公开(公告)号：US20230181353A1

公开(公告)日：2023-06-15

申请号：US17965606

申请日：2022-10-13

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Harikrishna Tandri ,  Menekhem Muz Zviman

IPC分类号： A61F7/00

CPC分类号： A61F7/0085 ,  A61F2007/0065 ,  A61F2007/0069 ,  A61F2007/126

摘要： The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The method and device provide for removal of fluid and cooling of various bodily fluid-containing spaces or surfaces, such as mucus-containing spaces or surfaces via delivery of a dry fluid not including a coolant into or upon the mucus-containing space or surface. Exposure of such mucus to the dry fluid results in evaporation of body fluid, removal of energy, cooling of the anatomical feature, and systemic cooling. In this fashion, therapeutic hypothermia may be achieved to provide for neuroprotection of various organs after ischemic insult, such the brain after cardiac arrest. Similarly, excess fluid removal may be achieved for treatment of cardiogenic shock or other conditions that cause significant fluid build-up, especially in cases of compromised renal function. Additionally, the invention may be used to reduce fever, and other conditions where removal of heat, energy and/or water are beneficial.

公开(公告)号：US09956113B2

公开(公告)日：2018-05-01

申请号：US14197518

申请日：2014-03-05

申请人： Board of Trustees of Leland Stanford Jr University

发明人： Peter Santa Maria ,  Brian Hsueh ,  Brian Kannard ,  Ritu Lal ,  Abhinav Ramani ,  John Paderi

IPC分类号： A61H9/00 ,  A61F7/00 ,  A61F7/02 ,  A61F7/03 ,  A61F7/08 ,  A61F7/10 ,  A61F7/12 ,  A61N7/00 ,  A61N1/36 ,  A61H39/04

CPC分类号： A61F7/02 ,  A61F7/03 ,  A61F2007/0042 ,  A61F2007/0043 ,  A61F2007/0045 ,  A61F2007/0047 ,  A61F2007/0055 ,  A61F2007/0065 ,  A61F2007/0086 ,  A61F2007/0088 ,  A61F2007/0091 ,  A61F2007/0226 ,  A61F2007/023 ,  A61F2007/0239 ,  A61F2007/0268 ,  A61F2007/0288 ,  A61H9/00 ,  A61H9/005 ,  A61H9/0057 ,  A61H9/0078 ,  A61H9/0092 ,  A61H39/04 ,  A61H2201/0103 ,  A61H2201/0184 ,  A61H2201/02 ,  A61H2201/0207 ,  A61H2201/0214 ,  A61H2201/0228 ,  A61H2201/0242 ,  A61H2201/0278 ,  A61H2201/1619 ,  A61H2201/1635 ,  A61H2201/164 ,  A61H2201/165 ,  A61H2201/5007 ,  A61H2201/501 ,  A61H2201/5097 ,  A61H2209/00 ,  A61H2230/50 ,  A61H2230/505 ,  A61N1/36042 ,  A61N7/00

摘要： A method for maintaining and/or increasing body temperature of a patient may involve delivering heat to a first location on a limb of the patient, delivering heat to a second location on the limb, apart from the first location, and applying intermittent compression to a third location on the limb, located between the first location and the second location. A device for maintaining and/or increasing body temperature of a patient may include a sleeve for positioning over at least part of one of the patient's limbs, first and second heat delivery members coupled with the sleeve, and an intermittent compression member coupled with the sleeve between the first and second heat delivery members.

公开(公告)号：US09775741B2

公开(公告)日：2017-10-03

申请号：US14266600

申请日：2014-04-30

申请人： BrainCool AB

发明人： Denise Barbut ,  Alan Rozenberg ,  John K Hoffman ,  Thomas H Shaffer

IPC分类号： A61F7/10 ,  A61F7/12 ,  A61K31/02 ,  A61M15/08 ,  A61M25/00 ,  A61F7/00 ,  A61M16/04 ,  A61M25/10 ,  A61M31/00 ,  A61M16/10

CPC分类号： A61F7/10 ,  A61F7/12 ,  A61F7/123 ,  A61F2007/0002 ,  A61F2007/0063 ,  A61F2007/0064 ,  A61F2007/0065 ,  A61F2007/0069 ,  A61K31/02 ,  A61M15/08 ,  A61M15/085 ,  A61M16/04 ,  A61M16/0409 ,  A61M16/0438 ,  A61M16/0454 ,  A61M16/0479 ,  A61M16/0486 ,  A61M16/107 ,  A61M25/003 ,  A61M25/0032 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/1011 ,  A61M31/00 ,  A61M2025/0034 ,  A61M2025/0036 ,  A61M2025/0073

摘要： Methods for cerebral cooling are described. Cooling assemblies include elongate tubular members, a reservoir containing a pressurized fluid, and a manifold connecting the reservoir and elongate tubular members. After insertion of the elongate tubular members into the patient's nostrils, a pressurized fluid is delivered onto a surface of the patient's nasal cavity through a plurality of ports in the elongate tubular members. The delivery of the fluid causes cooling by direct heat transfer through the nasopharynx and hematogenous cooling through the carotids and the Circle of Willis.

公开(公告)号：US20140358205A1

公开(公告)日：2014-12-04

申请号：US14288023

申请日：2014-05-27

申请人： Mary Jo Margaret Robke ,  Vicki Shapero Lurie

发明人： Mary Jo Margaret Robke ,  Vicki Shapero Lurie

IPC分类号： A61D1/00 ,  A61F7/10

CPC分类号： A61D1/00 ,  A61D9/00 ,  A61F7/10 ,  A61F2007/0065 ,  A61F2007/0068

摘要： The present invention provides a method and apparatus of evaporative cooling which targets one or more of an animal's muscle tissue areas, as the head and neck, chest, shoulder, back or gluteal muscles, and leg and ankle of the body chest, shoulder, back and gluteal muscles, and does not otherwise restrict movement of the animal. The apparatus of the present invention is formed of a lower layer and an upper layer, which together form a pocket for receiving a cooling means, wherein the pocket is adapted to open and dose. The apparatus of the present invention is contoured to position around one or more body areas of the animal and secured in the position for evaporative cooling of the animal.

摘要翻译： 本发明提供一种蒸发冷却的方法和装置，其靶向动物的肌肉组织区域中的一个或多个，如头颈部，胸部，肩部，背部或臀部肌肉，以及身体胸部，肩部，背部的腿部和踝部 和臀肌，并不会限制动物的运动。 本发明的装置由下层和上层形成，它们一起形成用于接收冷却装置的口袋，其中口袋适于打开和剂量。 本发明的装置的轮廓是围绕动物的一个或多个身体区域定位并固定在动物蒸发冷却的位置。

公开(公告)号：US08771330B1

公开(公告)日：2014-07-08

申请号：US12783542

申请日：2010-05-19

申请人： Christopher S. Roper ,  William B. Carter

发明人： Christopher S. Roper ,  William B. Carter

IPC分类号： A61F7/00

CPC分类号： A61F7/00 ,  A61F7/02 ,  A61F2007/0065 ,  A61F2007/0068

摘要： A personal artificial transpiration cooling system having a transpiration surface with a substrate, a transpiration membrane layer which is spaced from the substrate layer by one or more spacers to define one or more interior fluid flow channels between a first surface of the transpiration membrane layer and the substrate; and a stoma layer disposed adjacent a second surface of the permeable membrane layer, the stoma layer being spaced from the second surface of permeable membrane layer by a predetermined distance to define one or more cavities disposed between pores in the at least one stoma layer and the second surface of the permeable membrane layer. A fluid reservoir is provided in fluid communication with the one or more interior fluid flow channels, while the transpiration surface is configured to be worn by a human or an animal and the fluid reservoir is designed to be supported, in use, by the human or animal wearing the transpiration surface.

摘要翻译： 一种具有蒸发表面的个人人造蒸腾冷却系统，其具有基底，蒸发膜层，其通过一个或多个间隔物与所述基底层间隔开以限定所述蒸发膜层的第一表面和所述蒸发膜层之间的一个或多个内部流体流动通道 基质; 以及邻近所述可渗透膜层的第二表面设置的造口层，所述造口层与所述可渗透膜层的所述第二表面隔开预定距离，以限定设置在所述至少一个造口层中的孔之间的一个或多个空腔， 渗透膜层的第二表面。 流体储存器设置成与一个或多个内部流体流动通道流体连通，而蒸腾表面被构造成由人或动物佩戴，并且流体储存器被设计为在使用中由人类或 动物穿着蒸腾表面。

公开(公告)号：US20120083764A1

公开(公告)日：2012-04-05

申请号：US13315141

申请日：2011-12-08

申请人： DENISE BARBUT ,  Allan Rozenberg

发明人： DENISE BARBUT ,  Allan Rozenberg

IPC分类号： A61M11/00

CPC分类号： A61F7/12 ,  A61F7/123 ,  A61F2007/0065 ,  A61K31/02 ,  A61M11/02 ,  A61M11/06 ,  A61M15/08 ,  A61M15/085 ,  A61M16/04 ,  A61M16/0409 ,  A61M16/0438 ,  A61M16/0443 ,  A61M16/0459 ,  A61M16/0461 ,  A61M16/0479 ,  A61M16/0486 ,  A61M16/06 ,  A61M16/107 ,  A61M16/209 ,  A61M19/00 ,  A61M25/003 ,  A61M25/0032 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/1011 ,  A61M31/00 ,  A61M2016/0027 ,  A61M2025/0034 ,  A61M2025/0036 ,  A61M2025/0073 ,  A61M2202/0275 ,  A61M2205/3606

摘要： Methods for treating a migraine by cooling a patient's nasopharyngeal cavity are described. In one method, a cooling assembly is inserted into a nasal cavity through a patient's nostril. The cooling assembly includes a flexible balloon defining a chamber and a first elongate tubular member having a lumen in fluid communication with the chamber. A liquid having a temperature between about −20° C. and about 37° C. is infused through the lumen of the first elongate tubular member into the chamber, wherein the flexible balloon expands to place it in contact with the nasal cavity. In another method, an elongate member having a plurality of ports is inserted into the nasal cavity. A perfluorocarbon spray and a gas are then delivered onto a surface of the nasal cavity through the plurality of ports.

摘要翻译： 描述了通过冷却患者的鼻咽腔来治疗偏头痛的方法。 在一种方法中，通过病人的鼻孔将冷却组件插入鼻腔。 冷却组件包括限定腔室的柔性气囊和具有与腔室流体连通的内腔的第一细长管状构件。 将温度在约-20℃和约37℃之间的液体通过第一细长管状构件的内腔输入到腔室中，其中柔性气囊膨胀以使其与鼻腔接触。 在另一种方法中，具有多个端口的细长构件被插入到鼻腔中。 然后通过多个端口将全氟化碳喷雾和气体输送到鼻腔的表面上。

公开(公告)号：US07681253B2

公开(公告)日：2010-03-23

申请号：US11918335

申请日：2006-03-20

申请人： Toyohiro Kobayashi

发明人： Toyohiro Kobayashi

IPC分类号： A42B1/24

CPC分类号： A42C5/04 ,  A41D13/0056 ,  A41D27/13 ,  A42B1/008 ,  A61F9/045 ,  A61F2007/0007 ,  A61F2007/0031 ,  A61F2007/0065 ,  A61F2007/0258 ,  A61F2007/026 ,  F25D7/00 ,  F25D2400/26

摘要： This present invention is for cooling the forehead, face and armpit of a person or imparting cool feeling.The cooling member comprises a water-absorbing material sheet sandwiched between a flexible planar material provided with a ventilation means, having an adequate hardness, and capable of holding its shape, capable of being bent in a predetermined direction and in the reverse direction a plurality of times, and having a curvature in the predetermined direction and backing cloth having a similar area and a means for dividing the water-absorbing material sheet into parts each having an adequate area corresponding to a vent in such a way that water absorbed in the water absorbing material sheet does not flow out easily into adjacent parts and is used for cooling by allowing the water absorbing material sheet to absorb water and by using its heat of evaporation to cool the surroundings.The cooling member constitutes a brim portion of a hat, a sun visor or the like, or a pad portion for the forehead, face or armpit of the person and provides a means for imparting a cool feeling to each heat generating portion of the human body.As preparation for use, the cooling member is dipped into water and bent by applying a force reversely to the curvature in the predetermined direction. Consequently, excess water and water drops are squeezed out easily and uniformly with only the cooling member without wetting the hand of the person.

摘要翻译： 本发明是为了冷却人的前额，面部和腋下或赋予凉爽的感觉。 该冷却部件包括夹在具有通风装置的柔性平面材料之间的吸水材料片，该柔性平面材料具有足够的硬度并且能够保持其形状，能够沿预定方向和相反方向弯曲多个 时间，并且具有预定方向的曲率和具有相似面积的背衬，以及用于将吸水材料片分成各自具有对应于排气口的适当面积的部分的装置，使得吸收在吸水材料中的水 材料片不会容易地流出到相邻的部件中，并且通过允许吸水材料片吸收水并通过使用其蒸发热来冷却周围环境而用于冷却。 冷却构件构成帽子，遮阳板等的边缘部分，或者用于人的前额，面部或腋下的垫部分，并且为人体的每个发热部分提供凉爽感觉的装置 。 作为使用准备，将冷却部件浸入水中并通过在预定方向上施加与曲率相反的力而弯曲。 因此，只有冷却部件容易且均匀地挤出多余的水和水滴，而不会弄湿人的手。

公开(公告)号：US20050152844A1

公开(公告)日：2005-07-14

申请号：US11003015

申请日：2004-12-01

申请人： Denise Barbut ,  Allan Rozenberg ,  Thomas Shaffer

发明人： Denise Barbut ,  Allan Rozenberg ,  Thomas Shaffer

IPC分类号： A61F7/00 ,  A61F7/10 ,  A61N1/00 ,  A61L9/04

CPC分类号： A61F7/10 ,  A61F7/12 ,  A61F2007/0063 ,  A61F2007/0065

摘要： A method for transpulmonary cooling by providing a liquid having a boiling point of 38-300° C., more preferably 38-250° C., more preferably 38-200° C., more preferably 38-150° C., more preferably 38-80° C. The liquid is nebulized to form a mist. The mist is optionally cooled below room temperature and delivered to the airway of a patient so that the patient inhales the mist. The mist causes systemic cooling by evaporative heat loss when inhaled at room temperature and additionally by direct heat transfer when inhaled below room temperature. Compositions and medical devices for transpulmonary cooling are also provided.

公开(公告)号：US20050065582A1

公开(公告)日：2005-03-24

申请号：US10670491

申请日：2003-09-24

申请人： John Blackburn

发明人： John Blackburn

IPC分类号： A61F7/00 ,  A61F7/10

CPC分类号： A61F7/10 ,  A61F2007/0065

摘要： The invention is a method, inclusive of its associated device or apparatus, of more effectively cooling the human body by the process of an enhanced evaporation process. The method provides for the spraying a generally wide pattern of a fine mist spray of de-mineralized water on the skin to be cooled from either a non-pressurized container having a manual pump spray for discharging the water from the container, or a pressurized container having a propellant mixed with the de-mineralized water, where the pressurized container further has a manually operated actuator for discharging the water from the container. In the latter case, the propellant is one of nitrogen, carbon dioxide and air, preferably nitrogen.

摘要翻译： 本发明是一种包括其关联的装置或装置的方法，其通过增强的蒸发过程的过程更有效地冷却人体。 该方法提供了在要从要从容器中排出水的手动泵喷雾器的非加压容器或要从容器排出水的非压力容器的表面上喷洒脱矿水的细雾喷雾的大致宽的图案，或者加压容器 具有与去矿化水混合的推进剂，其中加压容器还具有用于从容器排出水的手动操作致动器。 在后一种情况下，推进剂是氮气，二氧化碳和空气中的一种，优选氮气。

公开(公告)号：US20020193026A1

公开(公告)日：2002-12-19

申请号：US10164299

申请日：2002-06-05

发明人： Keizo Ota ,  Tetsuhiro Watanabe

IPC分类号： B32B005/26 ,  B32B027/04 ,  B32B005/06 ,  B32B027/12

CPC分类号： A61F7/02 ,  A61F2007/0001 ,  A61F2007/0062 ,  A61F2007/0065 ,  A61F2007/0214 ,  A61F2007/0226 ,  A61F2007/0257 ,  A61F2007/0258 ,  A61F2007/026 ,  A61F2007/0261 ,  A61K8/0208 ,  A61K2800/242 ,  A61Q19/00 ,  Y10T442/3472 ,  Y10T442/3496 ,  Y10T442/3602 ,  Y10T442/365 ,  Y10T442/3707 ,  Y10T442/3764

摘要： The device of the present invention comprises a moisture-permeable base material, a water-bearing gel, and a covering material, which are laminated in this order. The base material comprises a moisture-permeable material, e.g., a cloth material made of a natural and/or artificial fiber, a polymeric film, or a polymeric sheet. The base material may be a laminate. The water-bearing gel comprises a water-absorbable polymer and water. The covering material may comprise a cloth material made of a natural and/or artificial fiber, a polymeric film, or a polymeric sheet. The device can be warmed or cooled. When it is warmed, it can evolve steam that results from water in the gel. Thus, it can be used to give moisutre to and warm up human body, or to cool down it.

摘要翻译： 本发明的装置包括依次层叠的透湿性基材，含水凝胶和覆盖材料。 基材包括透湿材料，例如由天然和/或人造纤维，聚合物膜或聚合物片制成的布料。 基材可以是层压体。 含水凝胶包含吸水聚合物和水。 覆盖材料可以包括由天然和/或人造纤维，聚合物膜或聚合物片材制成的布料。 该设备可以加热或冷却。 当它变暖时，它可以产生由凝胶中的水引起的蒸汽。 因此，它可以用于给人体带来温暖和温暖，或者冷却它。