公开(公告)号：US20240074682A1

公开(公告)日：2024-03-07

申请号：US18241658

申请日：2023-09-01

Applicant: DexCom, Inc.

Inventor： Berta Esteban Fernandez de Avila ,  Devon M. Headen ,  Stacy Hunt DuVall ,  Jiong Zou ,  Shane Richard Parnell ,  Nicholas Vincent Apollo ,  Joshua Ray Windmiller

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/318

CPC classification number: A61B5/14546 ,  A61B5/14865 ,  A61B5/318 ,  A61B5/6847

Abstract: Devices and methods for measuring a concentration of a target analyte in a biological fluid in vivo are provided herein. In some examples, a device includes an indwelling sensor and sensor electronics. The sensor may include a substrate; a first electrode disposed on the substrate; an ionophore disposed on the substrate to selectively transport the target ion to or within the first electrode; and a second electrode disposed on the substrate. The sensor electronics is configured to generate a signal corresponding to an electromotive force which is at least partially based on a potential difference that is generated between the first electrode and the second electrode responsive to the ionophore transporting the target ion to the first electrode.

公开(公告)号：US20250025076A1

公开(公告)日：2025-01-23

申请号：US18399162

申请日：2023-12-28

Applicant: DexCom, Inc.

Inventor： Shuyu Lin ,  Daiting Rong ,  Stacy Hunt DuVall ,  Wenjie Lan ,  Jason M. Halac ,  Jiong Zou ,  Devon M. Headen ,  Shanger Wang ,  Shane Richard Parnell ,  Berta Esteban Fernandez de Avila ,  Shannon Reuben Woodruff

IPC: A61B5/1473

Abstract: An analyte monitoring sensor configured for in vivo measurement of at least one analyte is provided, the sensor comprising a substrate having a substrate surface, an aptamer protective layer encapsulating at least a portion of the substrate surface, the aptamer protective layer permeable to the at least one analyte, one or more aptamer conjugates associated with at least a portion of the substrate surface and positioned between the aptamer protective layer and the substrate for obtaining measurements related to the at least one analyte in vivo. Methods of extending in vivo performance of the analyte monitoring sensor are also described.

公开(公告)号：US20230301553A1

公开(公告)日：2023-09-28

申请号：US18185455

申请日：2023-03-17

Applicant: Dexcom, Inc.

Inventor： Daiting Rong ,  Xiong Peng ,  Nicholas Vincent Apollo ,  Jonathan M. Hughes ,  Wenjie Lan ,  Chris W, Dring ,  Shane Richard Parnell ,  Ryan Lee Knoy ,  Peter C. Simpson ,  Joshua Ray Windmiller ,  Nai-Jen Chang ,  Jie Zhu ,  Matthew S. Brown ,  Eric Ruike Zhao

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/256 ,  A61B5/257

CPC classification number: A61B5/1451 ,  A61B5/14865 ,  A61B5/14532 ,  A61B5/256 ,  A61B5/257 ,  A61B5/14546

Abstract: Disclosed herein are systems and methods for a continuous analyte monitoring system for measuring a concentration of a first analyte and concentration of a second analyte in a host. One such system utilizes a working electrode and a reference electrode to measure glucose concentration and oxygen concentration in bodily fluid of a host. The system includes a sensor control circuit that applies a first bias condition to the sensor to measure a first signal generated by the sensor indicative of a concentration of the first analyte. The sensor control circuit also applies a second bias condition to the sensor to measure a second signal generated by the sensor indicative of a concentration of a second analyte at the host.

公开(公告)号：US20230073214A1

公开(公告)日：2023-03-09

申请号：US17945585

申请日：2022-09-15

Applicant: DexCom, Inc.

Inventor： Shanger Wang ,  Mahender Nath Avula ,  Chris Dring ,  Ted Tang Lee ,  Xiangyou Liu ,  Shane Richard Parnell ,  Jiong Zou

IPC: A61K9/00 ,  A61B5/145 ,  A61B5/1486 ,  A61K31/573

Abstract: The present disclosure relates generally to bioactive releasing membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the disclosure relates to novel bioactive releasing membranes, to devices and implantable devices including these membranes, methods for forming the bioactive releasing membranes on or around the implantable devices, and to methods for monitoring analyte levels in a biological fluid sample using an implantable analyte detection device.

公开(公告)号：US20220296867A1

公开(公告)日：2022-09-22

申请号：US17697701

申请日：2022-03-17

Applicant: DexCom, Inc.

Inventor： Mahender Nath Avula ,  Chris Dring ,  Ted Tang Lee ,  Xiangyou Liu ,  Shane Richard Parnell ,  Shanger Wang ,  Jiong Zou

IPC: A61M31/00 ,  A61B5/145

Abstract: The present disclosure relates generally to drug releasing membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the disclosure relates to novel drug releasing membranes, to devices and implantable devices including these membranes, methods for forming the drug releasing membranes on or around the implantable devices, and to methods for monitoring analyte levels in a biological fluid sample using an implantable analyte detection device.