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公开(公告)号:US08518951B2
公开(公告)日:2013-08-27
申请号:US13338726
申请日:2011-12-28
申请人: Dennis E. Hruby , Tove C. Bolken , Dongcheng Dai
发明人: Dennis E. Hruby , Tove C. Bolken , Dongcheng Dai
IPC分类号: A61K31/4965
CPC分类号: A61K31/496
摘要: Described herein are 4-methyl-piperazine-1-carbothioic acid amide derivatives and analogs, as well as compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by hemorrhagic fever viruses, such as Arenaviruses.
摘要翻译: 本文描述的是4-甲基 - 哌嗪-1-硫代羧酸酰胺衍生物和类似物以及含有它们的组合物,用于治疗或预防病毒感染和与之相关的疾病,特别是那些由出血热引起的病毒感染和相关疾病 病毒,如沙病毒属。
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公开(公告)号:US08492434B2
公开(公告)日:2013-07-23
申请号:US13402167
申请日:2012-02-22
申请人: Dennis E. Hruby , Tove C. Bolken , Sean Amberg , Dongcheng Dai
发明人: Dennis E. Hruby , Tove C. Bolken , Sean Amberg , Dongcheng Dai
IPC分类号: A61K31/34 , A61K31/38 , A61K31/195 , A61K31/16
CPC分类号: C07C251/86 , A61K31/165 , A61K31/343 , C07C251/76 , C07C251/82 , C07C2601/02 , C07C2601/14 , C07C2603/20 , C07D209/40 , C07D307/68 , C07D333/22 , C07D333/38 , Y02A50/387 , Y02A50/397
摘要: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, and Pichinde), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
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公开(公告)号:US08148428B2
公开(公告)日:2012-04-03
申请号:US12281081
申请日:2007-03-02
申请人: Dennis E. Hruby , Tove C. Bolken , Sean Amberg , Dongcheng Dai
发明人: Dennis E. Hruby , Tove C. Bolken , Sean Amberg , Dongcheng Dai
IPC分类号: A61K31/16
CPC分类号: C07C251/86 , A61K31/165 , A61K31/343 , C07C251/76 , C07C251/82 , C07C2601/02 , C07C2601/14 , C07C2603/20 , C07D209/40 , C07D307/68 , C07D333/22 , C07D333/38 , Y02A50/387 , Y02A50/397
摘要: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, and Pichinde), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
摘要翻译: 公开了通过施用治疗有效量的某些新化合物来治疗病毒感染的化合物,方法和药物组合物。 还公开了制备化合物的方法和使用该化合物的方法及其药物组合物。 特别地,公开了治疗和预防由出血热病毒引起的病毒感染,即,包括但不限于:链球菌科(Junin,Machupo,Guanarito,Sabia,Lassa,Tacaribe和Pichinde),丝状病毒科(埃博拉 马尔堡病毒),黄病毒科(黄热病,鄂木斯克出血热和Kyasanur森林病毒)和布尼瓦病毒(裂谷热)。
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公开(公告)号:US20110027227A1
公开(公告)日:2011-02-03
申请号:US12735392
申请日:2009-01-14
IPC分类号: A61K38/21 , A61K31/4184 , C07D403/04 , A61P31/14 , A61K39/00 , A61K31/7056 , A61K31/675 , C07D471/04 , A61K31/437
CPC分类号: C07D235/20 , A61K9/0014 , A61K9/0019 , A61K9/0073 , A61K9/0075 , A61K9/02 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4866 , A61K31/4184 , C07D471/04
摘要: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family is disclosed.
摘要翻译: 公开了通过施用治疗有效量的某些化合物来治疗病毒感染的化合物,方法和药物组合物。 还公开了制备化合物的方法和使用该化合物的方法及其药物组合物。 特别地,公开了由雷亚病毒家族引起的病毒感染的治疗和预防。
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公开(公告)号:US09199920B2
公开(公告)日:2015-12-01
申请号:US13402125
申请日:2012-02-22
申请人: Dennis E. Hruby , Tove C. Bolken , Sean M. Amberg , Dongcheng Dai
发明人: Dennis E. Hruby , Tove C. Bolken , Sean M. Amberg , Dongcheng Dai
IPC分类号: A61K31/16 , A61K31/34 , C07C251/86 , C07C243/36 , C07D333/24 , A61K31/165 , C07C251/76 , C07C251/82 , C07D209/40 , C07D307/68 , C07D333/22 , C07D333/38 , A61K31/343
CPC分类号: C07C251/86 , A61K31/165 , A61K31/343 , C07C251/76 , C07C251/82 , C07C2601/02 , C07C2601/14 , C07C2603/20 , C07D209/40 , C07D307/68 , C07D333/22 , C07D333/38 , Y02A50/387 , Y02A50/397
摘要: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, and Pichinde), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
摘要翻译: 公开了通过施用治疗有效量的某些新化合物来治疗病毒感染的化合物,方法和药物组合物。 还公开了制备化合物的方法和使用该化合物的方法及其药物组合物。 特别地,公开了治疗和预防由出血热病毒引起的病毒感染,即,包括但不限于:链球菌科(Junin,Machupo,Guanarito,Sabia,Lassa,Tacaribe和Pichinde),丝状病毒科(埃博拉 马尔堡病毒),黄病毒科(黄热病,鄂木斯克出血热和Kyasanur森林病毒)和布尼瓦病毒(裂谷热)。
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公开(公告)号:US08623347B2
公开(公告)日:2014-01-07
申请号:US12735392
申请日:2009-01-14
IPC分类号: A61K9/02 , A61K31/7056 , A61K31/437 , A61K31/4184 , A61K31/675 , A61K38/21 , A61K39/00
CPC分类号: C07D235/20 , A61K9/0014 , A61K9/0019 , A61K9/0073 , A61K9/0075 , A61K9/02 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/4866 , A61K31/4184 , C07D471/04
摘要: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by the Arenavirus family is disclosed.
摘要翻译: 公开了通过施用治疗有效量的某些化合物来治疗病毒感染的化合物,方法和药物组合物。 还公开了制备化合物的方法和使用该化合物的方法及其药物组合物。 特别地,公开了由雷亚病毒家族引起的病毒感染的治疗和预防。
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公开(公告)号:US20120107276A1
公开(公告)日:2012-05-03
申请号:US13338726
申请日:2011-12-28
申请人: Dennis E. Hruby , Tove C. Bolken , Dongcheng Dai
发明人: Dennis E. Hruby , Tove C. Bolken , Dongcheng Dai
IPC分类号: A61K31/495 , A61K31/7076 , A61P31/14 , A61K38/21 , A61K31/7056 , A61K31/7072 , A61K31/662
CPC分类号: A61K31/496
摘要: Described herein are 4-methyl-piperazine-1-carbothioic acid amide derivatives and analogs, as well as compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by hemorrhagic fever viruses, such as Arenaviruses.
摘要翻译: 本文描述的是4-甲基 - 哌嗪-1-硫代羧酸酰胺衍生物和类似物以及含有它们的组合物,用于治疗或预防病毒感染和与之相关的疾病,特别是那些由出血热引起的病毒感染和相关疾病 病毒,如沙病毒属。
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公开(公告)号:US20090036513A1
公开(公告)日:2009-02-05
申请号:US12281081
申请日:2007-03-02
申请人: Dennis E. Hruby , Tove C. Bolken , Sean Amberg , Dongcheng Dai
发明人: Dennis E. Hruby , Tove C. Bolken , Sean Amberg , Dongcheng Dai
IPC分类号: A61K31/381 , A61K31/34 , A61K31/165 , A61K31/40 , A61P31/00
CPC分类号: C07C251/86 , A61K31/165 , A61K31/343 , C07C251/76 , C07C251/82 , C07C2601/02 , C07C2601/14 , C07C2603/20 , C07D209/40 , C07D307/68 , C07D333/22 , C07D333/38 , Y02A50/387 , Y02A50/397
摘要: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, and Pichinde), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
摘要翻译: 公开了通过施用治疗有效量的某些新化合物来治疗病毒感染的化合物,方法和药物组合物。 还公开了制备化合物的方法和使用该化合物的方法及其药物组合物。 特别地,公开了治疗和预防由出血热病毒引起的病毒感染,即,包括但不限于:链球菌科(Junin,Machupo,Guanarito,Sabia,Lassa,Tacaribe和Pichinde),丝状病毒科(埃博拉 马尔堡病毒),黄病毒科(黄热病,鄂木斯克出血热和Kyasanur森林病毒)和布尼瓦病毒(裂谷热)。
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公开(公告)号:US20090180980A1
公开(公告)日:2009-07-16
申请号:US12162395
申请日:2007-01-31
申请人: Dennis E. Hruby , Tove C. Bolken , Dongcheng Dai
发明人: Dennis E. Hruby , Tove C. Bolken , Dongcheng Dai
IPC分类号: A61K31/496 , A61P31/12 , A61K31/7072 , A61K31/52 , A61K31/7064 , A61K31/662 , A61K38/21 , A61K31/708
CPC分类号: A61K31/496
摘要: Described herein are 4-methyl-piperazine-1-carbothioic acid amide derivatives and analogs, as well as compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by hemorrhagic fever viruses, such as Arenaviruses.
摘要翻译: 本文描述的是4-甲基 - 哌嗪-1-硫代羧酸酰胺衍生物和类似物以及含有它们的组合物,用于治疗或预防病毒感染和与之相关的疾病,特别是那些由出血热引起的病毒感染和相关疾病 病毒,如沙病毒属。
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公开(公告)号:US20130165493A1
公开(公告)日:2013-06-27
申请号:US13402167
申请日:2012-02-22
申请人: Dennis E. Hruby , Tove C. Bolken , Sean M. Amberg , Dongcheng Dai
发明人: Dennis E. Hruby , Tove C. Bolken , Sean M. Amberg , Dongcheng Dai
IPC分类号: C07D333/38 , C07D307/68 , C07D333/24 , C07C243/36 , C07D209/40
CPC分类号: C07C251/86 , A61K31/165 , A61K31/343 , C07C251/76 , C07C251/82 , C07C2601/02 , C07C2601/14 , C07C2603/20 , C07D209/40 , C07D307/68 , C07D333/22 , C07D333/38 , Y02A50/387 , Y02A50/397
摘要: Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed. In particular, the treatment and prophylaxis of viral infections such as caused by hemorrhagic fever viruses is disclosed, i.e., including but not limited to, Arenaviridae (Junin, Machupo, Guanarito, Sabia, Lassa, Tacaribe, and Pichinde), Filoviridae (Ebola and Marburg viruses), Flaviviridae (yellow fever, Omsk hemorrhagic fever and Kyasanur Forest disease viruses), and Bunyaviridae (Rift Valley fever).
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