/155 ,  A61K31/166 ,  A61K38/49 ,  A61K39/3955 ,  A61K45/06 ,  A61M1/0209 ,  A61M1/34 ,  C12Y301/21001 ,  A61K2300/00

摘要： Embodiments of the technology described herein are based upon the discoveries that neturophil extracellular traps (NETs) provide a stimulus for thrombus formation and that NETs are present in stored blood products. Accordingly, some embodiments relate to methods of treating and preventing toxicity of NETs and thrombosis caused by NETs. Additional embodiments are directed towards methods of treating stored blood products to prevent transfusion-related injuries.

摘要翻译： 本文描述的技术的实施方案基于neturophil细胞外捕获物（NETs）为血栓形成提供刺激并且NETs存在于储存的血液制品中的发现。 因此，一些实施方案涉及治疗和预防NETs的毒性和由NET引起的血栓形成的方法。 另外的实施方案涉及治疗存储的血液制品以防止输血相关损伤的方法。

公开(公告)号：US09642822B2

公开(公告)日：2017-05-09

申请号：US14119499

申请日：2012-05-25

申请人： Denisa D. Wagner ,  Tobias A. Fuchs ,  Simon De Meyer ,  Kimberly Martinod ,  Alexander Brill ,  Grace M. Thomas

发明人： Denisa D. Wagner ,  Tobias A. Fuchs ,  Simon De Meyer ,  Kimberly Martinod ,  Alexander Brill ,  Grace M. Thomas

IPC分类号： A61K31/166 ,  A61K31/155 ,  A61K38/46 ,  A61K39/395 ,  A61K45/06 ,  A61K38/49 ,  A61M1/34

CPC分类号： A61K38/465 ,  A61K31/155 ,  A61K31/166 ,  A61K38/49 ,  A61K39/3955 ,  A61K45/06 ,  A61M1/0209 ,  A61M1/34 ,  C12Y301/21001 ,  A61K2300/00

摘要： Embodiments of the technology described herein are based upon the discoveries that neturophil extracellular traps (NETs) provide a stimulus for thrombus formation and that NETs are present in stored blood products. Accordingly, some embodiments relate to methods of treating and preventing toxicity of NETs and thrombosis caused by NETs. Additional embodiments are directed towards methods of treating stored blood products to prevent transfusion-related injuries.

公开(公告)号：US20170185560A1

公开(公告)日：2017-06-29

申请号：US14998310

申请日：2015-12-26

申请人： Yuli Barcohen ,  Eli Kupermann ,  Alexander Brill

发明人： Yuli Barcohen ,  Eli Kupermann ,  Alexander Brill

IPC分类号： G06F13/42 ,  G06F9/22

CPC分类号： G06F13/4291 ,  G06F9/226 ,  G06F13/4282

摘要： Technologies for controlling timing calibration of a dedicated inter-integrated circuit data bus by a primary microcontroller are disclosed. The primary microcontroller performs a data transfer with a secondary integrated circuit using the dedicated inter-integrated circuit data bus, and determines a duration of the data transfer. If the duration is outside of an acceptable range, the primary microcontroller updates one or more data transfer timing parameters so that the duration of future data transfers are closer to the acceptable range.