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公开(公告)号：US08721699B2
公开(公告)日：2014-05-13
申请号：US12703425
申请日：2010-02-10
申请人： Denise Barbut , Allan Rozenberg , John K Hoffman
发明人： Denise Barbut , Allan Rozenberg , John K Hoffman
IPC分类号： A61F7/12
CPC分类号： A61F7/10 , A61F7/12 , A61F7/123 , A61F2007/0002 , A61F2007/0063 , A61F2007/0064 , A61F2007/0065 , A61F2007/0069 , A61K31/02 , A61M15/08 , A61M15/085 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0454 , A61M16/0479 , A61M16/0486 , A61M16/107 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/1011 , A61M31/00 , A61M2025/0034 , A61M2025/0036 , A61M2025/0073
摘要： A method for providing and adjusting cerebral cooling in response to changes in a physiological parameter. A spray having a boiling point between 38-300° C. is delivered to the surface of a patient's nasal cavities. The spray causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis. A physiological parameter, such as cerebral temperature, changes in cerebral blood flow or brain oxygenation is monitored. The delivery rate of the spray is adjusted in response to the physiological parameter.
摘要翻译： 一种用于响应于生理参数的变化来提供和调节脑冷却的方法。 沸点在38-300℃之间的喷雾剂被输送到患者鼻腔的表面。 喷雾通过直接通过鼻咽传播并通过颈动脉和威利斯圈造成血液冷却，导致冷却。 监测生理参数，如脑温，脑血流量或脑氧合变化。 响应于生理参数调节喷雾的输送速率。
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2.发明授权Methods and devices for non-invasive cerebral and systemic cooling alternating liquid mist/gas for induction and gas for maintenance 有权用于非侵入式脑和系统冷却交替液雾/气体进行感应和气体维护的方法和装置公开(公告)号：US09358150B2
公开(公告)日：2016-06-07
申请号：US13423561
申请日：2012-03-19
CPC分类号： A61F7/12 , A61F7/0085 , A61F7/123 , A61F2007/0006 , A61F2007/0065 , A61K9/007 , A61K31/02 , A61K47/06 , A61M15/08 , A61M16/04 , A61M16/0409 , A61M16/0438 , A61M16/0445 , A61M16/0479 , A61M16/0486 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M25/007 , A61M25/1011 , A61M31/00 , A61M2025/0034 , A61M2025/0036 , A61M2025/0073 , A61M2205/7545
摘要： Methods for cerebral and systemic cooling via a patient's nasopharyngeal cavity are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. A substantially dry gas is delivered through a lumen of the catheter onto the surface of the patient's nasal cavity. Evaporative heat loss cools the patient's nasal cavity. If additional cooling is needed, a liquid coolant is delivered through a separated lumen of the catheter. The liquid coolant is nebulized at a plurality of delivery ports on the distal end of the catheter and is delivered onto the surface of the patient's nasal cavity in combination with the dry gas. The dry gas enhances evaporation of the nebulized coolant and additional cooling is provided from the evaporative heat loss of the liquid coolant.
摘要翻译： 描述了通过患者鼻咽腔进行脑和全身冷却的方法。 在一种方法中，通过病人的鼻孔将冷却组件插入鼻腔。 将基本上干燥的气体通过导管的内腔输送到患者鼻腔的表面上。 蒸发热损失冷却患者的鼻腔。 如果需要额外的冷却，液体冷却剂通过导管的分离的内腔被输送。 液体冷却剂在导管远端上的多个输送口处被喷雾，并且与干燥气体一起被输送到病人鼻腔的表面上。 干燥气体增强雾化冷却剂的蒸发，并且由液体冷却剂的蒸发热损失提供另外的冷却。
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公开(公告)号：US08157767B2
公开(公告)日：2012-04-17
申请号：US12819116
申请日：2010-06-18
申请人： Allan Rozenberg , John K Hoffman , James Savage
发明人： Allan Rozenberg , John K Hoffman , James Savage
CPC分类号： A61F7/123 , A61F7/12 , A61F2007/0006 , A61F2007/0068 , A61F2007/0214 , A61F2007/0247 , A61M3/025 , A61M3/0295 , A61M13/003 , A61M16/0409 , A61M16/045 , A61M16/0461 , A61M16/0479 , A61M16/0486 , A61M16/208 , A61M16/209 , A61M25/10 , A61M2025/1052 , A61M2205/3606 , A61M2210/0618
摘要： A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure from the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon.
摘要翻译： 一种脑冷却装置，其使用加压源来输送在鼻腔中蒸发的流体以提供冷却，并且在远端上具有从加压源的一些压力膨胀的气囊。 该装置包括鼻导管，其具有位于远侧区域中的输送口和远端上的气囊。 导管的近端与低沸点流体的加压源流体连通。 位于加压源和导管之间的歧管将来自加压源的流体和压力分配到导管的第一腔，以通过输送端口将球囊和导管的第二腔膨胀以冷却鼻腔。 歧管中的止回阀确保首先将流体和压力传送到气囊。
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公开(公告)号：US08512280B2
公开(公告)日：2013-08-20
申请号：US13439772
申请日：2012-04-04
申请人： Allan Rozenberg , John K Hoffman , James Savage
发明人： Allan Rozenberg , John K Hoffman , James Savage
CPC分类号： A61F7/123 , A61F7/12 , A61F2007/0006 , A61F2007/0068 , A61F2007/0214 , A61F2007/0247 , A61M3/025 , A61M3/0295 , A61M13/003 , A61M16/0409 , A61M16/045 , A61M16/0461 , A61M16/0479 , A61M16/0486 , A61M16/208 , A61M16/209 , A61M25/10 , A61M2025/1052 , A61M2205/3606 , A61M2210/0618
摘要： A cerebral cooling device that uses a pressurized source to deliver a fluid that evaporates in the nasal cavity to provide cooling and has a balloon on the distal end that inflates from some of the pressure front the pressurized source. The device includes a nasal catheter having delivery ports located in the distal region and a balloon on the distal end. The proximal end of the catheter is in fluid communication with a pressurized source of a low boiling point fluid. A manifold located between the pressurized source and the catheter distributes the fluid and pressure from the pressurized source to a first lumen of the catheter to inflate the balloon and to a second lumen of the catheter through the delivery ports to cool the nasal cavity. A check valve in the manifold ensures that the fluid and pressure are first delivered to the balloon.
摘要翻译： 一种脑冷却装置，其使用加压源来输送在鼻腔中蒸发的流体以提供冷却，并且在远端上具有从加压源前面的一些压力膨胀的气囊。 该装置包括鼻导管，其具有位于远侧区域中的输送口和远端上的气囊。 导管的近端与低沸点流体的加压源流体连通。 位于加压源和导管之间的歧管将来自加压源的流体和压力分配到导管的第一腔，以通过输送端口将球囊和导管的第二腔膨胀以冷却鼻腔。 歧管中的止回阀确保首先将流体和压力传送到气囊。
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