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    N-(iminomethyl)amines derivatives, their preparation, their use as medicines and compositions containing them
    8.
    发明授权
    N-(iminomethyl)amines derivatives, their preparation, their use as medicines and compositions containing them 失效
    N-（亚氨基甲基）胺衍生物，它们的制备，它们作为药物和含有它们的组合物的用途

    公开(公告)号：US06482822B1

    公开(公告)日：2002-11-19

    申请号：US09787466

    申请日：2001-03-16

    申请人： Dennis Bigg ,  Pierre-Etienne Chabrier de Lassauniere ,  Serge Auvin ,  Jeremiah Harnett ,  Gérard Ulibarri

    发明人： Dennis Bigg ,  Pierre-Etienne Chabrier de Lassauniere ,  Serge Auvin ,  Jeremiah Harnett ,  Gérard Ulibarri

    IPC分类号： A61K315415

    CPC分类号： C07D333/38

    摘要： The invention concerns novel N-(iminomethyl)amine derivatives comprising in their skeleton the aminophenylamine, oxodiphenylamine, carbazole, phenazine, phenoxazine or oxodiphenyl motif, their use as medicines and pharmaceutical compositions containing them. The invention concerns in particular the following compounds: -4-{[2-thienyl(imino)methyl]amino}-N-[2-(phenylamino)phenyl]-benzenebutanamide; -4-{[2-thienyl(imino)methyl]amino}-N-[4-(phenylamino)phenyl]-benzenebutanamide; -N-′[4-(10H-phenothiazin-2-yloxy)phenyl]-2-thiophenecarboximidamide; -4-(4-{[amino(2-thienyl)methylidene]amino}phenyl)-N-(10H-phenothiazin-3-ylH)butanamide; -3-[(3-{[amino(2-thienyl)methylidene]amino}-benzyl)amino]-N-(4-anilinophenyl)propanamide; -N′-(4-{2-[(10H-phenothiazin-3-ylmethyl)amino]ethyl}phenyl-2-thiophene carboximidamide.

    摘要翻译： 本发明涉及在其骨架中包含氨基苯基胺，氧代二苯胺，咔唑，吩嗪，吩恶嗪或氧代二苯基基团的新型N-（亚氨基甲基）胺衍生物，它们作为药物和含有它们的药物组合物的用途。 本发明特别涉及以下化合物：-4 - {[2-噻吩基（亚氨基）甲基]氨基} -N- [2-（苯基氨基）苯基] - 苯丁酰胺; -4 - {[2-噻吩基（亚氨基）甲基]氨基} -N- [4-（苯基氨基）苯基] - 苯丁酰胺; -N - [4-（10H-吩噻嗪-2-基氧基）苯基] -2-噻吩甲酰胺; -4-（4 - {[氨基（2-噻吩基）亚甲基]氨基}苯基）-N-（10H-吩噻嗪-3-基）丁酰胺; -3 - [（3 - {[氨基（2-噻吩基）亚甲基]氨基} - 苄基）氨基] -N-（4-苯胺基苯基）丙酰胺; -N' - （4- {2 - [（10H-吩噻嗪-3-基甲基）氨基]乙基}苯基-2-噻吩甲脒。