公开(公告)号：US20060148012A1

公开(公告)日：2006-07-06

申请号：US10537309

申请日：2003-12-01

申请人： Derek Brown ,  Lisa Butler ,  Karen Cromie ,  Meryn Griffiths ,  Alstair Lawson ,  Daniel Lightwood

发明人： Derek Brown ,  Lisa Butler ,  Karen Cromie ,  Meryn Griffiths ,  Alstair Lawson ,  Daniel Lightwood

IPC分类号： G01N33/574

CPC分类号： C07K16/243 ,  C07K16/245 ,  G01N33/56972 ,  G01N33/582 ,  G01N33/6854

摘要： The present invention provides a homogeneous assay for identifying an antibody producing cell producing an antibody which binds to a selected antigen comprising: a) providing a population of antibody producing cells; b) incubating said population of antibody producing cells with a selected antigen and a labeled anti-antibody antibody, wherein said anti-antibody antibody is capable of distinguishing cells producing an antibody which binds to the selected antigen from those cells which do not; and c) identifying an antibody producing cell capable of producing an antibody which binds to the selected antigen.

摘要翻译： 本发明提供用于鉴定产生与所选抗原结合的抗体的产生抗体的细胞的均质测定法，包括：a）提供抗体产生细胞群; b）将所述抗体产生细胞群与所选择的抗原和标记的抗体抗体一起孵育，其中所述抗体抗体能够区分产生与所选抗原结合的抗体的细胞， 和c）鉴定能产生结合所选抗原的抗体的抗体产生细胞。

公开(公告)号：US20050114174A1

公开(公告)日：2005-05-26

申请号：US10722009

申请日：2003-11-25

申请人： Gary Raden ,  Eduardo Melo ,  Tolga Ekmekci ,  Thomas Soemo ,  Lisa Butler ,  Richard Moerloos

发明人： Gary Raden ,  Eduardo Melo ,  Tolga Ekmekci ,  Thomas Soemo ,  Lisa Butler ,  Richard Moerloos

IPC分类号： H04L12/24 ,  G06F17/60

CPC分类号： G06Q50/22 ,  G06F19/00 ,  H04L41/0681 ,  H04L43/0817 ,  Y10S707/99935

摘要： The present invention leverages a data gathering service to provide information regarding a system's health state via a computing entity, local and/or remote. This provides an optimized means to aggregate a single network's data and/or multiple networks' data, decreasing the amount of effort required by system administrators to manage health related alerts. In one instance of the present invention, a data gathering service aggregates health data from systems and provides access to this information via a communication means. In another instance of the present invention, aggregated, averaged data is utilized to provide manual and/or automatic control and/or management facilitation of health monitoring related tasks.

摘要翻译： 本发明利用数据收集服务来经由本地和/或远程的计算实体提供关于系统的健康状态的信息。 这提供了聚合单个网络数据和/或多个网络数据的优化方法，减少了系统管理员管理与健康相关的警报所需的工作量。 在本发明的一个实例中，数据收集服务聚集来自系统的健康数据，并且经由通信装置提供对该信息的访问。 在本发明的另一个实例中，利用汇总的平均数据来提供对健康监控相关任务的手动和/或自动控制和/或管理。

公开(公告)号：US20060009527A1

公开(公告)日：2006-01-12

申请号：US11223547

申请日：2005-09-09

申请人： Victoria Richon ,  Paul Marks ,  Richard Rifkind ,  Lisa Butler

发明人： Victoria Richon ,  Paul Marks ,  Richard Rifkind ,  Lisa Butler

IPC分类号： A61K31/19

CPC分类号： A61K31/4406 ,  A61K31/00 ,  A61K31/12 ,  A61K31/121 ,  A61K31/16 ,  A61K31/165 ,  A61K31/166 ,  A61K31/19 ,  A61K31/192 ,  A61K38/12 ,  A61K38/15

摘要： The present invention provides a novel method for treating and/or preventing thioredoxin (TRX)-mediated diseases and conditions, by administering to a subject in need of such treatment a therapeutically effective amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof. The HDAC inhibitor can alter the expression of a thioredoxin-binding-protein (e.g. TBP-2), which in turn can lead to an altered TRX/thioredoxin-binding-protein cellular binding interaction, resulting in an increase or decrease in the level or activity of cellular TRX, for example the expression level or reducing activity of TRX. Thus the present invention relates to the use of HDAC inhibitors in a method of preventing and/or treating a wide variety of thioredoxin (TRX)-mediated diseases and conditions, such as inflammatory diseases, allergic diseases, autoimmune diseases, diseases associated with oxidative stress or diseases characterized by cellular hyperproliferation.

公开(公告)号：US20050114502A1

公开(公告)日：2005-05-26

申请号：US10721727

申请日：2003-11-25

申请人： Gary Raden ,  Eduardo Fonseca Melo ,  Tolga Ekmekci ,  Thomas Soemo ,  Lisa Butler ,  Richard Moerloos

发明人： Gary Raden ,  Eduardo Fonseca Melo ,  Tolga Ekmekci ,  Thomas Soemo ,  Lisa Butler ,  Richard Moerloos

IPC分类号： G06F15/173 ,  G06F17/00

CPC分类号： G06F11/3006 ,  G06F11/3055 ,  G06F11/328 ,  G06F11/3495 ,  H04L43/0817 ,  H04L43/0882 ,  Y10S707/99935

摘要： The present invention leverages a data gathering service to provide information regarding a network system's health, performance and/or utilization via a computing entity, local and/or remote. This provides an optimized means to aggregate a single network's data and/or multiple networks' data, decreasing the amount of effort required by system administrators to keep a network operational and/or to provide control of its utilization and/or update a system's state. In one instance of the present invention, a data gathering service aggregates data from systems and provides access to this information via a communication means. In another instance of the present invention, aggregated data is utilized to provide manual and/or automatic control of one or more aspects of a system's utilization by an entity and/or a person. In yet another instance of the present invention, aggregated utilization data is employed to provide a management/productivity tool for end-users of a networked system.

摘要翻译： 本发明利用数据收集服务来通过本地和/或远程的计算实体提供关于网络系统的健康，性能和/或利用的信息。 这提供了优化的手段来聚合单个网络的数据和/或多个网络的数据，减少系统管理员为保持网络运行所需的工作量和/或提供其利用率和/或更新系统状态的控制。 在本发明的一个实例中，数据收集服务聚合来自系统的数据，并且经由通信装置提供对该信息的访问。 在本发明的另一个实例中，聚合数据被用于提供由实体和/或个人对系统利用的一个或多个方面的手动和/或自动控制。 在本发明的另一个实例中，采用聚合利用数据来为网络系统的终端用户提供管理/生产力工具。

公开(公告)号：US07993864B2

公开(公告)日：2011-08-09

申请号：US10537309

申请日：2003-12-01

申请人： Derek Thomas Brown ,  Lisa Butler ,  Karen Dorothy Cromie ,  Meryn Ruth Griffiths ,  Alastair David Griffiths Lawson ,  Daniel John Lightwood

发明人： Derek Thomas Brown ,  Lisa Butler ,  Karen Dorothy Cromie ,  Meryn Ruth Griffiths ,  Alastair David Griffiths Lawson ,  Daniel John Lightwood

IPC分类号： C12P21/08 ,  G01N33/53

CPC分类号： C07K16/243 ,  C07K16/245 ,  G01N33/56972 ,  G01N33/582 ,  G01N33/6854

摘要： The present invention provides a homogeneous assay for identifying an antibody producing cell producing an antibody which binds to a selected antigen comprising: a) providing a population of antibody producing cells; b) incubating said population of antibody producing cells with a selected antigen and a labeled anti-antibody antibody, wherein said anti-antibody antibody is capable of distinguishing cells producing an antibody which binds to the selected antigen from those cells which do not; and c) identifying an antibody producing cell capable of producing an antibody which binds to the selected antigen.

摘要翻译： 本发明提供用于鉴定产生与所选抗原结合的抗体的产生抗体的细胞的均质测定法，包括：a）提供抗体产生细胞群; b）将所述抗体产生细胞群与所选择的抗原和标记的抗体抗体一起孵育，其中所述抗体抗体能够区分产生与所选抗原结合的抗体的细胞， 和c）鉴定能产生结合所选抗原的抗体的抗体产生细胞。

公开(公告)号：US20060009526A1

公开(公告)日：2006-01-12

申请号：US11223405

申请日：2005-09-09

申请人： Victoria Richon ,  Paul Marks ,  Richard Rifkind ,  Lisa Butler

发明人： Victoria Richon ,  Paul Marks ,  Richard Rifkind ,  Lisa Butler

IPC分类号： A61K31/19

CPC分类号： A61K31/4406 ,  A61K31/00 ,  A61K31/12 ,  A61K31/121 ,  A61K31/16 ,  A61K31/165 ,  A61K31/166 ,  A61K31/19 ,  A61K31/192 ,  A61K38/12 ,  A61K38/15

摘要： The present invention provides a novel method for treating and/or preventing thioredoxin (TRX)-mediated diseases and conditions, by administering to a subject in need of such treatment a therapeutically effective amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof. The HDAC inhibitor can alter the expression of a thioredoxin-binding-protein (e.g. TBP-2), which in turn can lead to an altered TRX/thioredoxin-binding-protein cellular binding interaction, resulting in an increase or decrease in the level or activity of cellular TRX, for example the expression level or reducing activity of TRX. Thus the present invention relates to the use of HDAC inhibitors in a method of preventing and/or treating a wide variety of thioredoxin (TRX)-mediated diseases and conditions, such as inflammatory diseases, allergic diseases, autoimmune diseases, diseases associated with oxidative stress or diseases characterized by cellular hyperproliferation.

公开(公告)号：US20050114501A1

公开(公告)日：2005-05-26

申请号：US10721726

申请日：2003-11-25

申请人： Gary Raden ,  Eduardo Fonseca Melo ,  Tolga Ekmekci ,  Thomas Soemo ,  Lisa Butler ,  Richard Moerloos

发明人： Gary Raden ,  Eduardo Fonseca Melo ,  Tolga Ekmekci ,  Thomas Soemo ,  Lisa Butler ,  Richard Moerloos

IPC分类号： G06F15/16 ,  G06F15/173

CPC分类号： H04L43/14 ,  H04L41/22 ,  H04L43/02 ,  H04L43/0805 ,  H04L43/0876 ,  H04L43/16 ,  H04L67/306 ,  Y10S707/99935

摘要： The present invention leverages a data gathering service to provide information regarding a network system's health, performance and/or utilization via a computing entity, local and/or remote. This provides an optimized means to aggregate a single network's data and/or multiple networks' data, decreasing the amount of effort required by system administrators to keep a network operational and/or to provide control of its utilization and/or update a system's state. In one instance of the present invention, a data gathering service aggregates data from systems and provides access to this information via a communication means. In another instance of the present invention, aggregated data is utilized to provide manual and/or automatic control of one or more aspects of a system's utilization and/or state by an entity and/or a person.

摘要翻译： 本发明利用数据收集服务来通过本地和/或远程的计算实体提供关于网络系统的健康，性能和/或利用的信息。 这提供了优化的手段来聚合单个网络的数据和/或多个网络的数据，减少系统管理员为保持网络运行所需的工作量和/或提供其利用率和/或更新系统状态的控制。 在本发明的一个实例中，数据收集服务聚合来自系统的数据，并且经由通信装置提供对该信息的访问。 在本发明的另一个实例中，聚合数据被用于为实体和/或个人提供系统的利用和/或状态的一个或多个方面的手动和/或自动控制。