公开(公告)号：US06287801B1

公开(公告)日：2001-09-11

申请号：US08681192

申请日：1996-07-22

申请人： Derk Bergsma ,  Nabil Elshourbagy ,  Henry Sarau ,  Steven Ruben

发明人： Derk Bergsma ,  Nabil Elshourbagy ,  Henry Sarau ,  Steven Ruben

IPC分类号： C12N1512

CPC分类号： G01N33/68 ,  A61K38/00 ,  C07K14/705 ,  C12N2799/026 ,  G01N2333/726 ,  G01N2500/00

摘要： Human G-Protein Coupled Receptor HNFDS78 polypeptides and DNA (RNA) encoding such G-Protein Coupled Receptor HNFDS78 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such G-Protein Coupled Receptor HNFDS78 for the treatment of diseases, such as, atherosclerosis, inflammatory disease, and infectious disease. Antagonists against such G-Protein Coupled Receptor HNFDS78 and their use as a therapeutic to treat disease are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding G-protein coupled receptors and for detecting altered levels of the polypeptide in a host.

摘要翻译： 公开了人G-蛋白偶联受体HNFDS78多肽和编码这种G蛋白偶联受体HNFDS78的DNA（RNA）和通过重组技术产生此类多肽的方法。 还公开了利用这种G蛋白偶联受体HNFDS78用于治疗疾病如动脉粥样硬化，炎性疾病和感染性疾病的方法。 还公开了抗这种G蛋白偶联受体HNFDS78的拮抗剂及其作为治疗疾病的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码G蛋白偶联受体的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定法。

公开(公告)号：US20070275895A1

公开(公告)日：2007-11-29

申请号：US11738846

申请日：2007-04-23

申请人： D. Duan ,  Steven Ruben

发明人： D. Duan ,  Steven Ruben

IPC分类号： C07K14/435 ,  A61K38/17 ,  A61P15/00 ,  A61P19/00 ,  C12N15/63 ,  C12P21/00 ,  C12N5/10 ,  C07K16/18 ,  A61P35/00 ,  C07H21/04

CPC分类号： C07K14/4703 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/021 ,  C12N2799/026

摘要： The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.

摘要翻译： 本发明涉及作为抑制素相关蛋白家族成员的新型卵泡抑素-3蛋白。 特别地，提供编码人卵泡抑素-3蛋白的分离的核酸分子。 还提供了Follistatin-3多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定卵泡抑素-3活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测生殖系统相关疾病和细胞生长和分化调节紊乱的诊断方法以及用于治疗生殖系统相关疾病和调节细胞生长和分化的紊乱的治疗方法。

公开(公告)号：US20070048818A1

公开(公告)日：2007-03-01

申请号：US10868184

申请日：2004-06-16

申请人： Craig Rosen ,  Steven Ruben ,  George Komatsoulis

发明人： Craig Rosen ,  Steven Ruben ,  George Komatsoulis

IPC分类号： C07K14/47 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20070020277A1

公开(公告)日：2007-01-25

申请号：US11532050

申请日：2006-09-14

申请人： Henrik Olsen ,  Steven Ruben

发明人： Henrik Olsen ,  Steven Ruben

IPC分类号： A61K48/00 ,  C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  A61K39/395 ,  C07K14/82

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： The present invention relates to a novel protein, the Human Oncogene Induced Secreted Protein I (“HOIPS I”) protein. In particular, isolated nucleic acid molecules are provided encoding the human HOIPS I protein. HOIPS I polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Antibodies to human HOIPS I are also provided, as are diagnostic methods for detecting abnormal cell proliferation and differentiation disorders and therapeutic methods for treating the same.

摘要翻译： 本发明涉及一种新的蛋白质，即人癌基因诱导的分泌蛋白I（“HOIPS I”）蛋白质。 特别地，提供编码人HOIPS I蛋白的分离的核酸分子。 还提供HOIPS I多肽，载体，宿主细胞和用于制备其的重组方法。 还提供了人HOIPS I的抗体，以及用于检测异常细胞增殖和分化障碍的诊断方法以及用于治疗它们的治疗方法。

公开(公告)号：US20070015162A1

公开(公告)日：2007-01-18

申请号：US10670185

申请日：2003-09-25

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N5/06

CPC分类号： C12Q1/6883 ,  C07K14/47 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2500/04 ,  G01N2800/24

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating allergic and asthmatic disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗过敏性和哮喘性疾病。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20060246483A1

公开(公告)日：2006-11-02

申请号：US11366486

申请日：2006-03-03

申请人： Craig Rosen ,  Steven Ruben

发明人： Craig Rosen ,  Steven Ruben

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C07K14/47 ,  C07K16/18

CPC分类号： C07K14/47

摘要： The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cardiovascular diseases, disorders, and/or conditions related thereto. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.

摘要翻译： 本发明涉及人分泌的多肽，以及编码所述多肽的分离的核酸分子，其可用于诊断和治疗与之有关的心血管疾病，病症和/或病症。 结合这些多肽的抗体也包括在本发明中。 本发明还包括载体，宿主细胞，以及用于产生所述多核苷酸，多肽和/或抗体的重组和合成方法。 本发明还包括用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还包括用于抑制或增强本发明多肽的产生和功能的方法和组合物。

公开(公告)号：US20060166327A1

公开(公告)日：2006-07-27

申请号：US11389101

申请日：2006-03-27

申请人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

发明人： Daniel Soppet ,  Yi Li ,  Craig Rosen ,  Steven Ruben

IPC分类号： C07H21/04 ,  C12P21/06 ,  C07K14/705

CPC分类号： C07K14/7158 ,  A61K38/00 ,  C07K14/723

摘要： Human G-protein coupled receptor polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed were methods for utilizing such polypeptides for identifying antagonists and agonists to such polypeptides and methods of using the agonists and antagonists therapeutically to treat conditions related to the underexpression and overexpression of the G-protein coupled receptor polypeptides, respectively. Also disclosed are diagnostic methods for detecting a mutation in the G-protein coupled receptor nucleic acid sequences and an altered level of the soluble form of the receptors.

公开(公告)号：US20060099575A9

公开(公告)日：2006-05-11

申请号：US09949925

申请日：2001-09-12

申请人： Steven Ruben ,  Ann Ferrie ,  Craig Rosen ,  Kimberly Florence ,  Kenneth Carter ,  Daniel Soppet ,  Guo-Liang Yu ,  Charles Florence ,  Paul Young ,  Jian Ni ,  Gregory Endress ,  Ping Feng ,  Fouad Janat ,  Charles Birse

发明人： Steven Ruben ,  Ann Ferrie ,  Craig Rosen ,  Kimberly Florence ,  Kenneth Carter ,  Daniel Soppet ,  Guo-Liang Yu ,  Charles Florence ,  Paul Young ,  Jian Ni ,  Gregory Endress ,  Ping Feng ,  Fouad Janat ,  Charles Birse

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07K14/47

CPC分类号： C07K14/47

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20060062789A1

公开(公告)日：2006-03-23

申请号：US11266444

申请日：2005-11-04

申请人： Steven Ruben ,  Steven Barash ,  Gil Choi ,  Tristan Vaughan ,  David Hilbert

发明人： Steven Ruben ,  Steven Barash ,  Gil Choi ,  Tristan Vaughan ,  David Hilbert

IPC分类号： C07K16/24 ,  A61K39/395 ,  G01N33/53

CPC分类号： C07K14/70575 ,  A61K47/6849 ,  A61K49/0004 ,  A61K2039/505 ,  C07K14/52 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/622 ,  G01N33/564

摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.

公开(公告)号：US20060003378A1

公开(公告)日：2006-01-05

申请号：US11214796

申请日：2005-08-31

申请人： Paul Young ,  Steven Ruben ,  Craig Rosen ,  Henrik Olsen

发明人： Paul Young ,  Steven Ruben ,  Craig Rosen ,  Henrik Olsen

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention related to three novel recognition protein expressed by keratinocytes, wound-healing tissues and chondrosarcoma tissue. More specifically, isolated nucleic acid molecules are provided encoding human peptidoglycan recognition protein-related proteins, referred to herein as PGRP-K (Keratinocytes), PGRP-W (Wound-healing), and PGRP-C (Chondrosarcoma) of FIGS. 1A-B, FIGS. 2A-C, and FIG. 3, respectively, each having homology to both human peptidoglycan recognition protein (PGRP) as well as murine Tag-7. PGRP-K, PGRP-W, and PGRP-C polypeptides are also provided. Further provided are vectors, host cells and recombinant methods for producing the same. The invention also relates to both the inhibition and enhancement of activities of PGRP-K, PGRP-W, and PGRP-C polypeptides and diagnostic methods for detecting PGRP-K, PGRP-W, and PGRP-C gene expression.

摘要翻译： 本发明涉及由角质形成细胞，伤口愈合组织和软骨肉瘤组织表达的三种新型识别蛋白。 更具体地，提供分离的核酸分子，其编码人胶原聚糖识别蛋白相关蛋白（本文称为PGRP-K（角质形成细胞），PGRP-W（伤口愈合）和PGRP-C（软骨肉瘤））。 图1A-B， 图2A-C， 3，分别与人肽聚糖识别蛋白（PGRP）以及鼠Tag-7都具有同源性。 还提供了PGRP-K，PGRP-W和PGRP-C多肽。 进一步提供载体，宿主细胞和用于制备其的重组方法。 本发明还涉及PGRP-K，PGRP-W和PGRP-C多肽的活性的抑制和增强以及用于检测PGRP-K，PGRP-W和PGRP-C基因表达的诊断方法。