公开(公告)号：US20240252074A1

公开(公告)日：2024-08-01

申请号：US18425940

申请日：2024-01-29

Applicant: Dexcom, Inc.

Inventor： Sebastian Böhm ,  Anna Harley-Trochimczyk ,  Daiting Rong ,  Rui Ma ,  Wenjie Lan ,  Minglian Shi ,  Disha Sheth ,  Nicholas Kalfas ,  Vincent Crabtree ,  Kamuran Turksoy

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/0537 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1486 ,  G01N27/02 ,  G01N27/22 ,  G01N27/24 ,  G01N33/487

CPC classification number: A61B5/1495 ,  A61B5/0537 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6844 ,  G01N27/221 ,  G01N27/24 ,  G01N33/48707 ,  A61B5/0004 ,  A61B5/0031 ,  A61B2560/0223 ,  A61B2560/0252 ,  A61B2560/0276 ,  G01N27/026

Abstract: Various examples are directed to systems and methods of and using analyte sensors. An example analyte sensor system comprises an analyte sensor and a hardware device in communication with the analyte sensor. The hardware device may be configured to perform operations comprising applying a first bias voltage to the analyte sensor, the first bias voltage less than an operational bias voltage of the analyte sensor, measuring a first current at the analyte sensor when the first bias voltage is applied, and applying a second bias voltage to the analyte sensor. The operations may further comprise measuring a second current at the analyte sensor when the second bias voltage is applied, detecting a plateau bias voltage using the first current and the second current, determining that the plateau bias voltage is less than a plateau bias voltage threshold, and executing a responsive action at the analyte sensor.

公开(公告)号：US20200205705A1

公开(公告)日：2020-07-02

申请号：US16728945

申请日：2019-12-27

Applicant: DexCom, Inc.

Inventor： Ted Tang Lee ,  Anna Leigh Davis ,  Peter C. Simpson ,  Liang Wang ,  Shanger Wang ,  Jiong Zou ,  Stephen J. Vanslyke ,  Rui Ma ,  Wenjie Lan

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1473

Abstract: Various examples described herein are directed to systems, apparatuses, and methods for mitigating break-in in an analyte sensor. An example analyte sensor system comprises an analyte sensor applicator comprising a needle; an analyte sensor comprising at least a working electrode and a reference electrode, the analyte sensor positioned at least partially within a lumen of the needle; and a hydrating agent positioned within the lumen of the needle to at least partially hydrate the needle.

公开(公告)号：US20240423518A1

公开(公告)日：2024-12-26

申请号：US18828569

申请日：2024-09-09

Applicant: Dexcom, Inc.

Inventor： Sebastian Böhm ,  Anna Harley-Trochimczyk ,  Daiting Rong ,  Rui Ma ,  Wenjie Lan ,  Minglian Shi ,  Disha Sheth

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/0537 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1486 ,  G01N27/02 ,  G01N27/22 ,  G01N27/24 ,  G01N33/487

Abstract: Various examples are directed to systems and methods for operating an analyte sensor system using sensor electronics. An example method may comprise applying a bias voltage change to an analyte sensor bias voltage and measuring a current value for each of a plurality of time periods after application of the bias voltage change. The example method may also comprise determining an estimated impedance using the current values for the plurality of time periods and determining a characteristic of the analyte sensor using the estimated impedance. The example method may further comprise receiving from the analyte sensor a signal indicative of an analyte concentration, and determining an estimated analyte concentration level using the determined characteristic of the analyte sensor and the received signal.

公开(公告)号：US11638543B2

公开(公告)日：2023-05-02

申请号：US16929906

申请日：2020-07-15

Applicant: DexCom, Inc.

Inventor： Sebastian Bohm ,  Wenjie Lan ,  Thomas Robert Porter ,  Daiting Rong ,  Jason Halac

IPC: A61B5/1468 ,  A61B5/145 ,  C09D133/08

Abstract: Various examples are directed to a glucose sensor comprising a working electrode to support an oxidation reaction and a reference electrode to support a redox reaction. The reference electrode may comprise silver and silver chloride. The Glucose sensor may also comprise an anti-mineralization agent positioned at the reference electrode to reduce formation of calcium carbonate at the reference electrode.

公开(公告)号：US12114975B2

公开(公告)日：2024-10-15

申请号：US16728652

申请日：2019-12-27

Applicant: DexCom, Inc.

Inventor： Sebastian Bohm ,  Anna Claire Harley-Trochimczyk ,  Daiting Rong ,  Rui Ma ,  Wenjie Lan ,  Minglian Shi ,  Disha B. Sheth

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/0537 ,  A61B5/145 ,  A61B5/1473 ,  A61B5/1486 ,  G01N27/02 ,  G01N27/22 ,  G01N27/24 ,  G01N33/487

CPC classification number: A61B5/1495 ,  A61B5/0537 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6844 ,  G01N27/221 ,  G01N27/24 ,  G01N33/48707 ,  A61B5/0004 ,  A61B5/0031 ,  A61B2560/0223 ,  A61B2560/0252 ,  A61B2560/0276 ,  G01N27/026

Abstract: Various examples are directed to systems and methods for operating an analyte sensor system using sensor electronics. An example method may comprise applying a bias voltage change to an analyte sensor bias voltage and measuring a current value for each of a plurality of time periods after application of the bias voltage change. The example method may also comprise determining an estimated impedance using the current values for the plurality of time periods and determining a characteristic of the analyte sensor using the estimated impedance. The example method may further comprise receiving from the analyte sensor a signal indicative of an analyte concentration, and determining an estimated analyte concentration level using the determined characteristic of the analyte sensor and the received signal.

公开(公告)号：US20230064744A1

公开(公告)日：2023-03-02

申请号：US17899135

申请日：2022-08-30

Applicant: Dexcom, Inc.

Inventor： Samuel Isaac Epstein ,  Devon Headen ,  Avid Najdahmadi ,  Joseph J Baker ,  Kevin Cheng ,  Nicholas Vincent Apollo ,  Berta Esteban Fernandez de Avila ,  Daud Abd al-Malik Zoss ,  Wenjie Lan

IPC: A61B5/00 ,  A61B5/369

Abstract: An augmented analyte monitoring system is described. The augmented analyte monitoring system includes a wearable analyte monitoring device that includes a transmitter and an analyte sensor to obtain analyte data of a user, and an analyte augmentation wearable that includes one or more sensors (e.g., physical and/or biochemical sensors) to obtain additional physiological data for augmenting the analyte data of the user. The analyte augmentation wearable is communicably coupled to the wearable analyte monitoring device. The augmented analyte monitoring system further includes a sensor hub implemented at a computing device to obtain a data packet containing both the analyte data and the additional physiological data from at least one of the wearable analyte monitoring device or the analyte augmentation wearable, and augment the analyte data by storing the analyte data in association with the additional physiological data.

公开(公告)号：US20250025076A1

公开(公告)日：2025-01-23

申请号：US18399162

申请日：2023-12-28

Applicant: DexCom, Inc.

Inventor： Shuyu Lin ,  Daiting Rong ,  Stacy Hunt DuVall ,  Wenjie Lan ,  Jason M. Halac ,  Jiong Zou ,  Devon M. Headen ,  Shanger Wang ,  Shane Richard Parnell ,  Berta Esteban Fernandez de Avila ,  Shannon Reuben Woodruff

IPC: A61B5/1473

Abstract: An analyte monitoring sensor configured for in vivo measurement of at least one analyte is provided, the sensor comprising a substrate having a substrate surface, an aptamer protective layer encapsulating at least a portion of the substrate surface, the aptamer protective layer permeable to the at least one analyte, one or more aptamer conjugates associated with at least a portion of the substrate surface and positioned between the aptamer protective layer and the substrate for obtaining measurements related to the at least one analyte in vivo. Methods of extending in vivo performance of the analyte monitoring sensor are also described.

公开(公告)号：US20240389908A1

公开(公告)日：2024-11-28

申请号：US18673130

申请日：2024-05-23

Applicant: Dexcom, Inc.

Inventor： Nicholas Vincent Apollo ,  Jonathon Clemens ,  Wenjie Lan ,  Chris Dring

IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/1486

Abstract: Analyte monitoring device calibration is described. A calibration system generates calibration results for multiple analyte monitoring devices during a calibration evaluation process. To do so, the calibration system implements a calibration board that includes a single ground electrode shared by, but not physically connected to, the multiple analyte monitoring devices. An input voltage is applied to an analyte-sensing element of each of the multiple analyte monitoring devices. Analyte-sensing elements and the common ground electrode are placed into/in contact with a reference bath that includes a known concentration of an analyte to be measured. The input voltage causes each analyte-sensing element to generate an electrical current that is indicative of the reference bath analyte concentration. The calibration system includes a current meter that monitors the electrical current generated by each of the multiple analyte monitoring devices, which is interpreted by the calibration system to generate the calibration results.

公开(公告)号：US20230301553A1

公开(公告)日：2023-09-28

申请号：US18185455

申请日：2023-03-17

Applicant: Dexcom, Inc.

Inventor： Daiting Rong ,  Xiong Peng ,  Nicholas Vincent Apollo ,  Jonathan M. Hughes ,  Wenjie Lan ,  Chris W, Dring ,  Shane Richard Parnell ,  Ryan Lee Knoy ,  Peter C. Simpson ,  Joshua Ray Windmiller ,  Nai-Jen Chang ,  Jie Zhu ,  Matthew S. Brown ,  Eric Ruike Zhao

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/256 ,  A61B5/257

CPC classification number: A61B5/1451 ,  A61B5/14865 ,  A61B5/14532 ,  A61B5/256 ,  A61B5/257 ,  A61B5/14546

Abstract: Disclosed herein are systems and methods for a continuous analyte monitoring system for measuring a concentration of a first analyte and concentration of a second analyte in a host. One such system utilizes a working electrode and a reference electrode to measure glucose concentration and oxygen concentration in bodily fluid of a host. The system includes a sensor control circuit that applies a first bias condition to the sensor to measure a first signal generated by the sensor indicative of a concentration of the first analyte. The sensor control circuit also applies a second bias condition to the sensor to measure a second signal generated by the sensor indicative of a concentration of a second analyte at the host.

公开(公告)号：US20210015407A1

公开(公告)日：2021-01-21

申请号：US16929906

申请日：2020-07-15

Applicant: DexCom, Inc.

Inventor： Sebastian Bohm ,  Wenjie Lan ,  Thomas Robert Porter ,  Daiting Rong ,  Jason Halac

IPC: A61B5/145 ,  A61B5/1468 ,  C09D133/08 ,  C09D5/00 ,  C09D135/02 ,  C09D181/08 ,  C09D185/02

Abstract: Various examples are directed to a glucose sensor comprising a working electrode to support an oxidation reaction and a reference electrode to support a redox reaction. The reference electrode may comprise silver and silver chloride. The Glucose sensor may also comprise an anti-mineralization agent positioned at the reference electrode to reduce formation of calcium carbonate at the reference electrode.